Paolo Sassone-Corsi

Summary

Country: France

Publications

  1. ncbi request reprint Unique chromatin remodeling and transcriptional regulation in spermatogenesis
    Paolo Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Science 296:2176-8. 2002
  2. pmc Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch, France
    BMC Genomics 11:530. 2010
  3. ncbi request reprint Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
    P Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, B P 163, 67404 Illkirch Strasbourg, France
    Science 285:886-91. 1999
  4. ncbi request reprint CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells
    P Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Strasbourg, France
    Mol Reprod Dev 56:228-9. 2000
  5. ncbi request reprint CREM-dependent transcription in male germ cells controlled by a kinesin
    Betina Macho
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Science 298:2388-90. 2002
  6. pmc Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 101:10620-5. 2004
  7. ncbi request reprint The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation
    Jean Christophe Pointud
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Cell Sci 116:1847-58. 2003
  8. pmc Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
    Irene Yujnovsky
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 103:6386-91. 2006
  9. ncbi request reprint No circadian rhythms in testis: Period1 expression is clock independent and developmentally regulated in the mouse
    David Morse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, BP 10142, 67404 Illkirch Strasbourg, France
    Mol Endocrinol 17:141-51. 2003
  10. ncbi request reprint Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 129:945-55. 2002

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Unique chromatin remodeling and transcriptional regulation in spermatogenesis
    Paolo Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Science 296:2176-8. 2002
    ..Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance...
  2. pmc Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch, France
    BMC Genomics 11:530. 2010
    ..The CREMτ activator isoform is selectively expressed in haploid spermatids and plays an essential role in murine spermiogenesis...
  3. ncbi request reprint Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
    P Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, B P 163, 67404 Illkirch Strasbourg, France
    Science 285:886-91. 1999
    ..H3 appears to be a direct or indirect target of Rsk-2, suggesting that chromatin remodeling might contribute to mitogen-activated protein kinase-regulated gene expression...
  4. ncbi request reprint CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells
    P Sassone-Corsi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Strasbourg, France
    Mol Reprod Dev 56:228-9. 2000
    ..Recent results have shown that CREM needs a tissue-specific co-activator, ACT (activator of CREM in testis) to elicit its regulatory function in testis...
  5. ncbi request reprint CREM-dependent transcription in male germ cells controlled by a kinesin
    Betina Macho
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Science 298:2388-90. 2002
    ..Thus, a kinesin directly controls the activity of a transcriptional coactivator by a tight regulation of its intracellular localization...
  6. pmc Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 101:10620-5. 2004
    ..These results indicate that numerous postmeiotic genes under CREM control require the coactivator function of ACT. Thus, the fine-tuning of sperm development is achieved by the coordinated action of two transcriptional regulators...
  7. ncbi request reprint The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation
    Jean Christophe Pointud
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Cell Sci 116:1847-58. 2003
    ....
  8. pmc Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
    Irene Yujnovsky
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 103:6386-91. 2006
    ..Because dopamine is the major catecholamine in the retina, central for the neural adaptation to light, our findings establish a physiological link among photic input, dopamine signaling, and the molecular clock machinery...
  9. ncbi request reprint No circadian rhythms in testis: Period1 expression is clock independent and developmentally regulated in the mouse
    David Morse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, BP 10142, 67404 Illkirch Strasbourg, France
    Mol Endocrinol 17:141-51. 2003
    ..Taken together, our observations suggest that the testis, in contrast to all other peripheral tissues, lacks a functioning circadian clock...
  10. ncbi request reprint Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 129:945-55. 2002
    ..This defect is likely to be the primary cause of spermatogenic failure in the TLF mutant mice...
  11. pmc Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases
    Claudia Crosio
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Strasbourg, France
    Mol Cell Biol 22:874-85. 2002
    ..Since Aurora-A and Aurora-B are known to be overexpressed in a variety of human cancers, our findings provide an attractive link between cell transformation, chromatin modifications and a specific kinase system...
  12. pmc Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage
    Lucia Monaco
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, B P 10142, 67404 Illkirch, Strasbourg, France
    Proc Natl Acad Sci U S A 102:14244-8. 2005
    ..The highly similar Aurora-A kinase is not regulated by PARP-1. We propose that the specific inhibition of Aurora-B kinase activity by PARP-1 contributes to the physiological response to DNA damage...
  13. pmc Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression
    Aurelie Lardenois
    INSERM, U625, Universite Rennes 1, IFR140, Rennes, F 35042, France
    Reprod Biol Endocrinol 7:133. 2009
    ..Male mice lacking Fhl5 were reported to be fertile but displayed partially abnormal sperm maturation and morphology...
  14. ncbi request reprint Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance
    Matthew P Pando
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    Cell 110:107-17. 2002
    ..These results demonstrate that SCN hierarchical dominance can compensate for severe intrinsic genetic defects in peripheral clocks, but cannot induce rhythmicity in clock-defective tissues...
  15. ncbi request reprint Transcriptional control in male germ cells: general factor TFIIA participates in CREM-dependent gene activation
    Dario De Cesare
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    Mol Endocrinol 17:2554-65. 2003
    ..The two proteins also colocalize intracellularly in spermatocyte and spermatid cells. These findings contribute to the understanding of the highly specialized rules of transcriptional regulation in haploid germ cells...
  16. pmc A direct role of SRY and SOX proteins in pre-mRNA splicing
    Kenji Ohe
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, B P 163, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 99:1146-51. 2002
    ....
  17. pmc The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 103:2647-52. 2006
    ..Our findings underscore the importance of posttranscriptional gene regulation and of the microRNA pathway in the control of postmeiotic male germ cell differentiation...
  18. pmc X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein
    Sylvia G Lehmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, B P 10142, 67404 Illkirch, Strasbourg, France
    Proc Natl Acad Sci U S A 99:8225-30. 2002
    ....
  19. pmc Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
    Zdenka Travnickova-Bendova
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 99:7728-33. 2002
    ..Our results reveal that signaling-dependent activation of mPer genes is distinct from the CLOCK/BMAL1-driven transcription required within the clock feedback loop...
  20. ncbi request reprint Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases
    Nicolas Cermakian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404, Illkirch Strasbourg, France
    Curr Biol 12:844-8. 2002
    ..Our results establish a link between blue-light photoreceptors, probably cryptochromes, and the MAPK pathway to elicit light-induced transcriptional activation of clock genes...
  21. ncbi request reprint Microtubule-independent and protein kinase A-mediated function of kinesin KIF17b controls the intracellular transport of activator of CREM in testis (ACT)
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    J Biol Chem 280:31739-45. 2005
    ..These results indicate that cyclic AMP signaling controls CREM-mediated transcription in male germ cells through modification of KIF17b function...
  22. pmc Common pathways in circadian and cell cycle clocks: light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1
    Jun Hirayama
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    Proc Natl Acad Sci U S A 102:10194-9. 2005
    ..These findings provide strong evidence that circadian and cell cycle clocks share unique light-responsive pathways in zebrafish...
  23. ncbi request reprint Circadian clock control by SUMOylation of BMAL1
    Luca Cardone
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    Science 309:1390-4. 2005
    ..This reveals an additional level of regulation within the core mechanism of the circadian clock...
  24. pmc Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, and Université Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 102:2808-13. 2005
    ..Hence, H1T2 is a protein required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis...
  25. pmc The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners
    Evi Soutoglou
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, Department of Transcriptional and Post Transcriptional Control of Gene Regulation, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Mol Cell Biol 25:4092-104. 2005
    ....
  26. ncbi request reprint Specialized rules of gene transcription in male germ cells: the CREM paradigm
    Lucia Monaco
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 163, 67404 Illkirch, Strasbourg, France
    Int J Androl 27:322-7. 2004
    ..The function of ACT was found to be regulated by the testis-specific kinesin KIF17b. Here we discuss some aspects of the testis-specific transcription machinery, whose function is essential for the process of spermatogenesis...
  27. ncbi request reprint Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells
    Raffaella Catena
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    FEBS Lett 579:3401-10. 2005
    ..Our observations highlight how cleavage of ALF and coexpression with TFIIA and TRF2 increases the combinatorial possibilities for gene regulation at different developmental stages of spermatogenesis...
  28. ncbi request reprint Circadian regulator CLOCK is a histone acetyltransferase
    Masao Doi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Cell 125:497-508. 2006
    ..Identification of CLOCK as a novel type of DNA binding HAT reveals that chromatin remodeling is crucial for the core clock mechanism and identifies unforeseen links between histone acetylation and cellular physiology...
  29. ncbi request reprint Impaired light masking in dopamine D2 receptor-null mice
    Masao Doi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries 67404, Illkirch, Strasbourg, France
    Nat Neurosci 9:732-4. 2006
    ....
  30. ncbi request reprint Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    J Cell Sci 119:2819-25. 2006
    ..These results shed new light on the function of chromatoid bodies in the post-transcriptional regulation of gene expression in haploid germ cells...
  31. ncbi request reprint Testis-specific transcription mechanisms promoting male germ-cell differentiation
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France
    Reproduction 128:5-12. 2004
    ..In this review we summarize recent advances in the transcription machinery that is testis-specific, gene-selective and necessary for the process of spermatogenesis...
  32. ncbi request reprint Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals
    Enzo Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite Louis Pasteur, B P 163, 67404 Illkirch, Strasbourg, France
    J Cell Sci 116:441-5. 2003
    ..The recent identification of a role for the key regulatory factors SRY and WT1(+KTS) in pre-mRNA splicing indicates that important steps in the mammalian sex determination process are likely to operate at the post-transcriptional level...
  33. ncbi request reprint Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, B P 163, 67404 Illkirch, Strasbourg, France
    Nat Methods 1:249-54. 2004
  34. ncbi request reprint Functional analysis of transcription factors CREB and CREM
    Betina Macho
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    Methods Enzymol 370:396-415. 2003
  35. ncbi request reprint DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation
    Enzo Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, 67404 Illkirch, Strasbourg, France
    Mol Endocrinol 17:1445-53. 2003
    ..Here we review the mechanism of DAX-1 function in adrenal and gonadal differentiation, with special emphasis on recent results showing the critical role of DAX-1 protein misfolding in the pathogenesis of adrenal hypoplasia congenita...
  36. ncbi request reprint Heat shock affects trafficking of DAX-1 by inducing its rapid and reversible cytoplasmic localization
    Sylvia G Lehmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, B P 163, 67404 Illkirch, France
    Endocrine 28:137-44. 2005
    ..The heat shock effect is reversible and does not involve stimulation of the p38 and ERK pathways. Heat shock probably acts by inducing modifications of DAX-1 and increasing its partitioning in the insoluble cellular fraction...
  37. ncbi request reprint TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1
    Stefano Brancorsini
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, Strasbourg, France
    Cell Cycle 7:1415-22. 2008
    ..These findings indicate that TIPT could contribute to the precise timing of the molecular events in male germ cells, specifically by linking transcription to chromatin remodeling in round spermatids...
  38. ncbi request reprint Analysis of histone phosphorylation: coupling intracellular signaling to chromatin remodeling
    Romain Loury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Illkirch, Strasbourg, France
    Methods Enzymol 377:197-212. 2004
  39. ncbi request reprint Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons
    Masao Doi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Strasbourg, France
    J Biol Rhythms 22:127-39. 2007
    ..The authors' studies on mkp1 have identified for the first time a gene encoding a phosphatase that functions in light-dependent and time-of-day-dependent manners in the mammalian central clock structure SCN...
  40. doi request reprint DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing
    Kenji Ohe
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Dev Dyn 238:1595-604. 2009
    ..We conclude that DAX-1 and SOX6 proteins interact, have overlapped expression in the testis, and act antagonistically during pre-mRNA splicing. Developmental Dynamics 238:1595-1604, 2009. (c) 2009 Wiley-Liss, Inc...
  41. ncbi request reprint Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way
    Matthew P Pando
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Bioessays 24:419-26. 2002
    ..This review focuses on the advantages of using the zebrafish to study the development of the vertebrate circadian system and light-dependent signaling to the clock...
  42. ncbi request reprint Chromatin remodelling and epigenetic features of germ cells
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch, Strasbourg, France
    Nature 434:583-9. 2005
    ..Because stable genetic transmission to future generations is essential for life, understanding the control of these processes has far-reaching implications for human health and reproduction...
  43. ncbi request reprint Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility
    Kevin N Hogeveen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Hum Fertil (Camb) 9:73-9. 2006
    ..This sophisticated and complex regulation of gene expression in post-meiotic germ cells is governed by unique mechanisms specific to these cells and is fundamental to male fertility...
  44. ncbi request reprint Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons
    Claudia Crosio
    Department of Gene Expression, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France
    J Cell Sci 116:4905-14. 2003
    ..Our results underscore the importance of dynamic chromatin remodeling in the transcriptional response to various stimuli in neuronal cells...
  45. ncbi request reprint A specific programme of gene transcription in male germ cells
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, BP 10142, 67404 Illkirch Strasbourg, France
    Reprod Biomed Online 8:496-500. 2004
    ..The function of ACT is regulated by a testis-specific kinesin, KIF17b. This study discusses some aspects of the testis-specific transcription machinery, the function of which is essential for the process of spermatogenesis...
  46. pmc Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis
    Francoise Dantzer
    Intégrité du Génome, Unité Mixte de Recherche 7175, Ecole Superieure de Biotechnologie de Strasbourg, F 67412 Illkirch, France
    Proc Natl Acad Sci U S A 103:14854-9. 2006
    ..Altogether, our findings indicate that, in addition to its well known role in DNA repair, Parp-2 exerts essential functions during meiosis I and haploid gamete differentiation...
  47. ncbi request reprint Histone phosphorylation: how to proceed
    Romain Loury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, B P 10142, Illkirch, Strasbourg 67404, France
    Methods 31:40-8. 2003
    ..These powerful approaches are important as identification of the signaling transduction routes leading to chromatin remodeling is critical to an understanding of all cellular processes...
  48. ncbi request reprint Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM
    Giuseppe Servillo
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1, rue Laurent Fries, Illkirch, 67404, France
    Exp Cell Res 275:143-54. 2002
    ....
  49. ncbi request reprint Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
    Ullas Kolthur-Seetharam
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Strasbourg, France
    Cell Cycle 5:873-7. 2006
    ..Our findings establish a functional link between the two NAD+-dependent enzyme systems and provide a physiological interpretation for the mechanism of death in cells lacking SIRT1...
  50. ncbi request reprint Structural and functional features of transcription factors controlling the circadian clock
    Jun Hirayama
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, BP 10142, 67404 Illkirch, Strasbourg, France
    Curr Opin Genet Dev 15:548-56. 2005
    ..Various transcription factors constitute the molecular clock, and the signal transduction cascades governing their function appear to be crucial for the fine-tuning of the circadian cycle...
  51. ncbi request reprint Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients
    Sylvia G Lehmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France
    Hum Mol Genet 12:1063-72. 2003
    ....
  52. pmc The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1
    Aurore Morlon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 100:3977-82. 2003
    ..Thus, FHL2, as an inducible coactivator of AP-1, coordinately participates with Fos and Jun in the early transcriptional response to serum factors...
  53. ncbi request reprint ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
    Xiangli Yang
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 117:387-98. 2004
    ..These findings identify ATF4 as a critical regulator of osteoblast differentiation and function, and indicate that lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS...
  54. ncbi request reprint Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy
    Reprod Biomed Online 10:64-71. 2005
    ..The conservation of these elements and of their regulatory functions in human spermatogenesis indicates that they are likely to provide important insights into understanding the molecular mechanisms of human infertility...
  55. ncbi request reprint Circadian clock and breast cancer: a molecular link
    Saurabh Sahar
    Department of Pharmacology, School of Medicine, University of California at Irvine, Irvine, California 92697, USA
    Cell Cycle 6:1329-31. 2007
    ..Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer...
  56. doi request reprint Epigenetic control in male germ cells: a transillumination-assisted microdissection method for the analysis of developmentally regulated events
    Durga Prasad Mishra
    Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA, USA
    Methods Mol Biol 450:119-26. 2008
    ..This methodology is ideal to analyze nuclear chromatin condensation and allows further evaluation of epigenetic modifications in male germ cells...
  57. ncbi request reprint Negative control of circadian clock regulator E4BP4 by casein kinase Iepsilon-mediated phosphorylation
    Masao Doi
    Department of Biophysics and Biochemistry, Graduate School of Science, Univeristy of Tokyo, Japan
    Curr Biol 14:975-80. 2004
    ..These results not only demonstrate a phosphorylation-dependent regulatory mechanism for E4BP4 function but also highlight the role of CK1epsilon as a negative regulator for E4BP4-mediated repression of cPer2...
  58. pmc Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation
    Mahalakshmi Nair
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Dev Biol 320:446-55. 2008
    ..These findings suggest that Pygo2 is involved in the chromatin remodeling events that lead to nuclear compaction of male germ cells...
  59. pmc The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
    Yasukazu Nakahata
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Cell 134:329-40. 2008
    ..We propose that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals originated by cellular metabolites to the circadian clock...
  60. doi request reprint CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver
    Jure Acimovic
    Centre for Functional Genomics and Bio Chips, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia
    Biochem Biophys Res Commun 376:206-10. 2008
    ..We propose that cAMP signaling might generally be involved in the circadian regulation of cholesterol synthesis on the periphery...
  61. ncbi request reprint Plzf pushes stem cells
    Noora Kotaja
    Nat Genet 36:551-3. 2004
  62. ncbi request reprint Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family
    Pulak R Manna
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Mol Endocrinol 16:184-99. 2002
    ..These are the first observations to provide evidence for the functional involvement of a CREB/CREM family member in the acute regulation of trophic hormone-stimulated steroidogenesis and StAR gene expression...
  63. ncbi request reprint Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis
    Sarah Kimmins
    Department of Animal Science, McGill University, Montreal, Canada
    Mol Endocrinol 21:726-39. 2007
    ..These findings indicate that Aurora-B and Aurora-C serve specialized functions in mammalian spermatogenesis...
  64. ncbi request reprint Signaling to the circadian clock: plasticity by chromatin remodeling
    Yasukazu Nakahata
    Department of Pharmacology, School of Medicine, University of California, Irvine, California 92697, USA
    Curr Opin Cell Biol 19:230-7. 2007
    ..Recent advances in the field have revealed unexpected links between circadian regulators, chromatin remodeling and cellular metabolism...
  65. ncbi request reprint Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression
    Oliver Zwermann
    Division of Endocrinology, Department of Internal Medicine II, University of Freiburg, Germany
    Eur J Endocrinol 152:769-76. 2005
    ..The aim of this study was to investigate whether ACTH-R gene transcription is affected by DAX-1 and whether this mechanism is involved in down-regulation of ACTH-R expression in adrenocortical tumors...
  66. ncbi request reprint Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation
    Ippei Nagamori
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita City, Osaka 565 0871, Japan
    J Biol Chem 281:15073-81. 2006
    ..Finally, we demonstrate that the Tisp40DeltaTM-CREMtau heterodimer acts as a recruiter of HIRA, a histone chaperone, to CRE. Taken together, we propose that Tisp40 is an important transcriptional regulator during spermiogenesis...
  67. ncbi request reprint Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein
    Satoru Masubuchi
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Neurosci 25:4719-24. 2005
    ....
  68. ncbi request reprint Regulation of niemann-pick c1 gene expression by the 3'5'-cyclic adenosine monophosphate pathway in steroidogenic cells
    Nicolas Y Gevry
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, 3200 rue Sicotte, St Hyacinthe, Quebec J2S 7C6, Canada
    Mol Endocrinol 17:704-15. 2003
    ....
  69. pmc A small C-terminal sequence of Aurora B is responsible for localization and function
    Laetitia Scrittori
    Institut Albert Bonniot, Institut National de la Sante et de la Recherche Medicale, 38706 La Tronche Cedex, France
    Mol Biol Cell 16:292-305. 2005
    ..Our findings thus establish a small sequence as essential for the distinct localization and function of Aurora B...
  70. ncbi request reprint Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator)
    Takayoshi Isoda
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    FASEB J 17:144-51. 2003
    ..01) in CREM-/- vs. controls. These results demonstrate novel involvement of CREM in regulation of PP1 activity and of PLB, likely resulting in a potent frequency-dependent influence on cardiac function...
  71. ncbi request reprint Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids
    Raffaella Catena
    Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Dev Biol 296:231-238. 2006
    ..Our results show that intranuclear chromatin organization is critical for correct polar localization of H1T2 and that H1T2 can be a useful molecular marker revealing chromatin disorganization in spermatids...
  72. ncbi request reprint Editorial: Never enough--on the multiplicity and uniqueness of transcriptional regulators in postmeiotic male germ cells
    Paolo Sassone-Corsi
    Endocrinology 143:1575-7. 2002
  73. ncbi request reprint Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis
    Ilias Mylonis
    Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54 124, Greece
    J Biol Chem 279:11626-31. 2004
    ..Our data suggest that docking of protamine 1 to the nuclear envelope is an important intermediate step in spermiogenesis and reveal a novel role for SR protein kinases and p32...
  74. ncbi request reprint Estrogen mediates phosphorylation of histone H3 in ovarian follicle and mammary epithelial tumor cells via the mitotic kinase, Aurora B
    Z Tatiana Ruiz-Cortés
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada J2S 7C6
    Mol Endocrinol 19:2991-3000. 2005
    ..These results provide evidence for mitotic regulation in follicle development by estrogen and demonstrate a previously undiscovered mechanism for induction of cell proliferation in ovarian and mammary gland cells...
  75. pmc Production of fertile offspring from genetically infertile male mice
    Ryuzo Yanagimachi
    Institute for Biogenesis Research, Department of Anatomy and Reproductive Biology, University of Hawaii Medical School, Honolulu, HI 96822, USA
    Proc Natl Acad Sci U S A 101:1691-5. 2004
    ....
  76. ncbi request reprint The chromatoid body: a germ-cell-specific RNA-processing centre
    Noora Kotaja
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Nat Rev Mol Cell Biol 8:85-90. 2007
    ..This highly specialized structure might function as an intracellular focal domain that organizes and controls RNA processing in male germ cells...