Laure Segurel

Summary

Country: France

Publications

  1. doi request reprint Determinants of mutation rate variation in the human germline
    Laure Segurel
    Laboratoire Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris 75231, France email
    Annu Rev Genomics Hum Genet 15:47-70. 2014
  2. pmc Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study
    Laure Segurel
    Museum national d histoire naturelle, Centre National de la Recherche Scientifique UMR 5145, Universite Paris 7, Eco anthropologie et Ethnobiologie, Musée de l Homme, Paris, France
    PLoS Genet 4:e1000200. 2008
  3. doi request reprint Frequency of the AGT Pro11Leu polymorphism in humans: Does diet matter?
    Laure Segurel
    Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris Diderot Paris, UMR Eco Anthropologie et Ethnobiologie, France
    Ann Hum Genet 74:57-64. 2010
  4. pmc In the heartland of Eurasia: the multilocus genetic landscape of Central Asian populations
    Begoña Martínez-Cruz
    Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7, UMR 7206, Eco anthropologie et Ethnobiologie, Paris, France
    Eur J Hum Genet 19:216-23. 2011
  5. pmc Genetic diversity and the emergence of ethnic groups in Central Asia
    Evelyne Heyer
    Eco anthropologie et Ethnobiologie, UMR7206 Département Hommes Natures Sociétés, Musée de l Homme 17, Place du Trocadéro 75116 Paris, France
    BMC Genet 10:49. 2009
  6. doi request reprint Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming
    Carla Aimé
    Laboratoire Eco Anthropologie et Ethnobiologie, UMR 7206, Museum national d histoire naturelle, Centre National de la Recherche Scientifique, université Paris 7 Diderot, Paris, France
    Mol Biol Evol 30:2629-44. 2013
  7. doi request reprint Lactase persistence in central Asia: phenotype, genotype, and evolution
    Evelyne Heyer
    Eco anthropology and Ethnobiology Unit, Museum national d histoire naturelle, Universite Paris Diderot, France
    Hum Biol 83:379-92. 2011
  8. pmc Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia
    Carla Aimé
    Laboratoire d Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris, France
    Eur J Hum Genet 22:1201-7. 2014
  9. pmc Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia
    Laure Segurel
    1 Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris, France 2 Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Eur J Hum Genet 21:1146-51. 2013
  10. pmc Looking for signatures of sex-specific demography and local adaptation on the X chromosome
    Evelyne Heyer
    Human Population Genetics Team, UMR 7206 EcoAnthropologie MNHN CNRS UPD, 57 rue Cuvier, 75005 Paris, France
    Genome Biol 11:203. 2010

Collaborators

Detail Information

Publications11

  1. doi request reprint Determinants of mutation rate variation in the human germline
    Laure Segurel
    Laboratoire Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris 75231, France email
    Annu Rev Genomics Hum Genet 15:47-70. 2014
    ..We then consider the mutation rate as a product of evolution and discuss how and why it may have changed over time in primates. ..
  2. pmc Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study
    Laure Segurel
    Museum national d histoire naturelle, Centre National de la Recherche Scientifique UMR 5145, Universite Paris 7, Eco anthropologie et Ethnobiologie, Musée de l Homme, Paris, France
    PLoS Genet 4:e1000200. 2008
    ..This study suggests that differences in sex-specific migration rates may not be the only cause of contrasting male and female differentiation in humans, and that differences in effective numbers do matter...
  3. doi request reprint Frequency of the AGT Pro11Leu polymorphism in humans: Does diet matter?
    Laure Segurel
    Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris Diderot Paris, UMR Eco Anthropologie et Ethnobiologie, France
    Ann Hum Genet 74:57-64. 2010
    ..Hence, the distribution of the variation observed in the AGXT gene could be due to demographic history, rather than local adaptation to diet...
  4. pmc In the heartland of Eurasia: the multilocus genetic landscape of Central Asian populations
    Begoña Martínez-Cruz
    Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7, UMR 7206, Eco anthropologie et Ethnobiologie, Paris, France
    Eur J Hum Genet 19:216-23. 2011
    ..Contrary to what is generally thought, our results suggest that the recurrent expansions of eastern nomadic groups did not result in the complete replacement of local populations, but rather into partial admixture...
  5. pmc Genetic diversity and the emergence of ethnic groups in Central Asia
    Evelyne Heyer
    Eco anthropologie et Ethnobiologie, UMR7206 Département Hommes Natures Sociétés, Musée de l Homme 17, Place du Trocadéro 75116 Paris, France
    BMC Genet 10:49. 2009
    ....
  6. doi request reprint Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming
    Carla Aimé
    Laboratoire Eco Anthropologie et Ethnobiologie, UMR 7206, Museum national d histoire naturelle, Centre National de la Recherche Scientifique, université Paris 7 Diderot, Paris, France
    Mol Biol Evol 30:2629-44. 2013
    ..This suggests that human populations could have started to expand in Paleolithic times, and that strong Paleolithic expansions in some populations may have ultimately favored their shift toward agriculture during the Neolithic...
  7. doi request reprint Lactase persistence in central Asia: phenotype, genotype, and evolution
    Evelyne Heyer
    Eco anthropology and Ethnobiology Unit, Museum national d histoire naturelle, Universite Paris Diderot, France
    Hum Biol 83:379-92. 2011
    ..Using the surrounding haplotype, we estimate a date of expansion of the T allele around 6,000-12,000 yrs ago, which is consistent with archaeological records for the emergence of agropastoralism and pastoralism in Central Asia...
  8. pmc Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia
    Carla Aimé
    Laboratoire d Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris, France
    Eur J Hum Genet 22:1201-7. 2014
    ..Alternatively, current Central Asian herders may descent from populations who have first experienced a transition from hunter-gathering to sedentary agropastoralism, and then a second transition to nomadic herding. ..
  9. pmc Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia
    Laure Segurel
    1 Eco Anthropologie et Ethnobiologie, UMR 7206, Muséum National d Histoire Naturelle Centre National de la Recherche Scientifique Université Paris 7 Diderot, Paris, France 2 Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Eur J Hum Genet 21:1146-51. 2013
    ..As much effort has been devoted so far to searching for thrifty variants, we argue that more attention should be paid to the evolution of non-thrifty variants. ..
  10. pmc Looking for signatures of sex-specific demography and local adaptation on the X chromosome
    Evelyne Heyer
    Human Population Genetics Team, UMR 7206 EcoAnthropologie MNHN CNRS UPD, 57 rue Cuvier, 75005 Paris, France
    Genome Biol 11:203. 2010
    ..A population study comparing X-linked variation with that of the autosomes reveals that social organization has a clear impact on X chromosome genetic diversity and that the X chromosome shows a signature of local adaptation...
  11. doi request reprint Preserving immune diversity through ancient inheritance and admixture
    Laure Segurel
    Laboratoire d Eco Anthropologie et Ethnobiologie, UMR 7206, Museum national d histoire naturelle, Centre National de la Recherche Scientifique, université Paris 7 Diderot, Paris, France
    Curr Opin Immunol 30:79-84. 2014
    ..These studies collectively increase our knowledge of immune genes for which maintaining the functional diversity has conferred a strong selective advantage for host survival. ..