Y Touitou

Summary

Country: France

Publications

  1. doi request reprint [Dysfunctions of biological clocks and their treatments]
    Y Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculte de Medecine Pierre et Marie Curie, Inserm U 713, Paris, France
    Ann Pharm Fr 66:146-57. 2008
  2. ncbi request reprint [Evaluation of the effect of magnetic fields on the secretion of melatonin in humans and rats. Circadian study]
    Yvan Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 91 Bld de l Hôpital 75634 Paris
    Bull Acad Natl Med 186:1625-39; discussion 1639-41. 2002
  3. ncbi request reprint [Melatonin: what for?]
    Yvan Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75013 Paris
    Bull Acad Natl Med 189:879-89; discussion 889-91. 2005
  4. ncbi request reprint Human aging and melatonin. Clinical relevance
    Y Touitou
    Department of Biochemistry, Faculty of Medicine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Exp Gerontol 36:1083-100. 2001
  5. ncbi request reprint [Sleep disorders and hypnotic agents: a real public health issue]
    Y Touitou
    Président de l Académie nationale de Pharmacie, 4, avenue de l Observatoire, 75006 Paris
    Ann Pharm Fr 65:228-9. 2007
  6. ncbi request reprint Ethics, standards, and procedures of animal and human chronobiology research
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Pitie Salpetriere, Paris, France
    Chronobiol Int 23:1083-96. 2006
  7. ncbi request reprint Promoting adjustment of the sleep-wake cycle by chronobiotics
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine Pierre and Marie Curie Pitie Salpetriere, and INSERM U 713 Douleurs et stress, 91 Boulevard de l Hopital, 75013, Paris, France
    Physiol Behav 90:294-300. 2007
  8. ncbi request reprint Is melatonin the hormonal missing link between magnetic field effects and human diseases?
    Y Touitou
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie et Biologie Moléculaire, 91 bouleavrd de l Hôpital, 75013, Paris, France
    Cancer Causes Control 17:547-52. 2006
  9. ncbi request reprint Magnetic fields and the melatonin hypothesis: a study of workers chronically exposed to 50-Hz magnetic fields
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine Pitié Salpêtrière, 75013 Paris, France
    Am J Physiol Regul Integr Comp Physiol 284:R1529-35. 2003
  10. ncbi request reprint Cortisol secretion in the elderly. Influence of age, sex and cardiovascular disease in a Chinese population
    Zi Yan Zhao
    Anti Senility Research Center of Shandong, Shandong Academy of Medical Sciences, 250062, Jinan, PR China
    Steroids 68:551-5. 2003

Collaborators

Detail Information

Publications67

  1. doi request reprint [Dysfunctions of biological clocks and their treatments]
    Y Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculte de Medecine Pierre et Marie Curie, Inserm U 713, Paris, France
    Ann Pharm Fr 66:146-57. 2008
    ..Other drugs like B12 vitamin or psychotropic drugs have also been proposed as chronobiotics...
  2. ncbi request reprint [Evaluation of the effect of magnetic fields on the secretion of melatonin in humans and rats. Circadian study]
    Yvan Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 91 Bld de l Hôpital 75634 Paris
    Bull Acad Natl Med 186:1625-39; discussion 1639-41. 2002
    ....
  3. ncbi request reprint [Melatonin: what for?]
    Yvan Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75013 Paris
    Bull Acad Natl Med 189:879-89; discussion 889-91. 2005
    ..1-1.6). Other studies are required to confirm these results...
  4. ncbi request reprint Human aging and melatonin. Clinical relevance
    Y Touitou
    Department of Biochemistry, Faculty of Medicine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Exp Gerontol 36:1083-100. 2001
    ..Melatonin also has free radical-scavenging properties that have primarily been observed in vitro at pharmacological concentrations...
  5. ncbi request reprint [Sleep disorders and hypnotic agents: a real public health issue]
    Y Touitou
    Président de l Académie nationale de Pharmacie, 4, avenue de l Observatoire, 75006 Paris
    Ann Pharm Fr 65:228-9. 2007
  6. ncbi request reprint Ethics, standards, and procedures of animal and human chronobiology research
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Pitie Salpetriere, Paris, France
    Chronobiol Int 23:1083-96. 2006
    ....
  7. ncbi request reprint Promoting adjustment of the sleep-wake cycle by chronobiotics
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine Pierre and Marie Curie Pitie Salpetriere, and INSERM U 713 Douleurs et stress, 91 Boulevard de l Hopital, 75013, Paris, France
    Physiol Behav 90:294-300. 2007
    ....
  8. ncbi request reprint Is melatonin the hormonal missing link between magnetic field effects and human diseases?
    Y Touitou
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie et Biologie Moléculaire, 91 bouleavrd de l Hôpital, 75013, Paris, France
    Cancer Causes Control 17:547-52. 2006
    ..It is unlikely that malignancies or mood disorders reported by people exposed to 50/60-Hz EMF could be related to the disruption of the melatonin levels...
  9. ncbi request reprint Magnetic fields and the melatonin hypothesis: a study of workers chronically exposed to 50-Hz magnetic fields
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine Pitié Salpêtrière, 75013 Paris, France
    Am J Physiol Regul Integr Comp Physiol 284:R1529-35. 2003
    ....
  10. ncbi request reprint Cortisol secretion in the elderly. Influence of age, sex and cardiovascular disease in a Chinese population
    Zi Yan Zhao
    Anti Senility Research Center of Shandong, Shandong Academy of Medical Sciences, 250062, Jinan, PR China
    Steroids 68:551-5. 2003
    ..These results suggest that age (older than 60 years), disease and male sex are associated with increased morning serum cortisol levels in a Chinese population...
  11. ncbi request reprint [Evaluation of the effects of electric and magnetic fields in humans]
    Y Touitou
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, Paris
    Ann Pharm Fr 62:219-32. 2004
    ..Large-scale studies, implying numerous countries, carried on at present within the framework of the WHO should bring elements of answer to the unresolved questions...
  12. ncbi request reprint [Sleep disorders and hypnotic agents: medical, social and economical impact]
    Y Touitou
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, Inserm U 713, 91, Boulevard de l Hopital, F 75634 Paris Cedex 13
    Ann Pharm Fr 65:230-8. 2007
    ....
  13. ncbi request reprint Ethical principles and standards for the conduct of human and animal biological rhythm research
    Yvan Touitou
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Pitie Salpetriere, Paris, France
    Chronobiol Int 21:161-70. 2004
    ....
  14. ncbi request reprint Circadian rhythms of body temperature and motor activity in rodents their relationships with the light-dark cycle
    C Benstaali
    , , Paris, France
    Life Sci 68:2645-56. 2001
    ..The purpose of this review is to summarize the results obtained on the circadian rhythms of body temperature and motor activity throughout the daily cycle in order to clarify the relationships between these two functions...
  15. ncbi request reprint Endocrine functions in young men exposed for one night to a 50-Hz magnetic field. A circadian study of pituitary, thyroid and adrenocortical hormones
    B Selmaoui
    , , Paris, France
    Life Sci 61:473-86. 1997
    ....
  16. ncbi request reprint Melatonin synthesis in the rat harderian gland: age- and time-related effects
    Y Djeridane
    , , , 91, , Paris, 75013, France
    Exp Eye Res 72:487-92. 2001
    ..This study shows that, by contrast to the pineal gland, melatonin in Wistar rat Harderian gland does not exhibit daily variations and that aging does not affect the melatonin content of the gland...
  17. ncbi request reprint Effect of age and photoperiodic conditions on metabolism and oxidative stress related markers at different circadian stages in rat liver and kidney
    C Martin
    Laboratoire de Toxicologie, Faculte de Pharmacie, Universite Paris V, 4 avenue de l Observatoire, 75006 Paris, France
    Life Sci 73:327-35. 2003
    ..The observed variations in metabolism parameters underline the need for study designs in pharmaco-toxicology taking into account the possible risks induced by circadian changes, especially in aged subjects...
  18. ncbi request reprint Light pulse induces ALA-S gene expression in the rat Harderian gland
    Y Djeridane
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, INSERM UMRS 975, Paris, France
    J Physiol Pharmacol 61:115-7. 2010
    ..Our results suggest that light per se may regulate ALA-S gene expression in the rat HGs, and reveal that the ALA-S gene expression, and so heme biosynthesis, is under a photodynamic control...
  19. ncbi request reprint In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues
    A Bogdan
    Biochemical Department, , Paris, France
    J Endocrinol Invest 16:65-8. 1993
    ..Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability...
  20. pmc Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens
    Y Touitou
    Department of Biochemistry, , Paris, France
    Br J Cancer 74:1248-52. 1996
    ..The question thus arises as to the origin of these alterations, and whether they are related to a cause or a consequence of the disease, and their possible incidence upon therapeutic designs...
  21. ncbi request reprint Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats
    Y Djeridane
    Faculty of Medicine Pitié Salpêtrière, Medical Biochemistry and Molecular Biology, Paris, France
    J Endocrinol Invest 26:211-5. 2003
    ..Our results suggest that the pineal tetrapeptide Ala-Glu-Asp-Gly, does not seem to play a role, at least in vitro, in the control of melatonin secretion by the rat pineal gland...
  22. ncbi request reprint Impairment in clock-time estimation following right hemisphere ischemic damage
    C Morin
    Médecine Physique et Réadaptation Groupe Hospitalier Pitié Salpêtrière AP HP, Paris, France
    Brain Res Cogn Brain Res 22:305-7. 2005
    ..CTE, and not duration estimation, was disturbed in patients. RH patients made significantly more pathological advance errors than LH patients (43% vs. 12%). This study points out the RH dominance for CTE in stroke patients...
  23. ncbi request reprint Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder
    Sylvie Tordjman
    Center for Scientific Research, Unité de Recherche Mixte 7593, Vurnérabilité, Adaptation et Psychopathologie, Hopital Pitie Salpetriere, Rennes, France
    Biol Psychiatry 57:134-8. 2005
    ..Additionally, melatonin, a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology...
  24. doi request reprint Desynchronization of daily rest-activity rhythm in the days following light propofol anesthesia for colonoscopy
    G Dispersyn
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, Paris, France
    Clin Pharmacol Ther 85:51-5. 2009
    ..Light general anesthesia itself impairs synchronization of the circadian rest-activity rhythm to local time in patients by acting directly on the circadian clock...
  25. ncbi request reprint Role of school schedule, age, and parental socioeconomic status on sleep duration and sleepiness of Parisian children
    N Guerin
    Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Chronobiol Int 18:1005-17. 2001
    ..Overall, the sleep of this sample of Parisian children around 10 years of age was rather stable in its duration and timing, suggesting flexibility to adjust to the different school schedules...
  26. ncbi request reprint Isoproterenol-stimulated melatonin production by perifused rat pineal glands: age- and time-related effects
    Lobna Naïri-Skandrani
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie Medicale et Biologie Moleculaire, 91, Boulevard de l Hopital, 75013, Paris, France
    Neuro Endocrinol Lett 25:257-61. 2004
    ..The purpose of this study was to investigate and compare the effects of the beta-adrenergic agonist, isoproterenol, on induced increase in melatonin production in the pineal gland of young and old rats, at different circadian stages...
  27. ncbi request reprint Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30 to 60 years. A cross-sectional study
    Zi Yan Zhao
    Anti Senility Research Center of Shandong, Shandong Academy of Medical Sciences, 250062 Jinan, PR China
    Steroids 68:133-8. 2003
    ....
  28. ncbi request reprint Aging and the circadian rhythm of melatonin: a cross-sectional study of Chinese subjects 30-110 yr of age
    Zi Yan Zhao
    Anti Senility Research Center of Shandong, Shandong Academy of Medical Sciences, 250062 Jinan, PR China
    Chronobiol Int 19:1171-82. 2002
    ..No significant difference was found among the three younger groups, but nocturnal melatonin levels were significantly lower in the men in their 60s...
  29. ncbi request reprint Effect of a short photoperiod on circadian rhythms of body temperature and motor activity in old rats
    C Benstaali
    Service de Biochimie Medicale, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Pflugers Arch 444:73-9. 2002
    ..Our data show that the circadian rhythm of motor activity, but not of body temperature, responds age dependently to a photoperiod reduction...
  30. ncbi request reprint Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans?
    A Bogdan
    Laboratoire de Biochimie, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Life Sci 68:1607-15. 2001
    ..These data show that daytime fasting, modifications in sleep schedule and psychological and social habits during Ramadan induce changes in the rhythmic pattern of a number of hormonal variables...
  31. ncbi request reprint Old rats are more sensitive to photoperiodic changes. A study on pineal melatonin
    Yasmina Djeridane
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie Medicale et Biologie Moleculaire, 91 Boulevard de l Hopital, 75013 Paris, France
    Exp Gerontol 40:403-8. 2005
    ....
  32. ncbi request reprint Age-related modifications of circadian rhythm of serum leptin in healthy men
    Zi Yan Zhao
    Anti Senility Research Center of Shandong, Shandong Academy of Medical Sciences, Jinan, People s Republic of China
    Gerontology 48:309-14. 2002
    ..Leptin, the product of the ob gene, is secreted by the adipocyte and is involved in the regulation of body weight, energy homeostasis and a wide spectrum of biological activities...
  33. ncbi request reprint Lack of effect of ghrelin treatment on melatonin production in rat pineal and Harderian glands
    Yasmina Djeridane
    Faculte de Medecine, Pitie Salpetriere, Service de Biochimie Medicale et Biologie Moleculaire, 91, Boulevard de l Hopital, 75013, Paris, France
    Life Sci 76:2393-401. 2005
    ..At the concentrations used, ghrelin does not influence melatonin production in rat pineal and Harderian glands, and therefore is not involved in the regulation of melatonin secretion, at least under our experimental conditions...
  34. ncbi request reprint Hypoxic alterations of cortisol circadian rhythm in man after simulation of a long duration flight
    Olivier Coste
    Service de Biochimie et Biologie Moléculaire, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex, France
    Steroids 70:803-10. 2005
    ..Our data, which strongly suggest that prolonged mild hypoxia alters the expression of cortisol circadian rhythm, should be taken into account to interpret secretory rhythm changes after transmeridian flights...
  35. ncbi request reprint Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study
    Yasmina Djeridane
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie Médicale et Biologic Moléculaire, Boulevard de l Hopital, Paris, France
    Chronobiol Int 20:285-97. 2003
    ..The results also show that the control of melatonin production in the Harderian glands differ from that observed in the pineal gland...
  36. doi request reprint General anesthetics effects on circadian temporal structure: an update
    Garance Dispersyn
    Facult de Médecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, INSERM U713, Paris, France
    Chronobiol Int 25:835-50. 2008
    ..This topic is highly relevant to clinicians, especially those involved in that field of ambulatory practice responsible for post-operative patient care, including patient recovery and fatigue...
  37. ncbi request reprint Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks
    Brahim Selmaoui
    Faculté de Médecine Pitié Salpêtrière, Service de Biochimie Medicale et Biologie Moleculaire, 91 Boulevard de l Hôpital 75634 Paris Cedex 13, France
    Life Sci 73:3339-49. 2003
    ..Our study clearly shows that these hormones can be considered to be stable markers of the circadian time structure and therefore useful tools to validate rhythms' synchronisation of human subjects...
  38. ncbi request reprint Daily profiles of salivary and urinary melatonin and steroids in healthy prepubertal boys
    Yvan Touitou
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Médicale et Biologie Moléculaire and INSERM UMRS 975, Paris, France
    J Pediatr Endocrinol Metab 22:1009-15. 2009
    ..The data are of interest for the diagnosis and treatment of chronobiological disorders in prepubertal children...
  39. ncbi request reprint Ex vivo studies on the acute and chronic effects of DHEA and DHEA-sulfate on melatonin synthesis in young- and old-rat pineal glands
    Yasmina Djeridane
    Faculte de Medecine, Pitie Salpetriere, Service de Biochimie Medicale et Biologie Moleculaire, 91 Boulevard de l Hopital, 75013 Paris, France
    Steroids 69:343-9. 2004
    ..This work shows that DHEA-S (and not DHEA) is able, at pharmacological concentrations, to stimulate melatonin production by rat pineal glands regardless of the age of the animals...
  40. ncbi request reprint Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma
    Y Touitou
    , , Paris, France
    Horm Metab Res 21:272-4. 1989
    ..This is a rare and unusual case of adrenal pathology showing that a deficiency in 11 beta-hydroxylase activity does not rule out the presence of an adrenocortical adenoma...
  41. ncbi request reprint Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat
    C Becker
    , , Cellulaire et Fonctionnelle, , , 75634 Paris Cedex 13, France
    J Neurosci 21:262-9. 2001
    ..These data indicate that anticipation of social defeat induces a marked activation of cortical CCKergic neurons associated with anxiety-related behaviors in rats...
  42. doi request reprint Propofol anesthesia significantly alters plasma blood levels of melatonin in rats
    Garance Dispersyn
    Chronobiology Unit, Fondation Ophtalmologique A de Rothschild, 29 rue Manin, Paris, France
    Anesthesiology 112:333-7. 2010
    ..In this study, we examined the secretion of melatonin during 24 h after a 30-min propofol anesthesia in rats...
  43. ncbi request reprint Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects
    Isabelle Arnulf
    AP HP, centre d investigation clinique, Fédération des Pathologies du Sommeil et UPRES EA 2397, Paris, France
    Neuropsychopharmacology 27:843-51. 2002
    ....
  44. ncbi request reprint Chronobiology of alcohol: from chronokinetics to alcohol-related alterations of the circadian system
    Thierry Danel
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Chronobiol Int 21:923-35. 2004
    ..The concepts of chronopharmacology and chronotoxicology are of equal importance to the fields of occupational medicine and industry medicine...
  45. ncbi request reprint Hypoxic depression of melatonin secretion after simulated long duration flights in man
    Olivier Coste
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Pineal Res 37:1-10. 2004
    ..Our findings suggest that hypoxia may by itself contribute at least in part to postflight fatigue after long duration flights, and to the clinical disorders of jet lag in transmeridian flights through its effects on the circadian system...
  46. ncbi request reprint Human immune circadian system in prolonged mild hypoxia during simulated flights
    Olivier Coste
    Service de Biochimie Medicale et Biologie Moleculaire, Faculte de Medecine Pierre et Marie Curie, Paris, France
    Chronobiol Int 24:87-98. 2007
    ..Therefore, the authors conclude that mild hypobaric hypoxia does not seem to be responsible for any quantitative changes during long-haul flights in the immune assays commonly used in routine clinical medicine practice...
  47. ncbi request reprint Daily variation in the concentration of neuropeptide Y in the rat atrium: effects of age and photoperiodic conditions
    Yasmina Djeridane
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75013 Paris, France
    Peptides 25:1153-7. 2004
    ..In this paper we show that NPY concentrations in the rat atrium exhibit daily variations, which are maintained with ageing. Moreover, photoperiod greatly influences NPY levels in the atrium...
  48. ncbi request reprint Alcohol decreases the nocturnal peak of TSH in healthy volunteers
    Thierry Danel
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, 75013, Paris, France
    Psychopharmacology (Berl) 170:213-4. 2003
    ..Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night...
  49. ncbi request reprint Response of circulating leptin to Ramadan daytime fasting: a circadian study
    André Bogdan
    Laboratoire de Biochimie, Faculté de Médecine Pitié Salpétrière 91 boulevard de l Hôpital, 75013 Paris, France
    Br J Nutr 93:515-8. 2005
    ..No significant changes in amplitude or 24 h mean concentration were seen, but significant shifts of 5 h 30 min in peak and trough serum leptin levels were found on the twenty-third day of Ramadan...
  50. ncbi request reprint Prolonged mild hypoxia modifies human circadian core body temperature and may be associated with sleep disturbances
    Olivier Coste
    Service de Biochimie Medicale et Biologie Moleculaire, Faculté de Médecine Pitié Salpêtrière, Paris Cedex, France
    Chronobiol Int 21:419-33. 2004
    ..Mild hypoxia may therefore alter circadian structure and result in sleep disturbances. These results may explain in part the frequent complaints of prolonged post-flight fatigue after long flights, even when no time zones are crossed...
  51. ncbi request reprint Temporal pattern in consumption of the first drink of the day in alcohol-dependent persons
    Thierry Danel
    Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Pitié Salpêtrière, Paris, France
    Chronobiol Int 20:1093-102. 2003
    ..This rhythmicity seems to be a pertinent criterion for alcohol dependence syndrome...
  52. doi request reprint Melatonin and environmental lighting regulate ALA-S gene expression and So porphyrin biosynthesis in the rat harderian gland
    Said Lyoumi
    INSERM U 773, Centre de recherche Biomedicale Bichat Beaujon, Univ Paris Diderot, Paris, France
    Chronobiol Int 25:851-67. 2008
    ..Continuous light exposure abolishes the day-night ALA-S variation in the HG that is observed under standard 12 L:12 D conditions. Our results suggest that melatonin and environmental lighting regulate ALA-S gene expression in the rat HG...
  53. doi request reprint Circadian disruption of body core temperature and rest-activity rhythms after general (propofol) anesthesia in rats
    Garance Dispersyn
    Department of Biochemistry and Molecular Biology, Faculty of Medicine Pierre and Marie Curie, INSERM U713, Paris, France
    Anesthesiology 110:1305-15. 2009
    ..The authors examined whether general (propofol) anesthesia can impact the circadian temporal structure by disturbing circadian rest-activity and body temperature rhythms under normal light-dark conditions (light-dark 12:12 h) in rats...
  54. doi request reprint Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night
    Wafa Gadacha
    Laboratoire de Biochimie Médicale et Biologie Moléculaire, INSERM U 13, Faculte de Medecine Pierre et Marie Curie, Paris, France
    Redox Rep 14:154-8. 2009
    ..Resveratrol behaved as an antioxidant during the dark span and as a pro-oxidant during the light span. These data suggested a day/night rhythm in basal lipoperoxidation and in resveratrol antioxidant effect...
  55. doi request reprint Twenty-four-hour profiles of urinary excretion of calcium, magnesium, phosphorus, urea, and creatinine in healthy prepubertal boys
    Yvan Touitou
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Médicale et Biologie Moléculaire and Unité de Chronobiologie, Fondation Ophtalmologique A de Rothschild, 29 rue Manin, 75019 Paris, France
    Clin Biochem 43:102-5. 2010
    ..We thus documented the daily and overnight variations of urinary electrolytes (calcium, magnesium, and phosphorus), urea, and creatinine in prepubertal (Tanner stage I) boys...
  56. ncbi request reprint Diazepam affects both level and amplitude of rat locomotor activity rhythm but has no effect on core body temperature
    Yasmina Djeridane
    Faculte de Medecine, Pitie Salpetriere, Service de Biochimie Médicale et Biologie Moléculaire and INSERM U713, Paris, France
    Chronobiol Int 22:975-85. 2005
    ..The fact that diazepam affects locomotor activity, but not core body temperature, suggests that different mechanisms mediate the actions of diazepam on locomotor activity and on core body temperature...
  57. ncbi request reprint Impact of hypobaric hypoxia in pressurized cabins of simulated long-distance flights on the 24 h patterns of biological variables, fatigue, and clinical status
    Olivier Coste
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, Paris Cedex, France
    Chronobiol Int 24:1139-57. 2007
    ..Finally, though the observed biochemical changes were significant, their clinical relevance must be clarified in studies involving actual long-distance flights...
  58. ncbi request reprint Simulation of long-haul flights in humans: prolonged mild hypoxia does not alter the circadian time structure of plasma testosterone and gonadotrophins
    Olivier Coste
    Service de Biochimie Médicale et Biologie Moléculaire and INSERM U 713, Faculte de Medecine Pierre et Marie Curie, 75634 Paris Cedex 13, France
    Steroids 71:214-21. 2006
    ..We found no significant effects of hypoxia on the circadian profile of the gonadal axis hormones and, therefore, conclude that these hormones do not serve as valuable markers of post-flight alterations of the circadian system in human...
  59. doi request reprint Influence of electromagnetic fields emitted by GSM-900 cellular telephones on the circadian patterns of gonadal, adrenal and pituitary hormones in men
    Yasmina Djeridane
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, INSERM U713, 75013, Paris, France
    Radiat Res 169:337-43. 2008
    ..Our data show that the 900 MHz EMF exposure, at least under our experimental conditions, does not appear to affect endocrine functions in men...
  60. ncbi request reprint Cortisol diurnal variation in blood and saliva of patients with metastatic colorectal cancer: relevance for clinical outcome
    Marie Christine Mormon
    INSERM EPI 0118 Chronothérapeutique des cancers and Chronotherapy Unit, Federation des Maladies Sanguines et Tumorales, Villejuif, France
    Anticancer Res 22:1243-9. 2002
    ..In order to confirm these results in a non-hormone-dependent cancer, cortisol concentrations in serum and saliva were compared at different circadian stages, in patients with metastatic colorectal cancer. Patients and..
  61. ncbi request reprint Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status
    Marie Christine Mormont
    INSERM EPI 0118 Cancer Chronotherapeutics, Universite Paris XI, Hĵpital Paul Brousse, Villejuif, France
    Chronobiol Int 19:141-55. 2002
    ..Such 24h rhythm alterations appeared to be independent of conventional clinical factors...
  62. ncbi request reprint Alcohol consumption does not affect melatonin circadian synchronization in healthy men
    Thierry Danel
    Service d Addictologie, CHRU de Lille, 59037 Lille Cedex, France
    Alcohol Alcohol 41:386-90. 2006
    ....
  63. ncbi request reprint The phasing of circadian rhythms in mice kept under normal or short photoperiods
    Dietmar Weinert
    Institute of Zoology, Martin Luther University Halle Wittenberg, Germany
    Physiol Behav 84:791-8. 2005
    ..Also, the results are in good accordance with a modified two-oscillator model where lights-off triggers advances of an evening oscillator and lights-on delays a morning oscillator...
  64. ncbi request reprint Day-night variations of urinary glycosaminoglycans in healthy young men
    Yasmina Djeridane
    Clin Chim Acta 349:213-4. 2004
  65. ncbi request reprint Responses of the steroid circadian system to alcohol in humans: Importance of the time and duration of intake
    Thierry Danel
    Service d Endocrinologie et Maladies Métaboliques, Centre Hospitalier Regional Universitaire, 59037 Lille Cedex, France
    Chronobiol Int 23:1025-34. 2006
    ....
  66. ncbi request reprint Tumor antigen markers for the detection of solid cancers in inflammatory myopathies
    Zahir Amoura
    Service de Medecine Interne, Hopital Pitie Salpetriere, 47 83 Bd de l Hopital, 75013 Paris, France
    Cancer Epidemiol Biomarkers Prev 14:1279-82. 2005
    ....
  67. ncbi request reprint Aging and photoperiod affect the daily rhythm pattern of atrial natriuretic peptide in the rat atrium
    Hayet Soualmia
    Institut Supérieur des Technologies Médicales, Tunis, Tunisia
    Peptides 28:2356-60. 2007
    ..In conclusion, our results show that ANP concentrations in the rat atrium exhibit daily variations which are significantly affected by the daylength (photoperiod) change in aged rats...