Jacques A Sepulchre

Summary

Country: France

Publications

  1. pmc A hidden feedback in signaling cascades is revealed
    Alejandra C Ventura
    Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Comput Biol 4:e1000041. 2008
  2. doi request reprint Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations
    Jacques Alexandre Sepulchre
    Institut Non Lineaire de Nice, UMR 7335 CNRS, University of Nice Sophia Antipolis, 1361 Route des Lucioles, 06560 Valbonne, France
    Acta Biotheor 61:59-78. 2013
  3. pmc Retroactive signaling in short signaling pathways
    Jacques Alexandre Sepulchre
    Institut Non Lineaire de Nice, UMR 7335 CNRS University of Nice Sophia Antipolis, Valbonne, France
    PLoS ONE 7:e40806. 2012
  4. pmc Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011
  5. pmc Simple molecular networks that respond optimally to time-periodic stimulation
    Axel Cournac
    Institut Non Lineaire de Nice, Universite de Nice Sophia Antipolis, CNRS, Valbonne, France
    BMC Syst Biol 3:29. 2009
  6. ncbi request reprint Modeling the onset of virulence in a pectinolytic bacterium
    Jacques A Sepulchre
    Institut Non Lineaire de Nice, UNSA CNRS, 1361 Route des Lucioles, 06560 Valbonne Sophia Antipolis, France
    J Theor Biol 244:239-57. 2007

Collaborators

Detail Information

Publications6

  1. pmc A hidden feedback in signaling cascades is revealed
    Alejandra C Ventura
    Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Comput Biol 4:e1000041. 2008
    ..All these properties are shared by the complete mechanistic description and our simplified model, but not by previously derived phenomenological models of signaling cascades...
  2. doi request reprint Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations
    Jacques Alexandre Sepulchre
    Institut Non Lineaire de Nice, UMR 7335 CNRS, University of Nice Sophia Antipolis, 1361 Route des Lucioles, 06560 Valbonne, France
    Acta Biotheor 61:59-78. 2013
    ....
  3. pmc Retroactive signaling in short signaling pathways
    Jacques Alexandre Sepulchre
    Institut Non Lineaire de Nice, UMR 7335 CNRS University of Nice Sophia Antipolis, Valbonne, France
    PLoS ONE 7:e40806. 2012
    ..Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles...
  4. pmc Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
    Michelle L Wynn
    Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Syst Biol 5:156. 2011
    ..We hypothesize that targeted therapies such as kinase inhibitors can produce off-target effects as a consequence of retroactivity alone...
  5. pmc Simple molecular networks that respond optimally to time-periodic stimulation
    Axel Cournac
    Institut Non Lineaire de Nice, Universite de Nice Sophia Antipolis, CNRS, Valbonne, France
    BMC Syst Biol 3:29. 2009
    ..In elucidating the mechanisms underlying these responses through simple networks the goal is to pinpoint general principles which optimize the oscillatory responses of molecular networks...
  6. ncbi request reprint Modeling the onset of virulence in a pectinolytic bacterium
    Jacques A Sepulchre
    Institut Non Lineaire de Nice, UNSA CNRS, 1361 Route des Lucioles, 06560 Valbonne Sophia Antipolis, France
    J Theor Biol 244:239-57. 2007
    ..This first modeling of the regulation of pel genes opens the way to new confrontations between theoretical ideas with experiments and possible strategies to fight the soft-rot disease of plants...