Genomes and Genes


Chafia Touil-Boukoffa


Country: France


  1. Djaballah Ider F, Djaballah A, Djeraba Z, Chaib S, Touil Boukoffa C. Auto-immunity profile evaluation during different clinical manifestations of Behçet disease in Algerian patients: effect of corticosteroid treatment. Inflammopharmacology. 2019;: pubmed publisher
    ..Collectively, our data indicate the importance of evaluating the corticosteroid effect on immune responses associated with BD to ensure an adequate investigation of each related clinical manifestation. ..
  2. Benkhelifa S, Rafa H, Belhadef S, Ait Kaci H, Medjeber O, Belkhelfa M, et al. Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy. Inflammopharmacology. 2019;: pubmed publisher
    ..Thus, we suggest that iNOS/NO system may represent an attractive candidate biomarker for monitoring CRC progression, malignity and response to therapy. ..
  3. Boutemine I, Amri M, Amir Z, Fitting C, Mecherara Idjeri S, Layaida K, et al. Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats. J Ethnopharmacol. 2018;224:273-282 pubmed publisher
    ..Importantly, the mechanism underlying PLFO activities might implicate inhibition of inflammatory responses during gastric ulcer. ..
  4. Labsi M, Soufli I, Khelifi L, Amir Z, Touil Boukoffa C. In vivo treatment with IL-17A attenuates hydatid cyst growth and liver fibrogenesis in an experimental model of echinococcosis. Acta Trop. 2018;181:6-10 pubmed publisher
    ..Collectively, our results indicate an antihydatic effect and immunoprotective properties of IL-17A and suggest its potential therapeutic value against Echinococcus granulosus infection. ..
  5. Benchabane S, Belkhelfa M, Belguendouz H, Zidi S, Boudjelida A, Youinou P, et al. Interferon-β inhibits inflammatory responses mediators via suppression of iNOS signaling pathway in PBMCs from patients with primary Sjögren's syndrome. Inflammopharmacology. 2018;26:1165-1174 pubmed publisher
    ..Our data suggest that IFN-β could represent a potential candidate for targeting inflammation during pSS. ..
  6. Belkhelfa M, Beder N, Mouhoub D, Amri M, Hayet R, Tighilt N, et al. The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia. J Neuroimmunol. 2018;320:48-57 pubmed publisher
    ..Finally, the finding of necroptosis by impaired blood supply and inflammation state suggests that the cognitive impairment was caused by vascular disease and neuroinflammation. ..
  7. Touri K, Belguendouz H, Medjeber O, Djeraba Z, Lahmar K, Touil Boukoffa C. Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. Inflammopharmacology. 2018;26:1293-1303 pubmed publisher
    ..Hence, it appears that EEP attenuated retinal damages through the induction of Th2 response and the inhibition of NF-κB/NOS2 pathway. ..
  8. Djaballah Ider F, Djeraba Z, Chemli M, Dammene Debbihe N, Lounis D, Belguendouz H, et al. Influence of corticosteroid therapy on IL-18 and nitric oxide production during Behçet's disease. Inflammopharmacology. 2018;26:725-735 pubmed publisher
    ..Moreover, the relationship between these two inflammatory markers could constitute a predictable tool of BD clinical presentations and an early factor of therapy efficiency. ..
  9. Amri M, Touil Boukoffa C. A protective effect of the laminated layer on Echinococcus granulosus survival dependent on upregulation of host arginase. Acta Trop. 2015;149:186-94 pubmed publisher
    ..Our results indicate that the laminated layer protects E. granulosus against the NOS2 protective response through Arginase pathway, a hallmark of M2 macrophages. ..

More Information


  1. Ahmedi M, Belguendouz H, Messaoudene D, Mesbah Amroun H, Terahi M, Lahlou Boukoffa O, et al. [Influence of steroid hormones on the production of two inflammatory markers, IL-12 and nitric oxide, in Behçet's disease]. J Fr Ophtalmol. 2016;39:333-40 pubmed publisher
    ..In fact, male patients seem to have defective IL-12 down-regulation by estradiol and cortisol that increases Th1 immune responses. This may be implicated in the severe expression of BD in men. ..
  2. Medjeber O, Touri K, Rafa H, Djeraba Z, Belkhelfa M, Boutaleb A, et al. Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway. Inflammopharmacology. 2018;26:1469-1481 pubmed publisher
    ..Therefore, we suggest that propolis may constitute a potential candidate to modulate inflammation during Celiac Disease and has a potential therapeutic value. ..
  3. Behairi N, Belkhelfa M, Rafa H, Labsi M, Deghbar N, Bouzid N, et al. All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats. J Neuroimmunol. 2016;300:21-29 pubmed publisher
    ..Interestingly, ATRA pretreatment prevented the LPS-induced deleterious effects. ATRA could be a potent preventive approach in AD. ..
  4. Amri M, Touil Boukoffa C. In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pac J Trop Med. 2016;9:749-56 pubmed publisher
    ..Ginger may act, at least, through the [6]-gingerol. All our data suggest the promising use of ginger in the treatment of Echinococcus granulosus infection. ..
  5. Benchabane S, Boudjelida A, Toumi R, Belguendouz H, Youinou P, Touil Boukoffa C. A case for IL-6, IL-17A, and nitric oxide in the pathophysiology of Sjögren's syndrome. Int J Immunopathol Pharmacol. 2016;29:386-97 pubmed publisher
    ..With the purpose of improving both the diagnosis and prognosis, IL-6, IL-17A, and NO should be assayed in the serum and saliva of patients suspected of SS. ..
  6. Labsi M, Khelifi L, Mezioug D, Soufli I, Touil Boukoffa C. Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis. Asian Pac J Trop Med. 2016;9:211-20 pubmed publisher
    ..0001). Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE, suggesting its potential therapeutic role against Echinococcus granulosus infection. ..
  7. Zeghir Bouteldja R, Polomé A, Bousbata S, Touil Boukoffa C. Comparative proteome profiling of hydatid fluid from Algerian patients reveals cyst location-related variation in Echinococcus granulosus. Acta Trop. 2017;171:199-206 pubmed publisher
    ..Interestingly, our study also revealed that parasite antigenic protein expression variations reflect the differences observed in host immunostimulation. ..
  8. Khelifi L, Soufli I, Labsi M, Touil Boukoffa C. Immune-protective effect of echinococcosis on colitis experimental model is dependent of down regulation of TNF-? and NO production. Acta Trop. 2017;166:7-15 pubmed publisher
    ..Collectively, our data support the hygiene hypothesis and indicate that prior infection with E. granulosus can effectively protect mice from DSS-induced colitis by enhancing immune-regulatory mechanisms. ..