Umberto Simeoni

Summary

Country: France

Publications

  1. ncbi request reprint Ethical dilemmas in extreme prematurity: recent answers; more questions
    Umberto Simeoni
    Department of Neonatology, La Timone University Hospital, 264 rue Saint Pierre, 13385 Marseille, France
    Eur J Obstet Gynecol Reprod Biol 117:S33-6. 2004
  2. ncbi request reprint The neonatal kidney: implications for drug metabolism and elimination
    I Ligi
    Division of Neonatology, La Conception Hospital, AP HM, 147 Boulevard Baille, 13385 Marseille Cedex 5, France
    Curr Drug Metab 14:174-7. 2013
  3. doi request reprint Offspring of diabetic pregnancy: long-term outcomes
    Umberto Simeoni
    INSERM UMR608, Universite de la Mediterranee, France Faculté de Médecine, Universite de la Mediterranee, France Division of Neonatology, Assistance Publique Hopitaux de Marseille, France
    Semin Fetal Neonatal Med 14:119-24. 2009
  4. doi request reprint [Ethics in perinatal medicine: reflections from health care professionals in France, 2001-2008]
    U Simeoni
    Service de Medecine Neonatale, Hopital de la Conception, Hopitaux de Marseille, Marseille, France
    Arch Pediatr 16:S28-37. 2009
  5. ncbi request reprint [Developmental origins of adult cardio-vascular disease: an issue for very low birth weight infants?]
    U Simeoni
    Service de Neonatologie, Universite de la Mediterranee, Hopital de la Conception, APHM, EA2193, Marseille, France
    Arch Pediatr 14:557-9. 2007
  6. doi request reprint Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues
    Umberto Simeoni
    Division of Neonatology, Hopital la Conception, Assistance Publique Hopitaux de Marseille, 147 Boulevard Baille, 13385, Marseille, France
    Pediatr Nephrol 26:493-508. 2011
  7. ncbi request reprint Long-term circulatory and renal consequences of intrauterine growth restriction
    Umberto Simeoni
    Division of Neonatology, AP HM and EA2193, Universite de la Mediterranee, La Conception Hospital, 147 Boulevard Baille, 13385 Marseille Cedex 05, France
    Acta Paediatr 94:819-24. 2005
  8. doi request reprint Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats
    Farid Boubred
    INSERM UMR608, Faculte de Pharmacie, Universite de la Mediterranee, Marseille, France
    Am J Physiol Renal Physiol 297:F943-51. 2009
  9. doi request reprint Iatrogenic events in neonates: beneficial effects of prevention strategies and continuous monitoring
    Isabelle Ligi
    Division of Neonatology, La Conception Hospital, AP HM, 147 Boulevard Baille, 13385 Marseille, France
    Pediatrics 126:e1461-8. 2010
  10. ncbi request reprint Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats
    Farid Boubred
    Division of Neonatology, Hopital la Conception, Assistance Publique Hopitaux de Marseille, 147, boulevard Baille, 13385 Marseille, France
    Am J Physiol Renal Physiol 293:F1944-9. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Ethical dilemmas in extreme prematurity: recent answers; more questions
    Umberto Simeoni
    Department of Neonatology, La Timone University Hospital, 264 rue Saint Pierre, 13385 Marseille, France
    Eur J Obstet Gynecol Reprod Biol 117:S33-6. 2004
    ....
  2. ncbi request reprint The neonatal kidney: implications for drug metabolism and elimination
    I Ligi
    Division of Neonatology, La Conception Hospital, AP HM, 147 Boulevard Baille, 13385 Marseille Cedex 5, France
    Curr Drug Metab 14:174-7. 2013
    ..Drugs and toxic factors that may alter the constitution of the congenital nephron number endowment during this period may have long term consequences on arterial pressure and renal function at adulthood...
  3. doi request reprint Offspring of diabetic pregnancy: long-term outcomes
    Umberto Simeoni
    INSERM UMR608, Universite de la Mediterranee, France Faculté de Médecine, Universite de la Mediterranee, France Division of Neonatology, Assistance Publique Hopitaux de Marseille, France
    Semin Fetal Neonatal Med 14:119-24. 2009
    ....
  4. doi request reprint [Ethics in perinatal medicine: reflections from health care professionals in France, 2001-2008]
    U Simeoni
    Service de Medecine Neonatale, Hopital de la Conception, Hopitaux de Marseille, Marseille, France
    Arch Pediatr 16:S28-37. 2009
    ....
  5. ncbi request reprint [Developmental origins of adult cardio-vascular disease: an issue for very low birth weight infants?]
    U Simeoni
    Service de Neonatologie, Universite de la Mediterranee, Hopital de la Conception, APHM, EA2193, Marseille, France
    Arch Pediatr 14:557-9. 2007
  6. doi request reprint Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues
    Umberto Simeoni
    Division of Neonatology, Hopital la Conception, Assistance Publique Hopitaux de Marseille, 147 Boulevard Baille, 13385, Marseille, France
    Pediatr Nephrol 26:493-508. 2011
    ....
  7. ncbi request reprint Long-term circulatory and renal consequences of intrauterine growth restriction
    Umberto Simeoni
    Division of Neonatology, AP HM and EA2193, Universite de la Mediterranee, La Conception Hospital, 147 Boulevard Baille, 13385 Marseille Cedex 05, France
    Acta Paediatr 94:819-24. 2005
    ..In this review article, present knowledge about the background to renal dysfunction as seen in IUGR is summarized. The way in which arterial hypertension and cardiovascular dysfunction may be programmed in IUGR is also speculated...
  8. doi request reprint Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats
    Farid Boubred
    INSERM UMR608, Faculte de Pharmacie, Universite de la Mediterranee, Marseille, France
    Am J Physiol Renal Physiol 297:F943-51. 2009
    ..Early postnatal OF is a suitable model with which to study the long-term effects of postnatal growth in the pathogenesis of vascular disorders and renal disease...
  9. doi request reprint Iatrogenic events in neonates: beneficial effects of prevention strategies and continuous monitoring
    Isabelle Ligi
    Division of Neonatology, La Conception Hospital, AP HM, 147 Boulevard Baille, 13385 Marseille, France
    Pediatrics 126:e1461-8. 2010
    ..To assess the impact of continuous incident reporting and subsequent prevention strategies on the incidence of severe iatrogenic events and targeted priorities in admitted neonates...
  10. ncbi request reprint Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats
    Farid Boubred
    Division of Neonatology, Hopital la Conception, Assistance Publique Hopitaux de Marseille, 147, boulevard Baille, 13385 Marseille, France
    Am J Physiol Renal Physiol 293:F1944-9. 2007
    ..Factors other than glomerular number reduction are likely to contribute to the arterial hypertension induced by early postnatal OF...
  11. ncbi request reprint Ibubrofen in the treatment of patent ductus arteriosus in preterm infants: what we know, what we still do not know
    Isabelle Mercanti
    Div Neonatology, Parents Children Pole, Assistance Publique Hopitaux de Marseille and Université de la Méditerranée, Marseille, France
    Curr Pharm Des 18:3007-18. 2012
    ..Despite an understandable reluctance given the historical background of systematic, therapeutic closure of ductus arteriosus in preterm infants, there are no definite ethical obstacles to a placebo-controlled design...
  12. doi request reprint Altered angiogenesis in low birth weight individuals: a role for anti-angiogenic circulating factors
    Isabelle Ligi
    Department of Neonatology, La Conception Hospital, Marseille, France
    J Matern Fetal Neonatal Med 27:233-8. 2014
    ..Conclusions: Serum obtained from LBW babies contains factors that exhibit an antiangiogenic effect on ECFC proliferation and migration. VEGF/sVEGF/PF4 pathway seems to be involved in the EPCs dysfunction in LBW neonates. ..
  13. ncbi request reprint Effects of maternally administered drugs on the fetal and neonatal kidney
    Farid Boubred
    Faculte de Medecine, Université de la Méditerrannée and Assistance Publique Hôpitaux de Marseille, Hopital de la Conception, Service de Neonatologie, Marseille, France
    Drug Saf 29:397-419. 2006
    ..Although neonatal data for many drugs are reassuring, such findings stress the importance of long-term follow-up of infants exposed in utero to certain drugs that have been administered to the mother...
  14. doi request reprint Respiratory distress syndrome after elective caesarean section in near term infants: a 5-year cohort study
    Anais Berthelot-Ricou
    Faculte de Medecine, Université de la Méditerranée Assistance Publique Hôpitaux de Marseille, Pôle de gynécologie obstétrique et reproduction, Marseille, France
    J Matern Fetal Neonatal Med 26:176-82. 2013
    ..to assess the incidence of respiratory distress syndrome (RDS) in late preterm (34(0/7)-36(6/7)) and just term (37(0/7)-37(6/7)) infants born via elective caesarean section (CS) in a tertiary care maternity facility...
  15. doi request reprint Therapeutic closure of the ductus arteriosus: benefits and limitations
    Isabelle Mercanti
    Division of Neonatalogy, Children and Parents Pole, Assistance Publique Hopitaux de Marseille and Université de la Méditerranée, Marseille, France
    J Matern Fetal Neonatal Med 22:14-20. 2009
    ....
  16. doi request reprint Low birth weight infants and the developmental programming of hypertension: a focus on vascular factors
    Isabelle Ligi
    Service de Medecine Neonatale, Centre Hospitalier Universitaire La Conception, Marseille, France
    Semin Perinatol 34:188-92. 2010
    ..The key role of the endothelium, as shown by altered vasodilatation, angiogenesis, endothelial progenitor cells, and microparticle number and function, is discussed as a possible explanatory mechanism...
  17. ncbi request reprint Kidney gene expression analysis in a rat model of intrauterine growth restriction reveals massive alterations of coagulation genes
    Christophe Buffat
    Laboratoire de Biochimie et de Biologie Moleculaire, Hôpitaux La Conception, Marseille, France
    Endocrinology 148:5549-57. 2007
    ..These alterations in the kidneys have been reported as a probable cause for cardiovascular diseases in the adult...
  18. doi request reprint Iatrogenic events in admitted neonates: a prospective cohort study
    Isabelle Ligi
    Division of Neonatology, La Conception Hospital, EA 3279, Assistance Publique Hopitaux de Marseille, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet 371:404-10. 2008
    ..We aimed to assess the incidence, nature, preventability, and severity of iatrogenic events in a neonatal centre and to establish the association of patient characteristics with the occurrence of iatrogenic events in neonates...
  19. doi request reprint Clinical research in newborn infants: difficulties and specificity
    Isabelle Ligi
    Division of Neonatology, La Conception Hospital, Assistance Publique Hôpitaux de Marseille and Faculté de Médecine, Universite de la Mediterranee, Marseille, France
    Eur J Clin Pharmacol 67:29-32. 2011
    ..Clinical trials are essential in neonates to evaluate scientifically the efficacy and safety of drugs. However, major specificities condition clinical research in human neonates...
  20. doi request reprint [Neonatal meningitis due to Listeria monocytogenes after 3 weeks of maternal treatment during pregnancy]
    L Fayol
    Département de néonatologie, Hopital la Conception, Universite de la Mediterranee, Assistance Publique Hopitaux de Marseille, 13385 Marseille Cedex 05, France
    Arch Pediatr 16:353-6. 2009
    ..First-line treatment is based on high-dose amoxicillin (> or =6g/day) and must be used for at least 3 weeks for treatment of listeriosis during pregnancy. If the fetus survives, longer therapy until delivery can be discussed...
  21. ncbi request reprint [Extreme prematurity: the limits of neonatal resuscitation]
    U Simeoni
    Département de néonatologie, Hôpital de La Timone Enfants et Hôpital de la Conception, Assistance Publique, Hopitaux de Marseille, 264, rue Saint Pierre, 13385 Marseille
    J Gynecol Obstet Biol Reprod (Paris) 30:S58-63. 2001
    ..Rigorous criteria must be fulfilled for end of life decision making and procedures. Continuous assistance to the patient and to the parents is key determinant...
  22. ncbi request reprint [Neonatal hyperbilirubinemia: myths and realities]
    U Simeoni
    Département de néonatologie, Hôpital de la Timone Enfants, 264, rue Saint Pierre, 13385 Marseille, France
    Arch Pediatr 9:1072-3. 2002
    ..This paper reproduces the introducing talk of the round table conference on current management of neonatal hyperbilirubinemia held during the Journée d'Actualité Lorraine en Néonatologie (JALON 2002, Nancy, october 5th 2002)...
  23. doi request reprint A switch toward angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low birth weight preterm infants
    Isabelle Ligi
    INSERM, Unité Mixte de Recherche 608, Physiopathologie de l Endothélium Marseille, Marseille, France
    Blood 118:1699-709. 2011
    ....
  24. ncbi request reprint Adams-Oliver syndrome associated with cutis marmorata telangiectatica congenita and congenital cataract: a case report
    Laurence Fayol
    Faculte de Medecine, Universite de la Mediterranee, Assistance Publique Hôpitaux de Marseille Hôpital de La Conception, Département de néonatologie, 147 Boulevard Baille, 13 385 Marseille Cedex 05, France
    Am J Perinatol 23:197-200. 2006
    ..Adams-Oliver syndrome is a genetic defect that causes a vasculopathy and leads to a variety of phenotypes. This observation further supports the current understanding of the physiopathology of AOS...
  25. doi request reprint Apparent life-threatening events in presumably healthy newborns during early skin-to-skin contact
    Virginie Andres
    Neonatal Intensive Care Unit, La Conception University Hospital, Marseille, France
    Pediatrics 127:e1073-6. 2011
    ..Although many ALTEs are apparently caused by obstruction, we suggest that a standardized investigational workup be performed after an ALTE...
  26. ncbi request reprint Quantitative and qualitative study of gastric lipolysis in premature infants: do MCT-enriched infant formulas improve fat digestion?
    Céline Roman
    Service de Pédiatrie Multidisciplinaire, Hopital d Enfants de la Timone, 13385 Marseille Cedex 5, France
    Pediatr Res 61:83-8. 2007
    ..26% wt/wt) acid. Similar results were obtained with infants fed with human milk. MCT supplementation has no quantitative or qualitative effects on the intragastric lipolysis, which is not higher in premature infant than in adults...
  27. doi request reprint Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study
    Benedicte Gaborit
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, CNRS UMR 6612, Marseille, France
    Obesity (Silver Spring) 20:1200-5. 2012
    ..A high EF amount is associated with a lower coronary microvascular response, suggesting that EF could early influence endothelial function...
  28. ncbi request reprint Fetal and neonatal consequences of antenatal exposure to type 1 angiotensin II receptor-antagonists
    Maria Vendemmia
    Department of Neonatology, Hôpital de la Timone Enfants, Marseille, France
    J Matern Fetal Neonatal Med 18:137-40. 2005
    ..The second patient presented with hypocalvaria and developed fetal renal failure. The use of sartans during the two last trimesters of pregnancy should be strictly avoided...
  29. ncbi request reprint Characteristics of arterial stiffness in very low birth weight premature infants
    Laurent Tauzin
    Division of Neonatology, Assitance Publique, Hôpitaux de Marseille and Faculté de Médecine, Universite de la Mediterranee, 13000 Marseille, France
    Pediatr Res 60:592-6. 2006
    ..It can be speculated that early alteration of arterial elastic properties may pave the way for long-term elevation of arterial pressure in VLBW premature infants...
  30. ncbi request reprint [Blood product transfusion in the neonatal period]
    F Arnaud
    Service de neonatalogie, Faculte de Medecine, Universite de la Mediterranee, Hopital de la Conception, AP HM, Marseille, France
    Transfus Clin Biol 12:336-41. 2005
    ..However, a better understanding of the indications of blood transfusion and the provision of practice guidelines may justify a re-evaluation of prophylactic strategies for anemia of prematurity...
  31. ncbi request reprint Vascular mechanisms in the developmental programming of cardio-vascular disease
    L Tauzin
    Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    Pediatr Med Chir 27:18-23. 2005
    ..Several factors, such as impaired foetal growth, premature birth or postnatal growth of low birth weight infants may be involved, but to which extent is still unclear...
  32. ncbi request reprint Unanswered questions raised by antenatal diagnosis of renal and urinary tract abnormalities
    U Simeoni
    Department of Neonatology, La Timone University Hospital, Marseille, France
    Pediatr Med Chir 24:101-3. 2002
  33. doi request reprint The CURPAP study: an international randomized controlled trial to evaluate the efficacy of combining prophylactic surfactant and early nasal continuous positive airway pressure in very preterm infants
    Fabrizio Sandri
    Ospedale Maggiore, Bologna, Italy
    Neonatology 94:60-2. 2008
  34. doi request reprint [End of life in neonatal medicine in the light of French law]
    C Dageville
    Service de réanimation néonatale, Hopital Archet II, 151, Route de Saint Antoine de Ginestiere, 06202 Nice, France
    Gynecol Obstet Fertil 36:571-81. 2008