Research Topics
| V A SaksSummaryCountry: France Publications
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Publications
The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and aliveValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
J Physiol 586:2817-8. 2008
Intracellular Energetic Units regulate metabolism in cardiac cellsValdur Saks
Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
J Mol Cell Cardiol 52:419-36. 2012..This mechanism explains the regulation of respiration on beat to beat basis during workload changes under conditions of metabolic stability. This article is part of a Special Issue entitled "Local Signaling in Myocytes."..- Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosomeValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
Biochim Biophys Acta 1797:678-97. 2010..Systemic analysis of changes in the integrated system of energy metabolism is also helpful for better understanding of pathogenesis of many other diseases... - Molecular system bioenergetics: regulation of substrate supply in response to heart energy demandsValdur Saks
Laboratory of Bioenergetics, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
J Physiol 577:769-77. 2006..Regulation of malonyl-CoA levels by AMPK does not seem to work as a master on-off switch, but rather as a modulator of fatty acid import... - Heterogeneity of ADP diffusion and regulation of respiration in cardiac cellsValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
Biophys J 84:3436-56. 2003.... - Cardiac system bioenergetics: metabolic basis of the Frank-Starling lawValdur Saks
Structural and Quantitative Bioenergetics Research Group, Laboratory of Bioenergetics, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
J Physiol 571:253-73. 2006..Such integration of energetics with calcium signalling systems provides the basis for 'metabolic pacing', synchronizing the cellular electrical and mechanical activities with energy supply processes... 
Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolismV A Saks
Structural and Quantitative Bioenergetics Research Group, Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
Mol Cell Biochem 256:185-99. 2004..Such a complex structural and functional organisation of heart energy metabolism can be described quantitatively by mathematical models...- Intracellular energetic units in red muscle cellsV A Saks
Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
Biochem J 356:643-57. 2001..It is suggested that these complexes represent the basic pattern of organization of muscle-cell energy metabolism... - Is there the creatine kinase equilibrium in working heart cells?V A Saks
Laboratories of Bioenergetics, Joseph Fourier University, Grenoble, France
Biochem Biophys Res Commun 227:360-7. 1996.... - Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondriaFlorence Appaix
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
Exp Physiol 88:175-90. 2003.... - The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approachesValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
Subcell Biochem 46:27-65. 2007.... - Macrocompartmentation of total creatine in cardiomyocytes revisitedL Menin
Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
Mol Cell Biochem 220:149-59. 2001..It is concluded that there is no stable pool of creatine or phosphocreatine in the mitochondrial matrix in the intact muscle cells, and the total creatine pool is localized in only one macrocompartment--cytoplasm... - Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell functionR Guzun
Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, 2280 Rue de la Piscine, Grenoble Cedex 9, France
Amino Acids 40:1333-48. 2011.... - Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ. Importance of system level propertiesRita Guzun
Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
Biochim Biophys Acta 1787:1089-105. 2009.... - Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cellsT Andrienko
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
J Exp Biol 206:2059-72. 2003..Inside these complexes, mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures... - Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxesClaire Monge
INSERM U884, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
Can J Physiol Pharmacol 87:318-26. 2009.... - Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cellsKaren Guerrero
Laboratory of Fundamental and Applied Bioenergetics, INSERM E221, Joseph Fourier University, Grenoble, France
Mol Cell Biochem 337:239-49. 2010.... - Philosophical basis and some historical aspects of systems biology: from hegel to noble - applications for bioenergetic researchValdur Saks
INSERM U884, , , BP 53, Grenoble Cedex 9, France E Mails C M R G
Int J Mol Sci 10:1161-92. 2009..State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed... - Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genesMalgorzata Tokarska-Schlattner
Universite Joseph Fourier, Grenoble Cedex 9, France
Am J Physiol Regul Integr Comp Physiol 298:R1075-88. 2010..We propose that a blunted response to stress and reduced "danger signaling" is a prime component of toxic DXR action and can drive cardiac cells into pathology... - Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cellsNathalie Beraud
INSERM U884, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
J Bioenerg Biomembr 41:195-214. 2009..The differences observed in mitochondrial dynamics are related to specific structural organization and mitochondria-cytoskeleton interactions in these cells... - Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscleKaren Guerrero
Laboratoire de Bioénergétique Fondamentale et Appliquée, Institut National de la Santé et de la Recherche Médicale E221, Universite Joseph Fourier, Grenoble, France
Am J Physiol Regul Integr Comp Physiol 289:R1144-54. 2005.... - Interactions of ethanol drinking with n-3 fatty acids in rats: potential consequences for the cardiovascular systemAnnabelle Guiraud
TIMC IMAG, CNRS UMR 5525, Laboratoire PRETA Coeur et Nutrition, Faculte de Medecine, Universite Joseph Fourier, Grenoble, France
Br J Nutr 100:1237-44. 2008..Further studies are warranted to investigate the mechanisms by which moderate ED alters the metabolism of n-3 and whether n-3 are the mediators of the ED-induced cardioprotection... - Cardiac mechanoenergetics in silicoMarko Vendelin
Institute of Cybernetics, Akadeemia 21, 12618 Tallinn, Estonia
Neuro Endocrinol Lett 23:13-20. 2002..Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole... - Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytesMargus Eimre
Department of Pathophysiology, Centre of Molecular and Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia
Biochim Biophys Acta 1777:514-24. 2008.... - Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells. Importance of cell structure/organization for respiration regulationTiia Anmann
Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
Biochim Biophys Acta 1757:1597-606. 2006.... - Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibersAndrey V Kuznetsov
Department of Transplant Surgery, University Hospital Innsbruck, Austria
Anal Biochem 319:296-303. 2003..This will significantly expand the scope for screening and exchange of human biopsy samples between research centers, thus providing a new basis for functional analysis of mitochondrial defects in various diseases... - Non-beating HL-1 cells for confocal microscopy: application to mitochondrial functions during cardiac preconditioningSophie Pelloux
, 8 avenue Rockefeller, 69373 Lyon, France
Prog Biophys Mol Biol 90:270-98. 2006..Thus cardiac pharmacological preconditioning by K(ATP) channel openers might involve other routes than mitochondrial K channels targeting... - In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by MgATPases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatographyMaria Kulp
Faculty of Science, Tallinn Technical University, Tallinn, Estonia
Electrophoresis 25:2996-3002. 2004.... - Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusionAndrey V Kuznetsov
Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, A 6020 Innsbruck, Austria
Am J Physiol Heart Circ Physiol 286:H1633-41. 2004..These results demonstrate a complex pattern of multiple mitochondrial damage as determinants of CIR injury of the heart... - Mitochondrial subpopulations and heterogeneity revealed by confocal imaging: possible physiological role?Andrey V Kuznetsov
Daniel Swarovski Research Laboratory, Innsbruck Medical University, Innrain 66, A 6020 Innsbruck, Austria
Biochim Biophys Acta 1757:686-91. 2006..Possible physiological roles of intracellular mitochondrial heterogeneity and specializations are discussed... - Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cellsAndrey V Kuznetsov
Daniel Swarovski Research Laboratory, Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck A6020, Austria
Nat Protoc 3:965-76. 2008..As only a small amount of tissue is required for analysis, the protocol can be used in diagnostic settings in clinical studies. The permeabilization procedure and specific titration analysis can be completed in 2 h... - Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imagingAndrey V Kuznetsov
Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, Innsbruck, Austria
Transplantation 77:754-6. 2004..The purpose of the present study was to analyze the intracellular region-specific functional state of mitochondria after cold ischemia-reperfusion in a rat heart transplant model... - On the origin of intracellular compartmentation and organized metabolic systemsJudit Ovadi
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
Mol Cell Biochem 256:5-12. 2004..These phenomena demonstrated the physiological importance of the biophysical and biochemical mechanisms described in this review...