- The complex life of WT1Kay Dietrich Wagner
Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat Berlin, Germany
J Cell Sci 116:1653-8. 2003..Recently, it was also described that reduction of WT1 levels in the kidney results in glomerulosclerosis and upregulation of WT1 in the heart might contribute to neovascularization after infarction...
- A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory systemNicole Wagner
Inserm U636, Centre de Biochimie, Faculte des Sciences, Nice, France
Development 132:1327-36. 2005..Furthermore, neuron formation depends on distinct functions of alternatively spliced Wt1 products in the embryonic retina and the olfactory epithelium...
- Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1Nicole Wagner
Institut National de la Santé et de la Recherche Médicale U636, Centre de Biochimie, Faculte des Sciences, Universite de Nice, 06108 Nice, France
Am J Physiol Regul Integr Comp Physiol 291:R779-87. 2006..Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1...
- Renal abnormalities and their developmental originAndreas Schedl
INSERM, U636, F 06108 Nice, France
Nat Rev Genet 8:791-802. 2007..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops...
- The WTX/AMER1 gene family: evolution, signature and functionAgnes Boutet
INSERM, U636, F 06108 Nice, France
BMC Evol Biol 10:280. 2010..Interestingly, WTX seems to also localize to an intranuclear component called paraspeckles. In spite of the growing interest of molecular biologists in WTX, little is known about its paralogs and its phylogenetic history...
- Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovaryAnne Amandine Chassot
INSERM, U636, F 06108 Nice, France
Hum Mol Genet 17:1264-77. 2008..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development...
- A novel Wilms' tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastemaNicole Wagner
INSERM, U636, Nice, France
Pediatr Nephrol 23:1445-53. 2008..Given the requirement of WT1 for normal development of the kidney and heart, these data raise the hypothesis that the mutation identified was responsible for the severe phenotype observed in our patient...
- Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1Nicole Wagner
Inserm U636, Centre de Biochimie, Faculte des Sciences, 06108 Nice, France
Genes Dev 19:2631-42. 2005..These findings demonstrate that transcriptional activation of the TrkB neurotrophin receptor gene by the Wilms' tumor suppressor Wt1 is a crucial mechanism for normal vascularization of the developing heart...
- Wt1 is not essential for hematopoiesis in the mouseLinda King-Underwood
Section of Paediatric Oncology, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
Leuk Res 29:803-12. 2005..We conclude that Wt1 is not essential for murine hematopoiesis and that there may be significant differences in its role between mouse and man...
- The Wilms' tumor gene Wt1 is required for normal development of the retinaKay Dietrich Wagner
Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
EMBO J 21:1398-405. 2002..Taken together, our findings demonstrate a continuous requirement for Wt1 in normal retina formation with a critical role in Pou4f2-dependent ganglion cell differentiation...
- WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosisJian Kan Guo
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Hum Mol Genet 11:651-9. 2002....
- Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell developmentRoss A Poche
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Comp Neurol 510:237-50. 2008..Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells...
- Early gonadal development: exploring Wt1 and Sox9 functionJian Kan Guo
Human Molecular Genetics Unit, University of Newcastle upon Tyne, UK
Novartis Found Symp 244:23-31; discussion 31-42, 253-7. 2002..Our data indicate that Sox9 is sufficient to induce testis formation in mice. Here we will discuss our new data and present an updated model for Wt1 and Sox9 function in gonad formation and sex determination...
- The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6Haruhiko Akiyama
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 16:2813-28. 2002..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
- An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesisKay Dietrich Wagner
Inserm U636, Nice, France
Curr Biol 16:793-800. 2006....
- Sox9 in testis determinationAkio Kobayashi
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Ann N Y Acad Sci 1061:9-17. 2005..Therefore, Sox9 is essential for diverting an intrinsically ovarian program of organogenesis toward testis formation...
- The Sox9 transcription factor determines glial fate choice in the developing spinal cordC Claus Stolt
Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
Genes Dev 17:1677-89. 2003....
- Bone marrow transplantation can attenuate the progression of mesangial sclerosisJian Kan Guo
Department of Laboratory Medicine, Yale School of Medicine, M D 333 Cedar Street, P O Box 208035, New Haven, Connecticut 06520, USA
Stem Cells 24:406-15. 2006....
- Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartmentValerie P I Vidal
Inserm U636, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice, France
Curr Biol 15:1340-51. 2005..However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development...
- The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identityR Scott Heller
Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
Dev Biol 268:123-34. 2004..2 cells. The pancreatic phenotype of the pax6 mutants can be rescued with a YAC clone containing the human Pax6 gene...
- Functional analysis of Sox8 and Sox9 during sex determination in the mouseMarie Christine Chaboissier
INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
Development 131:1891-901. 2004..Finally, double knock-out analyses suggest that Sox8 reinforces Sox9 function in testis differentiation of mice...
- The transcriptional control of trunk neural crest induction, survival, and delaminationMartin Cheung
Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
Dev Cell 8:179-92. 2005..Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells...
- The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1Nicole Wagner
Inserm U636, Centre de Biochimie, Parc Valrose, 06108 Nice, France
J Am Soc Nephrol 15:3044-51. 2004..Taken together, these data identify nephrin as a direct transcriptional target for Wt1 and underline the importance of Wt1 as a key regulator in podocyte function...