Pierre Yves Scarabin

Summary

Country: France

Publications

  1. ncbi request reprint Hormone replacement therapy and circulating ICAM-1 in postmenopausal women--a randomised controlled trial
    P Y Scarabin
    INSERM, Cardiovascular Epidemiology Unit U258, Hopital Broussais, Paris, France
    Thromb Haemost 81:673-5. 1999
  2. ncbi request reprint Haemostasis in relation to dietary fat as estimated by erythrocyte fatty acid composition: the prime study
    P Y Scarabin
    INSERM Unité 258, Universite Paris Sud, Villejuif, France
    Thromb Res 102:285-93. 2001
  3. ncbi request reprint Plasma fibrinogen explains much of the difference in risk of coronary heart disease between France and Northern Ireland. The PRIME study
    Pierre Yves Scarabin
    Cardiovascular Epidemiology Unit U258, INSERM, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Atherosclerosis 166:103-9. 2003
  4. ncbi request reprint Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk
    Pierre Yves Scarabin
    INSERM Cardiovascular Epidemiology Unit U258, Villejuif, France
    Lancet 362:428-32. 2003
  5. doi request reprint Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study)
    Marianne Canonico
    Hormones and Cardiovascular disease, Univ Paris Sud, Villejuif, France
    Clin Endocrinol (Oxf) 77:905-10. 2012
  6. ncbi request reprint Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration
    Celine Straczek
    INSERM, Cardiovascular Epidemiology Unit, Villejuif, France
    Circulation 112:3495-500. 2005
  7. doi request reprint A J-shaped association between plasma testosterone and risk of ischemic arterial event in elderly men: the French 3C cohort study
    Véronique Soisson
    INSERM U108, Center for Research in Epidemiology and Population Health, Hormones and Cardiovascular disease team, Villejuif, France
    Maturitas 75:282-8. 2013
  8. ncbi request reprint Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Circulation 115:840-5. 2007
  9. doi request reprint Activated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen
    Marianne Canonico
    Hormones and Cardiovascular disease, CESP Centre for researchin Epidemiology and Population Health, U1018, INSERM, Villejuif, France
    Menopause 17:1122-7. 2010
  10. ncbi request reprint Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings
    Marianne Canonico
    INSERM Unit U780, Cardiovascular Section 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Maturitas 54:372-9. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Hormone replacement therapy and circulating ICAM-1 in postmenopausal women--a randomised controlled trial
    P Y Scarabin
    INSERM, Cardiovascular Epidemiology Unit U258, Hopital Broussais, Paris, France
    Thromb Haemost 81:673-5. 1999
    ....
  2. ncbi request reprint Haemostasis in relation to dietary fat as estimated by erythrocyte fatty acid composition: the prime study
    P Y Scarabin
    INSERM Unité 258, Universite Paris Sud, Villejuif, France
    Thromb Res 102:285-93. 2001
    ..01). No relationships were found between fatty acids and fibrinogen, vWf, PAI-1 or factor VII. The results of this study suggest that consumption of n-3 fatty acids derived from fish may favourably influence tPA-ag...
  3. ncbi request reprint Plasma fibrinogen explains much of the difference in risk of coronary heart disease between France and Northern Ireland. The PRIME study
    Pierre Yves Scarabin
    Cardiovascular Epidemiology Unit U258, INSERM, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Atherosclerosis 166:103-9. 2003
    ..These findings add to the epidemiological evidence that elevated fibrinogen is a major risk factor for coronary heart disease...
  4. ncbi request reprint Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk
    Pierre Yves Scarabin
    INSERM Cardiovascular Epidemiology Unit U258, Villejuif, France
    Lancet 362:428-32. 2003
    ..Transdermal ERT has little effect on haemostasis, but data assessing its effect on thrombotic process are scarce. We aimed to examine the effect of the route of oestrogen administration on VTE risk...
  5. doi request reprint Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study)
    Marianne Canonico
    Hormones and Cardiovascular disease, Univ Paris Sud, Villejuif, France
    Clin Endocrinol (Oxf) 77:905-10. 2012
    ..However, whether endogenous sex steroid hormones influence the plasma fibrinogen concentrations among postmenopausal women remains unclear...
  6. ncbi request reprint Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration
    Celine Straczek
    INSERM, Cardiovascular Epidemiology Unit, Villejuif, France
    Circulation 112:3495-500. 2005
    ..Transdermal estrogen may be safe with respect to VTE. We investigated the impact of the route of estrogen administration on the association between a prothrombotic mutation (factor V Leiden or prothrombin G20210A mutation) and VTE risk...
  7. doi request reprint A J-shaped association between plasma testosterone and risk of ischemic arterial event in elderly men: the French 3C cohort study
    Véronique Soisson
    INSERM U108, Center for Research in Epidemiology and Population Health, Hormones and Cardiovascular disease team, Villejuif, France
    Maturitas 75:282-8. 2013
    ..However, the relation between testosterone and cardiovascular disease is uncertain. We assessed the association of plasma sex hormones with the incidence of ischemic arterial disease (IAD) in elderly men...
  8. ncbi request reprint Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Circulation 115:840-5. 2007
    ..Transdermal estrogen may be safer. However, currently available data have limited the ability to investigate the wide variety of types of progestogen...
  9. doi request reprint Activated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen
    Marianne Canonico
    Hormones and Cardiovascular disease, CESP Centre for researchin Epidemiology and Population Health, U1018, INSERM, Villejuif, France
    Menopause 17:1122-7. 2010
    ..However, the differential effects of progesterone and norpregnanes on hemostasis have not yet been investigated...
  10. ncbi request reprint Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings
    Marianne Canonico
    INSERM Unit U780, Cardiovascular Section 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Maturitas 54:372-9. 2006
    ..Clinical research should be continued to assist patients and clinicians in making treatment decisions on the basis of an individual's benefits and risks...
  11. doi request reprint Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women
    Valérie Olié
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease, Universite Paris Sud, UMRS 1018, Villejuif, France
    Curr Opin Hematol 17:457-63. 2010
    ..Transdermal estrogens may be safer but early results need to be confirmed. This review provides a summary of the most recent findings regarding the VTE risk among oral versus transdermal estrogens users...
  12. ncbi request reprint Association of postmenopausal hormone replacement therapy with carotid atherosclerosis and soluble thrombomodulin: the vascular aging (EVA) study. Etude du Vieillissement Artériel
    Laure Petit
    The National Institute of Health and Medical Research INSERM, Unit 258, Paris, France
    Thromb Res 105:291-7. 2002
    ..This suggests that the possible beneficial effects of HRT on atherosclerosis may not go through the endothelial cell damage assessed by plasma thrombomodulin...
  13. ncbi request reprint Hormone replacement therapy use is associated with a lower occurrence of carotid atherosclerotic plaques but not with intima-media thickness progression among postmenopausal women. The vascular aging (EVA) study
    Gregoire Le Gal
    Unit 258, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Atherosclerosis 166:163-70. 2003
    ..Information on the impact of hormone replacement therapy (HRT) on carotid atherosclerosis is limited. Moreover, transdermal estrogens have not been investigated...
  14. doi request reprint Sex-specific risk factors for recurrent venous thromboembolism
    Valérie Olié
    INSERM, CEPH Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease team, F94807, Villejuif, France
    Thromb Res 130:16-20. 2012
    ..Men have higher risk of recurrent venous thromboembolism (VTE) than women but this sex difference remains unexplained. In addition, whether men and women share same risk factors for recurrent VTE is unclear...
  15. doi request reprint Hormone therapy and recurrence of venous thromboembolism among postmenopausal women
    Valérie Olié
    Hormones and Cardiovascular disease team, CEPH Centre for research in Epidemiology and Population Health, U1018, INSERM, F94807, Villejuit, France
    Menopause 18:488-93. 2011
    ..However, the impact of transdermal estrogens on VTE recurrence risk has not been investigated. The aim of our study was to assess the impact of HT by route of estrogen administration on the risk of recurrent VTE...
  16. doi request reprint Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens
    Pierre Yves Scarabin
    Inserm and University Paris XI, CESP Centre for research in Epidemiology and Population Health, UMR S 1018, Team 08 Hormones and Cardiovascular Disease, Villejuif, France
    Menopause 18:873-9. 2011
    ..Using calibrated automated thrombography, we tested the influence of the route of estrogen administration and progestogens on thrombin generation among postmenopausal women using hormone therapy...
  17. doi request reprint Association of influenza vaccination with reduced risk of venous thromboembolism
    Tienan Zhu
    Deparment of Vascular Medicine, University Paris Decartes and INSERM U765, Paris, France
    Thromb Haemost 102:1259-64. 2009
    ..71, 95% CI, 0.53-0.94) and for both provoked (OR 0.71, 95% CI, 0.53-0.97) and unprovoked VTE (OR 0.85, 95% CI, 0.59-1.23). This case-control study suggests that influenza vaccination is associated with a reduced risk of VTE...
  18. doi request reprint Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men
    Véronique Soisson
    Center for Research in Epidemiology and Population Health, Hormones and Cardiovascular disease, University Paris Sud, UMR S, Villejuif, France
    Atherosclerosis 223:244-9. 2012
    ..We investigated whether this association could be mediated or modified by traditional cardiovascular risk factors as well as inflammatory status...
  19. doi request reprint Progestogens and venous thromboembolism among postmenopausal women using hormone therapy
    Marianne Canonico
    Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease, Villejuif, France
    Maturitas 70:354-60. 2011
    ..In conclusion, progestogens may have differential effects on VTE risk according to the molecules and therefore represent an important potential determinant of the thrombotic risk among postmenopausal women using estrogens...
  20. doi request reprint Postmenopausal hormone therapy and venous thromboembolism
    Valérie Olié
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease, F 94807 Villejuif, France
    Thromb Res 127:S26-9. 2011
    ..Because venous thromboembolism (VTE) is the main harmful effect of HT among young postmenopausal women, reducing VTE risk appears to be a relevant strategy to improve the benefit/risk profile of HT among postmenopausal women...
  21. pmc High level of plasma estradiol as a new predictor of ischemic arterial disease in older postmenopausal women: the three-city cohort study
    Valérie Scarabin-Carré
    Centre for research in Epidemiology and Population Health, Inserm Unit 1018, Hormones and Cardiovascular disease, Villejuif, France V S, M C, G P B, P Y S Université Paris Sud, UMR S 1018, Villejuif, France V S, M C, P D, P Y S
    J Am Heart Assoc 1:e001388. 2012
    ..Despite evidence that estrogens may be involved in atherothrombosis, the role of endogenous sex steroid hormones in ischemic arterial disease among postmenopausal women remains uncertain...
  22. doi request reprint Estrogen receptor alpha gene variants and major depressive episodes
    Joanne Ryan
    INSERM, U 1061, Hôpital La Colombière, and University Montpellier 1, Montpellier, F 34000 France
    J Affect Disord 136:1222-6. 2012
    ..Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants and lifetime major depression has been insufficiently studied...
  23. doi request reprint Increased thrombin generation is associated with acute ischemic stroke but not with coronary heart disease in the elderly: the Three-City cohort study
    Laure Carcaillon
    Institut National de la Sante et de la Recherche Medicale INSERM, Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease, Villejuif, France
    Arterioscler Thromb Vasc Biol 31:1445-51. 2011
    ..Whether changes in this biomarker are relevant to arterial disease remains unknown. We investigated the association of thrombin generation with coronary heart disease (CHD) and acute ischemic stroke (AIS) in the elderly...
  24. pmc Oestrogen receptor polymorphisms and late-life depression
    Joanne Ryan
    Inserm U1061, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier Cedex 5, France
    Br J Psychiatry 199:126-31. 2011
    ..Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown...
  25. doi request reprint Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women
    Marianne Canonico
    Institut National de la Santé et de la Recherche Médicale INSERM Unit 780 U780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, Villejuif Cedex, F 94807 France
    J Clin Endocrinol Metab 93:3082-7. 2008
    ..This effect may be modulated by the expression of cytochromes P450 3A5 (CYP3A5) and 1A2 (CYP1A2) which are involved in the hepatic metabolism of estrogens...
  26. doi request reprint Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism: results from the E3N cohort study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, Cedex, France
    Arterioscler Thromb Vasc Biol 30:340-5. 2010
    ..Although recent data showed transdermal estrogens may be safe with respect to thrombotic risk, the impact of the route of estrogen administration and concomitant progestogens is not fully established...
  27. pmc Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, Villejuif Cedex, France
    BMJ 336:1227-31. 2008
    ..To assess the risk of venous thromboembolism in women using hormone replacement therapy by study design, characteristics of the therapy and venous thromboembolism, and clinical background...
  28. ncbi request reprint Estrogens in vascular biology and disease: where do we stand today?
    Jean Francois Arnal
    Department of Vascular Biology and Atherothrombosis, INSERM U858 I2MR, CHU Toulouse Rangueil, Toulouse, France
    Curr Opin Lipidol 18:554-60. 2007
    ..There is also evidence for a thrombogenic effect of oral estrogens. An understanding of the deleterious and beneficial effects of estrogens is thus required...
  29. doi request reprint Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study
    Pascale Gaussem
    Universite Paris Descartes, Paris, France
    Thromb Haemost 105:560-7. 2011
    ..This suggests that NOMAC/E2 could have a more favourable venous thromboembolism risk profile than LNG/EE; further epidemiological data are required to confirm this...
  30. doi request reprint Progestogen-only contraceptives and the risk of stroke: a meta-analysis
    Zeina Chakhtoura
    Department of Gynecology and Endocrinology, Hotel Dieu Hospital, AP HP, Paris Descartes University, Paris, France
    Stroke 40:1059-62. 2009
    ..The association between combined oral contraceptives (OC) use and increased risk of stroke has been reported. While progestogen-only contraceptives (POC) are commonly used worldwide, their impact on cardiovascular disease remains unclear...
  31. doi request reprint Estrogen receptor gene variants are associated with anxiety disorders in older women
    Joanne Ryan
    INSERM, U1061, Nervous System Pathologies Epidemiological and Clinical Research, Hôpital La Colombière, Montpellier, France
    Psychoneuroendocrinology 36:1582-6. 2011
    ..This study investigated whether ESR1 and ESR2 gene variants were associated with specific anxiety disorders in postmenopausal women and evaluated the potential modifying effect of hormone treatment (HT) on these associations...
  32. ncbi request reprint Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
    Karine Lacut
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Thromb Haemost 90:124-31. 2003
    ..The clinical relevance of these effects remains to be determined...
  33. ncbi request reprint Estrogen plus progestin and risk of venous thrombosis
    Pierre Yves Scarabin
    JAMA 293:1322; author reply 1322-3. 2005
  34. doi request reprint Synergism between non-O blood group and oral estrogen in the risk of venous thromboembolism among postmenopausal women: The ESTHER study
    Marianne Canonico
    Thromb Haemost 99:246-8. 2008
  35. doi request reprint [Hormone therapy and risk of venous thromboembolism: new insights from the ESTHER study]
    Marianne Canonico
    Med Sci (Paris) 24:228-31. 2008
  36. ncbi request reprint Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:587-91. 2002
    ..8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly...
  37. ncbi request reprint Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial
    Emmanuel Oger
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Arterioscler Thromb Vasc Biol 23:1671-6. 2003
    ..Oral estrogen replacement therapy (ERT) has been reported to induce APC resistance. Little is known about the effect of transdermal estrogen...
  38. ncbi request reprint Antithrombin Cambridge II (A384S): prevalence in patients of the Paris Thrombosis Study (PATHROS)
    Veronique Picard
    Blood 110:2777-8. 2007
  39. ncbi request reprint Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease
    Khadija Lahlou-Laforet
    Department of C L Psychiatry, Faculte de Medecine, Universite Paris Descartes, AP HP, Hopital Europeen Georges Pompidou, France
    Am J Cardiol 97:1287-91. 2006
    ....
  40. ncbi request reprint High plasma concentration of factor VIII coagulant is also a risk factor for venous thromboembolism in the elderly
    Emmanuel Oger
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Haematologica 88:465-9. 2003
    ..This study aimed to test the hypothesis that an association also exists in the elderly...