Jean Philippe Spano

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..Our report presents a case of hibernoma of the thigh whose the diagnosis initially suggested that it was a mixed liposarcoma with myxoid and well differentiated components...

..The aim of this study was to assess the safety and efficacy of gemcitabine plus axitinib versus gemcitabine alone...

..Special considerations of these AIDS-related and non-AIDS-related malignancies and their clinical and therapeutic aspects constitute the subject of this review...

..Several in vivo studies have already shown that Cox2 specific inhibitors (celecoxib, rofecoxib) have anti-tumor activity and clinical trials using Cox2 inhibitors are currently ongoing in patients with NSCLC...

..The aim of this study was to evaluate EGFR immunohistochemical reactivity in CRC biopsies, and to analyze its relationship with various histological and clinical characteristics and survival...

..Several in vivo studies have already shown that Cox2 specific inhibitors (celecoxib, rofecoxib) have anti-tumor activity and clinical trials using Cox2 inhibitors are currently ongoing in patients with NSCLC...

..Lung cancer patients often present with anemia, which was not associated with the presence of RI...

..In case of renal insufficiency, some other treatments such biphosphonates IV, capecitabin and platin salts need drug dosage adjustment or interruption...

..Both issues seem to be slightly but significantly more important in patients with bone metastases as compared to patients with a non-metastatic disease...

..A national multicenter study from 15 cancer centers in France analyzed IRMA data on patients with prostate cancer...

..The cross-sectional ONCOVIH study prospectively enrolled HIV-infected adults and children with newly diagnosed malignancies in France in 2006...

..These findings imply a better understanding of EGF-R and IL-6 cross-talk function in melanoma...

..Hence, we can state that targeting the COX-2 pathway is a promising strategy in the prevention and treatment of solid tumors. Ongoing trials are expected to answer - at least partly - the remaining questions concerning COX-2 and cancer...

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..The safety and pharmacokinetics of axitinib in combination with gemcitabine in patients with advanced pancreatic cancer was evaluated in the phase I portion of this trial. The randomized phase II portion was reported separately...

..Other anti-EGFR antibodies as well as small molecules inhibiting tyrosine kinase activity are currently explored in gastro-intestinal oncology...

..Although understanding of the role of PKC in tumor development is still incomplete, different agents are currently evaluated. This review discusses the available data, with special emphasis on clinical outcomes...

..e., starting treatment at an Hb level of 10-11 g/dl rather than waiting for Hb to fall to <10 g/dl) is associated with a faster achievement of an optimal Hb level, a lower transfusion requirement, and a maintained quality of life...

..An overview of established chemotherapies and immunotherapies, followed by a summary of trials testing the potential combination and new agent are explored...

..These recommendations might be the fruit of a new networking between HIV specialists and oncologists and of an improving knowledge of the pathogenesis and clinical features of these AIDS non-defining tumors...

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..This is explained by elective tubular expression of renal EGF/EGFR. In this paper, we focus on electrolyte disorders related to anti-EGFR treatment and discuss the tubular involvement of these drugs based on their renal expression...

..The evaluation of other combinations either with oxaliplatin or capecitabine, is ongoing, with preliminary reports of promising activity...

..Periodic monitoring of urinary protein should be carried out in anti-VEGF-treated patients and patients showing proteinuria need special referral to nephrologists...

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..The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer...

..The goal of this chapter is to describe the clinical and histological pattern of these malignant tumors, and to propose therapeutic guidelines for HIV patients with cancer...

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..The incorporation of new biomarkers or modalities for assessment of cardiac function may also become necessary to detect cardiac toxicity at earliest stage...

..Several controlled trials as first- or second-line therapy have started recently and over the next few years we should learn whether this approach will provide significant gains in efficacy...

..This review provides a summary of the rationale for using proteasome inhibitors and an update on available and ongoing clinical studies involving human malignancies...

..Currently post-surgical chemotherapy is recommended in stage III cancer of the rectum as in colon cancers at the same stage...

..The purpose of this article is to review the current knowledge in terms of the epidemiology, biology, prognosis, management and outcome of patients with NPC...

..Our data suggest that an aromatase inhibitor may be an effective treatment for ESS. Furthermore, routine ER and PR analyses could be useful to predict the response to hormonal therapy in ESS...

..The natural history of Kaposi's sarcoma (KS) is poorly documented. We attempted to identify factors predictive of progression and survival in HIV-infected patients with KS and CD4+ cell counts greater than 100/microL...

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..In the present study, we evaluated CXCR4 expression in non-small-cell lung cancer (NSCLC) and the relationship between CXCR4 expression and the prognosis of stage I disease...

..The aim of the study was to correlate the expression of a panel of molecular markers between primary CRC samples and metastases...

..8% (without CDSS) to 87.3% (with CDSS). Although this increase is lowered because of N- navigations (compliance rates are respectively 95% and 80% for N+ and N- navigations), the benefits of HIT outweighted its disadvantages in our study...

..Future recommendations for the treatment of elderly women with breast cancer should include a multidisciplinary approach and a global geriatric assessment before treatment with anti-HER-2 therapy or bevacizumab...

..Anticancer drugs used may be nephrotoxic or need dosage adjustment in a high number of cases...

..Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion. Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal. Clinicians should be aware to this complication...

..Since most available data come from retrospective studies, there is a need to validate these results in prospective trials...

..Few data are available from clinical trials for elderly patients receiving cetuximab...

..However, this retrospective data on a small sample size are considered preliminary and needs to be evaluated prospectively in a higher number of patients in a clinical trial...

..This exception may be due to the fact that, consequently to the cancer experience as such, this population might already be characterized by a reduced hippocampus with an episodic autobiographical memory deficit...

..Knowledge of this clinical toxicity and/or therapeutic target or novel biomarker of drug activity can aid clinicians choosing the optimal and least toxic regimen suitable for an individual patient...

..2%). Here, we also report that the level of PTEN protein expression is not an independent prognostic marker in early-stage NSCLC...

..Thus, the subcellular location of Apaf-1 (but not that of p53 or Hsp70) constitutes an accurate prognostic factor for overall survival in NSCLC...

..Given the feasibility of this pilot study, sequential chemotherapy concept should be investigated with newer cisplatin-based regimens using this approach in larger prospective studies...

..Several phase III trials are in progress in Europe and in the USA. Final judgment on the contribution of gemcitabine will not be made until the results of these further studies become available...

..Finally, a presentation is done about possible predictive factors for a relevant use of these molecules in the future...

..However, we discuss some of the main limits for these approaches of antitumour drug development and why significant work remains before a clinically useful drug can be proposed to patients...

..Our study confirms that daunorubicin is effective in patients with advanced KS. Daunorubicin is well tolerated over the long term in association with HAART...

..As a whole these data define temsirolimus as a promising new drug. Current and further developments are based on its association with chemotherapy in a concomitant or sequential way...

..We describe here a patient with lung adenocarcinoma which led to paraneoplastic cholestasis. We discuss the diagnosis and review the literature, emphasizing the pathophysiology of Stauffer's syndrome...

..Therefore, clinical and histologic assessments of response brings essential informations about the breast cancer hormonal sensitivity, but may also be predictor of the future (adjuvant or metastatic) treatment responsiveness...

..New chemoprevention trials are planned with collaborative efforts of researchers involved in fundamental or clinical studies...

..One of the main issues using the third generation of IA is their long-term side effects, especially bone turnover and lipid metabolism...

..Anemia associated with advanced colorectal cancers provides the same interest as for any metastatic tumor, as quality of life of patients is correlated to the hemoglobin's level...

..The finding of a profile linked to worse prognosis could allow pointing out tumours where EGFR overexpression is associated to disease progression and therefore could help to define EGFR- inhibitors' indications in colorectal cancer...

..This review of the literature analyses these questions with special concern on the carcinogenic role of cannabis, the potential antitumor effect of cannabinoids and the place of THC and its derivatives for supportive care in cancerology...