Genomes and Genes
- New insights into how Yersinia pestis adapts to its mammalian host during bubonic plagueElizabeth Pradel
Equipe Peste et Yersinia pestis INSERM U1019, Lille, France Centre National de la Recherche Scientifique UMR8204, Lille, France Institut Pasteur de Lille, Centre d Infection et d Immunité de Lille, Lille, France Univ Lille Nord de France, Lille, France UDSL, Centre d Infection et d Immunité de Lille, Lille, France
PLoS Pathog 10:e1004029. 2014..Our results suggest that (i) intracellular survival during the early stage of infection is important for plague and (ii) horizontal gene transfer was crucial in the acquisition of this ability...
- Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plagueFlorent Sebbane
Equipe Peste et Yersinia pestis, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, Lille, France
PLoS ONE 5:e14379. 2010..The results provide new evidence that primary septicemic plague is a distinct clinical entity and suggest that unusual forms of plague may be caused by atypical Y. pestis strains...
- Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune responseAnne Derbise
Equipe Peste et Yersinia pestis, Inserm U1019, Paris, France
J Infect Dis 207:1535-43. 2013..The involvement of both inhibitors in virulence remains subject to debate...
- Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plagueNadine Lemaitre
Laboratoire de Bacteriologie Hygiene, Centre Hospitalier Universitaire, Lille, France
PLoS ONE 7:e52503. 2012..Moreover, draining lymph nodes may serve as a reservoir for the continued release of Y. pestis into the blood - even after five days of intravenous antibiotic treatment...
- The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plagueFlorent Sebbane
Institut National de la Sante et de la Recherche Medicale, U801, Institut Pasteur de Lille, Lille, France
Infect Immun 77:1222-9. 2009..pestis strains in plague foci may be necessary. The results also highlight the importance of studying Y. pestis pathogenesis in the natural context of arthropod-borne transmission...
- Autophagosomes can support Yersinia pseudotuberculosis replication in macrophagesKevin Moreau
Cellular Microbiology of Infectious Pathogens, Center of Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France
Cell Microbiol 12:1108-23. 2010..pseudotuberculosis hijacks the autophagy pathway for its replication and also opens up new opportunities for deciphering the molecular basis of the host cell signalling response to intracellular Yersinia infection...
- TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosaLaurye Van Maele
Institut Pasteur de Lille, Centre d Infection et d Immunité de Lille, France
J Immunol 185:1177-85. 2010..These data define that TLR-induced activation of CD3(neg)CD127(+) cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues...
- Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrVCatherine Daniel
Laboratoire des Bactéries Lactiques et Immunité des Muqueuses, Institut Fédératif de Recherche 142, Institut Pasteur de Lille, Lille F 59021, France
Vaccine 27:1141-4. 2009..pseudotuberculosis infections. This constitutes the first proof of principle for a novel anti-Yersinia mucosal vaccination strategy using recombinant lactic acid bacteria...