V A Saks

Summary

Country: France

Publications

  1. pmc The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    J Physiol 586:2817-8. 2008
  2. pmc Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells
    Valdur Saks
    Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University Grenoble, France
    Int J Mol Sci 9:751-67. 2008
  3. pmc Philosophical basis and some historical aspects of systems biology: from Hegel to Noble - applications for bioenergetic research
    Valdur Saks
    INSERM U, Universite Joseph Fourier, Grenoble, France
    Int J Mol Sci 10:1161-92. 2009
  4. ncbi request reprint Intracellular Energetic Units regulate metabolism in cardiac cells
    Valdur Saks
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    J Mol Cell Cardiol 52:419-36. 2012
  5. ncbi request reprint Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosome
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    Biochim Biophys Acta 1797:678-97. 2010
  6. pmc Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands
    Valdur Saks
    Laboratory of Bioenergetics, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    J Physiol 577:769-77. 2006
  7. pmc Cardiac system bioenergetics: metabolic basis of the Frank-Starling law
    Valdur Saks
    Structural and Quantitative Bioenergetics Research Group, Laboratory of Bioenergetics, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    J Physiol 571:253-73. 2006
  8. ncbi request reprint Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism
    V A Saks
    Structural and Quantitative Bioenergetics Research Group, Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 256:185-99. 2004
  9. pmc Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Biophys J 84:3436-56. 2003
  10. pmc Intracellular energetic units in red muscle cells
    V A Saks
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Biochem J 356:643-57. 2001

Collaborators

Detail Information

Publications35

  1. pmc The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    J Physiol 586:2817-8. 2008
  2. pmc Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells
    Valdur Saks
    Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University Grenoble, France
    Int J Mol Sci 9:751-67. 2008
    ..The perspectives of further studies of these complex intracellular interactions in the framework of Systems Biology are discussed...
  3. pmc Philosophical basis and some historical aspects of systems biology: from Hegel to Noble - applications for bioenergetic research
    Valdur Saks
    INSERM U, Universite Joseph Fourier, Grenoble, France
    Int J Mol Sci 10:1161-92. 2009
    ..State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed...
  4. ncbi request reprint Intracellular Energetic Units regulate metabolism in cardiac cells
    Valdur Saks
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    J Mol Cell Cardiol 52:419-36. 2012
    ..This mechanism explains the regulation of respiration on beat to beat basis during workload changes under conditions of metabolic stability. This article is part of a Special Issue entitled "Local Signaling in Myocytes."..
  5. ncbi request reprint Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosome
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    Biochim Biophys Acta 1797:678-97. 2010
    ..Systemic analysis of changes in the integrated system of energy metabolism is also helpful for better understanding of pathogenesis of many other diseases...
  6. pmc Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands
    Valdur Saks
    Laboratory of Bioenergetics, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    J Physiol 577:769-77. 2006
    ..Regulation of malonyl-CoA levels by AMPK does not seem to work as a master on-off switch, but rather as a modulator of fatty acid import...
  7. pmc Cardiac system bioenergetics: metabolic basis of the Frank-Starling law
    Valdur Saks
    Structural and Quantitative Bioenergetics Research Group, Laboratory of Bioenergetics, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    J Physiol 571:253-73. 2006
    ..Such integration of energetics with calcium signalling systems provides the basis for 'metabolic pacing', synchronizing the cellular electrical and mechanical activities with energy supply processes...
  8. ncbi request reprint Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism
    V A Saks
    Structural and Quantitative Bioenergetics Research Group, Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 256:185-99. 2004
    ..Such a complex structural and functional organisation of heart energy metabolism can be described quantitatively by mathematical models...
  9. pmc Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Biophys J 84:3436-56. 2003
    ....
  10. pmc Intracellular energetic units in red muscle cells
    V A Saks
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Biochem J 356:643-57. 2001
    ..It is suggested that these complexes represent the basic pattern of organization of muscle-cell energy metabolism...
  11. ncbi request reprint Is there the creatine kinase equilibrium in working heart cells?
    V A Saks
    Laboratories of Bioenergetics, Joseph Fourier University, Grenoble, France
    Biochem Biophys Res Commun 227:360-7. 1996
    ....
  12. ncbi request reprint Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria
    Florence Appaix
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
    Exp Physiol 88:175-90. 2003
    ....
  13. ncbi request reprint Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells
    T Andrienko
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
    J Exp Biol 206:2059-72. 2003
    ..Inside these complexes, mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures...
  14. ncbi request reprint The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Subcell Biochem 46:27-65. 2007
    ....
  15. doi request reprint Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function
    R Guzun
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, 2280 Rue de la Piscine, Grenoble Cedex 9, France
    Amino Acids 40:1333-48. 2011
    ....
  16. doi request reprint Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ. Importance of system level properties
    Rita Guzun
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    Biochim Biophys Acta 1787:1089-105. 2009
    ....
  17. ncbi request reprint Macrocompartmentation of total creatine in cardiomyocytes revisited
    L Menin
    Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 220:149-59. 2001
    ..It is concluded that there is no stable pool of creatine or phosphocreatine in the mitochondrial matrix in the intact muscle cells, and the total creatine pool is localized in only one macrocompartment--cytoplasm...
  18. doi request reprint Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes
    Claire Monge
    INSERM U884, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    Can J Physiol Pharmacol 87:318-26. 2009
    ....
  19. doi request reprint Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells
    Karen Guerrero
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E221, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 337:239-49. 2010
    ....
  20. doi request reprint Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes
    Malgorzata Tokarska-Schlattner
    Universite Joseph Fourier, Grenoble Cedex 9, France
    Am J Physiol Regul Integr Comp Physiol 298:R1075-88. 2010
    ..We propose that a blunted response to stress and reduced "danger signaling" is a prime component of toxic DXR action and can drive cardiac cells into pathology...
  21. doi request reprint Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells
    Nathalie Beraud
    INSERM U884, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    J Bioenerg Biomembr 41:195-214. 2009
    ..The differences observed in mitochondrial dynamics are related to specific structural organization and mitochondria-cytoskeleton interactions in these cells...
  22. ncbi request reprint Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle
    Karen Guerrero
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Institut National de la Santé et de la Recherche Médicale E221, Universite Joseph Fourier, Grenoble, France
    Am J Physiol Regul Integr Comp Physiol 289:R1144-54. 2005
    ....
  23. doi request reprint Interactions of ethanol drinking with n-3 fatty acids in rats: potential consequences for the cardiovascular system
    Annabelle Guiraud
    TIMC IMAG, CNRS UMR 5525, Laboratoire PRETA Coeur et Nutrition, Faculte de Medecine, Universite Joseph Fourier, Grenoble, France
    Br J Nutr 100:1237-44. 2008
    ..Further studies are warranted to investigate the mechanisms by which moderate ED alters the metabolism of n-3 and whether n-3 are the mediators of the ED-induced cardioprotection...
  24. ncbi request reprint Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion
    Andrey V Kuznetsov
    Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, A 6020 Innsbruck, Austria
    Am J Physiol Heart Circ Physiol 286:H1633-41. 2004
    ..These results demonstrate a complex pattern of multiple mitochondrial damage as determinants of CIR injury of the heart...
  25. ncbi request reprint Cardiac mechanoenergetics in silico
    Marko Vendelin
    Institute of Cybernetics, Akadeemia 21, 12618 Tallinn, Estonia
    Neuro Endocrinol Lett 23:13-20. 2002
    ..Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole...
  26. ncbi request reprint In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by MgATPases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography
    Maria Kulp
    Faculty of Science, Tallinn Technical University, Tallinn, Estonia
    Electrophoresis 25:2996-3002. 2004
    ....
  27. doi request reprint Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes
    Margus Eimre
    Department of Pathophysiology, Centre of Molecular and Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia
    Biochim Biophys Acta 1777:514-24. 2008
    ....
  28. ncbi request reprint Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells. Importance of cell structure/organization for respiration regulation
    Tiia Anmann
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    Biochim Biophys Acta 1757:1597-606. 2006
    ....
  29. ncbi request reprint Mitochondrial subpopulations and heterogeneity revealed by confocal imaging: possible physiological role?
    Andrey V Kuznetsov
    Daniel Swarovski Research Laboratory, Innsbruck Medical University, Innrain 66, A 6020 Innsbruck, Austria
    Biochim Biophys Acta 1757:686-91. 2006
    ..Possible physiological roles of intracellular mitochondrial heterogeneity and specializations are discussed...
  30. ncbi request reprint Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers
    Andrey V Kuznetsov
    Department of Transplant Surgery, University Hospital Innsbruck, Austria
    Anal Biochem 319:296-303. 2003
    ..This will significantly expand the scope for screening and exchange of human biopsy samples between research centers, thus providing a new basis for functional analysis of mitochondrial defects in various diseases...
  31. ncbi request reprint Non-beating HL-1 cells for confocal microscopy: application to mitochondrial functions during cardiac preconditioning
    Sophie Pelloux
    INSERM E0226 Université Lyon1, 8 avenue Rockefeller, 69373 Lyon, France
    Prog Biophys Mol Biol 90:270-98. 2006
    ..Thus cardiac pharmacological preconditioning by K(ATP) channel openers might involve other routes than mitochondrial K channels targeting...
  32. ncbi request reprint Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging
    Andrey V Kuznetsov
    Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, Innsbruck, Austria
    Transplantation 77:754-6. 2004
    ..The purpose of the present study was to analyze the intracellular region-specific functional state of mitochondria after cold ischemia-reperfusion in a rat heart transplant model...
  33. doi request reprint Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells
    Andrey V Kuznetsov
    Daniel Swarovski Research Laboratory, Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck A6020, Austria
    Nat Protoc 3:965-76. 2008
    ..As only a small amount of tissue is required for analysis, the protocol can be used in diagnostic settings in clinical studies. The permeabilization procedure and specific titration analysis can be completed in 2 h...
  34. ncbi request reprint On the origin of intracellular compartmentation and organized metabolic systems
    Judit Ovadi
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Cell Biochem 256:5-12. 2004
    ..These phenomena demonstrated the physiological importance of the biophysical and biochemical mechanisms described in this review...