Lydie Sparfel

Summary

Country: France

Publications

  1. doi request reprint Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene
    Lydie Sparfel
    EA 4427 SeRAIC, Equipe Toxicité des hydrocarbures aromatiques polycycliques labellisée par la Ligue Nationale contre le Cancer, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, 35043 Rennes, France
    Toxicol Sci 114:247-59. 2010
  2. ncbi request reprint The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation
    Laurie Prigent
    UMR INSERM U1085, Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, Universite de Rennes 1, Rennes, France
    Eur J Immunol 44:1330-40. 2014
  3. doi request reprint Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst
    Marie Laure Pinel-Marie
    INSERM U620 EA4427 SeRAIC, IFR140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Free Radic Biol Med 47:825-34. 2009
  4. doi request reprint Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages
    Marie Laure Pinel-Marie
    Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, EA 4427 Signalisation et Réponses aux Agents Infectieux et Chimiques SeRAIC, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicology 290:89-95. 2011
  5. ncbi request reprint Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur la Santé, l Environnement et le Travail, Universite de Rennes 1, 35043 Rennes, France
    Free Radic Biol Med 71:133-45. 2014
  6. doi request reprint Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur lSanté, l Environnement et Travail, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicol Appl Pharmacol 262:217-22. 2012
  7. doi request reprint Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
    Normand Podechard
    UMR INSERM U620, Team Toxicity of Polycyclic Aromatic Hydrocarbons labellisée Ligue contre le Cancer, IFR140, Universite de Rennes 1, France
    Toxicol Lett 177:130-7. 2008
  8. doi request reprint Global effects of inorganic arsenic on gene expression profile in human macrophages
    Emilie Bourdonnay
    Inserm U620 EA SeRAIC Signalisations et Réponses aux Agents Infectieux et chimiques, IFR140 GFAS, Universite de Rennes 1, 35043 Rennes, France
    Mol Immunol 46:649-56. 2009
  9. ncbi request reprint Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha
    Lydie Sparfel
    INSERM U620, IFR 140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Carcinogenesis 27:656-63. 2006

Collaborators

Detail Information

Publications9

  1. doi request reprint Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene
    Lydie Sparfel
    EA 4427 SeRAIC, Equipe Toxicité des hydrocarbures aromatiques polycycliques labellisée par la Ligue Nationale contre le Cancer, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, 35043 Rennes, France
    Toxicol Sci 114:247-59. 2010
    ..Overall, these data, through identifying genes and signaling pathways targeted by PAHs in human macrophages, may contribute to better understand the molecular basis of the immunotoxicity of these environmental contaminants...
  2. ncbi request reprint The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation
    Laurie Prigent
    UMR INSERM U1085, Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, Universite de Rennes 1, Rennes, France
    Eur J Immunol 44:1330-40. 2014
    ..In conclusion, our data support the idea that AhR is a major player in T-cell physiology. ..
  3. doi request reprint Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst
    Marie Laure Pinel-Marie
    INSERM U620 EA4427 SeRAIC, IFR140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Free Radic Biol Med 47:825-34. 2009
    ....
  4. doi request reprint Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages
    Marie Laure Pinel-Marie
    Institut de Recherche sur la Santé, l Environnement et le Travail IRSET, EA 4427 Signalisation et Réponses aux Agents Infectieux et Chimiques SeRAIC, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicology 290:89-95. 2011
    ....
  5. ncbi request reprint Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur la Santé, l Environnement et le Travail, Universite de Rennes 1, 35043 Rennes, France
    Free Radic Biol Med 71:133-45. 2014
    ..However, modulation of Nrf2 levels does not modify the secretion of inflammatory cytokines from these T lymphocytes. ..
  6. doi request reprint Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes
    Claudie Morzadec
    UMR INSERM U1085, Institut de Recherche sur lSanté, l Environnement et Travail, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
    Toxicol Appl Pharmacol 262:217-22. 2012
    ....
  7. doi request reprint Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
    Normand Podechard
    UMR INSERM U620, Team Toxicity of Polycyclic Aromatic Hydrocarbons labellisée Ligue contre le Cancer, IFR140, Universite de Rennes 1, France
    Toxicol Lett 177:130-7. 2008
    ..Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical...
  8. doi request reprint Global effects of inorganic arsenic on gene expression profile in human macrophages
    Emilie Bourdonnay
    Inserm U620 EA SeRAIC Signalisations et Réponses aux Agents Infectieux et chimiques, IFR140 GFAS, Universite de Rennes 1, 35043 Rennes, France
    Mol Immunol 46:649-56. 2009
    ....
  9. ncbi request reprint Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha
    Lydie Sparfel
    INSERM U620, IFR 140, Universite de Rennes I, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Carcinogenesis 27:656-63. 2006
    ..These data further substantiate an unexpected and p53-independent action of PFTalpha for preventing toxicity of chemical carcinogens such as PAHs, through inhibition of CYP1 enzyme activities, especially that of CYP1B1...