Andreas Schedl

Summary

Country: France

Publications

  1. ncbi request reprint The complex life of WT1
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat Berlin, Germany
    J Cell Sci 116:1653-8. 2003
  2. ncbi request reprint A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Nice, France
    Development 132:1327-36. 2005
  3. ncbi request reprint Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1
    Nicole Wagner
    Institut National de la Santé et de la Recherche Médicale U636, Centre de Biochimie, Faculte des Sciences, Universite de Nice, 06108 Nice, France
    Am J Physiol Regul Integr Comp Physiol 291:R779-87. 2006
  4. ncbi request reprint Renal abnormalities and their developmental origin
    Andreas Schedl
    INSERM, U636, F 06108 Nice, France
    Nat Rev Genet 8:791-802. 2007
  5. pmc The WTX/AMER1 gene family: evolution, signature and function
    Agnes Boutet
    INSERM, U636, F 06108 Nice, France
    BMC Evol Biol 10:280. 2010
  6. doi request reprint Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    Anne Amandine Chassot
    INSERM, U636, F 06108 Nice, France
    Hum Mol Genet 17:1264-77. 2008
  7. doi request reprint A novel Wilms' tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema
    Nicole Wagner
    INSERM, U636, Nice, France
    Pediatr Nephrol 23:1445-53. 2008
  8. pmc Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Faculte des Sciences, 06108 Nice, France
    Genes Dev 19:2631-42. 2005
  9. ncbi request reprint Wt1 is not essential for hematopoiesis in the mouse
    Linda King-Underwood
    Section of Paediatric Oncology, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
    Leuk Res 29:803-12. 2005
  10. pmc The Wilms' tumor gene Wt1 is required for normal development of the retina
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
    EMBO J 21:1398-405. 2002

Collaborators

  • Holger Scholz
  • Kay Dietrich Wagner
  • Dirk G de Rooij
  • M Wegner
  • James Briscoe
  • K Pritchard-Jones
  • Marlies Elger
  • L Bugeon
  • Nicole Wagner
  • Marie Christine Chaboissier
  • Jian Kan Guo
  • Richard R Behringer
  • Akio Kobayashi
  • Agnes Boutet
  • Annette Hammes
  • Anne Amandine Chassot
  • Ross A Poche
  • Karin M Kirschner
  • Valerie P I Vidal
  • Linda King-Underwood
  • Martin Cheung
  • Susanne Lützkendorf
  • R Scott Heller
  • C Claus Stolt
  • Yiming Xing
  • Haruhiko Akiyama
  • Glenda Comai
  • Corinne Antignac
  • Giovanna Camerino
  • Fabien Nevo
  • Makoto M Taketo
  • Yasuhide Furuta
  • Mickael Afanetti
  • Hermien L Roepers-Gajadien
  • Etienne Berard
  • Elodie P Gregoire
  • Jean Francois Michiels
  • Fariba Ranc
  • Diane S Krause
  • Valerie P Vidal
  • Christoph Englert
  • Sylvie Delassus
  • Clive Lebozer
  • George Cotsarelis
  • Tariq Enver
  • Suzanne Little
  • Adrian Moore
  • Toon Min
  • Jean Paul Ortonne
  • Pleasantine Mill
  • Heinz Theres
  • Mandy Baker
  • Robyn Clutterbuck
  • Chi chung Hui
  • Nicolas Ortonne
  • Elizabeth Hirst
  • Anita Mynett
  • Hao Chang
  • Ole D Madsen
  • Palle Serup
  • Aihua Liu
  • E Bryan Crenshaw
  • Valerie I P Vidal
  • Doris A Stoffers
  • Henk J G van de Kant
  • Petra Lommes
  • Elisabeth Sock
  • James F Martin
  • Benoit de Crombrugghe
  • Valerie Vidal
  • Aswin L Menke
  • David Harrison
  • Marie Claire Gubler
  • Alan R Clarke
  • Frances Wong
  • Nicholas D Hastie

Detail Information

Publications23

  1. ncbi request reprint The complex life of WT1
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat Berlin, Germany
    J Cell Sci 116:1653-8. 2003
    ..Recently, it was also described that reduction of WT1 levels in the kidney results in glomerulosclerosis and upregulation of WT1 in the heart might contribute to neovascularization after infarction...
  2. ncbi request reprint A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Nice, France
    Development 132:1327-36. 2005
    ..Furthermore, neuron formation depends on distinct functions of alternatively spliced Wt1 products in the embryonic retina and the olfactory epithelium...
  3. ncbi request reprint Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1
    Nicole Wagner
    Institut National de la Santé et de la Recherche Médicale U636, Centre de Biochimie, Faculte des Sciences, Universite de Nice, 06108 Nice, France
    Am J Physiol Regul Integr Comp Physiol 291:R779-87. 2006
    ..Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1...
  4. ncbi request reprint Renal abnormalities and their developmental origin
    Andreas Schedl
    INSERM, U636, F 06108 Nice, France
    Nat Rev Genet 8:791-802. 2007
    ..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops...
  5. pmc The WTX/AMER1 gene family: evolution, signature and function
    Agnes Boutet
    INSERM, U636, F 06108 Nice, France
    BMC Evol Biol 10:280. 2010
    ..Interestingly, WTX seems to also localize to an intranuclear component called paraspeckles. In spite of the growing interest of molecular biologists in WTX, little is known about its paralogs and its phylogenetic history...
  6. doi request reprint Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    Anne Amandine Chassot
    INSERM, U636, F 06108 Nice, France
    Hum Mol Genet 17:1264-77. 2008
    ..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development...
  7. doi request reprint A novel Wilms' tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema
    Nicole Wagner
    INSERM, U636, Nice, France
    Pediatr Nephrol 23:1445-53. 2008
    ..Given the requirement of WT1 for normal development of the kidney and heart, these data raise the hypothesis that the mutation identified was responsible for the severe phenotype observed in our patient...
  8. pmc Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Faculte des Sciences, 06108 Nice, France
    Genes Dev 19:2631-42. 2005
    ..These findings demonstrate that transcriptional activation of the TrkB neurotrophin receptor gene by the Wilms' tumor suppressor Wt1 is a crucial mechanism for normal vascularization of the developing heart...
  9. ncbi request reprint Wt1 is not essential for hematopoiesis in the mouse
    Linda King-Underwood
    Section of Paediatric Oncology, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
    Leuk Res 29:803-12. 2005
    ..We conclude that Wt1 is not essential for murine hematopoiesis and that there may be significant differences in its role between mouse and man...
  10. pmc The Wilms' tumor gene Wt1 is required for normal development of the retina
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
    EMBO J 21:1398-405. 2002
    ..Taken together, our findings demonstrate a continuous requirement for Wt1 in normal retina formation with a critical role in Pou4f2-dependent ganglion cell differentiation...
  11. ncbi request reprint WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    Jian Kan Guo
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hum Mol Genet 11:651-9. 2002
    ....
  12. doi request reprint Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Comp Neurol 510:237-50. 2008
    ..Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells...
  13. ncbi request reprint Early gonadal development: exploring Wt1 and Sox9 function
    Jian Kan Guo
    Human Molecular Genetics Unit, University of Newcastle upon Tyne, UK
    Novartis Found Symp 244:23-31; discussion 31-42, 253-7. 2002
    ..Our data indicate that Sox9 is sufficient to induce testis formation in mice. Here we will discuss our new data and present an updated model for Wt1 and Sox9 function in gonad formation and sex determination...
  14. pmc The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2813-28. 2002
    ..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
  15. ncbi request reprint An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesis
    Kay Dietrich Wagner
    Inserm U636, Nice, France
    Curr Biol 16:793-800. 2006
    ....
  16. ncbi request reprint Sox9 in testis determination
    Akio Kobayashi
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Ann N Y Acad Sci 1061:9-17. 2005
    ..Therefore, Sox9 is essential for diverting an intrinsically ovarian program of organogenesis toward testis formation...
  17. pmc The Sox9 transcription factor determines glial fate choice in the developing spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
    Genes Dev 17:1677-89. 2003
    ....
  18. ncbi request reprint Bone marrow transplantation can attenuate the progression of mesangial sclerosis
    Jian Kan Guo
    Department of Laboratory Medicine, Yale School of Medicine, M D 333 Cedar Street, P O Box 208035, New Haven, Connecticut 06520, USA
    Stem Cells 24:406-15. 2006
    ....
  19. ncbi request reprint Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment
    Valerie P I Vidal
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice, France
    Curr Biol 15:1340-51. 2005
    ..However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development...
  20. ncbi request reprint The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
    R Scott Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Dev Biol 268:123-34. 2004
    ..2 cells. The pancreatic phenotype of the pax6 mutants can be rescued with a YAC clone containing the human Pax6 gene...
  21. ncbi request reprint Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    Marie Christine Chaboissier
    INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Development 131:1891-901. 2004
    ..Finally, double knock-out analyses suggest that Sox8 reinforces Sox9 function in testis differentiation of mice...
  22. ncbi request reprint The transcriptional control of trunk neural crest induction, survival, and delamination
    Martin Cheung
    Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Dev Cell 8:179-92. 2005
    ..Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells...
  23. ncbi request reprint The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Parc Valrose, 06108 Nice, France
    J Am Soc Nephrol 15:3044-51. 2004
    ..Taken together, these data identify nephrin as a direct transcriptional target for Wt1 and underline the importance of Wt1 as a key regulator in podocyte function...