Lydie Sparfel

Summary

Country: France

Publications

  1. ncbi Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene
    Lydie Sparfel
    EA 4427 SeRAIC, Equipe Toxicité des hydrocarbures aromatiques polycycliques labellisée par la Ligue Nationale contre le Cancer, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, 35043 Rennes, France
    Toxicol Sci 114:247-59. 2010
  2. ncbi Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst
    Marie Laure Pinel-Marie
    INSERM U620 EA4427 SeRAIC, IFR140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Free Radic Biol Med 47:825-34. 2009
  3. ncbi Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages
    Marie Laure Pinel-Marie
    Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, EA 4427 Signalisation et Réponses aux Agents Infectieux et Chimiques SeRAIC, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicology 290:89-95. 2011
  4. ncbi Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur lSanté, l Environnement et Travail, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicol Appl Pharmacol 262:217-22. 2012
  5. ncbi Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
    Normand Podechard
    UMR INSERM U620, Team Toxicity of Polycyclic Aromatic Hydrocarbons labellisée Ligue contre le Cancer, IFR140, Universite de Rennes 1, France
    Toxicol Lett 177:130-7. 2008
  6. ncbi Global effects of inorganic arsenic on gene expression profile in human macrophages
    Emilie Bourdonnay
    Inserm U620 EA SeRAIC Signalisations et Réponses aux Agents Infectieux et chimiques, IFR140 GFAS, Universite de Rennes 1, 35043 Rennes, France
    Mol Immunol 46:649-56. 2009
  7. ncbi Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha
    Lydie Sparfel
    INSERM U620, IFR 140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Carcinogenesis 27:656-63. 2006

Collaborators

Detail Information

Publications7

  1. ncbi Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene
    Lydie Sparfel
    EA 4427 SeRAIC, Equipe Toxicité des hydrocarbures aromatiques polycycliques labellisée par la Ligue Nationale contre le Cancer, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, 35043 Rennes, France
    Toxicol Sci 114:247-59. 2010
    ..Overall, these data, through identifying genes and signaling pathways targeted by PAHs in human macrophages, may contribute to better understand the molecular basis of the immunotoxicity of these environmental contaminants...
  2. ncbi Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst
    Marie Laure Pinel-Marie
    INSERM U620 EA4427 SeRAIC, IFR140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Free Radic Biol Med 47:825-34. 2009
    ....
  3. ncbi Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages
    Marie Laure Pinel-Marie
    Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, EA 4427 Signalisation et Réponses aux Agents Infectieux et Chimiques SeRAIC, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicology 290:89-95. 2011
    ....
  4. ncbi Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur lSanté, l Environnement et Travail, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicol Appl Pharmacol 262:217-22. 2012
    ....
  5. ncbi Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
    Normand Podechard
    UMR INSERM U620, Team Toxicity of Polycyclic Aromatic Hydrocarbons labellisée Ligue contre le Cancer, IFR140, Universite de Rennes 1, France
    Toxicol Lett 177:130-7. 2008
    ..Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical...
  6. ncbi Global effects of inorganic arsenic on gene expression profile in human macrophages
    Emilie Bourdonnay
    Inserm U620 EA SeRAIC Signalisations et Réponses aux Agents Infectieux et chimiques, IFR140 GFAS, Universite de Rennes 1, 35043 Rennes, France
    Mol Immunol 46:649-56. 2009
    ....
  7. ncbi Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha
    Lydie Sparfel
    INSERM U620, IFR 140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Carcinogenesis 27:656-63. 2006
    ..These data further substantiate an unexpected and p53-independent action of PFTalpha for preventing toxicity of chemical carcinogens such as PAHs, through inhibition of CYP1 enzyme activities, especially that of CYP1B1...