Olivier Thaunat

Summary

Country: France

Publications

  1. doi request reprint Humoral immunity in chronic allograft rejection: puzzle pieces come together
    Olivier Thaunat
    Service de Transplantation Rénale et d Immunologie Clinique, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon, France
    Transpl Immunol 26:101-6. 2012
  2. doi request reprint A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection
    Olivier Thaunat
    Hospices Civils de Lyon, Hopital Edouard Herriot, Service de Transplantation Rénale et d Immunologie Clinique, Lyon, France
    Kidney Int 81:207-19. 2012
  3. ncbi request reprint Amoxicillin-induced aseptic meningo-encephalitis
    O Thaunat
    Hopital St Joseph, Service de Medecine Interne et Maladies Infectieuses, 185 rue Raymond Losserand 75014 Paris, France
    Allergy 58:687-8. 2003
  4. doi request reprint Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis
    Olivier Thaunat
    Institut National de la Santé et de la Recherche Médicale U872, Centre de Recherche des Cordeliers, France
    J Immunol 185:717-28. 2010
  5. ncbi request reprint Direct and indirect effects of alloantibodies link neointimal and medial remodeling in graft arteriosclerosis
    Olivier Thaunat
    Universite Pierre et Marie Curie PARIS6, INSERM UMRS 681, Centre de Recherche des Cordeliers, Paris, France
    Arterioscler Thromb Vasc Biol 26:2359-65. 2006
  6. ncbi request reprint Is defective lymphatic drainage a trigger for lymphoid neogenesis?
    Olivier Thaunat
    Universite Pierre et Marie Curie Paris 6, INSERM UMR S 681, Centre de recherche des Cordeliers 75006, Paris, France
    Trends Immunol 27:441-5. 2006
  7. doi request reprint Chronic humoral rejection mediated by anti-HLA-DP alloantibodies: insights into the role of epitope sharing in donor-specific and non-donor specific alloantibodies generation
    Olivier Thaunat
    Universite de Lyon, F 69622, Lyon, France
    Transpl Immunol 20:209-11. 2009
  8. ncbi request reprint To biopsy or not to biopsy? Should we screen the histology of stable renal grafts?
    Olivier Thaunat
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Paris, France
    Transplantation 84:671-6. 2007
  9. doi request reprint Am"B"valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis
    Olivier Thaunat
    Universite de Lyon, and Service de Transplantation Rénale et d Immunologie Clinique, Hopital Edouard Herriot, 5 Place d Arsonval, Lyon Cedex 03, France
    Blood 116:515-21. 2010
  10. doi request reprint B cell survival in intragraft tertiary lymphoid organs after rituximab therapy
    Olivier Thaunat
    Renal Transplantation and Clinical Immunology Department, Edouard Herriot Hospital, HCL, Universite Claude Bernard Lyon I, INSERM U851, Lyon, France
    Transplantation 85:1648-53. 2008

Collaborators

Detail Information

Publications42

  1. doi request reprint Humoral immunity in chronic allograft rejection: puzzle pieces come together
    Olivier Thaunat
    Service de Transplantation Rénale et d Immunologie Clinique, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon, France
    Transpl Immunol 26:101-6. 2012
    ..The key challenges for the next few years will be to learn how these conceptual progresses can be translated into innovative B cell-targeting therapies to improve long-term allograft outcome...
  2. doi request reprint A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection
    Olivier Thaunat
    Hospices Civils de Lyon, Hopital Edouard Herriot, Service de Transplantation Rénale et d Immunologie Clinique, Lyon, France
    Kidney Int 81:207-19. 2012
    ..When intragraft immune regulation is insufficient, spreading of the local response against kidney autoantigens is favored...
  3. ncbi request reprint Amoxicillin-induced aseptic meningo-encephalitis
    O Thaunat
    Hopital St Joseph, Service de Medecine Interne et Maladies Infectieuses, 185 rue Raymond Losserand 75014 Paris, France
    Allergy 58:687-8. 2003
  4. doi request reprint Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis
    Olivier Thaunat
    Institut National de la Santé et de la Recherche Médicale U872, Centre de Recherche des Cordeliers, France
    J Immunol 185:717-28. 2010
    ..Identification of the molecular checkpoints critical for completion of the lymphoid neogenesis program should help develop innovative therapeutic strategies to fight chronic inflammation...
  5. ncbi request reprint Direct and indirect effects of alloantibodies link neointimal and medial remodeling in graft arteriosclerosis
    Olivier Thaunat
    Universite Pierre et Marie Curie PARIS6, INSERM UMRS 681, Centre de Recherche des Cordeliers, Paris, France
    Arterioscler Thromb Vasc Biol 26:2359-65. 2006
    ..We hypothesized that alloantibodies might be responsible for these 2 opposite but coordinated events...
  6. ncbi request reprint Is defective lymphatic drainage a trigger for lymphoid neogenesis?
    Olivier Thaunat
    Universite Pierre et Marie Curie Paris 6, INSERM UMR S 681, Centre de recherche des Cordeliers 75006, Paris, France
    Trends Immunol 27:441-5. 2006
    ..Antigens and immune effectors are rerouted towards the neoformed ectopic lymphoid structures. A self-perpetuating feedback loop, which further sustains the development of the local immune response, is now imposed...
  7. doi request reprint Chronic humoral rejection mediated by anti-HLA-DP alloantibodies: insights into the role of epitope sharing in donor-specific and non-donor specific alloantibodies generation
    Olivier Thaunat
    Universite de Lyon, F 69622, Lyon, France
    Transpl Immunol 20:209-11. 2009
    ..This case highlights the pathogenicity of anti-DP alloantibodies and suggests that it could be more meaningful to match the epitopes than the HLA antigens for the prevention of rejection...
  8. ncbi request reprint To biopsy or not to biopsy? Should we screen the histology of stable renal grafts?
    Olivier Thaunat
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Paris, France
    Transplantation 84:671-6. 2007
    ..In the present review, we summarize the available data from the literature to determine the pros and cons of protocol renal allograft biopsies. On the basis of this evidence, we discuss the ethical concerns raised by this procedure...
  9. doi request reprint Am"B"valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis
    Olivier Thaunat
    Universite de Lyon, and Service de Transplantation Rénale et d Immunologie Clinique, Hopital Edouard Herriot, 5 Place d Arsonval, Lyon Cedex 03, France
    Blood 116:515-21. 2010
    ..Caution should therefore be exercised when considering B-cell depletion because the therapeutic effect will depend on the relative contributions of the opposing B-cell activities at the time of the drug administration...
  10. doi request reprint B cell survival in intragraft tertiary lymphoid organs after rituximab therapy
    Olivier Thaunat
    Renal Transplantation and Clinical Immunology Department, Edouard Herriot Hospital, HCL, Universite Claude Bernard Lyon I, INSERM U851, Lyon, France
    Transplantation 85:1648-53. 2008
    ..In the present study, we evaluated the impact of rituximab therapy on TLOs associated with chronic active antibody-mediated rejection, a prototypic humoral chronic inflammatory condition...
  11. doi request reprint Lymphoid neogenesis in chronic rejection
    Olivier Thaunat
    Cordeliers Research Centre, University of Pierre and Marie Curie Paris 6, Paris, France
    Curr Opin Organ Transplant 13:16-9. 2008
    ..Although chronic rejection is currently one of the main causes of long-term allograft failure, its pathogenesis remains elusive, thereby preventing the development of effective therapy...
  12. pmc Immune responses elicited in tertiary lymphoid tissues display distinctive features
    Olivier Thaunat
    Universite Lyon 1, Villeurbanne, France
    PLoS ONE 5:e11398. 2010
    ..Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts...
  13. ncbi request reprint Lymphoid neogenesis in chronic rejection: the murderer is in the house
    Olivier Thaunat
    Universite Pierre et Marie Curie Paris 6, INSERM UMR S 681, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Curr Opin Immunol 18:576-9. 2006
    ..Accordingly, functional ectopic germinal centers develop within chronically rejected organs. This implies that, during chronic rejection, graft is at the same time the target and the site of elicitation of the alloimmune response...
  14. ncbi request reprint Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
    Olivier Thaunat
    Department of Renal Transplantation, Hopital Necker Enfants Malades, Paris, France
    Transplantation 80:1212-9. 2005
    ..The responsibility of sirolimus (SRL) for postrenal transplant anemia has never been proven, because SRL is usually combined with myelotoxic drugs, and because of the high incidence of anemia in the posttransplant period...
  15. pmc Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response
    Olivier Thaunat
    Institut National de la Santé et de la Recherche Médicale U681, Institut Biomedical des Cordeliers, Universite Pierre et Marie Curie, Paris VI 75006 Paris, France
    Proc Natl Acad Sci U S A 102:14723-8. 2005
    ....
  16. doi request reprint Antiangiogenic treatment prevents adventitial constrictive remodeling in graft arteriosclerosis
    Olivier Thaunat
    1 INSERM, UMR S 872, Les Cordeliers, Paris, France
    Transplantation 85:281-9. 2008
    ..We reasoned that blockade of the portal of entry of inflammatory effectors may constitute a strategy to prevent constrictive arterial remodeling...
  17. ncbi request reprint [Hepatic hydatidosis]
    Olivier Thaunat
    Service de Medecine Interne, Fondation Hopital Saint Joseph, Paris
    Presse Med 33:30. 2004
  18. doi request reprint Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection
    Clémence Deteix
    Universite Lyon 1, Villeurbanne, France
    J Immunol 184:5344-51. 2010
    ..Further studies will determine whether Th17 infiltration can be used as a prognosis tool and whether the Th17 subset constitutes a therapeutic target for slowing down chronic rejection...
  19. doi request reprint Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine
    Emmanuel Morelon
    Universite de Lyon, France
    Transpl Immunol 23:53-8. 2010
    ..Sirolimus maintenance therapy with Thymoglobulin induction is a promising regimen that may preserve renal function. Data are lacking, however, about the immunologic effects of combined Thymoglobulin-sirolimus...
  20. doi request reprint Retreatment by antithymocyte globulin for second kidney transplantation: efficacy, tolerance and safety
    Ezequiel Rodríguez-Reimúndes
    Division of Transplantation, Nephrology and Clinical Immunology, Hopital Edouard Herriot, Lyon, France
    Transpl Immunol 28:6-8. 2013
    ..The efficacy and tolerance of rATG when used as induction for the second time in patients undergoing retransplantation have not been evaluated...
  21. doi request reprint Pancreas retransplantation: a second chance for diabetic patients?
    Fanny Buron
    Service de Nephrologie, Médecine de Transplantation et d Immunologie Clinique, Hopital Edouard Herriot, Lyon, France
    Transplantation 95:347-52. 2013
    ..This study aims at evaluating pancreas retransplantation outcome...
  22. ncbi request reprint Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients
    Bharath Wootla
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S 872, Universite Paris Descartes, Unité Mixte de Recherche S 872, Institut National de la Sante et de la Recherche Medicale, Unite 872, Paris, France
    J Immunol 180:8455-60. 2008
    ..These data suggest that PFR-MCA hydrolysis may be used as a prognosis marker for CAN in renal-transplanted patients...
  23. doi request reprint [Atherogenesis: a dysimmune disease]
    Aditi Varthaman
    INSERM, UMR S 872, Les Cordeliers, Paris, F 75006 France
    Med Sci (Paris) 24:169-75. 2008
    ..The fine balance between the two extensions of the adaptive immune response is the key to a successful therapeutic approach towards atherosclerosis...
  24. doi request reprint Maintaining calcineurin inhibition after the diagnosis of post-transplant lymphoproliferative disorder improves renal graft survival
    Jean Emmanuel Serre
    Hospices Civils de Lyon, Hopital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie Clinique, Lyon, France
    Kidney Int 85:182-90. 2014
    ..Thus, maintaining calcineurin inhibition at a reduced dose after the diagnosis of PTLD seems safe and may improve renal graft outcome, possibly through better control of the recipient's humoral immune response. ..
  25. ncbi request reprint Atheroprotective effect of CD31 receptor globulin through enrichment of circulating regulatory T-cells
    Emilie Groyer
    INSERM UMR S 872, Paris, France
    J Am Coll Cardiol 50:344-50. 2007
    ..This study was designed to evaluate whether replacing CD31 (PECAM-1) signaling can restore the regulation of lymphocyte activation and improve experimental atherosclerosis...
  26. pmc Profiling sirolimus-induced inflammatory syndrome: a prospective tricentric observational study
    Fanny Buron
    Service de Transplantation, néphrologie et Immunologie Clinique de l Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France Université de Lyon, Lyon, France
    PLoS ONE 8:e53078. 2013
    ....
  27. doi request reprint Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect
    Hélène Perrin
    INSERM, U851, 21 Avenue Tony Garnier, Lyon, F 69007, France
    Nephrol Dial Transplant 24:1682-5. 2009
    ..New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes...
  28. doi request reprint Human mesenchymal stem cells and immunosuppressive drug interactions in allogeneic responses: an in vitro study using human cells
    F Buron
    INSERM U 851 Lyon, Université Lyon1, Villeurbanne, France
    Transplant Proc 41:3347-52. 2009
    ..However, little is known about their interactions with immunosuppressive drugs. The objective of this study was to assess these interactions in allogeneic responses...
  29. ncbi request reprint Nephrotic syndrome associated with hemophagocytic syndrome
    O Thaunat
    Department of Nephrology, Hopital Necker Enfants Malades, Paris, France
    Kidney Int 69:1892-8. 2006
    ..We postulate that abnormal T-cell activation and/or high pro-inflammatory cytokine levels during HPS might cause podocyte injuries, especially among African patients with a susceptible genetic background...
  30. ncbi request reprint Composite tissue allograft extends a helping hand to transplant immunologists
    O Thaunat
    Institut National de la Santé et de la Recherche Médicale U681, Institut Biomedical des Cordeliers, Universite Pierre et Marie Curie Paris VI, Paris, France
    Am J Transplant 6:2238-42. 2006
    ..In this sense, composite tissue allografts extend a helping hand to transplant immunologists...
  31. ncbi request reprint Type III cryoglobulinemia complicated by renal cortical necrosis
    Olivier Thaunat
    Department of Nephrology, AP HP, Hopital Necker Enfants Malades, Paris, France
    Am J Kidney Dis 45:e79-81. 2005
    ..Renal magnetic resonance imaging was a valuable tool in the evaluation of the extent of renal cortical necrosis and improvement in renal vascularization after treatment...
  32. pmc IVIg treatment reduces catalytic antibody titers of renal transplanted patients
    Ankit Mahendra
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Unité Mixte de Recherche S 872, Paris, France
    PLoS ONE 8:e70731. 2013
    ....
  33. ncbi request reprint [Sterile inflammatory response to ischemia-reperfusion injury: immediate and long term consequences on graft function]
    Olivier Thaunat
    Immunologie clinique et transplantation rénale, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon, et Inserm U851
    Bull Acad Natl Med 195:847-59; discussion 859. 2011
    ..Strategies capable of dampening the sterile inflammatory response induced by ischemia-reperfusion could therefore be beneficial, both for immediate post-transplantation graft function and for long-term outcome...
  34. ncbi request reprint [Cancer and immunosuppression: pro- and antitumoral effects of immunosuppressive drugs]
    Olivier Thaunat
    INSERM U 430, Institut Biomedical des Cordeliers, Paris, France
    Nephrol Ther 1:23-30. 2005
    ..If these antitumoral features are confirmed in human, this new immunosuppressive family will offer the unique opportunity to reduce both the incidence of rejection and cancer in organ transplant recipients...
  35. ncbi request reprint Renal cell carcinoma of the grafted kidney: how to improve screening and graft tracking
    Morgan Roupret
    Department of Urology, Hopital Necker Enfants Malades, Paris Cedex, France
    Transplantation 77:146-8. 2004
    ....
  36. ncbi request reprint Mycobacterium xenopi pulmonary infection in two renal transplant recipients under sirolimus therapy
    O Thaunat
    Service de Transplantation, Hopital Necker, Paris, France
    Transpl Infect Dis 6:179-82. 2004
    ..These two case reports suggest that sirolimus therapy may lead to an impairment of the immune response against intracellular pathogens such as M. xenopi...
  37. ncbi request reprint [Implication of the lymphoid neogenesis process in chronic rejection]
    Olivier Thaunat
    Med Sci (Paris) 22:110-1. 2006
  38. ncbi request reprint Severe human herpesvirus-8 primary infection in a renal transplant patient successfully treated with anti-CD20 monoclonal antibody
    Olivier Thaunat
    Blood 107:3009-10. 2006
  39. ncbi request reprint Complexity of antigenic determinants and humoral responses in vascular injury
    Olivier Thaunat
    Cardiovasc Res 68:183-5. 2005
  40. ncbi request reprint Is lymphoid neogenesis a therapeutic target for chronic rejection?
    Olivier Thaunat
    Am J Transplant 7:1312-3; author reply 1314. 2007
  41. ncbi request reprint Late introduction of sirolimus induces anemia in renal transplant recipients
    Olivier Thaunat
    Transplantation 83:1283; author reply 1284. 2007
  42. ncbi request reprint Topological determinants and consequences of adventitial responses to arterial wall injury
    Jean Baptiste Michel
    INSERM unit 698 and University Denis Diderot Paris 7, CHU Xavier Bichat, 46 rue Henri Huchard, 75018 Paris, France
    Arterioscler Thromb Vasc Biol 27:1259-68. 2007
    ..These adventitial events, therefore, have an impact not only on the vessel wall biology but also on the surrounding tissue...