Andreas Schedl

Summary

Country: France

Publications

  1. request reprint
    Schedl A. Renal abnormalities and their developmental origin. Nat Rev Genet. 2007;8:791-802 pubmed
    ..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops. ..
  2. Massa F, Schedl A. Awakening the Bowman: inhibition of CXCL12 signaling activates parietal epithelial cells. Kidney Int. 2018;94:1042-1044 pubmed publisher
    ..The data may open new therapeutic avenues for the treatment of glomerular diseases. ..
  3. Bandiera R, Sacco S, Vidal V, Chaboissier M, Schedl A. Steroidogenic organ development and homeostasis: A WT1-centric view. Mol Cell Endocrinol. 2015;408:145-55 pubmed publisher
    ..In addition, we will highlight some recent findings and open questions on how maintenance of steroidogenic organs is achieved in the adult organism. ..
  4. da Silva F, Massa F, Motamedi F, Vidal V, Rocha A, Gregoire E, et al. Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4. Dev Biol. 2018;441:42-51 pubmed publisher
    ..These results shed new light on the role of Rspo3 in heart development and demonstrate that LGR4 is the principal R-spondin 3 receptor in the heart. ..
  5. Neirijnck Y, Reginensi A, Renkema K, Massa F, Kozlov V, Dhib H, et al. Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int. 2018;93:1142-1153 pubmed publisher
    ..Taken together these data demonstrate a key role for SOX11 in normal kidney development and may suggest that variants in this gene predispose to CAKUT in humans. ..
  6. da Silva F, Massa F, Schedl A. Identifying Direct Downstream Targets: WT1 ChIP-Seq Analysis. Methods Mol Biol. 2016;1467:177-88 pubmed publisher
    ..This method can be adapted for a variety of different tissues and/or cell types to help understand the role of WT1 in regulating gene expression. ..
  7. Boutet A, Comai G, Schedl A. The WTX/AMER1 gene family: evolution, signature and function. BMC Evol Biol. 2010;10:280 pubmed publisher
    ..Divergent and conserved molecular functions of Wtx/Amer1, Amer2 and Amer3 are discussed. ..
  8. da Silva F, Rocha A, Motamedi F, Massa F, Basboga C, Morrison H, et al. Coronary Artery Formation Is Driven by Localized Expression of R-spondin3. Cell Rep. 2017;20:1745-1754 pubmed publisher
    ..These results identify a mechanism through which localized expression of RSPO3 induces proliferation of the coronary arteries at their stems and permits their formation. ..