Gerard Socie

Summary

Country: France

Publications

  1. ncbi New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia
    G Socie
    Service d Hematologie, Greffe de Moelle, Hopital Saint Louis, Paris, France
    J Clin Oncol 18:348-57. 2000
  2. ncbi Chronic graft-versus-host disease: clinical features and grading systems
    Gerard Socie
    Service d hématologie greffe de moelle, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475, Paris, France
    Int J Hematol 79:216-20. 2004
  3. ncbi Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression
    Gerard Socie
    Service d hématologie greffe de moelle, INSERM ERM 0220, Université Paris VII and Hôpital Saint Louis, Paris, France
    Blood 103:50-7. 2004
  4. ncbi Nonmalignant late effects after allogeneic stem cell transplantation
    Gerard Socie
    Hematology Stem Cell Transplantation, Hopital Saint Louis, Paris, France
    Blood 101:3373-85. 2003
  5. ncbi Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies
    G Socie
    Service d Hématologie Greffe de Moelle and Département de Bio Informatique, Hopital Saint Louis, Paris, France
    Blood 98:3569-74. 2001
  6. ncbi Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    G Socie
    Service d hématologie greffe de moelle, Unité Propre d Enseignement Supérieur UPRES EA 2378 Université Paris VII, France
    Transplantation 72:699-706. 2001
  7. ncbi Health and functional status of adult recipients 1 year after allogeneic haematopoietic stem cell transplantation
    G Socie
    Hematologie Greffe de Moelle, Hospital Saint Louis, Paris, France
    Br J Haematol 113:194-201. 2001
  8. ncbi Allogeneic hematopoietic stem cell transplantation: current issues and future prospects
    G Socie
    Service de Greffe de Moelle, Hopital Saint Louis, Paris, France
    Ann Med Interne (Paris) 150:642-55. 1999
  9. ncbi Long-term outcome after bone marrow transplantation for severe aplastic anemia
    Lionel Ades
    Service d hématologie greffe de moelle, INSERM ERM 0321, Hopital Saint Louis, Paris, France
    Blood 103:2490-7. 2004
  10. doi Influence of bone marrow graft B lymphocyte subsets on outcome after HLA-identical sibling transplants
    David Michonneau
    Service d Hématologie Greffe, Hopital Saint Louis, Paris, France
    Br J Haematol 145:107-14. 2009

Detail Information

Publications96

  1. ncbi New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia
    G Socie
    Service d Hematologie, Greffe de Moelle, Hopital Saint Louis, Paris, France
    J Clin Oncol 18:348-57. 2000
    ..To determine the incidence of and risk factors for second malignancies after allogeneic bone marrow transplantation (BMT) for childhood leukemia...
  2. ncbi Chronic graft-versus-host disease: clinical features and grading systems
    Gerard Socie
    Service d hématologie greffe de moelle, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475, Paris, France
    Int J Hematol 79:216-20. 2004
    ..A critical review of published grading systems failed to demonstrate that any system is better than the others. Prospective validation of the Johns Hopkins grading scale is timely and warranted...
  3. ncbi Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression
    Gerard Socie
    Service d hématologie greffe de moelle, INSERM ERM 0220, Université Paris VII and Hôpital Saint Louis, Paris, France
    Blood 103:50-7. 2004
    ..One-year TRM associated with the same 2 factors and with chronic GvHD...
  4. ncbi Nonmalignant late effects after allogeneic stem cell transplantation
    Gerard Socie
    Hematology Stem Cell Transplantation, Hopital Saint Louis, Paris, France
    Blood 101:3373-85. 2003
  5. ncbi Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies
    G Socie
    Service d Hématologie Greffe de Moelle and Département de Bio Informatique, Hopital Saint Louis, Paris, France
    Blood 98:3569-74. 2001
    ..Late complications occurred equally after both conditioning regimens (except for increased risk of cataract after CY-TBI and of alopecia with Bu-CY)...
  6. ncbi Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    G Socie
    Service d hématologie greffe de moelle, Unité Propre d Enseignement Supérieur UPRES EA 2378 Université Paris VII, France
    Transplantation 72:699-706. 2001
    ..It is not known, however, whether these factors are independent of other clinically recognized risk factors such as age and disease stage...
  7. ncbi Health and functional status of adult recipients 1 year after allogeneic haematopoietic stem cell transplantation
    G Socie
    Hematologie Greffe de Moelle, Hospital Saint Louis, Paris, France
    Br J Haematol 113:194-201. 2001
    ..4, P = 0.04). Decreased bone density was associated with chronic GvHD (OR = 3.9, P = 0.001). Thus, using routine tests in adult patients we were able to detect significant numbers of-non-symptomatic complications enabling early treatment...
  8. ncbi Allogeneic hematopoietic stem cell transplantation: current issues and future prospects
    G Socie
    Service de Greffe de Moelle, Hopital Saint Louis, Paris, France
    Ann Med Interne (Paris) 150:642-55. 1999
    ..These issues and prospects will include; stem cell sources, alternative donors, graft-versus-host disease, indications and long-term survival following allogeneic stem cell transplantation...
  9. ncbi Long-term outcome after bone marrow transplantation for severe aplastic anemia
    Lionel Ades
    Service d hématologie greffe de moelle, INSERM ERM 0321, Hopital Saint Louis, Paris, France
    Blood 103:2490-7. 2004
    ..Furthermore, avoidance of any IST before transplantation in patients with a sibling donor is a prerequisite for attaining such excellent results...
  10. doi Influence of bone marrow graft B lymphocyte subsets on outcome after HLA-identical sibling transplants
    David Michonneau
    Service d Hématologie Greffe, Hopital Saint Louis, Paris, France
    Br J Haematol 145:107-14. 2009
    ..32, 95% confidence interval: 0.11-0.92, P = 0.035). In conclusion, a higher B lineage-specific hematopoietic progenitor cells (CD34(+) CD19(+)) cell dose is associated with a significant decrease incidence of acute GvHD...
  11. ncbi Epstein-Barr virus (EBV) reactivation in allogeneic stem-cell transplantation: relationship between viral load, EBV-specific T-cell reconstitution and rituximab therapy
    Emmanuel Clave
    Laboratoire d Immunologie et d Histocompatibilité, Unité INSERM U396, Institut Universitaire d Hematologie, AP HP, Hopital Saint Louis, Paris, France
    Transplantation 77:76-84. 2004
    ..We decided to combine these methods to evaluate posttransplant EBV reactivation and rituximab therapy...
  12. doi MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease
    Wahid Boukouaci
    Laboratoire d Immunologie et d Histocompatibilité, Centre d Innovations Biomédicales Hématologie Oncologie Greffe CIB HOG, Institut Universitaire d Hématologie IUH, and INSERM, UMRS, 940, Hopital Saint Louis, Paris, France
    Blood 114:5216-24. 2009
    ..Altogether, these data suggest that the studied MICA genotype and phenotype specificities could be used as relevant biomarkers for cGVHD monitoring...
  13. ncbi Risk factors for late infections after allogeneic hematopoietic stem cell transplantation from a matched related donor
    Marie Robin
    Service d Hematologie, Greffe Hôpital Saint Louis, Paris, France
    Biol Blood Marrow Transplant 13:1304-12. 2007
    ..7, 95%CI: 1.4-5.1, P = .002). After HSCT, patients remain at high risk of infections even late after transplantation, in particular, with the above risk factors, and required a prolonged follow-up...
  14. ncbi Effective graft-versus-leukaemia effect after allogeneic stem cell transplantation using reduced-intensity preparative regimens in Fanconi anaemia patients with myelodysplastic syndrome or acute myeloid leukaemia
    Philippe Guardiola
    Bone Marrow Transplant Unit, Hopital Saint Louis, Paris, France
    Br J Haematol 122:806-9. 2003
    ..Even after transplantation, myeloid malignancies remain associated with a poor outcome in FA, and this argues in favour of early intervention when suitable donors are available...
  15. ncbi Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation
    Juliana Fernandes
    Haematology Department and Bone Marrow Transplant Unit, Hopital Saint Louis, Paris, France
    Br J Haematol 137:248-51. 2007
    ..Acute GVHD grades II-IV was observed in three patients. Three are alive, between 12 and 25 months after dUCBT. In conclusion, dUCBT is a promising procedure to treat early GF...
  16. ncbi Acute graft-versus-host disease in patients with Fanconi anemia or acquired aplastic anemia undergoing bone marrow transplantation from HLA-identical sibling donors: risk factors and influence on outcome
    Philippe Guardiola
    Service d Hématologie Greffe de Moelle Trèfle 3, Hopital Saint Louis, Paris, France
    Blood 103:73-7. 2004
    ..The impact of AGvHD on survival may not be limited to the early posttransplantation period and may be a major risk factor for head and neck carcinomas and late mortality in FA patients...
  17. ncbi Association of CD34 cell dose with hematopoietic recovery, infections, and other outcomes after HLA-identical sibling bone marrow transplantation
    Henrique Bittencourt
    Bone Marrow Transplant Unit, Cell Therapy Laboratory and Biostatistics Unit, Hospital Saint Louis, Paris, France
    Blood 99:2726-33. 2002
    ..In conclusion a CD34(+) cell dose of 3 x 10(6)/kg or more improved all hematopoietic recoveries, decreased the incidence of fungal infections and TRM, and improved overall survival...
  18. ncbi Low-dose thoracoabdominal irradiation for the treatment of refractory chronic graft-versus-host disease
    Marie Robin
    Bone Marrow Transplantation Unit, Hopital Saint Louis, Paris, France
    Transplantation 80:634-42. 2005
    ..Half of the patients with chronic graft-versus-host disease (GvHD) do not achieve a complete remission with first-line therapy. No clear recommendations are available regarding second-line treatments...
  19. ncbi Patterns of cytomegalovirus reactivation are associated with distinct evolutive profiles of immune reconstitution after allogeneic hematopoietic stem cell transplantation
    Hélène Moins-Teisserenc
    Laboratoire d Immunologie et d Histocompatibilité, Centre d Investigations Biomédicales Hématologie Oncologie Greffes, Paris, France
    J Infect Dis 198:818-26. 2008
    ..Evaluation of CMV-specific immune responses during the first episode of reactivation, together with extended phenotypes, could thus improve immune monitoring, especially in recipients at risk of uncontrolled viral reactivation...
  20. ncbi Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease
    Veronique Meignin
    Institut National de la Sante et de la Recherche Medicale INSERM, Universite Paris VII, Hopital Saint Louis, Paris, France
    Blood 103:360-2. 2004
    ..Donor-derived lymphoid cells were detected in the epithelium and the lamina propria, as expected. However, using our stringent criteria, no donor-derived cells could be proven to be epithelial...
  21. ncbi Long-term outcome of hepatitis C infection after bone marrow transplantation
    Regis Peffault De Latour
    Service d hématologie greffe de moelle, the Université Paris VII, Paris, France
    Blood 103:1618-24. 2004
    ..Systematic detection of HCV infection, liver biopsy, and therapeutic intervention are therefore warranted in long-term marrow transplant recipients...
  22. ncbi Clinical severity scores in gastrointestinal graft-versus-host disease
    Julie Abraham
    1 AP HP Hospital Saint Louis, Hematology Transplantation, Paris, France 2 AP HP Hospital Saint Louis, Pathology, Paris, France 3 Inserm U 728, Paris, France 4 AP HP Hospital Saint Louis, Gastroenterology, Paris, France 5 AP HP Hospital Saint Louis, DBIM, Paris, France 6 Inserm U 940, Paris, France 7 Address correspondence to Gérard Socie, M D, Ph D, Hematology Transplantation, Hospital Saint Louis 1 avenue Claude Vellefaux 75475, Paris Cedex 10, France
    Transplantation 97:965-71. 2014
    ..How these different scores correlate with each other and which have the greater impact on transplantation outcomes is, however, not clear...
  23. pmc Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation
    Regis Peffault De Latour
    Service d Hématologie Greffe, Assistance Publique Hopitaux de Paris, Hopital Saint Louis, France
    Blood 120:3353-9. 2012
    ..0001) and age-adjusted telomere length (hazard ratio, 0.4; 95% CI; 0.2-0.8; P = .01) were independently associated with TRM. In conclusion, age-adjusted recipients' telomere length is an independent biologic marker of TRM after HSCT...
  24. ncbi Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient
    Sebastien Maury
    Service d Hematologie, Hopital Henri Mondor, Creteil, France
    Haematologica 92:589-96. 2007
    ..We aimed to determine whether outcome after unrelated HSCT has improved in recent years and, if so, to determine the factors responsible for the improvement...
  25. ncbi Association of bone marrow natural killer cell dose with neutrophil recovery and chronic graft-versus-host disease after HLA identical sibling bone marrow transplants
    Jerome Larghero
    Cell Therapy Unit, Assistance Publique Hopitaux de Paris, Saint Louis Hospital, Paris, France
    Br J Haematol 138:101-9. 2007
    ..06 respectively). No specific cell subpopulation infused dose was associated with survival. In conclusion, a higher BM NK cell dose is associated with an increased speed of neutrophil recovery and a decreased incidence of cGvHD...
  26. ncbi Prospective assessment of bone turnover and clinical bone diseases after allogeneic hematopoietic stem-cell transplantation
    Anna D Petropoulou
    Service d Etaématologie Greffe, Hopital Saint Louis, AP HP, Universite Paris VII, Paris, France
    Transplantation 89:1354-61. 2010
    ..Bone complications after hematopoietic stem-cell transplantation (HSCT) are relatively frequent. Evaluation of biomarkers of bone turnover and dual energy x-ray absorptiometry (DEXA) are not known in this context...
  27. ncbi Primary Epstein-Barr virus infection with pneumonia transmitted by allogeneic bone marrow after transplantation
    Pierre Teira
    Service d Hématologie Allogreffe, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France
    Clin Infect Dis 43:892-5. 2006
    ..The virus must have been transmitted by the donor's bone marrow, which was positive for Epstein-Barr virus. The patient recovered after rituximab and corticosteroid therapy...
  28. ncbi ABO-mismatched marrow processing for transplantation: results of 114 procedures and analysis of immediate adverse events and hematopoietic recovery
    Jerome Larghero
    Cell Therapy Unit and Bone Marrow Transplant Department, Saint Louis Hospital, Paris, France
    Transfusion 46:398-402. 2006
    ..Technical and clinical data obtained after bone marrow (BM) processing with a continuous-flow cell separator (Cobe Spectra, Gambro BCT) are reported...
  29. doi Increased infection rate after preemptive rituximab treatment for Epstein-Barr virus reactivation after allogeneic hematopoietic stem-cell transplantation
    Anna D Petropoulou
    Service d Hématologie Greffe, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Universite Paris Diderot, Paris, France
    Transplantation 94:879-83. 2012
    ..The aim of our study was to evaluate the incidence of late infections and immune reconstitution after preemptive R treatment of EBV infection...
  30. pmc Long-term follow up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning
    Johanna Konopacki
    Hematologie Greffe, Hopital Saint Louis, Paris, France
    Haematologica 97:710-6. 2012
    ..We report the long-term follow up of patients who underwent hematopoietic stem cell transplantation from an HLA-matched sibling donor after this conditioning regimen...
  31. ncbi Homozygous status for HLA-E*0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation
    Ryad Tamouza
    Assistance publique Hôpitaux de Paris Groupement Hôspitalier et Universitaire Nord, Institut Universitaire d Hematologie, et Institut National de la Santé et de la Recherche Médicale U662, Hopital Saint Louis, Paris, France
    Transplantation 82:1436-40. 2006
    ..Given the dual role of human leukocyte antigen (HLA)-E molecules in innate and adaptive immune processes, we analyzed the impact of HLA-E polymorphism in genoidentical HSCT setting...
  32. doi Chronic kidney dysfunction in patients alive without relapse 2 years after allogeneic hematopoietic stem cell transplantation
    Imad Abboud
    Department of Nephrology and Transplantation, St Louis Hospital, Paris, France
    Biol Blood Marrow Transplant 15:1251-7. 2009
    ..Renal impairement was correlated with TBI and cGVHD. Minor incidence of CKD and a relative stability of renal function were noted between 2 and 5 years after HSCT...
  33. doi Initial liver involvement in acute GVHD is predictive for nonrelapse mortality
    Marie Robin
    Service d Hématologie Greffe, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Universite Paris 7, Paris, France
    Transplantation 88:1131-6. 2009
    ..The aim of this study was to evaluate potential predictors for overall survival at disease onset...
  34. doi Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation
    Anne Janin
    INSERM, U728, Paris, France
    Blood 113:1834-40. 2009
    ..Our observations therefore show that marrow cells in humans have a major role in epithelial cancer formation after allogeneic transplantation...
  35. doi Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease
    Paula Rodriguez-Otero
    Hematology Transplantation, Assistance Publique Hopitaux de Paris AP HP, Saint Louis Hospital, University Paris Diderot, Sorbonne Paris Cité, Paris, France
    Blood 119:5909-17. 2012
    ..Our results showed that fecal calprotectin and α(1)-AT levels at the time of diagnosis are predictive for responses to treatment but are not diagnostic markers for initial stage 1 to 3 GI-GVHD...
  36. pmc Long-term immune deficiency after allogeneic stem cell transplantation: B-cell deficiency is associated with late infections
    Elise Corre
    Service d Hématologie Greffe, and INSERM U728, Hopital Saint Louis, 1 Av Vellefaux, 75010 Paris, France
    Haematologica 95:1025-9. 2010
    ..Using Cox's models, only low B-cell counts at 12 (P=0.02) and 24 (P=0.001) months were associated with the hazard of developing late infection, in particular if patients did not develop chronic graft-versus-host disease...
  37. doi Similar overall survival using sibling, unrelated donor, and cord blood grafts after reduced-intensity conditioning for older patients with acute myelogenous leukemia
    Regis Peffault De Latour
    Service d Hématologie Greffe, Hopital Saint Louis, AP HP, Paris, France Equipe d accueil 3518, Hôpital Saint Louis and Université Paris 7, AP HP, Paris, France
    Biol Blood Marrow Transplant 19:1355-60. 2013
    ..26). Until prospective studies are completed, this study supports the recommendation to consider SIB donor, URD, or UCB for HCT for older patients with AML in complete remission...
  38. doi CD19+CD5+ B cells and B1-like cells following allogeneic hematopoietic stem cell transplantation
    Hélène Moins-Teisserenc
    INSERM UMRS 940, Institut Universitaire d Hematologie, Paris, France
    Biol Blood Marrow Transplant 19:988-91. 2013
    ....
  39. ncbi Busulfan-cyclophosphamide versus total body irradiation-cyclophosphamide as preparative regimen before allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia: what have we learned?
    Christele Ferry
    Service d hématologie greffe de moelle, Hopital Saint Louis, AP HP, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Exp Hematol 31:1182-6. 2003
    ..New approaches aiming at minimizing the toxicity without impairing the efficacy, such as targeted Bu plasma levels and nonmyeloablative conditioning regimens, seem promising but need to be evaluated further in future prospective studies...
  40. ncbi A white blood cell index as the main prognostic factor in t(8;21) acute myeloid leukemia (AML): a survey of 161 cases from the French AML Intergroup
    Stephanie Nguyen
    Department of Hematology, Hopital Saint Louis, Paris, France
    Blood 99:3517-23. 2002
    ..5; intermediate index, 2.5-20; high index, 20 or more). In multivariate analysis, the WBC index was the only prognostic factor for DFS (P =.003), complete remission duration (P =.002), and overall survival (P =.04)...
  41. doi Female genital chronic graft-versus-host disease: importance of early diagnosis to avoid severe complications
    Pierre Hirsch
    Service d Hématologie Greffe, Hopital Saint Louis, APHP, Paris, France
    Transplantation 93:1265-9. 2012
    ..Genital chronic graft-versus-host disease (GVHD) is a frequent but underdiagnosed complication of allogeneic stem-cell transplantation impairing quality of life...
  42. ncbi An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation
    Nicolas Dulphy
    Institut National de la Sante et de la Recherche Medicale, U662, Paris, France
    J Immunol 181:2227-37. 2008
    ..Altogether, CD56(bright) NK cells postallogeneic HSCT exhibit peculiar phenotypic and functional properties. Functional interactions between this subset and T cells may be important in shaping the immune response after HSCT...
  43. doi Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation
    Caroline Masserot
    Assistance Publique Hospitaux de Paris, Bone Marrow Transplant Unit, Saint Louis Hospital, Paris, France
    Cancer 113:3315-22. 2008
    ..Fanconi anemia (FA) is a chromosomal instability disorder with a very high risk of developing head and neck squamous cell carcinoma (HNSCC), most notably after hematopoietic stem cell transplantation (HSCT)...
  44. pmc Th17/Treg ratio in human graft-versus-host disease
    Philippe Ratajczak
    INSERM U728, and Université Paris 7 Denis Diderot, Paris, France
    Blood 116:1165-71. 2010
    ..Results in this third cohort of patients with skin disease confirmed those found in patients with GI GVHD. These analyses in 96 patients suggest that Th17/Treg ratio could be a sensitive and specific pathologic in situ biomarker of GVHD...
  45. doi Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius
    Gerard Socie
    Service d hématologie greffe de moelle, Hopital Saint Louis, Paris, France
    Blood 117:6375-82. 2011
    ..The addition of ATG-F to standard cyclosporine, methotrexate GVHD prophylaxis lowers the incidence and severity of cGVHD, and the risk of receiving IST without raising the relapse rate. ATG-F prophylaxis reduces cGVHD morbidity...
  46. doi NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation
    Philippe Haas
    INSERM, Paris, France
    Blood 117:1021-9. 2011
    ..This donor-ligand-driven NK-cell education model would suggest a sustained graft-versus-leukemia effect after HLA-mismatched HSCT...
  47. ncbi Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation
    Vanderson Rocha
    Hematology Department and Bone Marrow Transplant Unit, Hopital Saint Louis, Paris, France
    Blood 100:3908-18. 2002
    ..004). In conclusion, donor and recipient gene polymorphisms are informative genetic risk factors for selecting donor/recipient pairs and could help in the understanding of mechanisms involved in host defenses of BM transplant recipients...
  48. ncbi Epstein-Barr virus early-antigen antibodies before allogeneic haematopoietic stem cell transplantation as a marker of risk of post-transplant lymphoproliferative disorders
    Felix Agbalika
    Department of Microbiology, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Br J Haematol 136:305-8. 2007
    ..High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development...
  49. ncbi Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation
    Veronique Meignin
    Unite INSERM U 728, Institut d Hematologie, Hopital Saint Louis, Paris, France
    Exp Hematol 33:894-900. 2005
    ..The long-term CD4+CD25high T-cell reconstitution after allogeneic stem cell transplantation is unknown. Here, we evaluated whether recovery of this T-cell subset might be linked to the establishment of full donor/recipient tolerance...
  50. ncbi Prospective flow cytometric evaluation of nucleated red blood cells in cord blood units and relationship with nucleated and CD34(+) cell quantification
    Jerome Larghero
    Cell Therapy Unit and Bone Marrow Transplant Department, Saint Louis Hospital, Paris, France
    Transfusion 46:403-6. 2006
    ..Although it is important to have an accurate estimate of CD34(+) cell number, NRBCs could compromise white blood cell count and interfere with CD34(+) cell quantification...
  51. doi Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire
    Sophie Park
    Hematology, Hopital Cochin, Universite Paris V, Paris, France
    Eur J Haematol 90:355-64. 2013
    ..We describe a retrospective study determining prognostic factors for outcome after allo-SCT in consecutive 73 patients with CMML reported to the SFGM-TC registry between 1992 and 2009...
  52. doi Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome
    Lise Willems
    Service Hématologie Greffe, AP HP, Hopital Saint Louis, 1 avenue Claude Vellefaux, Paris, France
    Biol Blood Marrow Transplant 18:1295-301. 2012
    ..CDI was not associated either with severe complications or with an increased risk of mortality in this large cohort of patients...
  53. doi Steroid-refractory acute GVHD: lack of long-term improved survival using new generation anticytokine treatment
    Aliénor Xhaard
    Service d Hématologie Greffe, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Universite Paris 7, Paris, France
    Biol Blood Marrow Transplant 18:406-13. 2012
    ..Over an 11-year period, 3 treatment strategies, including 2 anticytokines, give similar results in patients with SR-aGVHD...
  54. doi The complex relationship between human herpesvirus 6 and acute graft-versus-host disease
    Claire Pichereau
    Hematology Transplantation, Service d Hématologie Greffe, AP HP, Hopital Saint Louis, Paris, France
    Biol Blood Marrow Transplant 18:141-4. 2012
    ..Furthermore, 17 patients without histopathological GVHD demonstrated a significant lymphoid infiltrate suggesting "pure" HHV-6-related manifestations, and these patients could have been spared steroid therapy...
  55. ncbi Palivizumab treatment of respiratory syncytial virus infection after allogeneic hematopoietic stem cell transplantation
    Flore Sicre de Fontbrune
    Hematologie Greffe, Universite Paris 7, Assistance Publique Hopitaux de Paris, Hopital Saint Louis, Paris, France
    Clin Infect Dis 45:1019-24. 2007
    ..Palivizumab did not prevent progression to lower respiratory infection and had no impact on the overall survival rate...
  56. doi Bone marrow microenvironment in fanconi anemia: a prospective functional study in a cohort of fanconi anemia patients
    Séverine Lecourt
    Cell Therapy Unit, Assistance Publique Hopitaux de Paris, Saint Louis Hospital, University Paris, Paris, France
    Stem Cells Dev 19:203-8. 2010
    ....
  57. pmc Broad-range PCR-electrospray ionization mass spectrometry for detection and typing of adenovirus and other opportunistic viruses in stem cell transplant patients
    Jerome Legoff
    Paris Diderot University, Sorbonne Paris Cité, INSERM U941, Microbiology Laboratory, Hopital Saint Louis, APHP, Paris, France
    J Clin Microbiol 51:4186-92. 2013
    ..The results of this study suggest that the Viral IC Spectrum assay performed on the PLEX-ID platform is reliable for adenovirus infection diagnosis in immunocompromised patients. ..
  58. ncbi Successful treatment of pulmonary mucormycosis in an allogenic bone-marrow transplant recipient with combined medical and surgical therapy
    Juliette Pavie
    Service des Maladies Infectieuses et Tropicales, Paris, France
    Scand J Infect Dis 36:767-9. 2004
    ..Treatment combining 4 months of amphotericin B, early surgical resection of infected tissue and discontinuation of immunosuppressive treatment allowed the cure of this mould infection...
  59. ncbi Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome
    Marie Robin
    Service d Hematologie, Greffe, Paris, France
    Haematologica 92:1254-7. 2007
    ..Risk factors for dAdV in unrelated HSCT recipients were previous Fanconi disease (p=0.03) and GVHD (p=0.02) in children, and cord blood source of stem cells (p=0.029) and GVHD (0.024) in adults...
  60. doi New autoimmune diseases after cord blood transplantation: a retrospective study of EUROCORD and the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation
    Thomas Daikeler
    EUROCORD, Hôpital Saint Louis Assistance Publique des Hôpitaux de Paris AP HP, University Paris VII, Paris, France
    Blood 121:1059-64. 2013
    ..With a median follow-up of 26 months (range, 2-91), 6 of 52 patients died as a consequence of ADs. We conclude that CBT may be followed by potentially life-threatening, mainly hematologic ADs...
  61. doi The spectrum of lung involvement in collagen vascular-like diseases following allogeneic hematopoietic stem cell transplantation: report of 6 cases and review of the literature
    Anne Bergeron
    Service de Pneumologie, Hopital Saint Louis, Universite Paris 7, UFR Denis Diderot, Paris, France
    Medicine (Baltimore) 90:146-57. 2011
    ..These lung manifestations had poor prognoses. Further studies are needed to determine the optimal therapy for these complications...
  62. ncbi Donor-derived cells and human graft-versus-host disease of the skin
    Hideyuki Murata
    Institut National de la Sante et de la Recherche Medicale INSERM, U728, Paris, France
    Blood 109:2663-5. 2007
    ..Because donor-derived cells were found at the site and at the time of maximum tissue damage, they could contribute to epidermal and microvessel repair...
  63. doi Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions
    Samuel Quentin
    Team Genome and Cancer, Hematology Laboratory Assistance Publique Hopitaux de Paris, Saint Louis Hospital, Paris, France
    Blood 117:e161-70. 2011
    ..These data have implications for staging and therapeutic managing in FA patients, and also to analyze the mechanisms of clonal evolution and oncogenesis in a background of genomic instability and BM failure...
  64. doi The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations
    Mariam Azarian
    Laboratoire d Immunologie et d Histocompatibilité, INSERM U662, Service d hématologie greffe de moelle, Hopital Saint Louis, CIB HOG, AP HP, Paris, France
    Transplantation 85:1859-62. 2008
    ..036, hazard ratio=2.28, 95% confidence interval=1.06-4.90). This could improve the genetic risk assessment of severe bacterial infections in allogeneic hematopoietic stem-cell transplantations...
  65. ncbi Long-term care after stem-cell transplantation
    Gerard Socie
    Hospital Saint Louis, Paris, France
    Hematol J 5:S39-43. 2004
  66. pmc Persistent poor long-term prognosis of allogeneic hematopoietic stem cell transplant recipients surviving invasive aspergillosis
    Géraldine Salmeron
    Assistance Publique Hopitaux de Paris, Service d Hématologie Greffe, Hopital Saint Louis, Paris, France
    Haematologica 97:1357-63. 2012
    ..Voriconazole treatment increases early survival of allogeneic hematopoietic stem cell transplant recipients with invasive aspergillosis. We investigated whether this survival advantage translates into an increased long-term survival...
  67. ncbi Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation
    Emmanuel Clave
    Laboratoire d Immunologie et d Histocompatibilité Assistance Publique Hôpitaux de Paris AP HP, Institut National de la Santé et de la Recherche Médicale INSERM U396, Hopital Saint Louis, Paris, Cedex 10, France
    Blood 105:2608-13. 2005
    ..7, P = .02) were associated with a better survival. Therefore, recipient host thymic function assessment could be helpful in predicting HSCT outcome and identifying patients who require a close immunologic monitoring...
  68. ncbi Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin
    Adrienne Madureira
    Hematology Bone Marrow Transplant Unit, Saint Louis Hospital, Universite Paris VII, 1 avenue Claude Vellefaux, 75010 Paris, France
    Int J Antimicrob Agents 30:551-4. 2007
    ..This high incidence of breakthrough invasive aspergillosis in this patient population receiving caspofungin therapy warrants further investigation...
  69. doi Unrelated cord blood transplantation: outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies
    Vanderson Rocha
    EUROCORD, EUROCORD ED, Hopital Saint Louis, Assistance Publique des Hopitaux de Paris, Paris, France
    Transplantation 95:1284-91. 2013
    ..Unrelated cord blood transplantation (UCBT) is associated with delayed hematopoietic recovery. Intrabone injection of cord blood cells (IB-UCBT) and double-UCBT (dUCBT) are designed to circumvent this problem...
  70. doi Acute and chronic skin graft-versus-host disease--pathophysiological aspects
    Gerard Socie
    AP HP, Hematology Transplantation, Saint Louis Hospital, 1 avenue Claude Vellefaux, Paris Cedex 10, France
    Curr Probl Dermatol 43:91-100. 2012
    ..In this chapter, we summarize some of the major advances in GVHD pathophysiology, and the potent translation of these from the bench to the bedside...
  71. ncbi Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation
    Ryad Tamouza
    Laboratoire d Immunologie et d Histocompatibilité AP HP, IUH, and INSERM U662, Hopital Saint Louis, Paris, France
    Transplantation 80:140-4. 2005
    ..20; P=0.03 and HR=2.12, P=0.048, respectively), suggesting that homozygous state for HLA-E*0101 allele is a risk factor for early severe bacterial infections and TRM in UD-BMT...
  72. ncbi Quantification of nucleated red blood cells in allogeneic marrow graft and impact of processing on recovery
    Jean Pierre Marolleau
    Cell Therapy Unit and the Bone Marrow Transplant Department, Public Assistance Hospitals of Paris, Saint Louis Hospital, Paris, France
    Transfusion 47:266-71. 2007
    ..While nucleated red blood cells (NRBCs) represent a subset of bone marrow (BM) cell subpopulation, the question of their quantification in BM grafts and the impact of BM processing on their recovery has not been addressed...
  73. doi Endothelial cell chimerism associated with graft rejection after human lung transplantation
    Hideyuki Murata
    1 INSERM, U728, Universite Paris 7, Department of Pathology, Hopital Saint Louis, Paris, France
    Transplantation 85:150-4. 2008
    ..By both methods, presence of chimeric endothelial cells was related to pathological signs of acute rejection (P<0.05)...
  74. pmc Impact of genetic abnormalities after allogeneic stem cell transplantation in multiple myeloma: a report of the Société Française de Greffe de Moelle et de Thérapie Cellulaire
    Damien Roos-Weil
    Hematology Department, University Hospital Pitie Salpetriere, Paris, France
    Haematologica 96:1504-11. 2011
    ..This study examines whether allogeneic stem cell transplantation could be of benefit for myeloma patients with high-risk cytogenetic abnormalities...
  75. doi Allogeneic hematopoietic cell transplant in HCV-infected patients
    Regis Peffault De Latour
    Service d Hématologie Greffe, Hopital Saint Louis, 75475 Paris, France
    J Hepatol 48:1008-17. 2008
    ..The pathophysiology of liver fibrosis is discussed as well as the present recommended therapy in this particular population...
  76. ncbi Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease
    Marjan Daneshpouy
    Laboratoire de Recherche Universitaire de Pathologie UPRES EA 2378, Institut Universitaire d Hematologie, the Service d Hématologie, Greffes de Moelle Osseuse, Hopital Saint Louis, Paris, France
    Blood 99:3033-40. 2002
    ..Systematic duodenal biopsy performed at the onset of digestive symptoms should allow early GVHR detection, and pathologic signs of GVHR, together with eosinophil density, might help modulate immunosuppressive therapy...
  77. ncbi Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
    Gerard Socie
    Service d Hématologie Greffe, and Institut National de la Santé et de la Recherche Médicale INSERM U728, Hospital Saint Louis, Paris, France
    Blood 109:2794-6. 2007
    ..These results emphasize the necessity of the current European randomized trial comparing IST with or without G-CSF and to alert physicians that adding G-CSF to IST is currently not standard treatment for SAA...
  78. doi Impact of donor-recipient major ABO mismatch on allogeneic transplantation outcome according to stem cell source
    Nicolas Blin
    AP HP, Saint Louis University Hospital, Hematology Department Transplant Unit, 1 avenue Claude Vellefaux, Paris, France
    Biol Blood Marrow Transplant 16:1315-23. 2010
    ..65; P = .04). Major ABO incompatibility mainly, if not exclusively, affects red blood cell engraftment after BM transplantation. Somewhat surprisingly, the graft-versus-plasma cell effect seems to be confined to this stem cell source...
  79. doi Allogeneic haematopoietic stem cell transplantation for myelofibrosis: a report of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
    Marie Robin
    Service d Hématologie Greffe, Hopital Saint Louis, AP HP, Paris, France Service d hématologie, Hopital du Haut leveque, Pessac, Universite Bordeaux, France
    Br J Haematol 152:331-9. 2011
    ..Multivariate analysis indicated that HLA-identical sibling donor, chronic phase disease and splenectomy in men had favourable impact on OS...
  80. pmc Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients
    Samir K Nabhan
    Eurocord Hospital Saint Louis, 1 avenue Claude Vellefaux, Paris, France
    Haematologica 95:1783-7. 2010
    ..Mechanisms of fertility recovery are discussed...
  81. doi Influence of nucleated cell dose on overall survival of unrelated cord blood transplantation for patients with severe acquired aplastic anemia: a study by eurocord and the aplastic anemia working party of the European group for blood and marrow transplant
    Regis Peffault De Latour
    Bone Marrow Transplant Unit, Saint Louis Hospital, Paris, France
    Biol Blood Marrow Transplant 17:78-85. 2011
    ..9 10(7) TNCs/kg prefreezing (45%, compared with 18% for recipients of ≤ 3.9 10(7) TNC/kg; HR, 0.4; P = .007). These results highlight the fundamental role of cell dose for both engraftment and OS in patients with SAA undergoing UCBT...
  82. pmc Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient
    Florence Chapeland-Leclerc
    EA 209 Eucaryotes Pathogènes Transports Membranaires et Chimiorésistance, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 54:1360-2. 2010
    ..Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates...
  83. pmc Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
    Raphael Ceccaldi
    INSERM U944, Assistance Publique Hopitaux de Paris, Saint Louis Hospital, Paris, France
    J Clin Invest 121:184-94. 2011
    ..Our results also highlight the importance of evaluating the cellular DNA damage checkpoint and repair pathways in cancer therapies in general...
  84. doi [Eculizumab in paroxysmal nocturnal hemoglobinuria]
    Gerard Socie
    Service d Hématologie Greffe, INSERM U728, Hopital Saint Louis, AP HP, 1, avenue Claude Vellefaux, 75010 Paris, France
    Med Sci (Paris) 25:1126-9. 2009
    ..The development of an anti-C5 monoclonal antibody (eculizumab) had profoundly modified the treatment of the the hemolytic form of the disease...
  85. ncbi Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus
    Rita Medeiros
    Unite de Genetique Moleculaire des Virus Respiratoires, URA CNRS 1966, Université Paris 7 EA302, Centre National de Référence du virus influenzae Région Nord, Institut Pasteur, Paris, France
    Antivir Ther 12:571-6. 2007
    ..Subsequent oral treatment with oseltamivir allowed complete recovery. Poor bioavailability of zanamivir in the peripheral lungs might have been limiting treatment efficacy in such an immunocompromised patient...
  86. doi Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies
    Anne Bergeron
    Service de Pneumologie, Universite Paris 7, UFR Denis Diderot, Assistance Publique Hopitaux de Paris, Hopital Saint Louis, Paris, France
    Chest 137:410-5. 2010
    ..The aim of our study was to evaluate the contribution of GM antigen detection in BAL to the diagnosis of IPA in hematologic patients...
  87. pmc Diagnosis of Fanconi anemia in patients with bone marrow failure
    Fernando O Pinto
    Hematology Laboratory APHP, INSERM U944, Universite Denis Diderot, Hopital Saint Louis, 1, Av Claude Vellefaux, 75010 Paris, France
    Haematologica 94:487-95. 2009
    ....
  88. ncbi Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation
    Aliénor Xhaard
    Service d Hématologie Transplantation, Hopital Saint Louis, Paris, France
    Transplantation 83:80-3. 2007
    ..The combination of a CMV-seropositive recipient and CMV-seronegative donor was the leading risk factor...
  89. ncbi Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports
    Frédéric Pène
    Medical Intensive Care Unit, Cochin Hospital, AP HP, Paris, France
    J Clin Oncol 24:643-9. 2006
    ....
  90. ncbi [Long-term follow-up after hematopoietic stem cell transplantation]
    Marie Robin
    Service d Hematologie, greffes de la moelle osseuse, Hopital Saint Louis, 75475 Paris Cedex 10, France
    Rev Prat 58:2123-8. 2008
    ..Metabolic- and organ toxicity as well as potential secondary malignancy require very long-term follow-up. Prevention and early treatment by a multidisciplinary team are essential for the optimal management of these patients...
  91. ncbi Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway
    Jean Soulier
    Genome Rearrangements and Cancer Laboratory, U462 INSERM, Laboratoire Central d Hématologie and Institut Universitaire d Hématologie, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    Blood 105:1329-36. 2005
    ..These results show that specific analysis of the FA/BRCA pathway, combined with clinical and chromosome breakage data, allows a comprehensive characterization of FA patients...
  92. ncbi National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report
    Paul J Martin
    Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 98109 1024, USA, and Hopital St Louis, Paris, France
    Biol Blood Marrow Transplant 12:491-505. 2006
    ..The use of consistent standards in clinical trial designs to evaluate agents that have activity in pathogenic pathways could facilitate advances in the treatment of chronic GVHD...
  93. doi Current challenges in chronic graft-versus-host disease
    Gerard Socie
    INSERM, U728, Paris, France
    Biol Blood Marrow Transplant 16:S146-51. 2010
    ..We will review recent advances on the 3 last mentioned unresolved areas...
  94. pmc IDO in human gut graft-versus-host disease
    Philippe Ratajczak
    INSERM, U, Paris, France
    Biol Blood Marrow Transplant 18:150-5. 2012
    ..Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD...
  95. ncbi Full thoracoscopic approach for surgical management of invasive pulmonary aspergillosis
    Dominique Gossot
    Thoracic Department, Institut Mutualiste Montsouris, Paris, France
    Ann Thorac Surg 73:240-4. 2002
    ..We report the use of full thoracoscopic management in 19 patients...
  96. pmc Acute graft-versus-host disease: from the bench to the bedside
    Gerard Socie
    Service d Hématologie Greffe, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, université Paris VII Denis Diderot, and Unité Inserm U728, Paris, France
    Blood 114:4327-36. 2009
    ..In this review, we summarize some of the major advances in GVHD pathophysiology, including the translation of these from the bench to the bedside, and discuss preclinical approaches that warrant further exploration in the clinic...