Juergen Siepmann

Summary

Country: France

Publications

  1. ncbi Stability of aqueous polymeric controlled release film coatings
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, 3 Rue du Prof Laguesse, 59006 Lille, France Electronic address
    Int J Pharm 457:437-45. 2013
  2. doi In-silico simulations of advanced drug delivery systems: what will the future offer?
    Juergen Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 454:512-6. 2013
  3. doi Mathematical modeling of drug dissolution
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 453:12-24. 2013
  4. doi Predicting drug release from HPMC/lactose tablets
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 441:826-34. 2013
  5. doi Modeling of diffusion controlled drug delivery
    Juergen Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    J Control Release 161:351-62. 2012
  6. doi Modeling drug release from PVAc/PVP matrix tablets
    F Siepmann
    College of Pharmacy, JE 2491, Univ Lille Nord de France, 3 rue du Professeur Laguesse, 59006 Lille, France
    J Control Release 141:216-22. 2010
  7. doi Higuchi equation: derivation, applications, use and misuse
    Juergen Siepmann
    Univ Lille Nord de France, College of Pharmacy, 3 rue du Professeur Laguesse, 59006 Lille, France
    Int J Pharm 418:6-12. 2011
  8. doi Mathematical modeling of drug delivery
    J Siepmann
    College of Pharmacy, JE 2491, University of Lille, 3 rue du Professeur Laguesse, 59006 Lille, France
    Int J Pharm 364:328-43. 2008
  9. doi Mathematical modeling of drug release from lipid dosage forms
    J Siepmann
    Univ Lille Nord de France, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 418:42-53. 2011
  10. ncbi Local controlled drug delivery to the brain: mathematical modeling of the underlying mass transport mechanisms
    J Siepmann
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 314:101-19. 2006

Collaborators

Detail Information

Publications29

  1. ncbi Stability of aqueous polymeric controlled release film coatings
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, 3 Rue du Prof Laguesse, 59006 Lille, France Electronic address
    Int J Pharm 457:437-45. 2013
    ..The aims are: (i) to provide a better understanding of the release patterns and potential changes thereof, and (ii) to help identifying strategies allowing for improved long term stability for specific types of polymer coatings. ..
  2. doi In-silico simulations of advanced drug delivery systems: what will the future offer?
    Juergen Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 454:512-6. 2013
    ..In the future it can be expected that this gap will be closed and that computer assisted device design will play a central role in the research on, and development of advanced drug delivery systems. ..
  3. doi Mathematical modeling of drug dissolution
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 453:12-24. 2013
    ....
  4. doi Predicting drug release from HPMC/lactose tablets
    J Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 441:826-34. 2013
    ..Thus, from a practical point of view, very simple equations can be used during product optimization, allowing estimating the effects of formulation parameters on drug release...
  5. doi Modeling of diffusion controlled drug delivery
    Juergen Siepmann
    University of Lille, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    J Control Release 161:351-62. 2012
    ..Due to the advances in information technology the importance of in silico optimization of advanced drug delivery systems can be expected to significantly increase in the future...
  6. doi Modeling drug release from PVAc/PVP matrix tablets
    F Siepmann
    College of Pharmacy, JE 2491, Univ Lille Nord de France, 3 rue du Professeur Laguesse, 59006 Lille, France
    J Control Release 141:216-22. 2010
    ....
  7. doi Higuchi equation: derivation, applications, use and misuse
    Juergen Siepmann
    Univ Lille Nord de France, College of Pharmacy, 3 rue du Professeur Laguesse, 59006 Lille, France
    Int J Pharm 418:6-12. 2011
    ..The aim of this review is to highlight the assumptions the derivation of the classical Higuchi equation is based on and to give an overview on the use and potential misuse of this equation as well as of related theories...
  8. doi Mathematical modeling of drug delivery
    J Siepmann
    College of Pharmacy, JE 2491, University of Lille, 3 rue du Professeur Laguesse, 59006 Lille, France
    Int J Pharm 364:328-43. 2008
    ..Ideally, the effects of the design parameters of the dosage form on the resulting drug concentration time profiles at the site of action and the pharmacodynamic effects will become predictable...
  9. doi Mathematical modeling of drug release from lipid dosage forms
    J Siepmann
    Univ Lille Nord de France, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France
    Int J Pharm 418:42-53. 2011
    ..In the future it would be highly desirable to combine mechanistic theories with the quantitative description of the drug fate in vivo, ideally including the pharmacodynamic efficacy of the treatments...
  10. ncbi Local controlled drug delivery to the brain: mathematical modeling of the underlying mass transport mechanisms
    J Siepmann
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 314:101-19. 2006
    ....
  11. doi Enzymatically degraded Eurylon 6 HP-PG: ethylcellulose film coatings for colon targeting in inflammatory bowel disease patients
    Youness Karrout
    College of Pharmacy, Universite Lille Nord de France, Lille, France
    J Pharm Pharmacol 62:1676-84. 2010
    ....
  12. doi Characterization of ethylcellulose: starch-based film coatings for colon targeting
    Youness Karrout
    College of Pharmacy, University of Lille, Lille, France
    Drug Dev Ind Pharm 35:1190-200. 2009
    ..The aim of this study was to provide efficient tools that can be used to easily adjust the key properties of novel polymeric film coatings allowing for colon targeting...
  13. ncbi pH-Sensitive polymer blends used as coating materials to control drug release from spherical beads: elucidation of the underlying mass transport mechanisms
    Florence Lecomte
    College of Pharmacy, Freie Universitaet Berlin, Kelchstrasse 31, 12169, Berlin, Germany
    Pharm Res 22:1129-41. 2005
    ..To elucidate the drug release mechanisms from pellets coated with pH-sensitive polymer blends...
  14. doi Colon targeting with bacteria-sensitive films adapted to the disease state
    Youness Karrout
    College of Pharmacy, Lille Northern University of France, Lille, France
    Eur J Pharm Biopharm 73:74-81. 2009
    ..Furthermore, Nutriose is known to provide pre-biotic effects, which can be of great benefit for these patients...
  15. doi Simulated food effects on drug release from ethylcellulose: PVA-PEG graft copolymer-coated pellets
    Susanne Muschert
    College of Pharmacy, Univ Lille Nord de France, Lille, France
    Drug Dev Ind Pharm 36:173-9. 2010
    ..Food effects might substantially alter drug release from oral controlled release dosage forms in vivo...
  16. ncbi Aqueous HPMCAS coatings: effects of formulation and processing parameters on drug release and mass transport mechanisms
    Florence Siepmann
    College of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
    Eur J Pharm Biopharm 63:262-9. 2006
    ....
  17. doi Novel preparation techniques for alginate-poloxamer microparticles controlling protein release on mucosal surfaces
    Katrin Moebus
    College of Pharmacy, Freie Universitat Berlin, Kelchstrasse 31, 12169 Berlin, Germany
    Eur J Pharm Sci 45:358-66. 2012
    ..The systems offer an interesting potential for the controlled mucosal delivery of protein drugs...
  18. doi Cast lipid implants for controlled drug delivery: importance of the tempering conditions
    Frauke Kreye
    Univ Lille Nord de France, College of Pharmacy, 59006 Lille, France
    J Pharm Sci 100:3471-81. 2011
    ..The size of the lipid particles depended on both the curing time and the temperature, and determined the size of the pores/channels through which water and drug diffuse. The importance of this aspect is often underestimated...
  19. doi Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets
    Susanne Muschert
    College of Pharmacy, University of Lille, Lille, France
    Eur J Pharm Biopharm 72:130-7. 2009
    ..g. osmolality. Thus, this type of controlled drug delivery system can be used for very different drugs and is robust...
  20. doi Novel polymeric film coatings for colon targeting: Drug release from coated pellets
    Youness Karrout
    College of Pharmacy, JE 2491, Universite Lille Nord de France, 3 rue du Professeur Laguesse, 59006 Lille, France
    Eur J Pharm Sci 37:427-33. 2009
    ..Furthermore, culture media containing specific colonic bacteria are presented providing an interesting potential as substitutes for fresh fecal samples...
  21. ncbi pH-sensitive polymer blends used as coating materials to control drug release from spherical beads: importance of the type of core
    Florence Lecomte
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Biomacromolecules 6:2074-83. 2005
    ..Using this knowledge the development/optimization of this type of drug delivery system can be facilitated and the safety of the pharmacotherapies be improved...
  22. ncbi Polymer blends used for the coating of multiparticulates: comparison of aqueous and organic coating techniques
    Florence Lecomte
    College of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany
    Pharm Res 21:882-90. 2004
    ..The purpose of this study was to use polymer blends for the coating of pellets and to study the effects of the type of coating technique (aqueous vs. organic) on drug release...
  23. ncbi Lipid implants as drug delivery systems
    Frauke Kreye
    University of Lille, College of Pharmacy, JE 2491, 3, rue du Professeur Laguesse, 59006 Lille, France
    Expert Opin Drug Deliv 5:291-307. 2008
    ..Lipid implants offer a great potential as parenteral controlled drug delivery systems, especially for protein-based drugs. A broad spectra of release patterns can be provided and acidic microclimates avoided...
  24. doi Alginate-poloxamer microparticles for controlled drug delivery to mucosal tissue
    Katrin Moebus
    College of Pharmacy, Freie Universitat Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:42-53. 2009
    ..The aim of this study was to prepare and characterize novel hydrogel-based delivery systems allowing for the controlled release of drugs to mucosal surfaces...
  25. ncbi Drug delivery to the upper small intestine window using gastroretentive technologies
    Alexander Streubel
    College of Pharmacy, Freie Universitat Berlin, Kelchstrasse 31, 12169 Berlin, Germany
    Curr Opin Pharmacol 6:501-8. 2006
    ..Approaches to achieving prolonged residence times of the devices in the upper part of the gastrointestinal tract include the use of bioadhesive, size-increasing, and floating drug delivery systems...
  26. ncbi How autocatalysis accelerates drug release from PLGA-based microparticles: a quantitative treatment
    Juergen Siepmann
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Biomacromolecules 6:2312-9. 2005
    ..Importantly, a quantitative relationship could be established between the dimension of the device and the resulting drug release patterns, taking the effects of autocatalysis into account...
  27. ncbi Gastroretentive drug delivery systems
    Alexander Streubel
    College of Pharmacy, Freie Universitat Berlin, Kelchstr 31, 12169 Berlin, Germany
    Expert Opin Drug Deliv 3:217-33. 2006
    ..Both single- and multiple-unit dosage forms are reviewed and, if available, results from in vivo trials are reported...
  28. doi Influence of urea and guanidine hydrochloride on lysozyme stability and thermal denaturation; a correlation between activity, protein dynamics and conformational changes
    Alain Hédoux
    Univ Lille Nord de France, F 59000 Lille, France
    Phys Chem Chem Phys 12:13189-96. 2010
    ..This comparison points out the exclusion of trehalose around the protein surface...
  29. ncbi A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations
    Juergen Siepmann
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Pharm Res 19:1885-93. 2002
    ..Monte Carlo simulations and sets of partial differential equations were used to describe the occurring chemical reactions and physical mass transport phenomena during drug release...