Hela Saidi

Summary

Country: France

Publications

  1. pmc Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development
    Hela Saidi
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    J Transl Med 5:28. 2007
  2. ncbi request reprint R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission
    Hela Saidi
    Unité INSERM U743 Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, Cedex 06, France
    Virology 358:55-68. 2007
  3. ncbi request reprint IFN-gamma-activated monocytes weakly produce HIV-1 but induce the recruitment of HIV-sensitive T cells and enhance the viral production by these recruited T cells
    Hela Saidi
    Universite Paris, Unité INSERM U743 Equipe Immunité et Biothérapie Muqueuse, 15 rue de l Ecole de Medecine, 75270 Paris, Cedex 06, France
    J Leukoc Biol 81:642-53. 2007
  4. ncbi request reprint Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies
    Hela Saidi
    Universite Rene Descartes Paris V, Unité Institut National de la Recherche et de la Santé INSERM Internationale 743 d Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Paris, France
    J Immunol 177:5540-9. 2006
  5. pmc Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins
    Mary Requena
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Immunology 123:508-18. 2008
  6. pmc Infection of macrophages and dendritic cells with primary R5-tropic human immunodeficiency virus type 1 inhibited by natural polyreactive anti-CCR5 antibodies purified from cervicovaginal secretions
    Jobin Eslahpazir
    Université Paris V and Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 Immunologie Humaine, Centre de Recherches des Cordeliers, Paris, France
    Clin Vaccine Immunol 15:872-84. 2008
  7. pmc Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1
    Marie Thérèse Melki
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Paris, France
    PLoS Pathog 6:e1000862. 2010
  8. doi request reprint Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment
    Hela Saidi
    Unité INSERM Internationale U743 Immunologie Humaine, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Hum Immunol 71:1-13. 2010
  9. doi request reprint Apical interactions of HIV type 1 with polarized HEC-1 cell monolayer modulate R5-HIV type 1 spread by submucosal macrophages
    Hela Saidi
    Université Paris Descartes Paris V, Unité INSERM U743 Immunologie Humaine, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    AIDS Res Hum Retroviruses 25:497-509. 2009
  10. ncbi request reprint Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner
    Hicham Bouhlal
    Université René Descartes Paris V and Institut National de la Santé et de la Recherche Médicale, Unité 743, Institut des Cordeliers, Paris, France
    J Immunol 178:1086-95. 2007

Collaborators

Detail Information

Publications18

  1. pmc Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development
    Hela Saidi
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    J Transl Med 5:28. 2007
    ..Plant lectins are candidate for microbicide development...
  2. ncbi request reprint R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission
    Hela Saidi
    Unité INSERM U743 Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, Cedex 06, France
    Virology 358:55-68. 2007
    ..This study suggests that R5 and X4 viruses can differentially use epithelial cells to ensure their own spread...
  3. ncbi request reprint IFN-gamma-activated monocytes weakly produce HIV-1 but induce the recruitment of HIV-sensitive T cells and enhance the viral production by these recruited T cells
    Hela Saidi
    Universite Paris, Unité INSERM U743 Equipe Immunité et Biothérapie Muqueuse, 15 rue de l Ecole de Medecine, 75270 Paris, Cedex 06, France
    J Leukoc Biol 81:642-53. 2007
    ....
  4. ncbi request reprint Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies
    Hela Saidi
    Universite Rene Descartes Paris V, Unité Institut National de la Recherche et de la Santé INSERM Internationale 743 d Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Paris, France
    J Immunol 177:5540-9. 2006
    ..This study highlights the use of Lf derivates as microbicide candidates to limit such interferences...
  5. pmc Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins
    Mary Requena
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Immunology 123:508-18. 2008
    ..Our data support a role of natural antibodies to DC-SIGN in the modulation of postnatal HIV transmission through breast-feeding and in the natural host defence against HIV-1 in infected individuals...
  6. pmc Infection of macrophages and dendritic cells with primary R5-tropic human immunodeficiency virus type 1 inhibited by natural polyreactive anti-CCR5 antibodies purified from cervicovaginal secretions
    Jobin Eslahpazir
    Université Paris V and Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 Immunologie Humaine, Centre de Recherches des Cordeliers, Paris, France
    Clin Vaccine Immunol 15:872-84. 2008
    ....
  7. pmc Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1
    Marie Thérèse Melki
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Paris, France
    PLoS Pathog 6:e1000862. 2010
    ....
  8. doi request reprint Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment
    Hela Saidi
    Unité INSERM Internationale U743 Immunologie Humaine, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Hum Immunol 71:1-13. 2010
    ..In conclusion, secreted cytokines within mucosae may differentially influence both the HIV-1 production within the mucosal target cells reservoir and its spread thorough the mucosal tissue...
  9. doi request reprint Apical interactions of HIV type 1 with polarized HEC-1 cell monolayer modulate R5-HIV type 1 spread by submucosal macrophages
    Hela Saidi
    Université Paris Descartes Paris V, Unité INSERM U743 Immunologie Humaine, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    AIDS Res Hum Retroviruses 25:497-509. 2009
    ..These observations challenge the question of the in vivo involvement of HIV-1 as a supraepithelial stimulus that likely modulates the susceptibility for HIV-1 of submucosal target cells in favor of its transmission...
  10. ncbi request reprint Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner
    Hicham Bouhlal
    Université René Descartes Paris V and Institut National de la Santé et de la Recherche Médicale, Unité 743, Institut des Cordeliers, Paris, France
    J Immunol 178:1086-95. 2007
    ..Thus, the virus uses complement to its advantage to facilitate early steps leading to infection following mucosal transmission of HIV...
  11. doi request reprint Potent in vitro inactivation of both free and cell-associated CCR5- and CXCR4-tropic HIV-1 by common commercial soap bars from South Africa
    Mohammad Ali Jenabian
    Université Paris Descartes Paris V, and Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France
    J Acquir Immune Defic Syndr 54:340-2. 2010
    ..These observations indicate a rapid inhibitory effect of soap and water on viral infectivity...
  12. pmc Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization
    Mohammad Ali Jenabian
    Université Paris Descartes Paris V, Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France
    AIDS Res Ther 7:16. 2010
    ..HIV-1 in genital secretions may be opsonized by several molecules including complement components. Opsonized HIV-1 by complement enhances the infection of various mucosal target cells, such as dendritic cells (DC) and epithelial cells...
  13. doi request reprint In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20)
    Mohammad Ali Jenabian
    Université Paris Descartes Paris V, and Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France
    J Antimicrob Chemother 64:1192-5. 2009
    ..Indeed, the combination of microbicides with complementary mechanisms of action is expected to increase the antiviral potency of the formulation...
  14. ncbi request reprint Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells
    Cedric Carbonneil
    INSERM U430, Institut des Cordeliers, Paris, France
    Int Immunol 16:1037-52. 2004
    ....
  15. pmc HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Inserm U668, Paris, France
    PLoS ONE 3:e3601. 2008
    ..Here, we investigate the impact of NK-DC cross-talk on maturation and functions of HIV-infected immature DCs...
  16. doi request reprint Combinatorial prevention of HIV transmission in women: the case for a vaginal microbicide
    Laurent Belec
    Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France, 15 20 rue Leblanc, 75 908 Paris Cedex 15, France
    Future Microbiol 6:731-7. 2011
    ..Finally, the combination of existing partially effective strategies for HIV prevention should be promoted, scaled-up and evaluated...
  17. doi request reprint Analysis of apoptotic pathways by multiparametric flow cytometry: application to HIV infection
    Hervé Lecoeur
    Unité d Immunophysiologie et Parasitisme Intracellulaire, Paris, France
    Methods Enzymol 442:51-82. 2008
    ..Several examples of combined staining of apoptotic cells are shown on peripheral blood lymphocytes from chronically HIV-infected patients, prone to undergo premature apoptosis...
  18. doi request reprint Microbicides: an emerging science of HIV-1 prevention in women-15th Conference on Retroviruses and Opportunistic Infections, Boston, USA, 3-6 February 2008
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Paris, France
    Rev Med Virol 19:69-76. 2009
    ....