- Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese miceChristine Ravinet Trillou
Central Nervous System Research, Sanofi Synthelabo, 31036 Toulouse Cedex, France
Am J Physiol Regul Integr Comp Physiol 284:R345-53. 2003..SR141716 had no effect in CB1 receptor knockout mice, which confirmed the implication of CB1 receptors in the activity of the compound. These findings suggest that SR141716 has a potential as a novel anti-obesity treatment...
- CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivityC Ravinet Trillou
Central Nervous System Research, Sanofi Synthelabo, Toulouse Cedex, France
Int J Obes Relat Metab Disord 28:640-8. 2004..To further define the physiological role of these receptors in the control of energy balance, we characterized the phenotype of CB1 receptor knockout (CB1(-/-)) mice maintained on an obesity-prone regimen or on a standard chow...