K Titier

Summary

Country: France

Publications

  1. ncbi request reprint Toxicological management of chlorophacinone poisoning
    F Lagrange
    Department of Clinical Pharmacology and Toxicology, Poison Control Center, Hopital Pellegrin, Bordeaux, France
    Acta Clin Belg Suppl 1:13-6. 1999
  2. ncbi request reprint In vivo and in vitro myocardial binding of risperidone and 9-hydroxyrisperidone
    Karine Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Toxicol Appl Pharmacol 180:145-9. 2002
  3. ncbi request reprint Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    Ther Drug Monit 27:634-40. 2005
  4. ncbi request reprint Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    J Anal Toxicol 31:200-7. 2007
  5. ncbi request reprint Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death
    Karine Titier
    Dept de Pharmacologie, Universite Victor Segalen, CHU de Bordeaux, INSERM Réseau de Pharmacoépidémiologie, Bordeaux, France
    Drug Saf 28:35-51. 2005
  6. ncbi request reprint Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice
    Karine Titier
    Department of Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen, Bordeaux, France
    Toxicol Appl Pharmacol 199:52-60. 2004
  7. ncbi request reprint High-performance liquid chromatographic method with diode array detection to identify and quantify atypical antipsychotics and haloperidol in plasma after overdose
    K Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 788:179-85. 2003
  8. ncbi request reprint High-performance liquid chromatographic method with diode array detection for identification and quantification of the eight new antidepressants and five of their active metabolites in plasma after overdose
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Bordeaux, France
    Ther Drug Monit 25:581-7. 2003
  9. ncbi request reprint [Plasmatic dosage of antiretroviral drugs by high performance liquid chromathography ]
    K Titier
    Laboratoire de Pharmacologie Clinique et de Toxicologie, Hôpital Pellegrin et Université Victor Ségalen, Bordeaux, France
    Therapie 57:169-74. 2002
  10. ncbi request reprint Simplified high-performance liquid chromatographic method for determination of risperidone and 9-hydroxyrisperidone in plasma after overdose
    K Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, Cedex, France
    J Chromatogr B Analyt Technol Biomed Life Sci 772:373-8. 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Toxicological management of chlorophacinone poisoning
    F Lagrange
    Department of Clinical Pharmacology and Toxicology, Poison Control Center, Hopital Pellegrin, Bordeaux, France
    Acta Clin Belg Suppl 1:13-6. 1999
    ..This case illustrates how toxicological management may facilitate toxicokinetics and therapeutic data acquisition...
  2. ncbi request reprint In vivo and in vitro myocardial binding of risperidone and 9-hydroxyrisperidone
    Karine Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Toxicol Appl Pharmacol 180:145-9. 2002
    ..5-fold higher than plasma levels. Binding parameters were similar both in vivo and in vitro. From this model, the relevance of in vitro electrophysiological studies to clinical plasma concentrations can be approached...
  3. ncbi request reprint Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    Ther Drug Monit 27:634-40. 2005
    ..It can be used to evaluate patient adherence to daily oral therapy, drug-drug interactions, or pharmacokinetic/pharmacodynamic relationships...
  4. ncbi request reprint Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    J Anal Toxicol 31:200-7. 2007
    ..This specific and sensitive method allows management of intoxication and is suitable for the routine determination of antidepressants in forensic investigation...
  5. ncbi request reprint Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death
    Karine Titier
    Dept de Pharmacologie, Universite Victor Segalen, CHU de Bordeaux, INSERM Réseau de Pharmacoépidémiologie, Bordeaux, France
    Drug Saf 28:35-51. 2005
    ..The assessment of cardiovascular safety, both preclinical and during premarketing clinical trials, needs to be supported by appropriately powered pharmacoepidemiology studies...
  6. ncbi request reprint Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice
    Karine Titier
    Department of Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen, Bordeaux, France
    Toxicol Appl Pharmacol 199:52-60. 2004
    ..These results underscore the importance of interpreting HERG channel data and electrophysiological data in the context of other pharmacokinetic parameters such as myocardium to plasma distribution...
  7. ncbi request reprint High-performance liquid chromatographic method with diode array detection to identify and quantify atypical antipsychotics and haloperidol in plasma after overdose
    K Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 788:179-85. 2003
    ..Both inter- and intra-day variation coefficients were lower than 11% for all drugs. This simple and rapid method (run time<15 min) is currently used for poison management...
  8. ncbi request reprint High-performance liquid chromatographic method with diode array detection for identification and quantification of the eight new antidepressants and five of their active metabolites in plasma after overdose
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Bordeaux, France
    Ther Drug Monit 25:581-7. 2003
    ..This method allows simple and rapid (run time 18 min) identification and quantification of the eight new antidepressants and five of their active metabolites. This method can be used for toxicologic purpose...
  9. ncbi request reprint [Plasmatic dosage of antiretroviral drugs by high performance liquid chromathography ]
    K Titier
    Laboratoire de Pharmacologie Clinique et de Toxicologie, Hôpital Pellegrin et Université Victor Ségalen, Bordeaux, France
    Therapie 57:169-74. 2002
    ..2% to 110.9% and both inter- and intra-day coefficients of variation were lower than 11%. The extraction recoveries were higher than 62%. This method is simple and shows good specificity with respect to commonly coprescribed drugs...
  10. ncbi request reprint Simplified high-performance liquid chromatographic method for determination of risperidone and 9-hydroxyrisperidone in plasma after overdose
    K Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, Cedex, France
    J Chromatogr B Analyt Technol Biomed Life Sci 772:373-8. 2002
    ..A good inter-assay accuracy (<116%) was achieved with inter-assay precision less than 12%. Quantification limits were 10 ng/ml. This rapid method (run time <5 min) is currently used for poison management...
  11. ncbi request reprint Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma
    Mireille Canal-Raffin
    Department of Clinical Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen Bordeaux 2, Bât IA, 33076 Bordeaux Cedex, France
    J Chromatogr B Analyt Technol Biomed Life Sci 814:61-7. 2005
    ..The limit of quantification concentration was 5 ng/ml. The absolute recovery of sertindole was higher than 99%. This rapid and sensitive method could be used for therapeutic drug monitoring as well as for overdose management...
  12. ncbi request reprint Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs
    Mireille Canal-Raffin
    Department of Clinical Pharmacology and Toxicology, INSERM U657, IFR 99, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    Biopharm Drug Dispos 27:171-9. 2006
    ..1 times higher than plasma concentrations. Using these data, the relevance of in vitro electrophysiological studies to clinical plasma concentrations has been appraised...
  13. doi request reprint Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats
    Mireille Canal-Raffin
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 865:106-13. 2008
    ..Applying these methods, a plasma toxicokinetic study of folpet in rats after intratracheal administration of Folpan 80WG showed that inhalation of folpet could be a route of exposure with an important systemic absorption...
  14. doi request reprint [Therapeutic drug monitoring of tyrosine-kinase inhibitors in the treatment of chronic myelogenous leukaemia: interests and limits]
    Stephane Bouchet
    CHU Pellegrin, Universite de Bordeaux, Bordeaux, France
    Therapie 65:213-8. 2010
    ..In conclusion, the level of proof of imatinib TDM in LMC varies between levels "recommended" and "potentially useful"...
  15. ncbi request reprint Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    Stephane Picard
    Department of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
    Blood 109:3496-9. 2007
    ..Therefore, monitoring of imatinib plasma levels could be very useful for the management of patients with CML or should at least be checked in the case of treatment failure or suboptimal response...
  16. doi request reprint A method to measure deferasirox in plasma using HPLC coupled with MS/MS detection and its potential application
    Emmanuelle Chauzit
    Département de Pharmacologie Clinique et Toxicologie, CHU de Bordeaux, Bordeaux, France
    Ther Drug Monit 32:476-81. 2010
    ..It allows evaluation of patient compliance, drug-drug interactions, and further investigations of pharmacokinetic/pharmacodynamic relationships...
  17. ncbi request reprint Postmortem redistribution of two antipsychotic drugs, haloperidol and thioridazine, in the rat
    Nadege Castaing
    CHU de Bordeaux, Laboratoire de Pharmacologie Clinique et Toxicologie, F 33076 Bordeaux, France
    J Anal Toxicol 30:419-25. 2006
    ..For the lungs, a decrease of 50% was observed between 0 and 48 h. Only myocardium and muscle concentrations did not change with the postmortem delay...
  18. ncbi request reprint Fully automated analytical method for mycophenolic acid quantification in human plasma using on-line solid phase extraction and high performance liquid chromatography with diode array detection
    Mathilde Daurel-Receveur
    CHU de Bordeaux, Département de Pharmacologie Clinique et de Toxicologie, Bordeaux F33000, France
    Ther Drug Monit 28:505-11. 2006
    ..6% to 100.4% and the interday accuracy varied from 97.1% to 100.8%. The extraction efficiency was greater than 90%. This method is simple and shows a good specificity with respect to commonly co-prescripted drugs...
  19. ncbi request reprint Accuracy of information on substance use recorded in medical charts of patients with intentional drug overdose
    Marie Tournier
    Unité INSERM U657, Université Victor Segalen Bordeaux2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Psychiatry Res 152:73-9. 2007
    ..The usefulness of systematic toxicological assays during hospitalization for IDO should be assessed in further studies exploring whether such information allows medical management to be modified and contributes to improving prognosis...
  20. ncbi request reprint Quantification of eight new antidepressants and five of their active metabolites in whole blood by high-performance liquid chromatography-tandem mass spectrometry
    Nadege Castaing
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    J Anal Toxicol 31:334-41. 2007
    ..This specific and sensitive method allows management of intoxication and is suitable for the routine determination of antidepressants in forensic investigations...
  21. ncbi request reprint High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, University Victor Segalen, Pellegrin Hospital, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ther Drug Monit 24:417-24. 2002
    ..This method allows accurate therapeutic monitoring of amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, efavirenz, and nevirapine...
  22. ncbi request reprint Identification and quantitation by high-performance liquid chromatography of mancozeb following derivatization by 1,2-benzenedithiol
    Ikram Debbarh
    Departement of Pharmacology, EA 525, université Victor Segalen 33076 Bordeaux, France
    J Anal Toxicol 28:41-5. 2004
    ..The lower limits of detection and quantitation were estimated to be 0.1 and 0.25 microg/mL, respectively. This simple new method has been applied to determine mancozeb concentration in rat urine samples from urinary excretion studies...