Thomas Similowski

Summary

Country: France

Publications

  1. pmc Comparison of bedside measurement of cardiac output with the thermodilution method and the Fick method in mechanically ventilated patients
    Jesus Gonzalez
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care 7:171-8. 2003
  2. pmc Impediment in upper airway stabilizing forces assessed by phrenic nerve stimulation in sleep apnea patients
    F Series
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec City, Quebec, Canada
    Respir Res 6:99. 2005
  3. pmc Continuous control of endotracheal cuff pressure and tracheal wall damage: a randomized controlled animal study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 11:R109. 2007
  4. ncbi request reprint Iatrogenic-induced dysfunction of the neuromuscular respiratory system
    Thomas Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Clin Chest Med 25:155-66. 2004
  5. ncbi request reprint [Diaphragmatic eventration which is neither hernia nor rupture]
    Thomas Similowski
    Service de Pneumologie et Reanimation, groupe hospitalier La Pitié La Salpêtrière, Assiistance Publique Hôpitaux de Paris, 75651 Paris
    Rev Prat 53:1684-5. 2003
  6. ncbi request reprint [Chronic obstructive pulmonary disease in France: the patients' perspective. Results of an international survey (Confronting COPD)]
    Thomas Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris 75
    Presse Med 32:1403-9. 2003
  7. ncbi request reprint [Practical management of the elevated hemidiaphragm]
    T Similowski
    Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Rev Mal Respir 22:2S68-77. 2005
  8. ncbi request reprint Comparison of magnetic and electrical phrenic nerve stimulation in assessment of phrenic nerve conduction time
    T Similowski
    Service de Pneumologie et Réanimation and Laboratoire de Physiopathologie Respiratoire, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Appl Physiol (1985) 82:1190-9. 1997
  9. ncbi request reprint The potential impact of anaemia of chronic disease in COPD
    T Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and UPRES EA2397 Université Paris VI Pierre et Marie Curie, Paris, France
    Eur Respir J 27:390-6. 2006
  10. ncbi request reprint [Physiopathology of chronic respiratory insufficiency]
    T Similowski
    Service de pneumologie et réanimation Groupe hospitalier La Pitié La Salpêtrière 75651 Paris
    Rev Prat 51:1066-71. 2001

Detail Information

Publications84

  1. pmc Comparison of bedside measurement of cardiac output with the thermodilution method and the Fick method in mechanically ventilated patients
    Jesus Gonzalez
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care 7:171-8. 2003
    ..Indeed, the interchangeability of the methods is a clinically relevant question; for instance, in view of the debate about the risk-benefit balance of right heart catheterization...
  2. pmc Impediment in upper airway stabilizing forces assessed by phrenic nerve stimulation in sleep apnea patients
    F Series
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec City, Quebec, Canada
    Respir Res 6:99. 2005
    ..Phrenic nerve stimulation applied during wakefulness is a unique tool to assess Upper airway dynamic properties and to measure the overall mechanical effects of the inspiratory process on UA stability...
  3. pmc Continuous control of endotracheal cuff pressure and tracheal wall damage: a randomized controlled animal study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 11:R109. 2007
    ..We hypothesized that efficient continuous control of the endotracheal cuff pressure using a pneumatic device would reduce tracheal ischemic lesions in piglets ventilated for 48 hours through a high-volume, low-pressure endotracheal tube...
  4. ncbi request reprint Iatrogenic-induced dysfunction of the neuromuscular respiratory system
    Thomas Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Clin Chest Med 25:155-66. 2004
    ....
  5. ncbi request reprint [Diaphragmatic eventration which is neither hernia nor rupture]
    Thomas Similowski
    Service de Pneumologie et Reanimation, groupe hospitalier La Pitié La Salpêtrière, Assiistance Publique Hôpitaux de Paris, 75651 Paris
    Rev Prat 53:1684-5. 2003
  6. ncbi request reprint [Chronic obstructive pulmonary disease in France: the patients' perspective. Results of an international survey (Confronting COPD)]
    Thomas Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris 75
    Presse Med 32:1403-9. 2003
    ..In this paper, we present the results of the French part of the international survey "Confronting COPD in North America and Europe" concerning the impact of COPD from the perspective patients'...
  7. ncbi request reprint [Practical management of the elevated hemidiaphragm]
    T Similowski
    Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Rev Mal Respir 22:2S68-77. 2005
  8. ncbi request reprint Comparison of magnetic and electrical phrenic nerve stimulation in assessment of phrenic nerve conduction time
    T Similowski
    Service de Pneumologie et Réanimation and Laboratoire de Physiopathologie Respiratoire, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Appl Physiol (1985) 82:1190-9. 1997
    ..5 Tesla. These findings may be the result of phrenic nerve depolarization occurring more distally than expected with CMS, which may have clinical implications regarding the diagnosis and follow-up of phrenic nerve lesions...
  9. ncbi request reprint The potential impact of anaemia of chronic disease in COPD
    T Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and UPRES EA2397 Université Paris VI Pierre et Marie Curie, Paris, France
    Eur Respir J 27:390-6. 2006
    ..When this body of knowledge is available, the question of the putative benefits of raising haemoglobinaemia in chronic obstructive pulmonary disease will have to be addressed...
  10. ncbi request reprint [Physiopathology of chronic respiratory insufficiency]
    T Similowski
    Service de pneumologie et réanimation Groupe hospitalier La Pitié La Salpêtrière 75651 Paris
    Rev Prat 51:1066-71. 2001
    ..The effects of hypoxemia on cellular functions make chronic respiratory insufficiency a systemic disease...
  11. ncbi request reprint Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation
    Mathieu Raux
    Assistance Publique Hopitaux de Paris, Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Anesthesiology 107:746-55. 2007
    ..In normal humans during noninvasive ventilation, the authors used an experimental model of patient-ventilator asynchrony to determine whether premotor cortical activation occurs in this setting...
  12. ncbi request reprint Dyspnea in mechanically ventilated critically ill patients
    Matthieu Schmidt
    Assistance Publique Hopitaux de Paris, Service de Pneumologie et Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Crit Care Med 39:2059-65. 2011
    ..The objective of this study was to assess the prevalence of dyspnea in mechanically ventilated patients, identify its clinical correlates, and examine its impact on clinical outcomes...
  13. ncbi request reprint Intravenous adenosine activates diffuse nociceptive inhibitory controls in humans
    Capucine Morelot-Panzini
    Assistance Publique Hopitaux de Paris, Groupe hospitalier Pitié Salpêtrière Charles Foix, Service de Pneumologie et Reanimation Medicale, Paris, France
    J Appl Physiol (1985) 115:697-703. 2013
    ..The temporal dissociation between adenosine-induced dyspnea and RIII inhibition suggests that C fibers other than pulmonary ones might be involved. ..
  14. doi request reprint Abnormal respiratory-related evoked potentials in untreated awake patients with severe obstructive sleep apnoea syndrome
    Christine Donzel-Raynaud
    AP HP, Groupe Hospitalier Pitie Salpetriere, Laboratoire de Physiopathologie Respiratoire, Paris, France
    Clin Physiol Funct Imaging 29:10-7. 2009
    ..We hypothesized that respiratory-related evoked potentials' alterations during wake, if indeed a feature of the obstructive sleep apnoea syndrome, should be present in untreated severe patients...
  15. doi request reprint Neurally adjusted ventilatory assist increases respiratory variability and complexity in acute respiratory failure
    Matthieu Schmidt
    Assistance Publique Hopitaux de Paris, Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, and Université Paris 6 Pierre et Marie Curie, Paris, France
    Anesthesiology 112:670-81. 2010
    ..The authors reasoned that NAVA should produce a more "natural" or variable breathing pattern than other modes. This study compared respiratory variability and complexity during pressure support ventilation (PSV) and NAVA...
  16. pmc Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans
    Mathieu Raux
    Universite Pierre et Marie Curie PARIS6, UPRES EA 2397, Paris, France
    J Physiol 578:569-78. 2007
    ..g. asthma attacks) would have important pathophysiological implications: it could for example contribute to explain why sleep is both altered and deleterious in such situations...
  17. ncbi request reprint Diaphragmatic dysfunction in patients with idiopathic inflammatory myopathies
    Antonio Teixeira
    UPRES EA 2397, Universite Pierre et Marie Curie Paris VI, Paris, France
    Neuromuscul Disord 15:32-9. 2005
    ..35+/-1.48 cm H2O) than in IBM and in PM (P<0.05). Diaphragm weakness is frequent and probably overlooked in inflammatory myopathies. Further studies are needed to delineate the clinical relevance of these results...
  18. doi request reprint Diaphragm pacing after bilateral implantation of intradiaphragmatic phrenic stimulation electrodes through a transmediastinal endoscopic minimally invasive approach: pilot animal data
    Jalal Assouad
    Department of Thoracic Surgery, Assistance Publique Hopitaux de Paris, Tenon Hospital, Paris, France
    Eur J Cardiothorac Surg 42:333-9. 2012
    ..The present experimental work assesses the feasibility, safety and efficacy of a trans-mediastinal implantation of intradiaphragmatic phenic nerve stimulation electrodes using a flexible gastroscope through a cervical incision...
  19. doi request reprint Repetitive magnetic stimulation of the phrenic nerves for diaphragm conditioning: a normative study of feasibility and optimal settings
    Dan Adler
    Service de Pneumologie et Réanimation et Centre de Neurostimulation Respiratoire, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Appl Physiol Nutr Metab 36:1001-8. 2011
    ..rCMS appears feasible and should be investigated for diaphragm conditioning in appropriate clinical populations...
  20. doi request reprint Diaphragm pacing improves sleep in patients with amyotrophic lateral sclerosis
    Jesus Gonzalez-Bermejo
    Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, 47 83 Bd de l Hopital, Paris, France
    Amyotroph Lateral Scler 13:44-54. 2012
    ..In conclusion, in these severe patients not expected to experience spontaneous improvements, diaphragm conditioning improved sleep and there were hints at diaphragm function changes...
  21. doi request reprint Identification of prolonged phrenic nerve conduction time in the ICU: magnetic versus electrical stimulation
    Alexandre Demoule
    Service de Pneumologie et Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Bd de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 37:1962-8. 2011
    ..CMS is an easy noninvasive tool to assess PN integrity, but co-activates muscles that could contaminate surface chest electromyographic recordings...
  22. doi request reprint Sustained preinspiratory cortical potentials during prolonged inspiratory threshold loading in humans
    Lysandre Tremoureux
    Universite Paris 6, Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83 Bd de l Hopital, 75651 Paris Cedex 13, France
    J Appl Physiol (1985) 108:1127-33. 2010
    ..How this translates to respiratory disease involving acute changes in respiratory mechanics remains to be determined...
  23. ncbi request reprint Short-term training-dependent plasticity of the corticospinal diaphragm control in normal humans
    Alexandre Demoule
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 160:172-80. 2008
    ..2+/-1.6 ms, p=0.003, with facilitation). These results are closely comparable with similar data in locomotor muscle. They provide a neurophysiological basis for the capacity of normal humans to rapidly acquire diaphragmatic skills...
  24. doi request reprint Intrathoracic phrenic pacing: a 10-year experience in France
    Francoise Le Pimpec-Barthes
    Department of Thoracic Surgery, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris Descartes University, Paris, France
    J Thorac Cardiovasc Surg 142:378-83. 2011
    ..Phrenic pacing is an alternative to positive-pressure ventilation in selected patients, mostly in cases of upper spinal cord injury. We evaluated results of phrenic pacing performed by video-assisted thoracic surgery (VATS)...
  25. ncbi request reprint Conduction velocity of the human phrenic nerve in the neck
    Capucine Morelot-Panzini
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie et Réanimation, Paris, France
    J Electromyogr Kinesiol 19:122-30. 2009
    ..To measure phrenic nerve conduction velocity in the neck in humans...
  26. pmc Inspiratory resistances facilitate the diaphragm response to transcranial stimulation in humans
    Chrystèle Locher
    Universite Pierre et Marie Curie Paris 6, UPRES EA 2397, Paris, France
    BMC Physiol 6:7. 2006
    ..The aim of this study was to test this hypothesis by examining the effects of inspiratory resistive loading on the response of the diaphragm to transcranial magnetic stimulation...
  27. ncbi request reprint Dyspnea and surface inspiratory electromyograms in mechanically ventilated patients
    Matthieu Schmidt
    Universite Paris 6, Pierre et Marie Curie, ER10, Paris, France
    Intensive Care Med 39:1368-76. 2013
    ..Surface electromyograms (sEMGs) of extradiaphragmatic inspiratory muscles were responsive to respiratory loading/unloading...
  28. ncbi request reprint Dyspnea as a noxious sensation: inspiratory threshold loading may trigger diffuse noxious inhibitory controls in humans
    Capucine Morelot-Panzini
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie et de Réanimation, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Neurophysiol 97:1396-404. 2007
    ..This confirms the noxious nature of certain types of breathlessness, thus opening new physiological and perhaps therapeutic perspectives...
  29. doi request reprint Diaphragm electromyographic activity as a predictor of weaning failure
    Martin Dres
    Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
    Intensive Care Med 38:2017-25. 2012
    ....
  30. doi request reprint Attenuation of obstructive sleep apnea by compression stockings in subjects with venous insufficiency
    Stefania Redolfi
    Inserm U CRICM, Sleep Disorders Unit, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Am J Respir Crit Care Med 184:1062-6. 2011
    ..Chronic venous insufficiency (CVI) promotes fluid accumulation in the legs that can be counteracted by compression stockings...
  31. doi request reprint Simplified recording technique for the identification of inspiratory premotor potentials in humans
    Mathieu Raux
    Universite Pierre et Marie Curie PARIS6, ER10upmc, Paris, France
    Respir Physiol Neurobiol 171:67-70. 2010
    ..This could make the study of respiratory premotor potentials easier in difficult clinical environments...
  32. ncbi request reprint Intracortical inhibition and facilitation of the response of the diaphragm to transcranial magnetic stimulation
    Alexandre Demoule
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    J Clin Neurophysiol 20:59-64. 2003
    ....
  33. doi request reprint Source of human ventilatory chaos: lessons from switching controlled mechanical ventilation to inspiratory pressure support in critically ill patients
    Laurence Mangin
    Université Paris 7 and Service de Physiologie Explorations fonctionnelles, Hopital Bichat, AP HP, Paris, France
    Respir Physiol Neurobiol 161:189-96. 2008
    ....
  34. ncbi request reprint Reduced breathing variability as a predictor of unsuccessful patient separation from mechanical ventilation
    Marc Wysocki
    UPRES EA 2397, Universite Paris VI Pierre et Marie Curie, Paris, France
    Crit Care Med 34:2076-83. 2006
    ....
  35. ncbi request reprint Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans
    Selma Mehiri
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 154:406-18. 2006
    ....
  36. pmc Effects of maturation and acidosis on the chaos-like complexity of the neural respiratory output in the isolated brainstem of the tadpole, Rana esculenta
    Christian Straus
    Service Central d explorations fonctionnelles respiratoires, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Am J Physiol Regul Integr Comp Physiol 300:R1163-74. 2011
    ..According to the ventilatory generators homology theory, this may also be the case in mammals...
  37. ncbi request reprint Effects of exhaustive incremental treadmill exercise on diaphragm and quadriceps motor potentials evoked by transcranial magnetic stimulation
    Eric Verin
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitié Slapêtriète, Assistance Publique Hospitaux de Paris, 75013 Paris, France
    J Appl Physiol 96:253-9. 2004
    ..01, respectively). Studies using paired stimuli confirmed a likely intracortical mechanism for this depression. Our data confirm significant depression of both diaphragm and quadriceps MEPs after incremental treadmill exercise...
  38. doi request reprint Reversal of pulmonary hypertension after diaphragm pacing in an adult patient with congenital central hypoventilation syndrome
    Capucine Morelot-Panzini
    Assistance Publique Hopitaux de Paris, Groupe hospitalier Pitié Salpêtrière Charles Foix, Service de Pneumologie et Reanimation Medicale, Paris, France
    Int J Artif Organs 36:434-8. 2013
    ..In some patients hypoventilation is permanent, in which case ventilatory support must be extended to the waking hours. Diaphragm pacing can prove useful in such situations. 
..
  39. doi request reprint Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study
    Alexandre Demoule
    University Paris 6 Pierre et Marie Curie, ER10, Paris, France
    Am J Respir Crit Care Med 188:213-9. 2013
    ..Diaphragmatic insults occurring during intensive care unit (ICU) stays have become the focus of intense research. However, diaphragmatic abnormalities at the initial phase of critical illness remain poorly documented in humans...
  40. doi request reprint Prognostic value of efficiently correcting nocturnal desaturations after one month of non-invasive ventilation in amyotrophic lateral sclerosis: a retrospective monocentre observational cohort study
    Jesus Gonzalez-Bermejo
    Assistance Publique Hopitaux de Paris, Service de Pneumologie et Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Amyotroph Lateral Scler Frontotemporal Degener 14:373-9. 2013
    ..95 - 0.99), p = 0.010), but also inadequate ventilation in the first month (HR = 2.32 (1.09 - 4.94), p = 0.029). In conclusion, in ALS patients NIV effectiveness to correct nocturnal desaturations is an independent prognostic factor. ..
  41. pmc Impaired cortical processing of inspiratory loads in children with chronic respiratory defects
    Brigitte Fauroux
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Paris, 75571 France
    Respir Res 8:61. 2007
    ..The aim of the present study was to compare the presence, the latencies and the amplitudes of the P1, N1, P2, and N2 components of the RREPs in children with chronic lung or neuromuscular disease...
  42. ncbi request reprint Optimized analysis of surface electromyograms of the scalenes during quiet breathing in humans
    Francois Hug
    UPRES EA 2397, Universite Pierre et Marie Curie Paris VI, Paris, France
    Respir Physiol Neurobiol 150:75-81. 2006
    ..An averaging method triggered from a respiratory flow signal can identify and characterize a low phasic inspiratory activity of the scalenes within a noisy surface signal...
  43. doi request reprint Dyspnea-pain counterirritation induced by inspiratory threshold loading: a laser-evoked potentials study
    Guillaume Bouvier
    Universite Paris 6, Laboratoire de Physiopathologie Respiratoire, Paris, France
    J Appl Physiol (1985) 112:1166-73. 2012
    ..However, its clinical application is limited because of the strong discomfort associated with the electrical stimuli required to elicit the RIII reflex...
  44. doi request reprint Neurally adjusted ventilatory assist improves patient-ventilator interaction during postextubation prophylactic noninvasive ventilation
    Matthieu Schmidt
    Universite Paris 6 Pierre et Marie Curie, ER10, Paris, France
    Crit Care Med 40:1738-44. 2012
    ..To compare the respective impact of pressure support ventilation and naturally adjusted ventilatory assist, with and without a noninvasive mechanical ventilation algorithm, on patient-ventilator interaction...
  45. pmc Chaotic dynamics of cardioventilatory coupling in humans: effects of ventilatory modes
    Laurence Mangin
    Hopital Bichat Claude Bernard, Service de Physiologie, Paris, France
    Am J Physiol Regul Integr Comp Physiol 296:R1088-97. 2009
    ..Taken together these findings reinforce the role of ventilation in the CVC process...
  46. ncbi request reprint Functional magnetic resonance imaging suggests automatization of the cortical response to inspiratory threshold loading in humans
    Mathieu Raux
    Department of Experimental Medicine, Transcranial Magnetic Stimulation Laboratory McGill University Health Centre, Montreal, QC, Canada Université Paris 6, ER10UPMC Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France Assistance Publique Hôpitaux de Paris, Departement d Anesthesie Reanimation, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Respir Physiol Neurobiol 189:571-80. 2013
    ..We conclude that the respiratory-related cortical activation observed in response to ITL is likely due to automated, attention-independent mechanisms. Also, ITL activates cortical circuits right from the first breath...
  47. doi request reprint Diaphragmatic function is preserved during severe hemorrhagic shock in the rat
    Serge Carreira
    From the Department of Pneumology and Medical Intensive Care and ER10, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris APHP, Universite Pierre et Marie Curie Paris 6, Paris, France S C ER10 and UMR INSERM, Universite Pierre et Marie Curie, Paris, France M L D Department of Orthopedic Surgery, Hopital de Bicetre, APHP, and ER 3509, Universite Paris Sud, Le Kremlin Bicetre, Paris, France M S Department of Emergency Medicine and Surgery, Hopital Pitie Salpetriere, APHP, UMR INSERM 956 and Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Paris 6 M P P Department of Emergency Medicine and Surgery, Hopital Pitie Salpetriere, UMR INSERM 956 and Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Paris 6 B R Department of Pneumology and Medical Intensive Care, Hopital Pitie Salpetriere, and ER10, Université Pierre et Marie Curie T S UMRS INSERM 974 CNRS 7215, Institut de Myologie, Université Pierre et Marie Curie Paris 6 UM76, Paris, France C C and Department of Pneumology and Medical Intensive Care, Hopital Pitie Salpetriere, and UMR INSERM 974 CNRS 7215, Université Pierre et Marie Curie Paris 6 A D
    Anesthesiology 120:425-35. 2014
    ..The authors examined the impact of a hemorrhagic shock on the diaphragm...
  48. ncbi request reprint Upper airway afferents are sufficient to evoke the early components of respiratory-related cortical potentials in humans
    Christine Donzel-Raynaud
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie et de Réanimation, Groupe Hospitalier Pitie Salpetriere, 47 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    J Appl Physiol 97:1874-9. 2004
    ..Per contra, in this setting, pulmonary afferents do not suffice to evoke these components...
  49. doi request reprint Facilitatory conditioning of the supplementary motor area in humans enhances the corticophrenic responsiveness to transcranial magnetic stimulation
    Mathieu Raux
    Dept of Anesthesiology and Critical Care, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Appl Physiol (1985) 108:39-46. 2010
    ..These results demonstrate that 5-Hz rTMS over the SMA can increase the excitability of M1(DIA). These observations are consistent with the hypothesis of a functional connection between SMA and M1(DIA)...
  50. doi request reprint Is obstructive sleep apnea a problem in Parkinson's disease?
    Valerie Cochen De Cock
    Sleep Disorders Unit, Pitie Salpetriere Hospital, APHP, Paris, France
    Sleep Med 11:247-52. 2010
    ..Upper airway dysfunction in PD may promote obstructive sleep apnea. However, the frequency and clinical relevance of sleep-disordered breathing in PD remains unclear...
  51. ncbi request reprint Validation of surface recordings of the diaphragm response to transcranial magnetic stimulation in humans
    Alexandre Demoule
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hopitaux de Paris, France
    J Appl Physiol 94:453-61. 2003
    ..It is possible to reliably measure the latency of the diaphragm response to transcranial magnetic stimulation with adequately positioned surface electrodes...
  52. pmc Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake?
    Lysandre Tremoureux
    UMR_S1158, Inserm Université Paris 6, Paris, France
    PLoS ONE 9:e84534. 2014
    ..We hypothesized that the wake-related maintenance of spontaneous breathing in patients with CCHS could involve supplementary motor area...
  53. ncbi request reprint Effects of neck flexion and mouth opening on inspiratory flow dynamics in awake humans
    Eric Verin
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, 75651 Paris, France
    J Appl Physiol 92:84-92. 2002
    ..05). Mouth opening alone did not exert any significant influence. We conclude that the position of the neck has a discernible impact on the flow behavior through the nonphasically active UA faced with a negative Pd...
  54. pmc The supplementary motor area exerts a tonic excitatory influence on corticospinal projections to phrenic motoneurons in awake humans
    Louis Laviolette
    Universite Paris 6, ER10upmc, Paris, France
    PLoS ONE 8:e62258. 2013
    ..The SMA could therefore participate in the increased resting state of the respiratory motor system during wake (i.e. "wakefulness drive to breathe")...
  55. doi request reprint Dynamic respiratory mechanics and exertional dyspnoea in pulmonary arterial hypertension
    Pierantonio Laveneziana
    Departementde Physiologie, Faculte de MedecinePierre et Marie Curie, Site Pitié Salpêtrière, Paris, France
    Eur Respir J 41:578-87. 2013
    ..We conclude that DH-induced mechanical constraints and excessive ventilatory demand occurred in these young nonsmoking PAH patients with no spirometric obstruction and was associated with exertional dyspnoea...
  56. pmc Invasive pulmonary aspergillosis in patients with decompensated cirrhosis: case series
    Hélène Prodanovic
    Assistance Publique Hopitaux de Paris, Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, Paris, France
    BMC Gastroenterol 7:2. 2007
    ..Liver failure has been suspected to be a risk factor for aspergillosis...
  57. doi request reprint Minimally invasive trans-mediastinal endoscopic approach to insert phrenic stimulation electrodes in the human diaphragm: a preliminary description in cadavers
    Jalal Assouad
    Department of Thoracic Surgery, Hopital Tenon, Assistance Publique Hopitaux de Paris, 4 rue de Chine, 75020 Paris, France
    Eur J Cardiothorac Surg 40:e142-5. 2011
    ..The aim of this experimental work is to demonstrate the feasibility of trans-mediastinal bilateral implantation of PN electrodes using a flexible gastroscope introduced through a cervical incision in human cadavers...
  58. ncbi request reprint Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy
    Arnaud Chambellan
    Service de Pneumologie, CHU de Nantes, Boulevard Jacques Monod, 44093 Nantes Cedex 1, France
    Chest 128:1201-8. 2005
    ..This study describes the distribution and prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy (LTOT)...
  59. ncbi request reprint Expiratory-synchronized sleep in a quadriplegic patient using inspiratory neck muscles to breathe
    Isabelle Arnulf
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and UPRES EA 397, Universite Paris VI, Paris, France
    Sleep Breath 7:143-6. 2003
    ..This case report illustrates the powerful adaptability of the respiratory and sleep control systems to maintain each vital function...
  60. doi request reprint Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel
    Christian Straus
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Service Central d explorations fonctionnelles respiratoires, F 75013 Paris, France
    Respir Physiol Neurobiol 171:171-4. 2010
    ..This is the first documented case of pharmacologically restored chemosensitivity in CCHS. It suggests that a very potent progestin such as desogestrel could unveil latent chemosensitive neural circuits...
  61. doi request reprint Analgesic effects of dyspnoea: "Air hunger" does not inhibit the spinal nociception reflex in humans
    Capucine Morelot-Panzini
    Assistance Publique Hopitaux de Paris, Service de Pneumologie et Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Paris, France Universite Paris 6, ER10upmc, Paris, France Electronic address
    Respir Physiol Neurobiol 190:81-5. 2014
    ..Air hunger failed to inhibit the RIII reflex. We conclude that the mechanisms of air hunger induced analgesia do not include a spinal contribution and are therefore mostly central. ..
  62. ncbi request reprint Unrecognized suffering in the ICU: addressing dyspnea in mechanically ventilated patients
    Matthieu Schmidt
    ER10, Universite Paris 6 Pierre et Marie Curie, Paris, France
    Intensive Care Med 40:1-10. 2014
    ..Although increasing attention is being given to the detection and treatment of pain, very little is given to the detection and treatment of dyspnea (defined as "breathing discomfort")...
  63. ncbi request reprint Effects of hypercapnia and hypocapnia on ventilatory variability and the chaotic dynamics of ventilatory flow in humans
    Marie Noelle Fiamma
    Université Pierre et Marie Curie Paris, Paris, France
    Am J Physiol Regul Integr Comp Physiol 292:R1985-93. 2007
    ..However, complexity persists in the quasi-absence of automatic drive. Ventilatory variability and complexity could be determined by the interaction between the respiratory central pattern generator and suprapontine structures...
  64. doi request reprint Postintensive care unit psychological burden in patients with chronic obstructive pulmonary disease and informal caregivers: A multicenter study
    Sandra De Miranda
    AP HP, Hopital Saint Louis, Medical ICU and Biostatistics Department, Paris, France
    Crit Care Med 39:112-8. 2011
    ....
  65. doi request reprint Effects of venous compression of the legs on overnight rostral fluid shift and obstructive sleep apnea
    Stefania Redolfi
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Unité Fonctinonelle des Pathologies du Sommeil, 47 83 boulevard de l Hopital, Paris Cedex 13, Paris, France
    Respir Physiol Neurobiol 175:390-3. 2011
    ..016) and a median 42% reduction in the increase in neck circumference (P=0.016). These results provide proof-of-principle that overnight fluid displacement into the neck plays a causative role in OSA...
  66. ncbi request reprint Control of tracheal cuff pressure: a pilot study using a pneumatic device
    Alexandre Duguet
    Unite de Reanimation, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Bd de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 33:128-32. 2007
    ....
  67. ncbi request reprint [Diagnosis and management of exacerbations and acute respiratory failure in patients with chronic obstructive pulmonary disease]
    Thomas Similowski
    Service de Pneumologie et Reanimation, Groupe Hospitalier La Pitié Salpêtrière, 75651 Paris 13
    Rev Prat 54:1438-44. 2004
    ..The prevention of acute episodes of COPD is best achieved through tobacco cessation and influenza vaccine. Finally, an acute episode may be an opportunity to make a diagnosis of COPD if this has not been done before...
  68. ncbi request reprint Patients aged 90 years or older in the intensive care unit
    Alexandre Demoule
    Unite de Reanimation, Service de Pneumologie et de Réanimation, Groupe Hospitalier Pitié SalpItriêre, 47 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    J Gerontol A Biol Sci Med Sci 60:129-32. 2005
    ..The aim of this preliminary study is to compare the management and outcome of patients aged 90 years or older admitted to a respiratory ICU with those of patients aged 70 years or younger...
  69. ncbi request reprint Uncontrollable high-frequency tachypnea in a case of unilateral medial medullary infarct
    Laurent Ducros
    Département d Anesthésie Réanimation SMUR, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, 2 rue Ambroise Pare, 75010 Paris, France
    Intensive Care Med 29:841-4. 2003
    ..Medullary infarcts can be associated with breathing disorders that usually consist in central hypoventilation...
  70. doi request reprint Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir.
    Christian Straus
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Service Central d Explorations Fonctionnelles Respiratoires et Service de Pneumologie et Réanimation Médicale, F 75013 Paris, France
    Respir Physiol Neurobiol 178:357-8. 2011
    ..Desogestrel should not be prescribed to CCHS patients with a respiratory purpose until the results of a pending clinical trial (clinicaltrials.gov. NCT01243697) are available...
  71. ncbi request reprint Successful reimplantation of a phrenic nerve stimulator after traumatic exteriorisation
    Francoise Le Pimpec-Barthes
    Department of Thoracic Surgery Hôpital Européen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France
    Eur J Cardiothorac Surg 29:117-8. 2006
    ..This strategy can, exceptionally, be considered if removal and subsequent implantation is impossible or refused...
  72. ncbi request reprint Simplified method to measure respiratory-related changes in arterial pulse pressure in patients receiving mechanical ventilation
    Capucine Morelot-Panzini
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Chest 124:665-70. 2003
    ..In the absence of automation, this can be uneasy in clinical practice. The objective of this study was to test an alternative approach (expiratory pause) that should be easier to apply...
  73. ncbi request reprint Proportional-assist ventilation compared with pressure-support ventilation during exercise in volunteers with external thoracic restriction
    Marc Wysocki
    Institut Mutualiste Montsouris, Paris, France
    Crit Care Med 32:409-14. 2004
    ..The aim of this study was to compare noninvasive PAV and pressure-support ventilation (PSV) in healthy volunteers with external thoracic restriction at rest and during exercise...
  74. ncbi request reprint Validation of improved recording site to measure phrenic conduction from surface electrodes in humans
    Eric Verin
    UPRES EA 2397, Universite Pierre et Marie Curie Paris VI, 75013 Paris, France
    J Appl Physiol 92:967-74. 2002
    ..With ES and CMS, apparently uncontaminated signals could be consistently recorded from surface electrodes...
  75. ncbi request reprint Effects of mandibular advancement on upper airway dynamics in awake normal subjects: a pilot study with phrenic nerve stimulation
    Eric Verin
    Service de Physiologie, CHU de Rouen, Rouen, France GRHV EA 3830, Universite de Rouen, Rouen, France
    Sleep Med 7:368-73. 2006
    ..Mandibular advancement (MA) can be an alternative to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea syndrome. This study was designed to describe its effects on upper airway mechanics...
  76. ncbi request reprint Discriminative power of phrenic twitch-induced dynamic response for diagnosis of sleep apnea during wakefulness
    Eric Verin
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada G1V 4G5
    J Appl Physiol 94:31-7. 2003
    ..7 ml. cmH(2)O x s(-1). These included five nonapneic and six apneic patients. We conclude that UA dynamic properties studied with BAMPS during wakefulness significantly differ between nonapneic and apneic patients...
  77. ncbi request reprint Superiority of nasal mask pressure over mouth pressure, as a surrogate of diaphragm twitch-related esophageal pressure, in healthy humans
    Antonio Teixeira
    Hôpital Gériatrique de Moyen Séjour, Service de Medecine A, Plaisir, France
    Respir Physiol Neurobiol 159:236-40. 2007
    ..We conclude that Pmask-CMS is a better surrogate of Pes-CMS than Pm-CMS...
  78. ncbi request reprint [Chronic obstructive lung disease, a world public health issue, a challenge for each and hope for all]
    Jean Francois Muir
    Presse Med 32:1154-5. 2003
  79. ncbi request reprint Mild intermittent asthma: CT assessment of bronchial cross-sectional area and lung attenuation at controlled lung volume
    Catherine Beigelman-Aubry
    Department of Radiology, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris 13, France
    Radiology 223:181-7. 2002
    ....
  80. ncbi request reprint Interaction between genioglossus and diaphragm responses to transcranial magnetic stimulation in awake humans
    Wei Wang
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec City, Quebec, Canada
    Exp Physiol 92:739-47. 2007
    ....
  81. ncbi request reprint Effect of voluntary facilitation on the diaphragmatic response to transcranial magnetic stimulation
    Tarek Sharshar
    Respiratory Muscle Laboratory, Royal Brompton and Harefield National Health Service, Trust and King s College Hospital, London SW3 6NP, UK
    J Appl Physiol (1985) 95:26-34. 2003
    ....
  82. ncbi request reprint Mechanical model of the inspiratory pump
    Sergio Basso Ricci
    Laboratoire de Mécanique des Solides CNRS, Polytechnique, Mines, Ponts and Chaussées, Palaiseau, France
    J Biomech 35:139-45. 2002
    ..This opens the possibility of predicting the behaviour of the respiratory system during diseases involving changes in its mechanical or geometrical characteristics...
  83. doi request reprint Concomitant responses of upper airway stabilizing muscles to transcranial magnetic stimulation in normal men
    Frederic Series
    Centre de Pneumologie Hôpital Laval, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, Canada
    Exp Physiol 93:496-502. 2008
    ..We conclude that transcranial magnetic stimulation applied in the genioglossus area induces a concomitant motor response of upper airway stabilizing muscles with consistent changes in their motor responses during inspiratory manoeuvres...
  84. ncbi request reprint Chaotic dynamics of resting ventilatory flow in humans assessed through noise titration
    Marc Wysocki
    Hamilton Medical AG, Via Nova, CH 7403 Rhäzuns, Switzerland
    Respir Physiol Neurobiol 153:54-65. 2006
    ..This study shows that the noise titration approach evidences a chaotic dimension to the behavior of ventilatory flow over time in normal humans during tidal breathing...