Research Topics
Genomes and GenesSpecies | Eric ThervetSummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
Histologic recurrence of Henoch-Schonlein Purpura nephropathy after renal transplantation on routine allograft biopsyEric Thervet
Universite Paris Descartes, Paris, France
Transplantation 92:907-12. 2011..However, its true incidence is unknown. The aim of this study was to investigate this recurrence incidence using routine allograft biopsies (RBs)...
Combined posttransplant prophylactic IVIg/anti-CD 20/plasmapheresis in kidney recipients with preformed donor-specific antibodies: a pilot studyAlexandre Loupy
INSERM, U970, Paris Cardiovascular Research Center PARCC, Paris, France
Transplantation 89:1403-10. 2010....
Effects of cinacalcet in renal transplant patients with hyperparathyroidismMarie Courbebaisse
Service d Explorations Fonctionnelles, Hôpital Necker Enfants Malades Assistance Publique Hôpitaux de Paris, Paris, France
Am J Nephrol 35:341-8. 2012..Long-term treatment with cinacalcet may increase urinary calcium excretion and the risk of renal calcium deposits and may alter renal graft function...
[Involvement of endoplasmic reticulum stress in solid organ transplantation]Nicolas Pallet
INSERM U775, Centre Universitaire des Saints Peres, Paris, France
Med Sci (Paris) 26:397-403. 2010....
Incidence of infectious complications in highly sensitized renal transplant recipients treated by rituximab: a case-controlled studyAnne Scemla
Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
Transplantation 90:1180-4. 2010..Use of rituximab for various indications in renal transplantation is increasing. However, tolerance and complications associated with rituximab therapy remain controversial...
Urinary procollagen III aminoterminal propeptide (PIIINP): a fibrotest for the nephrologistBalsam El Ghoul
Department of Nephrology, Universite Paris Descartes, Hopital Necker, Paris, France
Clin J Am Soc Nephrol 5:205-10. 2010..Thus, a noninvasive alternative to KB is required. Collagen type III amino-terminal propeptide (PIIINP) is a degradation product of collagen type III, the increase of which may reflect an ongoing fibrotic process...
Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapyDany Anglicheau
Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
Am J Transplant 5:595-603. 2005..In patients with SRL-based therapy, genotyping of the CYP3As genes may help to optimize the SRL management in transplant recipients...
Cholecalciferol supplementation does not protect against renal allograft structural and functional deterioration: a retrospective studyMarie Courbebaisse
Service de Nephrologie, Hôpital Tenon Assistance Publique Hôpitaux de Paris et Université Paris VI, Paris, France
Transplantation 91:207-12. 2011..Renal models of chronic kidney injury and clinical observational studies have suggested that vitamin D analogues may protect against the epithelial-to-mesenchymal transition (EMT), interstitial inflammation, and fibrosis...
Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicityNicolas Pallet
INSERM U775 and Université Paris Descartes, Paris, France
Pharmacol Res 61:71-5. 2010..In conclusion, we describe here a new potential target of recombinant human erythropoietin and our results provide an interesting framework for further nephroprotective therapies based on recombinant human erythropoietin...
[Endoplasmic reticulum stress in kidney diseases: a question of life and death?]Nicolas Pallet
INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, 45, rue des Saints Pères, 75006 Paris, France
Nephrol Ther 5:173-80. 2009..The purpose of this review is to summarize the existing data concerning the role of the endoplasmic reticulum stress during kidney injury and to clarify its precise role in chronic kidney disease...
Role of pharmacogenetics of immunosuppressive drugs in organ transplantationEric Thervet
Service de transplantation rénale, Hopital Necker, Paris, France
Ther Drug Monit 30:143-50. 2008....
High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipientsGuillaume Bollée
Laboratoire d Anatomie Pathologique, Hopital Necker, APHP, and Université René Descartes, Paris, France
Clin J Am Soc Nephrol 3:1461-8. 2008..Intravenous immunoglobulins (IVIg) may induce acute renal failure associated with tubular vacuolization. Although the use of IVIg is increasing in kidney transplantation, their impact on graft histology and function remains unknown...
New computerized color image analysis for the quantification of interstitial fibrosis in renal transplantationVannary Meas-Yedid
Institut Pasteur, Quantitative Image Analysis Unit, Cell Biology and Infection Department, CNRS URA 2582, Paris, France
Transplantation 92:890-9. 2011..Currently, assessed by semiquantitative analysis in the Banff classification, IF quantification is limited by pathologist's subjective interpretation...
Long-term outcome of third kidney transplantsAlexandre Loupy
Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, and Université René Descartes, Paris, France
Nephrol Dial Transplant 22:2693-700. 2007....
Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantationNicolas Pallet
INSERM U775 and Université Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
Transplantation 88:605-13. 2009....
Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipientsEric Thervet
INSERM UMR S490, Centre Universitaire des Saints Peres, Paris, France
Transplantation 76:1233-5. 2003..Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5. Heterozygotes (genotype CYP3A5*1/*3) also express the enzyme. We postulated that CYP3A5 polymorphism is associated with tacrolimus pharmacokinetic variations...
Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteriesGuillaume Canaud
Universite Paris Descartes, Paris, France
Am J Kidney Dis 55:558-65. 2010..Together, these data suggest that acute glomerular ischemia may lead to glomerular collapse in kidney transplants...
Autophagy protects renal tubular cells against cyclosporine toxicityNicolas Pallet
INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, Paris, France
Autophagy 4:783-91. 2008..Taken together, these results demonstrate that CsA, through ER stress induction, activates autophagy as a protection against cell death...
Sirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical resultsEric Thervet
Service de transplantation rénale, Hopital Necker, Paris, France
Int J Nanomedicine 1:269-81. 2006..Other studies are mandatory to define the population who can benefit from this maneuver. Finally, complete CsA avoidance has been already reported and is currently under clinical investigation...
Clinical outcomes during the first three months posttransplant in renal allograft recipients managed by C2 monitoring of cyclosporine microemulsionEric Thervet
Service de Nephrologie et Transplantation Renale, Hopital St Louis, Paris, France
Transplantation 76:903-8. 2003..Efficacy and safety results from the first 3 months are presented here...
CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantationDany Anglicheau
Unité INSERM UMR S490, Centre Universitaire des Saints Peres, Paris, France
Clin Pharmacol Ther 75:422-33. 2004..We postulated that, in renal transplant recipients, these SNPs could be associated with interindividual variations in cyclosporine pharmacokinetics...
Impact of surgical procedures and complications on outcomes of third and subsequent kidney transplantsAlexandre Loupy
Service de transplantation rénale, Hopital Necker, Paris, France
Transplantation 83:385-91. 2007..Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant...
Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stabilityNicolas Pallet
, Molecular Toxicology, , , Paris, France
Kidney Int 67:2422-33. 2005....
Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an updateDany Anglicheau
Universite Rene Descartes, Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, 149 rue de Sevres, 75743, Cedex 15, Paris, France
Pharmacogenomics 8:835-49. 2007..It is now of utmost importance to prospectively test these initial results to improve the individualized use of these drugs...
Quantification of interstitial fibrosis by image analysis on routine renal biopsy in patients receiving cyclosporineAude Servais
Department of Renal Transplantation, Universite Paris 5 Rene Descartes, Necker Hospital, Paris, France
Transplantation 84:1595-601. 2007..We performed a retrospective analysis to calculate IF on routine renal biopsies performed at 1 year posttransplant...
Proteinuria >0.5 g/d, a prevalent prognostic factor for patient and graft survival in kidney transplantationFelix Cantarovich
Hopital Necker, Service de Transplantation Adultes, Paris, France
Clin Transplant 24:175-80. 2010..5 g/d) or Scr (< or = or >120 micromol/L) along with the log-rank test for all comparisons were computed. Statistical significance was set with p-value < 0.05...
Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrheaDamien Roos-Weil
Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, Paris, France
Transplantation 92:61-9. 2011..Norovirus (NoV) and sapovirus (SaV) have been sporadically reported to cause chronic diarrhea in immunocompromised patients...
The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stressNicolas Bouvier
INSERM U775, Centre Universitaire des Saints Peres, Paris, France
J Biol Chem 287:14557-68. 2012..In a rat model of acute ischemic stress, we show that the UPR is activated in parallel with VEGFA, bFGF, and ANG expression and independently of HIF-1α...
FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosisJulien Zuber
Universite Paris Descartes, Paris, France
Nephrol Dial Transplant 24:3847-54. 2009..We hypothesized that Tregs might accumulate within the graft since enrichment of Tregs has been frequently described in chronically inflamed tissues...
Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patientsMarie Courbebaisse
Service d Explorations Fonctionnelles, Hopital Necker Enfants Malades, AP HP, Paris, France
Kidney Int 75:646-51. 2009..Hence, cholecalciferol treatment significantly increased serum 25-hydroxy vitamin D and decreased parathyroid hormone levels with no adverse effects in 25-hydroxy vitamin D-deficient renal transplant patients...
Prospective comparison of the use of sirolimus and cyclosporine in recipients of a kidney from an expanded criteria donorAntoine Durrbach
Department of Nephrology and Transplantation, Hôpital du Kremlin Bicêtre, Le Kremlin Bicetre, Paris, France
Transplantation 85:486-90. 2008..1% vs. CsA 8.3%; P=0.7 and 44.7+/-16.6 vs. 41.9+/-15.2 mL/min; P=0.54 respectively). These results do not support the use of SRL immediately after transplantation in expanded criteria donor recipients...
Kidney transplant in black recipients: are African Europeans different from African Americans?Nicolas Pallet
Service de transplantation rénale, Hopital Necker, Paris, France
Am J Transplant 5:2682-7. 2005..The results of renal transplantation in patients of African origin could be improved with universal immunosuppressive drug coverage...
Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schönlein PurpuraEvangeline Pillebout
Nephrology Department, Hopital Saint Louis, 1 av C Vellefaux, Paris, France
Kidney Int 78:495-502. 2010..The small population size of our study does not permit definitive conclusions; however, we suggest that treatment of adults with severe HSP by adding cyclophosphamide provides no benefit compared with steroids alone...
Brief communication: case reports of ribavirin treatment for chronic hepatitis EVincent Mallet
Institut Cochin, Université Paris Descartes Unité Mixte de Recherche S1016, Paris, France
Ann Intern Med 153:85-9. 2010..There is currently no accepted treatment of chronic hepatitis E virus (HEV) infection...
HNF1B-related diabetes triggered by renal transplantationJulien Zuber
Service de Transplantation Rénale Adulte, Universite Paris Descartes, Paris Cedex 15, France
Nat Rev Nephrol 5:480-4. 2009..He had a history of gout, but his fasting blood glucose and glycated hemoglobin concentrations had been normal before transplantation...
Response of human renal tubular cells to cyclosporine and sirolimus: a toxicogenomic studyNicolas Pallet
INSERM U775, Universite Paris V, Centre Universitaire des Saints Peres, Paris, France
Toxicol Appl Pharmacol 229:184-96. 2008..Further studies are needed to evaluate if ER stress detection in tubular cells in human biopsies can predict CsA nephrotoxicity...
Potential nonclassical effects of vitamin D in transplant recipientsMarie Courbebaisse
Service de Néphrologie et Dialyses, Hopital Tenon, AP HP, Paris, France
Transplantation 89:131-7. 2010..One may speculate that it could be a part of the explanation for the increased incidence of some complications observed after transplantation. Large intervention trials may therefore be of interest in this specific population...
Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantationDany Anglicheau
Service de Néphrologie et de transplantation rénale, Hopital Saint Louis, Paris, France
Nephrol Dial Transplant 18:2409-14. 2003..Corticosteroids induce both CYP3A and P-gp activity. This study was designed to investigate the presence of a clinically significant interaction between steroids and tacrolimus after renal transplantation...
Benefit-risk assessment of ciclosporin withdrawal in renal transplant recipientsEric Thervet
Service de Nephrologie et Transplantation Renale, Hopital Saint Louis, Paris, France
Drug Saf 27:457-76. 2004....
Tryptophan depletion and the kinase GCN2 mediate IFN-γ-induced autophagySophie Fougeray
INSERM U775, Paris, France
J Immunol 189:2954-64. 2012..These findings assign to IFN-γ a novel function in the regulation of autophagy, which, in turn, modulates IFN-γ-induced secretion of inflammatory cytokines...
The genetics of kidney transplantationNicolas Pallet
INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, 45, rue des Saints Pères, 75006 Paris, France
Hum Genet 131:317-23. 2012..Such enterprises will only be successful with the creation of international consortiums that connect partners in clinical, industrial, and academic transplant medicine...
Successful renal retransplantation after post-transplant lymphoproliferative diseaseAlexandre Karras
Nephrology and Renal Transplantation, , Paris, France
Am J Transplant 4:1904-9. 2004..In conclusion, renal retransplantation can be considered in patients with monomorphic PTLD history, without major risk of hematological recurrence...
A retrospective analysis of thalidomide therapy in non-HIV-related Kaposi's sarcomaLaurence Fardet
Department of Dermatology, Hospital Saint Louis, Paris, France
Dermatology 215:202-5. 2007..Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of human malignancies. Several studies have suggested its interest for treating AIDS-related Kaposi's sarcoma...
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and PharmacogenomicsLaurent Becquemont
Univ Paris Sud, Faculty of Medicine Paris Sud, Pharmacology Department, Assistance Publique Hopitaux de Paris, Hopital Bicetre, Le Kremlin Bicetre, France
Pharmacogenomics 12:113-24. 2011..We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests...
[Recent approaches of quantification of interstitial fibrosis in renal transplantation]Aude Servais
Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
Med Sci (Paris) 25:945-50. 2009..The prognostic value of quantitative image analysis might be increased by techniques addressing the dynamics of fibrosis matrix generation...
[Non phosphocalcic actions of vitamin D]Marie Courbebaisse
Hopital Tenon, AP HP, 4, rue de la Chine, 75020 Paris, France
Med Sci (Paris) 26:417-21. 2010..We present here the non phosphocalcic actions of vitamin D...
Early conservative intervention for candida contamination of preservative fluid without allograft nephrectomyGuillaume Canaud
Department of Kidney Transplantation, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
Nephrol Dial Transplant 24:1325-7. 2009..Fungal contamination of kidney allograft preservative fluid can lead to renal arteritis and arterial wall rupture...
Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS)Guillaume Canaud
Department of Kidney Transplantation, Necker Hospital, 149 rue de Sevres, 75015, Paris, USA
Nephrol Dial Transplant 25:1321-8. 2010..However, the predictive value of this classification to assess the risk of recurrence after transplantation has not been addressed...
[Recents advances in the pharmacology of immunosuppressive drugs used in organ transplantation]Eric Thervet
Service de transplantation et de soins intensifs, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
Med Sci (Paris) 24:961-6. 2008..A prospective study has been conducted to demonstrate the clinical consequences of this pharmacogenetic approach...
Outcome of relapse in lupus nephritis: roles of reversal of renal fibrosis and response of inflammation to therapyGary S Hill
Hôpital Broussais and INSERM Unité 430, Hopital St Louis, and Hôpital Bichat, Paris, France
Kidney Int 61:2176-86. 2002..However, not all patients do so. This report explores the roles of response of inflammation to therapy and of glomerular scarring and interstitial fibrosis and their potential reversal to outcome of renal relapse...
Pharmacogenetics in solid organ transplantation: present knowledge and future perspectivesDany Anglicheau
, , Paris, France
Transplantation 78:311-5. 2004..Present challenges are to determine the genes of interest and to validate such determination prospectively in clinical practice...
Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literatureAlexandre Karras
, , Paris, France
Transplantation 77:238-43. 2004..This rare disease is usually secondary to herpes viridae infections, mostly cytomegalovirus and Epstein-Barr virus in severely immunocompromised patients. Despite aggressive treatment, the prognosis remains poor...
Down syndrome maternal serum screening in patients with renal diseaseAlexandra Benachi
Department of Obstetrics and Gynecology, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Am J Obstet Gynecol 203:60.e1-4. 2010..The objective of the study was to determine the value of maternal serum Down syndrome screening in patients affected by renal disease...
c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic ChangesNicolas Pallet
Unité INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, 75006 Paris, France
J Transplant 2012:348604. 2012..Our results suggest that CsA activates JNK signaling, which, in turn, may participate in the morphological alterations through the regulation of Snail-1 expression...
Chronic graft dysfunction in renal transplant patients: potential role of plasminogen activator inhibitor type 1Anis Lahlou
Service de Nephrologie A, Association Claude Bernard and INSERM U 489, Hopital Tenon, Paris, France
Transplantation 73:1290-5. 2002..We aimed to determine whether PAI-1 secretion in renal transplant patients is correlated with the decline in renal function after transplantation...
Long-term renal allograft outcome after simultaneous kidney and pancreas transplantationJean Philippe Rerolle
, Service d'Urologie, , Paris, France
Nephrol Dial Transplant 17:905-9. 2002..This might be caused by acute rejection episodes or be due to more severe nephrotoxicity after SPK, because of higher doses of calcineurin inhibitors, or higher sensitivity to calcineurin-inhibitor nephrotoxicity...
[Henoch-Shönlein purpura]Evangeline Pillebout
Service de Nephrologie et Transplantation Renale, Hopital Saint Louis, Paris, France
Nephrol Ther 5:663-75. 2009..These specific treatments are still controversial and their efficacy has to be evaluated...
5% topical imiquimod tolerance in transplant recipientsAmel Mebazaa
Department of Dermatology, Saint Louis Hospital, Paris, France
Dermatology 215:130-3. 2007..Topical imiquimod is a new immunomodulator agent approved for genital warts, actinic keratosis (AK) or carcinoma, occurring in immunocompetent patients...
Henoch-Schönlein Purpura in adults: outcome and prognostic factorsEvangeline Pillebout
INSERM U426, Faculte de Medecine X Bichat, Université Paris 07, Paris, France
J Am Soc Nephrol 13:1271-8. 2002..Identification of clinical and histologic prognostic factors may permit the design of appropriate therapeutic prospective studies...
