Research Topics
Species | Jean Nicolas TournierSummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
Fever-like thermal conditions regulate the activation of maturing dendritic cellsJean Nicolas Tournier
Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, La Tronche Cedex, France
J Leukoc Biol 73:493-501. 2003..These results provide evidence that temperature regulates cytokine secretion and DC functions, both of which are of particular importance in bacterial diseases...- Contribution of toxins to the pathogenesis of inhalational anthraxJean Nicolas Tournier
Pôle interactions hôte pathogènes, Département de Biologie des Agents Transmissibles, CRSSA, F 38702 La Tronche Cedex, France
Cell Microbiol 9:555-65. 2007..The pathophysiology of inhalational anthrax thus involves interactions between toxins and various cell partners, throughout the course of infection... 
Microenvironmental impact on lung cell homeostasis and immunity during infectionJean Nicolas Tournier
Centre de Recherches du Service de Santédes Armées, Unité Interactions Hôte Pathogène, La Tronche, France
Expert Rev Vaccines 7:457-66. 2008..We thus focus on the dynamics of such cellular interactions within the lung and stress the critical role played by airway epithelial cells in modulating immunity...- Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cellsJean Nicolas Tournier
Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, La Tronche Cedex, France
J Immunol 174:4934-41. 2005..These results suggest that ET produced during infection impairs DC functions and cooperates with LT to suppress the innate immune response. This may represent a new strategy developed by B. anthracis to escape the host immune response... - Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracisJean Nicolas Tournier
CRSSA, Unité Interactions Hôte Pathogène, Département de Biologie des Agents Transmissibles, BP 87, F 38702 La Tronche, France
Expert Rev Anti Infect Ther 7:219-36. 2009..anthracis, which will logically lead to better vaccines (and therapeutics), there also needs to be the same level of open-mindedness applied to the politics of anthrax... 
Host-pathogen interactions: a biological rendez-vous of the infectious nonself and danger models?Jean Nicolas Tournier
Unité interactions hôtepathogène, Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, Grenoble, France
PLoS Pathog 2:e44. 2006- [Anthrax revisited: Bacillus anthracis toxins as novel actors of immune escape?]Jean Nicolas Tournier
Département de Biologie des Agents Transmissibles, CRSSA, 38702 La Tronche cedex France
Bull Acad Natl Med 190:155-63; discussion 163-7. 2006..Next, we address the main results concerning the toxin effects on immune system through impairing the dendritic cell functions, and we analyze the singular role of anthrax toxins in immune evasion... - Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary routeAurelie Cleret
Unité Interactions Hôte Pathogène, Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, 38702 La Tronche, France
J Immunol 178:7994-8001. 2007..Our results demonstrate that LDCs are central to spore transport immediately after infection. The rapid kinetics of pathogen transport may contribute to the clinical features of inhalational anthrax... - Resident CD11c+ lung cells are impaired by anthrax toxins after spore infectionAurelie Cleret
, , , La Tronche, France
J Infect Dis 194:86-94. 2006..Similar results were obtained after preincubation with purified toxins. Our results suggest that anthrax toxins secreted during infection impair LDC function and suppress the innate immune response... 
Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthraxKévin Garraud
Unité Interactions Hôte Agents Pathogènes, Institut de Recherche Biomédicale des Armées, Centre de Recherches du Service de Sante des Armees, La Tronche, France
Infect Immun 80:131-42. 2012..anthracis. This work demonstrates the important roles of both IL-17 signaling and neutrophils in clearing this pathogen and surviving pulmonary B. anthracis infection...- Efficacy of a vaccine based on protective antigen and killed spores against experimental inhalational anthraxYves P Gauthier
Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Santé des Armées Emile Pardé, 38702 La Tronche, France
Infect Immun 77:1197-207. 2009..Conversely, immunization with PA alone did not elicit protection. These results demonstrate that the association of PA and spores is very much more effective than PA alone against experimental inhalational anthrax... - Anthrax toxins: a weapon to systematically dismantle the host immune defensesJean Nicolas Tournier
Unité Interactions Hôte Pathogène, Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, 38702 La Tronche, France
Mol Aspects Med 30:456-66. 2009..We also discuss some open issues which should be addressed to gain a comprehensive insight into the complex relationship that B. anthracis establishes with the host... - Cytoskeleton as an emerging target of anthrax toxinsYannick Trescos
Unité Interactions Hôte Agents Pathogènes, Institut de Recherche Biomédicale des Armées, Centre de Recherche du Service de Sante des Armees, BP 87, 24 avenue des Maquis du Grésivaudan 38702 La Tronche Cedex, France
Toxins (Basel) 4:83-97. 2012..We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity... - Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccinesAudrey Ferrier Rembert
Unité de virologie, Centre de Recherches du Service de Santé des Armées CRSSA Emile Pardé, F 38702 Grenoble, France
Vaccine 25:4809-17. 2007..These studies show that the CPXV/mouse model is valuable for the initial assessment of smallpox vaccines... - Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccineAudrey Ferrier-Rembert
Unité de virologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, F 38702 Grenoble, France
Vaccine 26:1794-804. 2008..Further investigations are necessary with MVA to determine the optimal conditions of immunisation to induce at long-term immunogenicity and protection observed with the 1st generation smallpox vaccine... - Evidence for adjuvanticity of anthrax edema toxinAnne Quesnel-Hellmann
, , , BP87, F-38702 La Tronche cedex; France
Vaccine 24:699-702. 2006..These results clearly show an adjuvant effect of EF, which is consistent with the data concerning the cellular effects of EF on antigen-presenting cells...