Research Topics
Species | Nicolas SirventSummaryCountry: France Publications
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Detail Information
Publications
Non-metastatic Ewing's sarcoma of the ribs: the French Society of Pediatric Oncology ExperienceN Sirvent
Paediatric Department, hôpital de l Archet II, BP 3079, 06202, Cedex 3, Nice, France
Eur J Cancer 38:561-7. 2002..Our study confirms the prognostic significance of response to initial chemotherapy. Radiation therapy may be withheld in selected cases, but seems necessary in patients with pleural effusion...- Hypothalamic dysfunction associated with neuroblastoma: evidence for a new Paraneoplastic syndrome?Nicolas Sirvent
Service de Pediatrie, Unité d Oncologie et Hématologie Pédiatrique, CHU de Nice, France
Med Pediatr Oncol 40:326-8. 2003 
Prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with acute lymphoblastic leukaemia (ALL) treated without cranial irradiation: results of European Organization for Research and Treatment of Cancer (EORTC) Children Nicolas Sirvent
Department of Pediatrics, CHU Nice, France
Eur J Cancer 47:239-47. 2011..To evaluate the prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with ALL enrolled from 1989 to 1996 in the EORTC 58881 trial...- [Judicial framework for medical decision-making concerning minors]N Sirvent
Service de Pediatrie, CHU de Nice, Hopital Archet 2, 151 Avenue de Saint Antoine Ginestière, Nice Cedex 3, France
Arch Pediatr 17:S3-6. 2010..This new "autonomy" of minors gives rise to at least two reservations: i) the difficulty involved in assessment of a minor's degree of discernment; ii) the minor's vulnerability with respect to his or her entourage... - [Paradoxes in the judicial institution concerning decision-making in pediatric oncology]N Sirvent
Service de Pediatrie, CHU de Nice, Hopital Archet 2, 151 Avenue de Saint Antoine Ginestière, Nice Cedex 3, France
Arch Pediatr 17:S16-25. 2010.... - Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcomaNicolas Sirvent
Laboratory of Solid Tumor Genetics, Nice University Hospital, 06107 Nice, France
Cancer Genet Cytogenet 195:12-8. 2009..The involvement of the DUX4 region might represent the genetic hallmark of a novel subclass of small round cell tumors... - Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: results of the EORTC CLG Study 58881Nicolas Sirvent
Department of Pediatrics, CHU Nice, Nice, France
Pediatr Blood Cancer 49:344-8. 2007..OTD was not an independent prognostic factor. These results may be due to the use of risk-adjusted intensive chemotherapy comprising high-dose methotrexate... - Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomasAntoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Faculty of Medicine, 28 Avenue de Valombrose, 06107 Nice, France
Cancer Lett 273:323-30. 2009..These sequences might be activated for centromeric function by epigenetic mechanisms... - Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCRNicolas Sirvent
Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
Am J Surg Pathol 31:1476-89. 2007..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone... - Bone mineral density in adult survivors of childhood acute leukemia: impact of hematopoietic stem cell transplantation and other treatment modalitiesMarion Le Meignen
Department of Paediatric Onco Hematology, Hospital L Archet II, Nice, France
Blood 118:1481-9. 2011..Patients who received a transplant with gonadal deficiency have a reduced femoral BMD which might increase the fracture risk later in life... - NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutantsNadia Lounnas
INSERM U895 C3M Centre Méditerranéen de Médecine Moléculaire, Nice, France
Int J Cancer 125:308-17. 2009..The T315I mutation escapes all currently used Bcr-Abl inhibitors and is likely to become a major clinical problem as it is associated with a poor clinical outcome... - Monosomy 9q and trisomy 16q in a case of congenital solitary infantile myofibromatosisNicolas Sirvent
, CHU de Nice, France
Virchows Arch 445:537-40. 2004..This clonal abnormality has not been reported in other tumors and is different from the chromosome 6q deletion reported in the single previous reported IM karyotype... - [Recombinant activated factor VII in paediatric practice. Universal hemostatic agent?]F Monpoux
Unité d hémato oncologie infantile, Service de Pediatrie, hôpital de l Archet II, 151, Route de Saint Antoine de Ginestiere, 06202 Nice Cedex 3, France
Arch Pediatr 17:1210-9. 2010..This bibliographical work is not an accurate guide of recommendations but should allow everyone to get an idea of situations where the use of this drug should or might be considered... - Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alterationFlorence Pedeutour
University of Nice Sophia Antipolis, CNRS, UMR 6543, Nice, France
Pediatr Blood Cancer 58:798-800. 2012..HMGA2 is the main target of clonal aberrations encountered in lipomas. This result supports the hypothesis that benign lipomatous tumors harboring PLAG1 or HMGA2 rearrangement could constitute a unique pathogenetic entity... 
French "real life" experience of clofarabine in children with refractory or relapsed acute lymphoblastic leukaemiaPascale Trioche
Department of Pediatric, APHP, Hopital Antoine Beclere, Service de Pediatrie, 157 rue de la Porte de Trivaux, 92141 Clamart Cedex, France
Exp Hematol Oncol 1:39. 2012....- [From cytogenetics to cytogenomics of adipose tissue tumors: 2. Malignant adipose tissue tumors]Florence Pedeutour
Laboratoire de Genetique, Hopital de l Archet, CHU de Nice, 151, Route de Saint Antoine de Ginestiere, BP 3079, 06202 Nice Cedex 3
Bull Cancer 91:317-23. 2004..The genetics of pleomorphic liposarcoma is still obscure. Pleomorphic liposarcomas show complex karyotypes with many numerical and structural chromosomal aberrations. To date, no specific molecular abnormality has been identified... - Tumour response to paclitaxel in an adult with relapsed nephroblastomaAntoine Italiano
Antoine Lacassagne Centre, Department of Medical Oncology, Nice, France
Lancet Oncol 6:252-3. 2005 - Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cellsCatherine Frelin
, Physiopathologie de la Survie et de Mort Cellulaires et Infetions Virales, Nice, France
Blood 105:804-11. 2005..NF-kappaB inhibition did not affect normal CD34+ hematopoietic precursors, suggesting that it could represent a new adjuvant strategy for AML treatment... - Successful use of recombinant factor VIIa for management of severe menorrhagia in an adolescent with an acquired inhibitor of human thrombinL Giovannini
, , CHU Nice, France
Acta Paediatr 93:841-3. 2004..Conclusion: This is the first report of an anti-human thrombin antibody associated with severe bleeding in a child. Recombinant factor VIIa could represent a novel therapeutic approach for such patients... - [Fighting cancer via NF-kappa B inhibition]N Sirvent
, , , CHU Nice, BP 3079, 06202 Nice Cedex 3, France
Arch Pediatr 10:632-4. 2003 - Multicenter randomized trial of chewing gum for preventing oral mucositis in children receiving chemotherapyVirginie Gandemer
Department of Paediatrics, Teaching Hospitals 35203 Rennes Cedex, France
J Pediatr Hematol Oncol 29:86-94. 2007..72%, P=0.03). In the multivariate analysis, the risk of oral mucositis was related only to the type of chemotherapy regimen, suggesting that further strategies for preventing oral mucositis could be mainly based on these criteria...