Research Topics
Species | Philippe Gabriel StegSummaryCountry: France Publications
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Publications
RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndromePh Gabriel Steg
INSERM U 698, Paris, France
Eur Heart J 32:2541-54. 2011..To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS)...
DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarctionPhilippe Gabriel Steg
Department of Cardiology, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Eur Heart J 25:2187-94. 2004..To determine whether late recanalization of an occluded infarct artery after acute myocardial infarction is beneficial...- Predischarge C-reactive protein and 1-year outcome after acute coronary syndromesPhilippe Gabriel Steg
Department of Cardiology, Hopital Bichat, Paris, France
Am J Med 119:684-92. 2006..To investigate the relationship between high-sensitivity C-reactive protein and cardiovascular events following acute coronary syndrome... - Patterns of use and potential impact of early beta-blocker therapy in non-ST-elevation myocardial infarction with and without heart failure: the Global Registry of Acute Coronary EventsMichael Emery
The University of Michigan Cardiovascular Center, Ann Arbor, MI 48109-0477, USA
Am Heart J 152:1015-21. 2006..CONCLUSIONS: Many eligible patients do not receive early BB therapy. Treatment with early BBs may have a beneficial impact on hospital and 6-month mortality in all patients, including those presenting with heart failure... - Autopsy prevalence of coronary atherosclerosis in patients with fatal strokeFernando Gongora Rivera
Department of Neuropathology Raymond Escourolle, La Salpetriere Hospital, France
Stroke 38:1203-10. 2007..The objective of the study was to establish the prevalence of coronary atherosclerosis and MI after fatal stroke... 
Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosisGaia Sirimarco
Department of Cardiology, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Stroke 44:373-9. 2013..We examined the association among carotid atherosclerosis, history of atherothrombotic events, and risk of coronary events...- A history of stroke/transient ischemic attack indicates high risks of cardiovascular event and hemorrhagic stroke in patients with coronary artery diseaseGregory Ducrocq
INSERM U 698 and Cardiology, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Circulation 127:730-8. 2013..We aimed to further characterize the risk of ischemic and bleeding events associated with a history of stroke/TIA in patients with coronary artery disease... - Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndroPhilippe Gabriel Steg
AP HP, Hopital Bichat, Paris, France
Am Heart J 164:817-24.e13. 2012.... - Symptoms, functional status and quality of life in patients with controlled and uncontrolled atrial fibrillation: data from the RealiseAF cross-sectional international registryP Gabriel Steg
INSERM U, Paris, France
Heart 98:195-201. 2012..Rate control and rhythm control are accepted management strategies for atrial fibrillation (AF)... - Reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary interventionMorgane Ethgen
INSERM, U738, Paris, F 75018 France
Trials 10:29. 2009..The aim of this study was to assess the reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention... - Improving the management of non-ST elevation acute coronary syndromes: systematic evaluation of a quality improvement programme European QUality Improvement Programme for Acute Coronary Syndrome: the EQUIP-ACS project protocol and designMarcus D Flather
Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, SW7 6NP, UK
Trials 11:5. 2010.... - Excess risk attributable to traditional cardiovascular risk factors in clinical practice settings across Europe - The EURIKA StudyEliseo Guallar
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
BMC Public Health 11:704. 2011..The objective of this study was to estimate the excess risk attributable, firstly, to the presence of CVD risk factors and, secondly, to the lack of control of these risk factors in primary prevention care across Europe... - Rationale and methods of the European Study on Cardiovascular Risk Prevention and Management in Daily Practice (EURIKA)Fernando Rodriguez-Artalejo
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autonoma de Madrid, CIBER of Epidemiology and Public Health, Madrid 28029, Spain
BMC Public Health 10:382. 2010..It will also assess physicians' knowledge and attitudes about CVD prevention as well as the barriers impeding effective risk factor management in clinical practice... - Impact of in-hospital revascularization on survival in patients with non-ST-elevation acute coronary syndrome and congestive heart failurePhilippe Gabriel Steg
INSERM U 698, Recherche Clinique en Athérothrombose, Universite Paris VII, Centre Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris, Cedex 18, France
Circulation 118:1163-71. 2008..The aims of this study were to describe the use of revascularization in non-ST-elevation acute coronary syndrome and CHF and to analyze its impact on survival... - Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysisPhilippe Gabriel Steg
INSERM U, Paris, France
Circulation 122:2131-41. 2010.... - Mortality following placement of drug-eluting and bare-metal stents for ST-segment elevation acute myocardial infarction in the Global Registry of Acute Coronary EventsPh Gabriel Steg
INSERM U 698 Recherche Clinique en Athérothrombose, université Paris VII Denis Diderot, Assistance Publique Hopitaux de Paris, Centre Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Eur Heart J 30:321-9. 2009..To assess mortality after drug-eluting stent (DES) or bare-metal stent (BMS) for ST-segment elevation myocardial infarction (STEMI)... - One-year cardiovascular event rates in outpatients with atherothrombosisPh Gabriel Steg
Departement de Cardiologie, Hopital Bichat Claude Bernard, Paris, France
JAMA 297:1197-206. 2007.... - Fondaparinux with UnfracTionated heparin dUring Revascularization in Acute coronary syndromes (FUTURA/OASIS 8): a randomized trial of intravenous unfractionated heparin during percutaneous coronary intervention in patients with non-ST-segment elevation acPhilippe Gabriel Steg
INSERM U 698, Recherche Clinique en Athérothrombose, Universite Paris 7, Denis Diderot, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
Am Heart J 160:1029-34, 1034.e1. 2010..There is uncertainty regarding the optimal adjunctive unfractionated heparin (UFH) regimen for percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) treated with fondaparinux... - Atherothrombosis and the role of antiplatelet therapyPh G Steg
INSERM U 698, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Paris, France
J Thromb Haemost 9:325-32. 2011.... - Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of CardiologyPhilippe Gabriel Steg
INSERM U 698, Université Paris Diderot and Centre Hospitalier Bichat, Assistance Publique Hopitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France
Eur Heart J 32:1854-64. 2011..Finally, the research implications of bleeding (measuring and reporting bleeding in trials, the importance of bleeding as an outcome measure, and bleeding as a subject for future research) are also discussed... - A randomised trial of three counselling strategies for lifestyle changes in patients with hypercholesterolemia treated with ezetimibe on top of statin therapy (TWICE)Philippe Gabriel Steg
INSERM U 698, université Paris VII Denis Diderot, Hopital Bichat Claude Bernard, AP HP, 46, rue Henri Huchard 75018 Paris, France
Arch Cardiovasc Dis 101:723-35. 2008..To compare the impact of three patient counselling strategies for lifestyle changes and to assess the safety and efficacy of ezetimibe on top of statin therapy in hypercholesterolemic high risk patients... - Microparticle-linked tissue factor activity and increased thrombin activity play a potential role in fibrinolysis failure in ST-segment elevation myocardial infarctionMarie Genevieve Huisse
Department of Haematology, AP HP, Hopital Bichat, Paris, France
Thromb Haemost 101:734-40. 2009..83 [14.83-40.43] mug/ml) than in controls (35.83 [27.9-43.94] mug/ml), p = 0.045. In conclusion, fibrinolysis failure in AMI is characterised by a higher procoagulant state associated with TF-MP and a lower plasmin generation... - Clinical outcomes according to permanent discontinuation of clopidogrel or placebo in the CHARISMA trialJean Philippe Collet
Inserm unit 937, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, bureau 236, 47, Boulevard de l Hopital, 75013 Paris, France
Arch Cardiovasc Dis 102:485-96. 2009..Late discontinuation of clopidogrel after an acute coronary syndrome or stent placement may be associated with a clinical rebound effect... - Universal reperfusion therapy can be implemented: lessons from 20 years of management of patients admitted within 6 hours of symptom onset with ST-segment elevation acute myocardial infarctionJean Michel Juliard
Centre Hospitalier Bichat Claude Bernard, AP HP, 46, 75018 Paris, France
Arch Cardiovasc Dis 102:259-67. 2009..To describe longitudinal trends in patients' characteristics, management and hospital outcomes over 20 years of therapy for ST-segment elevation myocardial infarction (STEMI)... - Prevalence of embolic signals in acute coronary syndromesElena Meseguer
INSERM U 698 and Paris Diderot University, Bichat Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Stroke 41:261-6. 2010..The purpose of this study was to assess the prevalence of embolic signals (ES) in acute coronary syndromes (ACS) and their association with stroke... - A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effectsPhilippa C Lavallee
Department of Neurology and Stroke Centre, Bichat Claude Bernard University Hospital, Denis Diderot University and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
Lancet Neurol 6:953-60. 2007..We evaluated the effects of rapid assessment of patients with TIA on clinical decision making, length of hospital stay, and subsequent stroke rates... - [Clinical characteristics, management and pronostic evolution of patients admitted within six hours of symptom onset with st-segment elevation acute myocardial infarction complicated by cardiogenic shock : twenty year monocentric experience]Sami Marouene
CHU Bichat Claude Bernard, Paris, France
Tunis Med 90:715-9. 2012..BACKGROUND : Cardiogenic shock is one of the most serious complications of the acute myocardial infarction. Advances in interventional cardiology and early reperfusion strategy improved its management... - Prevalence of coronary atherosclerosis in patients with cerebral infarctionPierre Amarenco
INSERM U 698 and Paris Diderot University, Paris, France
Stroke 42:22-9. 2011.... - External validity of clinical trials in acute myocardial infarctionPhilippe Gabriel Steg
Department of Cardiology, Hopital Bichat, Paris, France
Arch Intern Med 167:68-73. 2007.... - Acute coronary angiographic findings in survivors of out-of-hospital cardiac arrestZacharias Alexandros Anyfantakis
Institut National de la Sante et de la Recherche Medicale, Universite Paris, Groupe Hospitalier Bichat Claude Bernard, Paris, France
Am Heart J 157:312-8. 2009..The objective of this study was to assess the prevalence of coronary lesions on emergency angiography in survivors of OHCA... - Determinants and prognostic impact of heart failure complicating acute coronary syndromes: observations from the Global Registry of Acute Coronary Events (GRACE)Philippe Gabriel Steg
Centre Hospitalier Universitaire Bichat Beaujon, Assistance Publique Hopitaux de Paris, France
Circulation 109:494-9. 2004..Few data are available on the impact of heart failure (HF) across all types of acute coronary syndromes (ACS)... - Long-term clinical outcomes after rescue angioplasty are not different from those of successful thrombolysis for acute myocardial infarctionPhilippe Gabriel Steg
Department of Cardiology, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Eur Heart J 26:1831-7. 2005..This study aimed to compare long-term outcomes after successful thrombolysis vs. systematic attempted rescue PTCA... - Association of changes in clinical characteristics and management with improvement in survival among patients with ST-elevation myocardial infarctionEtienne Puymirat
Assistance Publique Hopitaux de Paris AP HP, Hopital Europeen Georges Pompidou, Department of Cardiology, Universite Paris Descartes, and INSERM U 970, Paris, France
JAMA 308:998-1006. 2012..The contemporary decline in mortality reported in patients with ST-segment elevation myocardial infarction (STEMI) has been attributed mainly to improved use of reperfusion therapy... - Risk score to predict serious bleeding in stable outpatients with or at risk of atherothrombosisGregory Ducrocq
INSERM U 698 Recherche Clinique en Athérothrombose, Department of Cardiology, Centre Hospitalier Universitaire Bichat Claude Bernard, 46 rue Henri Huchard, Paris Cedex, France
Eur Heart J 31:1257-65. 2010..To develop a risk score to quantify bleeding risk in outpatients with or at risk of atherothrombosis... - Ischemia-modified albumin in acute strokeHalim Abboud
Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
Cerebrovasc Dis 23:216-20. 2007..Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels... - Does lay media ranking of hospitals reflect lower mortality in treating acute myocardial infarction?Karine Chevreul
AP HP, URC Eco and UPEC EA 4393, Paris, France
Arch Cardiovasc Dis 105:489-98. 2012..Ranking of hospitals by lay media has attracted widespread attention but may not accurately reflect quality. Acute myocardial infarction (AMI) mortality is a straightforward measure of clinical outcome frequently used by ranking algorithms... - Screening for abdominal aortic aneurysm in coronary care unit patients with acute myocardial infarction using portable transthoracic echocardiographyCaroline Cueff
Cardiology Department, AP HP, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France
Eur Heart J Cardiovasc Imaging 13:574-8. 2012..We aimed to evaluate the feasibility of AAA screening at bedside using a portable cardiac ultrasound (US) echo machine and to determine the prevalence of AAA in population with AMI... - Gender differences in hospital mortality and use of percutaneous coronary intervention in acute myocardial infarction: microsimulation analysis of the 1999 nationwide French hospitals databaseCarine Milcent
PSE Paris Jourdan Sciences Economiques L Ecole des Hautes Etudes en Sciences Sociales, Centre National de la Recherche Scientifique, Paris, France
Circulation 115:833-9. 2007..This difference has been ascribed to their older age, more frequent comorbidities, and less frequent use of revascularization. The aim of this study is to assess these factors in relation to excess mortality in women... - Prevalence and determinants of subdiaphragmatic visceral infarction in patients with fatal strokeHalim Abboud
Assistance Publique Hopitaux de Paris, Paris, France
Stroke 38:1442-6. 2007..We therefore investigated the prevalence of SDVI in subjects who died from stroke. We also evaluated the yield of SDVI diagnosis for stroke subtyping... - Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trialPhilippe Gabriel Steg
Service de cardiologie, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Circulation 108:2851-6. 2003.... - Delphi-consensus weights for ischemic and bleeding events to be included in a composite outcome for RCTs in thrombosis preventionAgnes Dechartres
UMR S 738, INSERM, Paris, France
PLoS ONE 6:e18461. 2011..To weight ischemic and bleeding events according to their severity to be used in a composite outcome in RCTs in the field of thrombosis prevention... - Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation MyocardTabassome Simon
Department of Pharmacology, Clinical Research Unit, APHP, St Antoine Hospital, UMPC Paris 06 University, 27 rue Chaligny, Paris, France
Circulation 123:474-82. 2011..This analysis compares treatment outcomes for patients in the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) who did or did not receive clopidogrel and/or PPIs... - Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE)Philippe Gabriel Steg
Hopital Bichat, Paris, France
Am J Cardiol 90:358-63. 2002..0001), and recurrent angina with ST-segment changes occurred before discharge in 10%, 10%, and 9% of patients, respectively (p = 0.2644). GRACE provides a detailed and comprehensive global description of the spectrum of patients with ACS... - Rapid desensitization procedure for patients with aspirin hypersensitivity undergoing coronary stentingStephane Silberman
Department of Cardiology, Hopital Bichat, Paris, France
Am J Cardiol 95:509-10. 2005..No late allergic reactions or adverse cardiac events were seen after a mean follow-up of 14 months. A rapid challenge-desensitization procedure may allow introduction of aspirin at therapeutic doses within a few hours... - In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosisJuan Antonio Moreno
INSERM U, Paris, France
Eur Heart J 33:252-63. 2012..We analysed the relationship between CD163 solubilization and elastase in vitro, in macrophage culture, ex vivo in human atherosclerotic plaque samples, and in vivo, in plasma of patients with coronary artery disease... - Comparison of clinical presentations and outcomes between patients with TGFBR2 and FBN1 mutations in Marfan syndrome and related disordersDavid Attias
Centre de référence pour le syndrome de Marfan et apparentés, Hopital Bichat, Paris, France
Circulation 120:2541-9. 2009..TGFBR2 mutations were recognized recently among patients with a Marfan-like phenotype. The associated clinical and prognostic spectra remain unclear... - Stroke is a coronary heart disease risk equivalent: implications for future clinical trials in secondary stroke preventionPierre Amarenco
INSERM U-698 and Denis Diderot University-Paris VII, France
Eur Heart J 29:1605-7. 2008 - Effects of adherence to guidelines for the control of major cardiovascular risk factors on outcomes in the REduction of Atherothrombosis for Continued Health (REACH) Registry EuropePatrice P Cacoub
AP HP Service de Médecine Interne, Groupe Hospitalier La Pitié Salpêtrière, 47 83, Boulevard de l Hopital, 75013 Paris, France
Heart 97:660-7. 2011..To examine the impact of cardiovascular risk factor control on 3-year cardiovascular event rates in patients with stable symptomatic atherothrombotic disease in Europe... - Comparison of thrombolysis followed by broad use of percutaneous coronary intervention with primary percutaneous coronary intervention for ST-segment-elevation acute myocardial infarction: data from the french registry on acute ST-elevation myocardial infNicolas Danchin
Division of Coronary Artery Disease and Intensive Cardiac Care, Hopital Europeen Georges Pompidou, Assistance Publique des Hôpitaux de Paris and Faculté René Descartes, Universite Paris 5, 20 rue Leblanc, 75015 Paris, France
Circulation 118:268-76. 2008.... - Immediate vs delayed intervention for acute coronary syndromes: a randomized clinical trialGilles Montalescot
Institut de Cardiologie, Bureau 2 236, Centre Hospitalier Universitaire Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
JAMA 302:947-54. 2009..International guidelines recommend an early invasive strategy for patients with high-risk acute coronary syndromes without ST-segment elevation, but the optimal timing of intervention is uncertain... - Unprotected left main revascularization in patients with acute coronary syndromesGilles Montalescot
Institut de Cardiologie, Bureau 2 236, Centre Hospitalier Universitaire Pitie Salpetriere, 47 Blvd de l Hopital, 75013 Paris, France
Eur Heart J 30:2308-17. 2009.... - Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention 1-year results from the STEEPLE (SafeTy and efficacy of enoxaparin in percutaneous coronary intervention patients, an international randomized evaluation) trialGilles Montalescot
Institut du Coeur, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
JACC Cardiovasc Interv 2:1083-91. 2009..Our purpose was to evaluate long-term mortality and identify factors associated with 1-year mortality in patients who underwent elective percutaneous coronary intervention (PCI)... - Impact of anticoagulation levels on outcomes in patients undergoing elective percutaneous coronary intervention: insights from the STEEPLE trialGilles Montalescot
Institut de Cardiologie AP HP and INSERM Unit no 856, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Eur Heart J 29:462-71. 2008..To determine the relationship between anticoagulation levels during percutaneous coronary intervention, and ischaemic events and bleeding... - Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control studyNadine Ajzenberg
Hématologie et Immunologie, Hopital Bichat, Paris, France
J Am Coll Cardiol 45:1753-6. 2005..The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT)... - A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) tGilles Montalescot
Institut de Cardiologie Pitié Salpêtriére University Hospital, Assistence Publique Hôpiteux de Paris APHP, Paris, France
J Am Coll Cardiol 48:931-8. 2006..We sought to compare the antiplatelet effects of three clopidogrel loading doses (LDs)... - B-type natriuretic peptide and echocardiographic determination of ejection fraction in the diagnosis of congestive heart failure in patients with acute dyspneaPhilippe Gabriel Steg
Cardiology, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Chest 128:21-9. 2005..Echocardiography and B-type natriuretic peptide (BNP) are diagnostic tests for congestive heart failure (CHF), but an emergency diagnosis can be difficult... - Myocardial infarction after blunt chest trauma: usefulness of cardiac ECG-gated CT and MRI for positive and aetiologic diagnosisGregory Malbranque
Department of Cardiology, University Hospital Bichat APHP, 46 rue Henri Huchard, Paris, France
Emerg Radiol 18:271-4. 2011..In these two cases, cardiac CT and MRI were useful to noninvasively explore these lesions... - Quality of reporting internal and external validity data from randomized controlled trials evaluating stents for percutaneous coronary interventionMorgane Ethgen
Institut National de la Santé et la Recherche Médiale, INSERM U738, Paris, France
BMC Med Res Methodol 9:24. 2009..The objective of our study was to evaluate the quality of reporting internal and external validity data in published reports of RCTs assessing the stents for percutaneous coronary interventions... - Prognostic significance of renal insufficiency in patients presenting with acute coronary syndrome (the Prospective Multicenter SYCOMORE study)Raphaelle Dumaine
Pitie Salpetriere Hospital, Paris, France
Am J Cardiol 94:1543-7. 2004..One third of patients with ACS presented with renal insufficiency. After adjustment for potential confounders, decreasing renal function was independently associated with in-hospital death, bleeding, and contrast-induced nephropathy... - Age and lack of beta-blocker therapy are associated with increased long-term mortality after primary coronary angioplasty for acute myocardial infarctionJean Michel Juliard
Division of Cardiology, Hopital Bichat, AP HP, 46 rue Henri Huchard, 75877 Cedex 18, Paris, France
Int J Cardiol 88:63-8. 2003..Few studies have examined the long-term outcome of primary PTCA for acute myocardial infarction, especially in thrombolysis-eligible patients... - Relation of mortality of primary angioplasty during acute myocardial infarction to door-to-Thrombolysis In Myocardial Infarction (TIMI) timeJean Michel Juliard
Cardiology Department, Hopital Bichat, AP HP, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Am J Cardiol 91:1401-5. 2003..After linear logistic regression, only age (odds ratio [OR] 1.79 per 10 years), female gender (OR 3.56), and door-to-TIMI 3 time (OR 1.27 per 15 minutes) were independently correlated with in-hospital mortality... - Impact of collateral flow to the occluded infarct-related artery on clinical outcomes in patients with recent myocardial infarction: a report from the randomized occluded artery trialPh Gabriel Steg
INSERM U 698 and Département de Cardiologie, Centre Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris Cedex 18, France
Circulation 121:2724-30. 2010..Collateral flow to the infarct artery territory after acute myocardial infarction may be associated with improved clinical outcomes and may also impact the benefit of subsequent recanalization of an occluded infarct-related artery... - Circulating secretory phospholipase A2 activity predicts recurrent events in patients with severe acute coronary syndromesZiad Mallat
Institut National de la Santé et la Recherche Médicale, INSERM U541, Institut Fédératif de Recherche IRF Circulation, Paris, France
J Am Coll Cardiol 46:1249-57. 2005..The purpose of this study was to determine the prognostic value of circulating secretory phospholipase A2 (sPLA2) activity in patients with acute coronary syndromes (ACS)... - Renal function, atherothrombosis extent, and outcomes in high-risk patientsRaphaelle L Dumaine
Pitie Salpetriere University Hospital, Paris, France
Am Heart J 158:141-148.e1. 2009..Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD... - Extent of, and factors associated with, delay to hospital presentation in patients with acute coronary disease (the GRACE registry)Robert J Goldberg
University of Massachusetts Medical School, Worcester, Massachusetts, USA
Am J Cardiol 89:791-6. 2002.... - Impact of prehospital thrombolysis for acute myocardial infarction on 1-year outcome: results from the French Nationwide USIC 2000 RegistryNicolas Danchin
Service de cardiologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
Circulation 110:1909-15. 2004..Limited data are available on the impact of prehospital thrombolysis (PHT) in the "real-world" setting... - Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006Keith A A Fox
Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Edinburgh, Scotland
JAMA 297:1892-900. 2007.... - Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction?Frederick A Spencer
Department of Medicine, McMaster University, Faculty of Health Sciences, 1200 Main St W, Hamilton, Canada, L8N 3Z5
Circulation 116:2793-801. 2007..Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world" setting... - Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary EventsKristen Franklin
Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
Arch Intern Med 164:1457-63. 2004..There are limited data describing the presenting characteristics, management, and outcomes of diabetic and nondiabetic patients with an acute coronary syndrome (ACS)... - Resting heart rate in cardiovascular diseaseKim Fox
Royal Brompton Hospital, Sydney Street, London SW3 6NP, England
J Am Coll Cardiol 50:823-30. 2007..These findings suggest that the potential role of HR and its modulation should be considered in future cardiovascular guidance documents... - Patterns of use of heparins in ACS. Correlates and hospital outcomes: the Global Registry of Acute Coronary Events (GRACE)Werner Klein
Medizinische Universitätsklinik Graz, Klinische Abteilung für Kardiologie, Auenbruggerplatz 5, Graz, Styria 8036, Austria
Thromb Haemost 90:519-27. 2003..We can conclude that UFH tends to be used more frequently than LMWH, but hospital outcomes appeared to be better with LMWH after adjusting for covariables... - Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot TrialShamir R Mehta
McMaster University and the Population Health Research Institute, Hamilton Health Sciences, General Division, 237 Barton St E, Hamilton, Ontario, Canada L6K 1B8
Circulation 111:1390-7. 2005..We performed a randomized trial to determine the safety and feasibility of fondaparinux in the percutaneous coronary intervention (PCI) setting... - [Acute coronary syndrome with ST-segment elevation]Olivier Varenne
Services de cardiologie I Hôpital Cochin 75679 Paris
Rev Prat 53:611-8. 2003..New fibrinolytics and optimisation of antithrombotic regimen in association with coronary stents have dramatically reduced in-hospital mortality... - Enoxaparin in non-ST segment elevation acute coronary syndromes: duration of therapy is essential to benefitPhilippe Gabriel Steg
Eur Heart J 25:1667-9. 2004 - [Acute coronary syndromes: a change of paradigm]Philippe Gabriel Steg
Med Sci (Paris) 20:132-3. 2004 - Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational studyKim A Eagle
University of Michigan Cardiovascular Center, Ann Arbor, Michigan, USA
Am J Med 117:73-81. 2004..The reasons for noncompliance are complex, and may be elucidated by future studies of medical and social determinants... - Is primary angioplasty more effective than prehospital fibrinolysis in diabetics with acute myocardial infarction? Data from the CAPTIM randomized clinical trialEric Bonnefoy
Service de cardiologie, Hopital Cardio Vasculaire et Pneumologique Louis Pradel, BP Lyon Montchat, 69394 Lyon Cedex 03, France
Eur Heart J 26:1712-8. 2005..It found a similar incidence of the primary endpoint of death, recurrent MI, or stroke at 30 days with both strategies. We report here the outcome in the diabetic subgroup... - Prevalence and impact of metabolic syndrome on hospital outcomes in acute myocardial infarctionMarianne Zeller
Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, Faculty of Medicine, University of Burgundy, Dijon, France
Arch Intern Med 165:1192-8. 2005.... - Combined Abciximab REteplase Stent Study in acute myocardial infarction (CARESS in AMI)Carlo Di Mario
Royal Brompton Hospital, London, United Kingdom
Am Heart J 148:378-85. 2004..If a mechanical recanalization is likely to be performed in an emergency, it is probably desirable that the patient receives abciximab, the glycoprotein IIb/IIIa antagonist with the strongest evidence of benefit for angioplasty in AMI... - Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to goKim A Eagle
University of Michigan Cardiovascular Center, Ann Arbor, MI 48109 0477, USA
Eur Heart J 29:609-17. 2008..Many patients who are eligible for acute reperfusion therapy receive it after substantial delays or not at all. We wanted to determine whether over the years more patients are receiving reperfusion therapy... - Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trialCarlo Di Mario
Royal Brompton Hospital and Imperial College, London UK
Lancet 371:559-68. 2008..To assess the best management, we randomised patients with STEMI treated by thrombolysis and abciximab at a non-interventional hospital to immediate transfer for PCI, or to standard medical therapy with transfer for rescue angioplasty... - Revascularization before noncardiac surgery: is there an impact of drug-eluting stent thrombosis?Philippe Gabriel Steg
J Am Coll Cardiol 50:1398; author reply 1399. 2007 - Increasing use of single and combination medical therapy in patients hospitalized for acute myocardial infarction in the 21st century: a multinational perspectiveRobert J Goldberg
Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, USA
Arch Intern Med 167:1766-73. 2007..Current practice guidelines recommend the routine use of several effective cardiac medications in hospital survivors of acute myocardial infarction (AMI)... - Impact of prior peripheral arterial disease and stroke on outcomes of acute coronary syndromes and effect of evidence-based therapies (from the Global Registry of Acute Coronary Events)Debabrata Mukherjee
Gill Heart Institute and the University of Kentucky, Lexington, Kentucky, USA
Am J Cardiol 100:1-6. 2007..In conclusion, outcomes after ACS are worse in patients with PAD or stroke, with the highest risk in patients with the 2 conditions and the use of evidence-based therapies are associated with improved outcomes in all ACS subgroups... - Use of proven therapies in non-ST-elevation acute coronary syndromes according to evidence-based risk stratificationGustavo B F Oliveira
Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil
Am Heart J 153:493-9. 2007..Our objective was to evaluate the relationship between risk stratification and therapeutic decision making in patients with non-ST-segment elevation acute coronary syndromes... - Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the I(f) inhibitor ivabradine in paKim Fox
Royal Brompton Hospital, Sydney Street, London, UK
Am Heart J 152:860-6. 2006..RESULTS: The first patient was randomized in January 2005. CONCLUSION: BEAUTIFUL will be the first major outcome trial of a specific HR-reducing agent. The study results are expected in 2008... - WEST: new data on the integration of early thrombolysis and mechanical intervention in the early management of STEMIPhilippe Gabriel Steg
Eur Heart J 27:1511-2. 2006 - The diagnostic and prognostic impact of the redefinition of acute myocardial infarction: lessons from the Global Registry of Acute Coronary Events (GRACE)Shaun G Goodman
Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Am Heart J 151:654-60. 2006..The impact and prognostic value of the redefinition of myocardial infarction (MI) with more sensitive markers have not been evaluated prospectively in a large, less selected population with acute coronary syndrome (ACS)... - Medication performance measures and mortality following acute coronary syndromesChristopher B Granger
Duke University Medical Center, Durham, NC, USA
Am J Med 118:858-65. 2005..To identify patient and health care factors which are related to the use of medical treatments that comprise quality measures and to assess the relation of these measures with mortality... - Relation between body mass index, waist circumference, and death after acute myocardial infarctionMarianne Zeller
Laboratory of Experimental and Cardiovascular Physiopathology and Pharmacology, IFR Santé STIC, Faculty of Medicine, 7 bd Jeanne d Arc, 21000 Dijon, France
Circulation 118:482-90. 2008..However, waist circumference (WC) may be a better marker of cardiovascular risk than BMI. We used data from a contemporary French population-based cohort of patients with AMI to analyze the impact of WC and BMI on death rates...