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Genomes and Genes | Michael SchumacherSummaryCountry: France Publications
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Publications
Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male ratsEmanuela Leonelli
Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via G. Balzaretti 9, 20133 Milano, Italy
Mech Ageing Dev 126:1159-63. 2005..These findings support the potential role of PBR ligands to prevent aging-associated peripheral nerve degeneration...- Pregnenolone sulfate in the brain: a controversial neurosteroidMichael Schumacher
UMR 788 Inserm, University Paris Sud 11, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
Neurochem Int 52:522-40. 2008.... - Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous systemMichael Schumacher
INSERM UMR 788, 80, rue du General Leclerc, 94276 Kremlin Bicêtre, France
Endocr Rev 28:387-439. 2007..The recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging... - Progesterone: therapeutic opportunities for neuroprotection and myelin repairMichael Schumacher
UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
Pharmacol Ther 116:77-106. 2007..A concept is emerging that progesterone may exert different actions and use different signaling mechanisms in normal and injured neural tissue... 
Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cellsCosima Fonte
Unité Mixte de Recherche 488 and Equipe 120 Institut National de la Santé et de la Recherche Médicale 80, rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
Proc Natl Acad Sci U S A 102:14260-5. 2005....- 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injuryDelphine Meffre
UMR788 INSERM and University Paris 11 Steroids, Neuroprotection, Neuroregeneration, Kremlin Bicetre, France
J Steroid Biochem Mol Biol 104:293-300. 2007..This decrease has less impact in pseudopregnant females since they have high plasmatic and brain levels of PROG compared to males... - Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brainPhilippe Liere
Institut National de la Santé et de la Recherche Médicale U488, 94276 Kremlin Bicêtre, France
J Lipid Res 45:2287-302. 2004..Given their abundance in rodent brain, the structural characterization and biological functions of L-PREG and L-DHEA in the central nervous system merit considerable attention... - Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the keyPhilippe Liere
Unité Mixte de Recherche 788, INSERM, University Paris Sud 11, 94276 Kremlin Bicêtre, France
J Lipid Res 50:2430-44. 2009.... - Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell lineJulien Grenier
Inserm UMR488, Faculte de Medecine Paris Sud, 80, rue du General Leclerc, 94276 Le Kremlin Bicetre, France
J Steroid Biochem Mol Biol 97:342-52. 2005.... - Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytesJulien Grenier
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
Mol Endocrinol 20:254-67. 2006..Altogether, these results highlight the cell specificity and the time dependence of p160s recruitment by the activated GR in glial cells, revealing the complexity of GR-p160 assembly in the nervous system... - Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditionsAmalia Trousson
INSERM UMR788, Universite Paris Sud 11, 80, rue du Général Leclerc 94276 Le Kremlin Bicêtre Cedex, France
J Steroid Biochem Mol Biol 104:305-11. 2007..Altogether, these results reveal that the p160s are not interchangeable and that their recruitment by the GR is a multiparametric event... - Developmental expression of genes involved in neurosteroidogenesis: 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in the rat brainChrystelle Ibanez
Institut National de la Sante et de la Recherche Medicale, Unité 488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 94276 Bicêtre, France
Endocrinology 144:2902-11. 2003..These results demonstrate variations in the expression of a gene coding for an enzyme critically involved in progesterone synthesis in the hippocampus throughout postnatal development... - In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patientsSébastien Weill-Engerer
INSERM U488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 94276, Le Kremlin Bicetre, France
Brain Res 969:117-25. 2003.... - Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytesCosima Fonte
INSERM UMR788, University Paris Sud Paris XI, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
J Steroid Biochem Mol Biol 104:220-7. 2007..Moreover, in astrocytes the opposite effects of CBP and p300 could lead to a balance in the transactivation potency of the GR, in order to fine tune the action of glucocorticoids... - Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelinationMichael Schumacher
INSERM U488, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
Growth Horm IGF Res 14:S18-33. 2004.... 
Hormonal influences in multiple sclerosis: new therapeutic benefits for steroidsMartine El-Etr
INSERM UMR 788 and University Paris Sud 11, 80 rue du General Leclerc, 94276, Kremlin Bicetre, France
Maturitas 68:47-51. 2011....- Progesterone receptors: a key for neuroprotection in experimental strokeAiling Liu
Unité Mixte de Recherche 788 Institut National de la Santé et de la Recherche Médicale and University Paris Sud, 80, rue du General Leclerc, 94276 Kremlin Bicêtre, France
Endocrinology 153:3747-57. 2012..Collectively, our data clarify the relative roles of PR and allopregnanolone in neuroprotection after stroke... - Progesterone and progestins: neuroprotection and myelin repairMichael Schumacher
UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
Curr Opin Pharmacol 8:740-6. 2008.... - Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesisMarcel Tawk
Unité Mixte de Recherche 788, INSERM and University Paris Sud 11, Biomedical Institute of Bicêtre, 94276 Kremlin Bicêtre, France
J Neurosci 31:3729-42. 2011..The present findings attribute to Wnt/β-catenin pathway components an essential role in myelin gene expression and myelinogenesis... - Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patientsSébastien Weill-Engerer
INSERM U 488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 54276 Le Kremlin Bicêtre, France
J Clin Endocrinol Metab 87:5138-43. 2002..High levels of key proteins implicated in the formation of plaques and neurofibrillary tangles were correlated with decreased brain levels of PREGS and DHEAS, suggesting a possible neuroprotective role of these neurosteroids in AD... - Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cellsJulien Grenier
Institut National de la Santé et de la Recherche Médicale Unité 488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
Mol Endocrinol 18:2866-79. 2004..We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system... - The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injuryDelphine Meffre
INSERM U488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
J Neurochem 93:1314-26. 2005.... - Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptorsRashad Hussain
Unité Mixte de Recherche 788 Institut National de la Santé et de la Recherche Médicale and University Paris Sud 11, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
Endocrinology 152:3820-31. 2011..They may thus open new perspectives for the use of progestins, which selectively target PR, to promote the endogenous regeneration of myelin... - Thyroid hormone deiodinases in the central and peripheral nervous systemFrançoise Courtin
INSERM U 488, 94276 Le Kremlin Bicetre, France
Thyroid 15:931-42. 2005..On the basis of available data summarized in this review, D2 and D3 clearly contribute to determine T(3) concentrations depending on the area of the nervous system, the state of development, and the pathophysiologic conditions... - The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptorsMartine El-Etr
Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 788, Université Paris 11, 94276, Le Kremlin Bicetre, France
Endocrinology 147:2737-43. 2006..Together these results point to a novel mechanism by which the neuroactive steroid PREGS may potentiate an autocrine excitatory loop in GnRH neurons... - Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neuronsJennifer Rakotomamonjy
Unité Mixte de Recherche 788, Institut National de Santé et de Recherche Médicale INSERM and University Paris Sud 11, Kremlin Bicetre, France
FASEB J 25:3999-4010. 2011..A new and nonhormonal effect of mifepristone is thus revealed... - Steroid receptors in various glial cell lines expression and functional studiesFrancoise Cadepond
INSERM U488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre, France
Ann N Y Acad Sci 973:484-7. 2002..Mineralocorticosteroid receptor mRNA was less abundant, with no corresponding binding and lack of transcriptional activity. Other steroid receptors were not significantly detected... - Control of cell survival and proliferation of postnatal PSA-NCAM(+) progenitorsNathalie Gago
INSERM U 488, 80, rue du General Leclerc, 94276, Bicetre, France
Mol Cell Neurosci 22:162-78. 2003..For these "early PSA-NCAM(+) progenitors," insulin-like growth factor 1 and EGF seem to play a pivotal role in the control of cell death and cell proliferation... - Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosisThierry Bordet
Trophos, Parc Scientifique de Luminy, Marseille Cedex, France
J Pharmacol Exp Ther 322:709-20. 2007..TRO19622 may have therapeutic potential for ALS and other motor neuron and neurodegenerative diseases... - Basis of progesterone protection in spinal cord neurodegenerationMaria Claudia Gonzalez Deniselle
Laboratory of Neuroendocrine Biochemistry, Department of Human Biochemistry, Faculty of Medicine, Instituto de Biologia y Medicina Experimental, University of Buenos Aires, Obligado 2490, 1428 Buenos Aires, Argentina
J Steroid Biochem Mol Biol 83:199-209. 2002..Recovery of morphology and molecular motoneuron parameters of Wobbler mice receiving progesterone, suggest a new and important role for this hormone in the prevention of spinal cord neurodegenerative disorders... - Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNSWen-Wu Li
Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
Exp Neurol 202:250-4. 2006..These results indicate a sex-associated divergence in remyelination efficiency that occurs with ageing that is unaffected by the removal of gonadal sources of sex steroid hormones... - Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cellsGhislaine Groyer
Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale and University Paris Sud 11, 94276 Le Kremlin Bicetre, France
Endocrinology 147:4339-50. 2006..These data support a physiological role for HSD2 regulation of glucocorticosteroid concentrations in nerve SC... - SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repairBadia Ferzaz
Discovery Research, Central Nervous System Research Department, Sanofi Synthelabo Recherche, 31 avenue P Vaillant Couturier, 92225 Bagneux Cedex, France
J Pharmacol Exp Ther 301:1067-78. 2002..g., SSR180575) promote neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases (e.g., peripheral neuropathies or amyotrophic lateral sclerosis)... - Steroid effects on glial cells: detrimental or protective for spinal cord function?Alejandro F De Nicola
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Ann N Y Acad Sci 1007:317-28. 2003..Thus, PROG effects on glial cells go in parallel with morphological and biochemical evidence of survival of damaged motoneurons... - 3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferationNathalie Gago
INSERM U 488, Bicetre, France
J Neurosci Res 78:770-83. 2004.... - Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneuronsSusana L Gonzalez
Institute of Biology and Experimental Medicine, Laboratory of Neuroendocrine, Obligado 2490, 1428 Buenos Aires, Argentina
J Steroid Biochem Mol Biol 94:143-9. 2005..Thus, PROG treatment constitutes a new approach to sustain neuronal function after injury... - [Unusual mechanism of action and assembly of the glucocorticoid receptor and its coactivators in glial cells]Julien Grenier
Inserm UMR 488, , , France
Med Sci (Paris) 22:16-8. 2006 - Progesterone treatment of spinal cord injury: Effects on receptors, neurotrophins, and myelinationAlejandro F De Nicola
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
J Mol Neurosci 28:3-15. 2006..Furthermore, PROG-induced BDNF might regulate, in a paracrine or autocrine fashion, the function of neurons and glial cells and prevent the generation of damage... - The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brainMarc Verleye
Departement de Pharmacologie, Biocodex, Zac de Mercières, Chemin d Armancourt, Compiegne, France
Pharmacol Biochem Behav 82:712-20. 2005.... - Cellular basis for progesterone neuroprotection in the injured spinal cordFlorencia Labombarda
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina
J Neurotrauma 19:343-55. 2002..PROG effects on GAP-43 also appear to accelerate reparative responses to injury. As the cellular basis for PROG neuroprotection becomes better understood it may prove of therapeutic benefit to spinal cord injury patients... - Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cordFlorencia Labombarda
Laboratory of Neuroendocrine Biochemistry, Institute of Experimental Biology and Medicine, and Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
J Neurotrauma 23:181-92. 2006.... - Progesterone treatment reduces NADPH-diaphorase/nitric oxide synthase in Wobbler mouse motoneuron diseaseMaria Claudia Gonzalez Deniselle
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, University of Buenos Aires, Argentina
Brain Res 1014:71-9. 2004.... - Progesterone restores retrograde labeling of cervical motoneurons in Wobbler mouse motoneuron diseaseMaria Claudia Gonzalez Deniselle
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Biochemistry, Faculty of Medicine, University of Buenos, Obligado 2490, 1428 Buenos Aires, Argentina
Exp Neurol 195:518-23. 2005..The latter mechanism could improve the traffic of neurotrophic factors from the forelimb muscles into the ailing motoneurons, improving neuromuscular function in this murine model of HMD... - Downregulation of steroidogenic acute regulatory protein (StAR) gene expression by cyclic AMP in cultured Schwann cellsYasmina Benmessahel
INSERM U488, , France
Glia 45:213-28. 2004..Since StAR gene expression is stimulated by cAMP in classical steroidogenic cells, our work is the first demonstration of a negative regulation of StAR gene by cAMP... - Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron diseaseMaria Claudia Gonzalez Deniselle
Instituto de Biologia y Medicina Experimental, Departamento de Bioquimica Humana, Facultad de Medicina, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina
Neurobiol Dis 11:457-68. 2002..However, because the gene mutation in Wobbler mice is still unknown, further studies are needed to unveil the action of PROG and the mechanism of neuronal death in this genetic model of neurodegeneration... - Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneuronsMaria Claudia Gonzalez Deniselle
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Dep of Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina
Exp Neurol 203:406-14. 2007....