Marcello Solinas

Summary

Country: France

Publications

  1. ncbi request reprint Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release
    Davide Quarta
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:35-42. 2007
  2. ncbi request reprint Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
    Marcello Solinas
    Centre National de la Recherche Scientifique UMR 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Nat Protoc 1:1194-206. 2006
  3. pmc Endocannabinoid system involvement in brain reward processes related to drug abuse
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Pharmacol Res 56:393-405. 2007
  4. pmc Reversal of cocaine addiction by environmental enrichment
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, Centre National de la Recherche Scientifique, Poitiers F 86022, France
    Proc Natl Acad Sci U S A 105:17145-50. 2008
  5. ncbi request reprint Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique VMR6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    J Pharmacol Exp Ther 321:1127-34. 2007
  6. pmc Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    Psychopharmacology (Berl) 209:191-202. 2010
  7. doi request reprint Prevention and treatment of drug addiction by environmental enrichment
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS 6187, Pôle Biologie Santeé, 1 Rue George Bonnet, Bat 633, Poitiers 86022, France
    Prog Neurobiol 92:572-92. 2010
  8. doi request reprint Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, CNRS, Poitiers, France
    Neuropsychopharmacology 34:1102-11. 2009
  9. pmc Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine
    Claudia Chauvet
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS, Poitiers, France
    Neuropsychopharmacology 34:2767-78. 2009
  10. ncbi request reprint The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
    J Pharmacol Exp Ther 321:370-80. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release
    Davide Quarta
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:35-42. 2007
    ..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release...
  2. ncbi request reprint Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
    Marcello Solinas
    Centre National de la Recherche Scientifique UMR 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Nat Protoc 1:1194-206. 2006
    ....
  3. pmc Endocannabinoid system involvement in brain reward processes related to drug abuse
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Pharmacol Res 56:393-405. 2007
    ..Altogether, evidence points to the endocannadinoid system as a promising target for the development of medications for the treatment of drug abuse...
  4. pmc Reversal of cocaine addiction by environmental enrichment
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, Centre National de la Recherche Scientifique, Poitiers F 86022, France
    Proc Natl Acad Sci U S A 105:17145-50. 2008
    ....
  5. ncbi request reprint Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique VMR6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    J Pharmacol Exp Ther 321:1127-34. 2007
    ..Nicotinic, but not muscarinic, modulation of THC discrimination involves elevations in endogenous levels of anandamide...
  6. pmc Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    Psychopharmacology (Berl) 209:191-202. 2010
    ....
  7. doi request reprint Prevention and treatment of drug addiction by environmental enrichment
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS 6187, Pôle Biologie Santeé, 1 Rue George Bonnet, Bat 633, Poitiers 86022, France
    Prog Neurobiol 92:572-92. 2010
    ..This theoretical framework highlights the importance of stress in each phase of drug addiction and strongly suggests that life conditions of abstinent addicts should be considered as part of their treatment...
  8. doi request reprint Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, CNRS, Poitiers, France
    Neuropsychopharmacology 34:1102-11. 2009
    ..Altogether our results demonstrate that exposure to complex environments during early stages of life produce dramatic changes in the striatum that result in reduced reactivity to drugs of abuse...
  9. pmc Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine
    Claudia Chauvet
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS, Poitiers, France
    Neuropsychopharmacology 34:2767-78. 2009
    ..Altogether, these results support the hypothesis that EE can reduce cocaine-induced craving and highlight the importance of positive life conditions in facilitating abstinence and preventing relapse to cocaine addiction...
  10. ncbi request reprint The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
    J Pharmacol Exp Ther 321:370-80. 2007
    ....
  11. ncbi request reprint Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse
    Marcello Solinas
    Institut de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique 6187, University of Poitiers, 86022 Poitiers, France
    J Neurosci 27:5615-20. 2007
    ..Importantly, MLA reversed the effects of cannabinoids at doses that did not produce depressant or toxic effects, further pointing to alpha7 nicotinic antagonists as potentially useful agents in the treatment of cannabis abuse in humans...
  12. doi request reprint Environmental enrichment does not reduce the rewarding and neurotoxic effects of methamphetamine
    Nathalie Thiriet
    Institut de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    Neurotox Res 19:172-82. 2011
    ..Our results demonstrate that the rewarding and neurotoxic effects of METH are not reduced by EE and highlight the great risks associated with the increased popularity of this drug amongst the young population...
  13. pmc Loss of environmental enrichment increases vulnerability to cocaine addiction
    Joëlle Nader
    INSERM U 1084, Experimental and Clinical Neurosciences Laboratory, Neurobiology and Neuropharmacology Addiction Group, Poitiers, France
    Neuropsychopharmacology 37:1579-87. 2012
    ..These results indicate that positive life conditions during early stages of life, if they are not maintained at adulthood, may have negative emotional consequences and increase the risks to develop drug addiction...
  14. doi request reprint Early exposure to environmental enrichment alters the expression of genes of the endocannabinoid system
    Rana El Rawas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, CNRS, 1 rue Georges Bonnet, Poitiers, F 86022, France
    Brain Res 1390:80-9. 2011
    ....
  15. pmc Environmental enrichment during adolescence regulates gene expression in the striatum of mice
    Nathalie Thiriet
    Institut de Biologie et Physiologie Cellulaires, University of Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France
    Brain Res 1222:31-41. 2008
    ..The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported...
  16. doi request reprint Environmental enrichment decreases the rewarding but not the activating effects of heroin
    Rana El Rawas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, CNRS, 40 Avenue du Recteur Pineau, Poitiers 86022, France
    Psychopharmacology (Berl) 203:561-70. 2009
    ..We have recently found that the behavioral effects of cocaine as well as its ability to increase expression of zif-268 are reduced in mice reared in enriched environments (EE)...
  17. pmc Effects of environmental enrichment on the incubation of cocaine craving
    Claudia Chauvet
    University of Poitiers, 1 Rue George Bonnet, 86022 Poitiers, France
    Neuropharmacology 63:635-41. 2012
    ....
  18. ncbi request reprint Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum
    Nathalie Thiriet
    Centre National de la Recherche Scientifique 6187, University of Poitiers, 86000 Poitiers, France
    J Neurosci 25:5273-9. 2005
    ..Given the similarity between the cell death patterns induced by METH and by disorders such as Huntington's disease, our results suggest that NPY analogs might be useful therapeutic agents against some neurodegenerative processes...
  19. ncbi request reprint Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 98:408-19. 2006
    ..Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes...
  20. ncbi request reprint Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Neuropsychopharmacology 30:2035-45. 2005
    ..These findings support the proposed therapeutic utility of cannabinoid agonists and antagonists in eating disorders...
  21. ncbi request reprint Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:2046-57. 2005
    ....
  22. pmc The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys
    Zuzana Justinova
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 25:5645-50. 2005
    ..These findings strongly suggest that release of endogenous cannabinoids is involved in brain reward processes and that activation of cannabinoid CB(1) receptors by anandamide could be part of the signaling of natural rewarding events...
  23. ncbi request reprint Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  24. ncbi request reprint Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in rats
    Leigh V Panlilio
    Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:646-57. 2007
    ..This enhanced anxiogenic effect-which was verified in Experiment 3 using another model of anxiety, the light-dark test-may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1...
  25. doi request reprint Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
    Giovanni Laviola
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Neurobiol Dis 31:159-68. 2008
    ..Additionally we discuss why some of the effects of environmental enrichment question the validity of current animal models of mental disorders...
  26. ncbi request reprint Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, NIDA IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 179:576-86. 2005
    ..Caffeine is a non-selective adenosine receptor antagonist in vitro, but involvement of different adenosine receptor subtypes, particularly adenosine A1 and A 2A receptors, in the central effects of caffeine remains a matter of debate...
  27. ncbi request reprint Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats
    Marcello Solinas
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institute of Health, Room 318, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA
    Psychopharmacology (Berl) 179:804-12. 2005
    ..Many behavioral effects of delta-9-tetrahydrocannabinol (THC), including its discriminative-stimulus effects, are modulated by endogenous opioid systems...
  28. ncbi request reprint Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine
    Cristina Cadoni
    Department of Toxicology, University of Cagliari and Centre of Excellence for Neurobiology of Addiction, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 18:2326-34. 2003
    ..The present results indicate that a sensitized dopamine response in the nucleus accumbens core is a general feature of the expression of behavioural sensitization...
  29. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 307:977-86. 2003
    ..Therefore, adenosine A1 and A2A receptors appear to play important but differential roles in the modulation of the discriminative-stimulus effects of methamphetamine and cocaine...
  30. ncbi request reprint Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens
    Marcello Solinas
    Section of Preclinical Pharmacology, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 22:6321-4. 2002
    ..This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages...