- Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult ageC Tourrel
Laboratory of Physiopathology of Nutrition, Centre National de la Recherche Scientifique ESA 7059, Université Paris7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
Diabetes 50:1562-70. 2001..Further studies are needed to understand the dissociation between beta-cell regeneration and the lack of improvement in beta-cell function...
- Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4Cécile Tourrel
LPPN, CNRS UMR 7059, Universite Paris 7, Paris, France
Diabetes 51:1443-52. 2002..Under these conditions, GLP-1 represents a unique tool because of its beta-cell replenishing effect in spontaneously diabetic rodents. It may prove to be an invaluable agent for the prevention of human type 2 diabetes...