Michael Schumacher

Summary

Country: France

Publications

  1. ncbi Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milano, Italy
    Mech Ageing Dev 126:1159-63. 2005
  2. ncbi Pregnenolone sulfate in the brain: a controversial neurosteroid
    Michael Schumacher
    UMR 788 Inserm, University Paris Sud 11, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Neurochem Int 52:522-40. 2008
  3. ncbi Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system
    Michael Schumacher
    INSERM UMR 788, 80, rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Endocr Rev 28:387-439. 2007
  4. ncbi Progesterone: therapeutic opportunities for neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Pharmacol Ther 116:77-106. 2007
  5. ncbi 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
    Delphine Meffre
    UMR788 INSERM and University Paris 11 Steroids, Neuroprotection, Neuroregeneration, Kremlin Bicetre, France
    J Steroid Biochem Mol Biol 104:293-300. 2007
  6. pmc Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells
    Cosima Fonte
    Unité Mixte de Recherche 488 and Equipe 120 Institut National de la Santé et de la Recherche Médicale 80, rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Proc Natl Acad Sci U S A 102:14260-5. 2005
  7. ncbi Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line
    Julien Grenier
    Inserm UMR488, Faculte de Medecine Paris Sud, 80, rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    J Steroid Biochem Mol Biol 97:342-52. 2005
  8. pmc Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key
    Philippe Liere
    Unité Mixte de Recherche 788, INSERM, University Paris Sud 11, 94276 Kremlin Bicêtre, France
    J Lipid Res 50:2430-44. 2009
  9. doi Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: a key role for progesterone receptors and steroidal modulators of GABA(A) receptors
    Florencia Labombarda
    UMR 788, Inserm and University Paris Sud, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Neuropharmacology 71:46-55. 2013
  10. ncbi Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes
    Cosima Fonte
    INSERM UMR788, University Paris Sud Paris XI, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    J Steroid Biochem Mol Biol 104:220-7. 2007

Collaborators

Detail Information

Publications48

  1. ncbi Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    Emanuela Leonelli
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milano, Italy
    Mech Ageing Dev 126:1159-63. 2005
    ..These findings support the potential role of PBR ligands to prevent aging-associated peripheral nerve degeneration...
  2. ncbi Pregnenolone sulfate in the brain: a controversial neurosteroid
    Michael Schumacher
    UMR 788 Inserm, University Paris Sud 11, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Neurochem Int 52:522-40. 2008
    ....
  3. ncbi Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system
    Michael Schumacher
    INSERM UMR 788, 80, rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Endocr Rev 28:387-439. 2007
    ..The recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging...
  4. ncbi Progesterone: therapeutic opportunities for neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Pharmacol Ther 116:77-106. 2007
    ..A concept is emerging that progesterone may exert different actions and use different signaling mechanisms in normal and injured neural tissue...
  5. ncbi 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
    Delphine Meffre
    UMR788 INSERM and University Paris 11 Steroids, Neuroprotection, Neuroregeneration, Kremlin Bicetre, France
    J Steroid Biochem Mol Biol 104:293-300. 2007
    ..This decrease has less impact in pseudopregnant females since they have high plasmatic and brain levels of PROG compared to males...
  6. pmc Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells
    Cosima Fonte
    Unité Mixte de Recherche 488 and Equipe 120 Institut National de la Santé et de la Recherche Médicale 80, rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Proc Natl Acad Sci U S A 102:14260-5. 2005
    ....
  7. ncbi Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line
    Julien Grenier
    Inserm UMR488, Faculte de Medecine Paris Sud, 80, rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    J Steroid Biochem Mol Biol 97:342-52. 2005
    ....
  8. pmc Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key
    Philippe Liere
    Unité Mixte de Recherche 788, INSERM, University Paris Sud 11, 94276 Kremlin Bicêtre, France
    J Lipid Res 50:2430-44. 2009
    ....
  9. doi Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: a key role for progesterone receptors and steroidal modulators of GABA(A) receptors
    Florencia Labombarda
    UMR 788, Inserm and University Paris Sud, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Neuropharmacology 71:46-55. 2013
    ..Altogether, these findings identify both PR and GABA(A) receptors as important targets for neuroprotection by progestagens after spinal cord injury...
  10. ncbi Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes
    Cosima Fonte
    INSERM UMR788, University Paris Sud Paris XI, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    J Steroid Biochem Mol Biol 104:220-7. 2007
    ..Moreover, in astrocytes the opposite effects of CBP and p300 could lead to a balance in the transactivation potency of the GR, in order to fine tune the action of glucocorticoids...
  11. ncbi In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients
    Sébastien Weill-Engerer
    INSERM U488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 94276, Le Kremlin Bicetre, France
    Brain Res 969:117-25. 2003
    ....
  12. ncbi Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain
    Philippe Liere
    Institut National de la Santé et de la Recherche Médicale U488, 94276 Kremlin Bicêtre, France
    J Lipid Res 45:2287-302. 2004
    ..Given their abundance in rodent brain, the structural characterization and biological functions of L-PREG and L-DHEA in the central nervous system merit considerable attention...
  13. ncbi Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes
    Julien Grenier
    Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Mol Endocrinol 20:254-67. 2006
    ..Altogether, these results highlight the cell specificity and the time dependence of p160s recruitment by the activated GR in glial cells, revealing the complexity of GR-p160 assembly in the nervous system...
  14. ncbi Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions
    Amalia Trousson
    INSERM UMR788, Universite Paris Sud 11, 80, rue du Général Leclerc 94276 Le Kremlin Bicêtre Cedex, France
    J Steroid Biochem Mol Biol 104:305-11. 2007
    ..Altogether, these results reveal that the p160s are not interchangeable and that their recruitment by the GR is a multiparametric event...
  15. ncbi Developmental expression of genes involved in neurosteroidogenesis: 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in the rat brain
    Chrystelle Ibanez
    Institut National de la Sante et de la Recherche Medicale, Unité 488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 94276 Bicêtre, France
    Endocrinology 144:2902-11. 2003
    ..These results demonstrate variations in the expression of a gene coding for an enzyme critically involved in progesterone synthesis in the hippocampus throughout postnatal development...
  16. ncbi Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination
    Michael Schumacher
    INSERM U488, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Growth Horm IGF Res 14:S18-33. 2004
    ....
  17. ncbi Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells
    Julien Grenier
    Institut National de la Santé et de la Recherche Médicale Unité 488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Mol Endocrinol 18:2866-79. 2004
    ..We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system...
  18. pmc Progesterone receptors: a key for neuroprotection in experimental stroke
    Ailing Liu
    Unité Mixte de Recherche 788 Institut National de la Santé et de la Recherche Médicale and University Paris Sud, 80, rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Endocrinology 153:3747-57. 2012
    ..Collectively, our data clarify the relative roles of PR and allopregnanolone in neuroprotection after stroke...
  19. ncbi Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients
    Sébastien Weill-Engerer
    INSERM U 488, Stéroïdes et Système Nerveux, 80 rue du General Leclerc, 54276 Le Kremlin Bicêtre, France
    J Clin Endocrinol Metab 87:5138-43. 2002
    ..High levels of key proteins implicated in the formation of plaques and neurofibrillary tangles were correlated with decreased brain levels of PREGS and DHEAS, suggesting a possible neuroprotective role of these neurosteroids in AD...
  20. doi The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination
    Rashad Hussain
    UMR 788 INSERM and Université Paris Sud, 94276 Kremlin Bicêtre, France
    Brain 136:132-46. 2013
    ....
  21. doi Hormonal influences in multiple sclerosis: new therapeutic benefits for steroids
    Martine El-Etr
    INSERM UMR 788 and University Paris Sud 11, 80 rue du General Leclerc, 94276, Kremlin Bicetre, France
    Maturitas 68:47-51. 2011
    ....
  22. doi Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis
    Marcel Tawk
    Unité Mixte de Recherche 788, INSERM and University Paris Sud 11, Biomedical Institute of Bicêtre, 94276 Kremlin Bicêtre, France
    J Neurosci 31:3729-42. 2011
    ..The present findings attribute to Wnt/β-catenin pathway components an essential role in myelin gene expression and myelinogenesis...
  23. doi Progesterone and progestins: neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Curr Opin Pharmacol 8:740-6. 2008
    ....
  24. ncbi The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury
    Delphine Meffre
    INSERM U488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
    J Neurochem 93:1314-26. 2005
    ....
  25. doi Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors
    Rashad Hussain
    Unité Mixte de Recherche 788 Institut National de la Santé et de la Recherche Médicale and University Paris Sud 11, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
    Endocrinology 152:3820-31. 2011
    ..They may thus open new perspectives for the use of progestins, which selectively target PR, to promote the endogenous regeneration of myelin...
  26. ncbi Thyroid hormone deiodinases in the central and peripheral nervous system
    Françoise Courtin
    INSERM U 488, 94276 Le Kremlin Bicetre, France
    Thyroid 15:931-42. 2005
    ..On the basis of available data summarized in this review, D2 and D3 clearly contribute to determine T(3) concentrations depending on the area of the nervous system, the state of development, and the pathophysiologic conditions...
  27. ncbi The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors
    Martine El-Etr
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 788, Université Paris 11, 94276, Le Kremlin Bicetre, France
    Endocrinology 147:2737-43. 2006
    ..Together these results point to a novel mechanism by which the neuroactive steroid PREGS may potentiate an autocrine excitatory loop in GnRH neurons...
  28. ncbi Downregulation of steroidogenic acute regulatory protein (StAR) gene expression by cyclic AMP in cultured Schwann cells
    Yasmina Benmessahel
    INSERM U488, Kremlin Bicetre, France
    Glia 45:213-28. 2004
    ..Since StAR gene expression is stimulated by cAMP in classical steroidogenic cells, our work is the first demonstration of a negative regulation of StAR gene by cAMP...
  29. doi Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons
    Jennifer Rakotomamonjy
    Unité Mixte de Recherche 788, Institut National de Santé et de Recherche Médicale INSERM and University Paris Sud 11, Kremlin Bicetre, France
    FASEB J 25:3999-4010. 2011
    ..A new and nonhormonal effect of mifepristone is thus revealed...
  30. ncbi Steroid receptors in various glial cell lines expression and functional studies
    Francoise Cadepond
    INSERM U488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    Ann N Y Acad Sci 973:484-7. 2002
    ..Mineralocorticosteroid receptor mRNA was less abundant, with no corresponding binding and lack of transcriptional activity. Other steroid receptors were not significantly detected...
  31. ncbi Control of cell survival and proliferation of postnatal PSA-NCAM(+) progenitors
    Nathalie Gago
    INSERM U 488, 80, rue du General Leclerc, 94276, Bicetre, France
    Mol Cell Neurosci 22:162-78. 2003
    ..For these "early PSA-NCAM(+) progenitors," insulin-like growth factor 1 and EGF seem to play a pivotal role in the control of cell death and cell proliferation...
  32. ncbi Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
    Thierry Bordet
    Trophos, Parc Scientifique de Luminy, Marseille Cedex, France
    J Pharmacol Exp Ther 322:709-20. 2007
    ..TRO19622 may have therapeutic potential for ALS and other motor neuron and neurodegenerative diseases...
  33. ncbi Cellular basis for progesterone neuroprotection in the injured spinal cord
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina
    J Neurotrauma 19:343-55. 2002
    ..PROG effects on GAP-43 also appear to accelerate reparative responses to injury. As the cellular basis for PROG neuroprotection becomes better understood it may prove of therapeutic benefit to spinal cord injury patients...
  34. ncbi SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair
    Badia Ferzaz
    Discovery Research, Central Nervous System Research Department, Sanofi Synthelabo Recherche, 31 avenue P Vaillant Couturier, 92225 Bagneux Cedex, France
    J Pharmacol Exp Ther 301:1067-78. 2002
    ..g., SSR180575) promote neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases (e.g., peripheral neuropathies or amyotrophic lateral sclerosis)...
  35. ncbi Basis of progesterone protection in spinal cord neurodegeneration
    Maria Claudia Gonzalez Deniselle
    Laboratory of Neuroendocrine Biochemistry, Department of Human Biochemistry, Faculty of Medicine, Instituto de Biologia y Medicina Experimental, University of Buenos Aires, Obligado 2490, 1428 Buenos Aires, Argentina
    J Steroid Biochem Mol Biol 83:199-209. 2002
    ..Recovery of morphology and molecular motoneuron parameters of Wobbler mice receiving progesterone, suggest a new and important role for this hormone in the prevention of spinal cord neurodegenerative disorders...
  36. ncbi Steroid effects on glial cells: detrimental or protective for spinal cord function?
    Alejandro F De Nicola
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 1007:317-28. 2003
    ..Thus, PROG effects on glial cells go in parallel with morphological and biochemical evidence of survival of damaged motoneurons...
  37. ncbi 3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation
    Nathalie Gago
    INSERM U 488, Bicetre, France
    J Neurosci Res 78:770-83. 2004
    ....
  38. ncbi Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons
    Susana L Gonzalez
    Institute of Biology and Experimental Medicine, Laboratory of Neuroendocrine, Obligado 2490, 1428 Buenos Aires, Argentina
    J Steroid Biochem Mol Biol 94:143-9. 2005
    ..Thus, PROG treatment constitutes a new approach to sustain neuronal function after injury...
  39. ncbi [Unusual mechanism of action and assembly of the glucocorticoid receptor and its coactivators in glial cells]
    Julien Grenier
    Inserm UMR 488, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Med Sci (Paris) 22:16-8. 2006
  40. ncbi The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain
    Marc Verleye
    Departement de Pharmacologie, Biocodex, Zac de Mercières, Chemin d Armancourt, Compiegne, France
    Pharmacol Biochem Behav 82:712-20. 2005
    ....
  41. ncbi Progesterone treatment of spinal cord injury: Effects on receptors, neurotrophins, and myelination
    Alejandro F De Nicola
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
    J Mol Neurosci 28:3-15. 2006
    ..Furthermore, PROG-induced BDNF might regulate, in a paracrine or autocrine fashion, the function of neurons and glial cells and prevent the generation of damage...
  42. ncbi Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells
    Ghislaine Groyer
    Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale and University Paris Sud 11, 94276 Le Kremlin Bicetre, France
    Endocrinology 147:4339-50. 2006
    ..These data support a physiological role for HSD2 regulation of glucocorticosteroid concentrations in nerve SC...
  43. ncbi Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS
    Wen Wu Li
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Exp Neurol 202:250-4. 2006
    ..These results indicate a sex-associated divergence in remyelination efficiency that occurs with ageing that is unaffected by the removal of gonadal sources of sex steroid hormones...
  44. ncbi Progesterone restores retrograde labeling of cervical motoneurons in Wobbler mouse motoneuron disease
    Maria Claudia Gonzalez Deniselle
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Department of Biochemistry, Faculty of Medicine, University of Buenos, Obligado 2490, 1428 Buenos Aires, Argentina
    Exp Neurol 195:518-23. 2005
    ..The latter mechanism could improve the traffic of neurotrophic factors from the forelimb muscles into the ailing motoneurons, improving neuromuscular function in this murine model of HMD...
  45. ncbi Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Institute of Experimental Biology and Medicine, and Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Neurotrauma 23:181-92. 2006
    ....
  46. ncbi Progesterone treatment reduces NADPH-diaphorase/nitric oxide synthase in Wobbler mouse motoneuron disease
    Maria Claudia Gonzalez Deniselle
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, University of Buenos Aires, Argentina
    Brain Res 1014:71-9. 2004
    ....
  47. ncbi Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease
    Maria Claudia Gonzalez Deniselle
    Instituto de Biologia y Medicina Experimental, Departamento de Bioquimica Humana, Facultad de Medicina, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina
    Neurobiol Dis 11:457-68. 2002
    ..However, because the gene mutation in Wobbler mice is still unknown, further studies are needed to unveil the action of PROG and the mechanism of neuronal death in this genetic model of neurodegeneration...
  48. ncbi Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons
    Maria Claudia Gonzalez Deniselle
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, and Dep of Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina
    Exp Neurol 203:406-14. 2007
    ....