R Timpl

Summary

Country: France

Publications

  1. ncbi Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases
    M P d'Ortho
    INSERM U296, Faculte de Medecine, Creteil, France
    Eur J Biochem 250:751-7. 1997
  2. ncbi Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp
    T Sasaki
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    FEBS Lett 509:181-5. 2001
  3. ncbi Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican
    A Aspberg
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, P O Box 94, SE 221 00 Lund, Sweden
    J Biol Chem 274:20444-9. 1999
  4. pmc Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins
    J F Talts
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:863-70. 1999
  5. ncbi Nidogen-2: a new basement membrane protein with diverse binding properties
    E Kohfeldt
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Mol Biol 282:99-109. 1998
  6. ncbi Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope
    W Göhring
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 255:60-6. 1998
  7. ncbi The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan
    N Ettner
    Max Planck Institut fur Biochemie, Martinsried, Germany
    FEBS Lett 430:217-21. 1998
  8. ncbi Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
    N Miosge
    Abteilung Histologie, Universitat Gottingen, Germany
    Cell Mol Life Sci 54:606-13. 1998
  9. pmc Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin
    T Sasaki
    Max Planck Institut f r Biochemie, D 82152 Martinsried, Germany
    EMBO J 17:1606-13. 1998
  10. ncbi The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans
    J C Brown
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 250:39-46. 1997

Collaborators

Detail Information

Publications62

  1. ncbi Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases
    M P d'Ortho
    INSERM U296, Faculte de Medecine, Creteil, France
    Eur J Biochem 250:751-7. 1997
    ..Their location at the surface of cells implies that they could play a significant role in the modulation of cell-matrix interactions...
  2. ncbi Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp
    T Sasaki
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    FEBS Lett 509:181-5. 2001
    ..There it could play a role in angiogenesis steps requiring RGD-dependent integrins...
  3. ncbi Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican
    A Aspberg
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, P O Box 94, SE 221 00 Lund, Sweden
    J Biol Chem 274:20444-9. 1999
    ..No difference in affinity was found for deglycosylated fibulin-1, indicating that the proteoglycan C-type lectin domains bind to the protein part of fibulin-1...
  4. pmc Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins
    J F Talts
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:863-70. 1999
    ..This demonstrated similar binding repertoires for the LG modules of three basement membrane proteins involved in cell-matrix interactions and supramolecular assembly...
  5. ncbi Nidogen-2: a new basement membrane protein with diverse binding properties
    E Kohfeldt
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Mol Biol 282:99-109. 1998
    ..Both nidogens were cell-adhesive for a restricted number of cell lines, with nidogen-2 having a higher activity. Together, these data suggest that nidogen-2 can compensate for some but not all functional activities ascribed to nidogen-1...
  6. ncbi Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope
    W Göhring
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 255:60-6. 1998
    ..Neither nidogen, BM-40 or perlecan domain III-2 interfered with the binding of PDGF to its alpha and beta receptors, however, suggesting that these interactions may be mainly used for storage of PDGF in the extracellular matrix...
  7. ncbi The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan
    N Ettner
    Max Planck Institut fur Biochemie, Martinsried, Germany
    FEBS Lett 430:217-21. 1998
    ..This localized the binding activities to the LN module, which contains two basic sequences suitable for heparin interactions...
  8. ncbi Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
    N Miosge
    Abteilung Histologie, Universitat Gottingen, Germany
    Cell Mol Life Sci 54:606-13. 1998
    ....
  9. pmc Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin
    T Sasaki
    Max Planck Institut f r Biochemie, D 82152 Martinsried, Germany
    EMBO J 17:1606-13. 1998
    ..Immunological assays demonstrated variable secretion by cultured human cells of M2BP, which was detected in the extracellular matrix of several mouse tissues...
  10. ncbi The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans
    J C Brown
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 250:39-46. 1997
    ..05-0.2 microM and about 2 microM). Perlecan domain V therefore seems to participate in the supramolecular assembly and cell connections of basement membranes...
  11. pmc Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Germany
    EMBO J 16:3035-43. 1997
    ..This was demonstrated by surface plasmon resonance assay which showed a distinct interaction between domains N and II with a Kd of approximately 0.7 microM...
  12. ncbi Drosophila laminin binds to mammalian nidogen and to heparan sulfate proteoglycan
    U Mayer
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 245:745-50. 1997
    ..The data suggest the existence of a nidogen analog and heparan sulfate proteoglycans in Drosophila, which remain to be identified...
  13. ncbi Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins
    T Sasaki
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    FEBS Lett 460:280-4. 1999
    ..The colocalization of these proteins emphasizes the potential for in vivo interactions...
  14. pmc Perlecan maintains the integrity of cartilage and some basement membranes
    M Costell
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    J Cell Biol 147:1109-22. 1999
    ....
  15. ncbi Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma
    Y C Gu
    Department of Cell and Molecular Biology, Lund University, Sweden
    Eur J Haematol 67:176-84. 2001
    ..Thus one mechanism by which glucocorticoids regulate haematopoiesis may be by altering the relative proportions of extracellular matrix proteins...
  16. ncbi Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
    J Mol Biol 314:751-63. 2001
    ..Immunological studies showed a similar partial processing in cell culture and tissues and the persistence of the released fragment in tissues. This indicated that both N-terminal regions of the gamma2 chain may have a function in vivo...
  17. ncbi Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies
    A Ries
    Max Planck Institut fur Biochemie, Am Klopferspitz 18 A, D 82152 Martinsried, Germany
    Eur J Biochem 268:5119-28. 2001
    ..Three of the antibodies showed strongly reduced binding to G2 and G3 after complex formation with either a perlecan domain or laminin-1...
  18. pmc Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan
    M Kvansakul
    Biophysics Section, Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BW, UK
    EMBO J 20:5342-6. 2001
    ..We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain...
  19. ncbi Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan
    M Hopf
    Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
    J Mol Biol 311:529-41. 2001
    ..This implicates a complex cluster of heterotypic interaction sites apparently important for the supramolecular organization of perlecan in tissues...
  20. ncbi Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix
    C Wiberg
    Department of Cell and Molecular Biology, University of Lund, BMC Plan C12, Lund S 221 84, Sweden
    J Biol Chem 276:18947-52. 2001
    ..In solid phase assay using recombinant collagen VI fragments, it was shown that the alpha2(VI) chain probably plays a role in the interaction...
  21. ncbi The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding
    A I Olin
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, BMC Plan C12, SE 221 84 Lund, Sweden
    J Biol Chem 276:1253-61. 2001
    ..Electron microscopy confirmed the mapping and demonstrated that hyaluronan-aggrecan complexes can be cross-linked by the fibulins...
  22. ncbi Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
    J Mol Biol 301:1179-90. 2000
    ..Together, these data indentify endostatin-XV as an angiogenesis inhibitor, which differs from endostatin-XVIII in several important functional details...
  23. ncbi Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues
    J F Talts
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Biol Chem 275:35192-9. 2000
    ..Immunogold staining demonstrated an association of the alpha4 chain primarily with microfibrillar regions rather than with basement membranes, while laminin alpha2 chains appear primarily associated with various basement membranes...
  24. ncbi Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis
    J Dixelius
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Blood 95:3403-11. 2000
    ..In conclusion, our data show that endostatin induces tyrosine kinase activity and enhanced apoptosis in FGF-treated endothelial cells...
  25. ncbi The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin
    E Hohenester
    Biophysics Section, Blackett Laboratory, Imperial College, London, United Kingdom
    Mol Cell 4:783-92. 1999
    ..A calcium-coordinated sulfate ion is suggested to mimic the binding of anionic oligosaccharides. The structure demonstrates a conserved function of the LG module in calcium-dependent lectin-like alpha-DG binding...
  26. ncbi Structural characterization of recombinant domain II of the basement membrane proteoglycan perlecan
    M Costell
    Max Planck Institut fur Biochemie, Martinsried, Germany
    FEBS Lett 396:127-31. 1996
    ..The domain also showed N-glycosylation of a single acceptor site and 7-8 O-linked oligosaccharides. The latter were located mainly in the link region within proline-rich sequences...
  27. ncbi Binding properties and protease stability of recombinant human nidogen
    U Mayer
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 227:681-6. 1995
    ..Since such degradation could be important for basement membrane remodelling, this difference between human and mouse may be biologically significant...
  28. pmc A single EGF-like motif of laminin is responsible for high affinity nidogen binding
    U Mayer
    Max Planck Institut fur Biochemie, Martinsried, Germany
    EMBO J 12:1879-85. 1993
    ..This identifies repeat 4 as the only binding structure. The sequence of repeat 4 is well conserved in the human and in part in the Drosophila laminin B2 chain.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. ncbi Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta
    J C Brown
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Cell Sci 107:329-38. 1994
    ..No inhibition was observed with an Arg-Gly-Asp-containing peptide...
  30. ncbi Purification and structural characterization of intact and fragmented nidogen obtained from a tumor basement membrane
    M Paulsson
    Eur J Biochem 156:467-78. 1986
    ..The data suggest a multidomain structure for nidogen containing sites highly susceptible to proteolytic cleavage...
  31. ncbi Recombinant expression and structural and binding properties of alpha 1(VI) and alpha 2(VI) chains of human collagen type VI
    E Tillet
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 221:177-85. 1994
    ..Purified globular domains did not bind these ligands indicating the localization of binding sites within the triple-helical domain. Both chains showed a distinct affinity for heparin but failed to bind to various collagen types...
  32. pmc Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin
    E Hahn
    Gut 21:63-71. 1980
    ....
  33. ncbi Binding of mouse and human fibulin-2 to extracellular matrix ligands
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    J Mol Biol 254:892-9. 1995
    ..This indicated multifunctional binding properties for fibulin-2 and several alternative routes for its integration into basement membranes and other extracellular structures...
  34. ncbi Structural characterization of two variants of fibulin-1 that differ in nidogen affinity
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    J Mol Biol 245:241-50. 1995
    ..Self aggregation into nest-like oligomers was observed at high concentrations of fibulin-1 which was not sensitive to EDTA...
  35. ncbi The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV
    P Maurer
    Abt Biophysikalische Chemie, Biozentrum University, Basel, Switzerland
    J Mol Biol 253:347-57. 1995
    ..The EC domain was also shown by surface plasmon resonance assay to be responsible for calcium-dependent binding to collagen IV with an affinity (Kd = 19 microM) only sixfold lower than that of intact human BM-40...
  36. ncbi Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice
    R Fassler
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Exp Cell Res 222:111-6. 1996
    ..They also indicate that repair involves complex regulatory processes which are obviously different for each of the four proteins studied...
  37. ncbi Binding of nidogen and the laminin-nidogen complex to basement membrane collagen type IV
    M Aumailley
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Eur J Biochem 184:241-8. 1989
    ..A more diverse collagen-IV-binding pattern was observed for the laminin nidogen complex, whereby interactions may involve both nidogen and short-arm structures of laminin...
  38. ncbi Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain
    E Tillet
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 228:160-8. 1995
    ..Whether this process also occurs in situ remains to be shown...
  39. ncbi Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 240:427-34. 1996
    ..Since fibulin-2 is an abundant component of small and large blood vessels it could be a major target for proteolysis during vascular injuries...
  40. ncbi Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules
    M A Burg
    La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 271:26110-6. 1996
    ....
  41. ncbi Binding of the proteoglycan decorin to collagen type VI
    D J Bidanset
    Department of Cell Biology, University of Alabama, Birmingham 35294
    J Biol Chem 267:5250-6. 1992
    ..Possible functional roles of these interactions are discussed...
  42. ncbi Structural properties of recombinant domain III-3 of perlecan containing a globular domain inserted into an epidermal-growth-factor-like motif
    B Schulze
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 231:551-6. 1995
    ..Together the data demonstrated a proper folding of recombinant domain III-3 similar to its structure in the native protein and provided the first structural evidence for a novel globular protein motif L4 based on an EGF-like scaffold...
  43. ncbi Characterization of a novel calcium-binding 90-kDa glycoprotein (BM-90) shared by basement membranes and serum
    M Kluge
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Eur J Biochem 193:651-9. 1990
    ..Thus, BM-90 appears to be a novel basement membrane protein whose functions remain to be studied...
  44. ncbi Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site
    J Stetefeld
    Abteilungen für Strukturforschung and Proteinchemie, Max Planck Institut fur Biochemie, Martinsried, Germany
    J Mol Biol 257:644-57. 1996
    ..They also indicate that the crucial residues in the binding loops provide direct contacts with nidogen and explain the synergism between loops a and c which is essential for binding...
  45. pmc Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells
    K Mann
    Max Planck Institut fur Biochemie, Martinsried, FRG
    EMBO J 8:65-72. 1989
    ..The latter was shown to be functional in cell attachment to nidogen. Binding sites for laminin and collagen IV are present on the C-terminal globule but not yet precisely localized...
  46. ncbi Structure of mouse type IV collagen. Amino-acid sequence of the C-terminal 511-residue-long triple-helical segment of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain
    U Schwarz
    Eur J Biochem 157:49-56. 1986
    ..The data indicate a remote evolutionary relationship of the triple-helical sequences of the two constituent chains of basement membrane collagen...
  47. ncbi Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1
    M Hopf
    Abteilung Proteinchemie, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Struct Biol 8:634-40. 2001
    ..A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding...
  48. pmc Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8
    A Sonnenberg
    Department of Immunohaematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    J Cell Biol 110:2145-55. 1990
    ..Adhesion to E3 may also be brought about by other receptor molecules, possibly proteoglycans, not belonging to the integrin family...
  49. ncbi Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression
    M V Friedrich
    Max Planck Institut fur Biochemie, Germany
    Eur J Biochem 267:3149-59. 2000
    ..This indicates, as for mammalian species, a distinct role of perlecan during Drosophila development...
  50. ncbi Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4
    R Giltay
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Matrix Biol 18:469-80. 1999
    ..A particularly prominent feature was the staining of variable sets of large and small blood vessels...
  51. ncbi Importance of nidogen binding to laminin gamma1 for branching epithelial morphogenesis of the submandibular gland
    Y Kadoya
    Department of Animal Physiology, Uppsala University, Biomedical Center, Sweden
    Development 124:683-91. 1997
    ..We suggest that nidogen could be an important mesenchymal factor for submandibular gland development...
  52. ncbi Properties of the extracellular calcium binding module of the proteoglycan testican
    E Kohfeldt
    Max Planck Institut fur Biochemie, Martinsried, Germany
    FEBS Lett 414:557-61. 1997
    ..No clear evidence was obtained for collagen binding, indicating that EC modules found in different proteins may not share similar functions...
  53. ncbi Deposition of collagen VI in the extracellular matrix during mouse embryogenesis correlates with expression of the alpha 3(VI) subunit gene
    M Dziadek
    Institute of Reproduction and Development, Monash Medical Centre, Clayton, Victoria, Australia
    Exp Cell Res 226:302-15. 1996
    ..This correlation is consistent with the proposal that expression of alpha 3(VI) chains regulates the formation and secretion of collagen VI trimers and collagen VI matrix deposition during development...
  54. ncbi Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues
    D P Reinhardt
    Shriners Hospital for Crippled Children, Portland, Oregon 97201, USA
    J Biol Chem 271:19489-96. 1996
    ....
  55. pmc Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution
    E Hohenester
    Department of Crystallography, Birkbeck College, London WC1E 7HX, UK e hohenester cryst bbk ac uk
    EMBO J 17:1656-64. 1998
    ..Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling...
  56. ncbi The role of the alpha3(VI) chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI assembly, secretion, and matrix deposition in an alpha3(VI)-deficient cell line
    S R Lamande
    Orthopaedic Molecular Biology Research Unit, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Biol Chem 273:7423-30. 1998
    ..These data demonstrated that alpha3(VI) is essential for the formation of stable collagen VI molecules and subdomains N10-N7 are not required for molecular assembly...
  57. ncbi Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands
    T C Pan
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia
    Eur J Biochem 215:733-40. 1993
    ..The broad interaction repertoire of BM-90 is comparable to that of nidogen and both proteins may have similar roles as connecting elements in the extracellular matrix...
  58. pmc Zinc-dependent dimers observed in crystals of human endostatin
    Y H Ding
    Department of Cellular and Molecular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 95:10443-8. 1998
    ....
  59. ncbi Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration
    M Raghunath
    Department of Dermatology, University of Munster, Germany
    J Invest Dermatol 112:97-101. 1999
    ..This suggests interaction of fibulin-2 with both fibronectin fibrils and fibrillin microfibrils, and is consistent with in vitro binding data...
  60. ncbi Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin
    R W Stephens
    Department of Virology, University of Helsinki, Finland
    Eur J Biochem 207:937-42. 1992
    ....
  61. ncbi Supramolecular assembly of basement membranes
    R Timpl
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Bioessays 18:123-32. 1996
    ..Thus many molecular interactions, of variable affinities, determine the final shape of basement membranes and their preferred subanatomical localization...
  62. ncbi Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis
    K Kadoya
    Skin Biology Research Laboratories, Shiseido Life Science Research Centre, 2 12 1 Fukuura, Kanazawa Ku, Yokohama shi 236 8643, Japan
    Br J Dermatol 153:607-12. 2005
    ..Fibulin-5 was recently found as a secreted extracellular matrix protein that functions as a scaffold for elastic fibres. However, the distribution of fibulin-5 in human skin and its changes during the ageing process are not known...