Michel E Safar

Summary

Country: France

Publications

  1. ncbi request reprint Arterial stiffness: a simplified overview in vascular medicine
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:1-18. 2007
  2. ncbi request reprint Pulse pressure: a help in medical semiology for metabolic syndrome
    Michel E Safar
    Paris Descartes University AP HP, Hotel Dieu Hospital, Diagnosis Center, Paris, France
    Am J Hypertens 20:204-5. 2007
  3. ncbi request reprint Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension
    Michel E Safar
    Diagnosis Centre, Hotel Dieu Hospital, Paris, France
    J Hypertens 23:1159-66. 2005
  4. ncbi request reprint Vascular development, pulse pressure, and the mechanisms of hypertension
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Hypertension 46:205-9. 2005
  5. ncbi request reprint Arterial stiffness and peripheral arterial disease
    Michel E Safar
    The Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:199-211. 2007
  6. ncbi request reprint Systolic hypertension in elderly patients
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, Paris, France
    Semin Cardiothorac Vasc Anesth 10:203-5. 2006
  7. ncbi request reprint Atherosclerosis, arterial stiffness and antihypertensive drug therapy
    Michel E Safar
    The Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:331-51. 2007
  8. ncbi request reprint Obesity, arterial stiffness, and cardiovascular risk
    Michel E Safar
    Hypertension and Cardiovascular Prevention Unit, Diagnosis Center, Hotel Dieu Hospital, 75181 Paris Cedex 04, France
    J Am Soc Nephrol 17:S109-11. 2006
  9. ncbi request reprint Pulse pressure monitoring of open antihypertensive therapy
    Michel E Safar
    Diagnostic Center, Hopital Hotel Dieu, 75181 Paris, France
    Am J Hypertens 17:1088-94. 2004
  10. ncbi request reprint Metabolic syndrome and age-related progression of aortic stiffness
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    J Am Coll Cardiol 47:72-5. 2006

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Arterial stiffness: a simplified overview in vascular medicine
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:1-18. 2007
    ..Arterial elasticity is a common index of medical semiology, easier to understand than blood pressure measurement. This chapter summarizes the most classical aspects which are important to understand in vascular medicine...
  2. ncbi request reprint Pulse pressure: a help in medical semiology for metabolic syndrome
    Michel E Safar
    Paris Descartes University AP HP, Hotel Dieu Hospital, Diagnosis Center, Paris, France
    Am J Hypertens 20:204-5. 2007
  3. ncbi request reprint Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension
    Michel E Safar
    Diagnosis Centre, Hotel Dieu Hospital, Paris, France
    J Hypertens 23:1159-66. 2005
    ..Whether the aldosterone synthase gene polymorphism (ASGP) CYP11B2 influences the age-related changes in blood pressure (BP) and arterial stiffness in hypertensive subjects has never been investigated...
  4. ncbi request reprint Vascular development, pulse pressure, and the mechanisms of hypertension
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Hypertension 46:205-9. 2005
    ..We suggest that hypertension results from early developmental vascular mechanisms that direct BP toward the higher percentiles of the Gaussian distribution curve...
  5. ncbi request reprint Arterial stiffness and peripheral arterial disease
    Michel E Safar
    The Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:199-211. 2007
    ..This disease raises the question to which extent sclerosis in 'atherosclerosis' is necessary per se to cause an increase in systolic blood pressure...
  6. ncbi request reprint Systolic hypertension in elderly patients
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, Paris, France
    Semin Cardiothorac Vasc Anesth 10:203-5. 2006
    ..In older subjects, systolic blood pressure and pulse pressure are higher, whereas diastolic blood pressure is lower than in younger subjects...
  7. ncbi request reprint Atherosclerosis, arterial stiffness and antihypertensive drug therapy
    Michel E Safar
    The Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:331-51. 2007
    ....
  8. ncbi request reprint Obesity, arterial stiffness, and cardiovascular risk
    Michel E Safar
    Hypertension and Cardiovascular Prevention Unit, Diagnosis Center, Hotel Dieu Hospital, 75181 Paris Cedex 04, France
    J Am Soc Nephrol 17:S109-11. 2006
    ..This report focuses on the role of arterial stiffness in individuals with obesity and on the association between this hemodynamic feature and cardiovascular risk...
  9. ncbi request reprint Pulse pressure monitoring of open antihypertensive therapy
    Michel E Safar
    Diagnostic Center, Hopital Hotel Dieu, 75181 Paris, France
    Am J Hypertens 17:1088-94. 2004
    ..Pulse pressure (PP) >60 mm Hg is an independent predictor of cardiovascular (CV) risk. Controlled studies showed that, unlike systolic and diastolic blood pressure (BP), PP responds minimally to placebo or no treatment...
  10. ncbi request reprint Metabolic syndrome and age-related progression of aortic stiffness
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    J Am Coll Cardiol 47:72-5. 2006
    ..Metabolic syndrome involves an increased progression of arterial stiffness with age and, thus, favors premature senescence...
  11. doi request reprint Hypertension and vascular dynamics in men and women with metabolic syndrome
    Michel E Safar
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    J Am Coll Cardiol 61:12-9. 2013
    ..This pulsatile hemodynamic abnormality contributes independently to increase age- and sex-mediated CV risk, justifying new research regarding Framingham scores and drug treatment...
  12. ncbi request reprint Diastolic blood pressure and mortality in the elderly with cardiovascular disease
    Athanase D Protogerou
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Hypertension 50:172-80. 2007
    ....
  13. ncbi request reprint Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension
    Annie Rudnichi
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Am J Hypertens 17:321-7. 2004
    ..Few studies have examined to what extent genes might modulate the changes of systolic and diastolic blood pressure (BP) with age although, in older populations, systolic BP and diastolic BP vary with age in opposite directions...
  14. doi request reprint Effects of antihypertensive drugs on central blood pressure in humans: a preliminary observation
    Davide Agnoletti
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    Am J Hypertens 26:1045-52. 2013
    ..Our aim was to assess the hemodynamic effect of a 12-week treatment with amlodipine 5mg, or candesartan 8mg, or indapamide sustained-release 1.5mg, in comparison with placebo...
  15. ncbi request reprint Heart rate and pulse pressure amplification in hypertensive subjects
    Pierre Laurent
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 16:363-70. 2003
    ..Amplification of PP is known to be influenced by heart rate (HR), but the impact of this alteration has never been tested in patients with hypertension...
  16. ncbi request reprint Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
    ....
  17. ncbi request reprint Aortic pulse wave velocity index and mortality in end-stage renal disease
    Jacques Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Kidney Int 63:1852-60. 2003
    ..Nevertheless, because age, blood pressure, heart rate, and gender are strong determinants of both arterial stiffness and mortality, the individual relevance of PWV measurements remains controversial...
  18. doi request reprint Urinary aldosterone-to-active-renin ratio: a useful tool for predicting resolution of hypertension after adrenalectomy in patients with aldosterone-producing adenomas
    Jean Jacques Mourad
    Hypertension Unit, Avicenne Hospital, AP HP, Paris XIII University EA 3412, Paris, France
    Am J Hypertens 21:742-7. 2008
    ..The purpose of this study was to determine the preoperative clinical and biological factors that predict the clinical outcomes after surgery, in subjects with aldosterone-producing adenomas (APAs)...
  19. ncbi request reprint Gender influence on metabolic syndrome's effects on arterial stiffness and pressure wave reflections in treated hypertensive subjects
    Athanase D Protogerou
    Diagnosis and Therapeutic Center, Hotel Dieu Hospital, Paris, France
    Atherosclerosis 193:151-8. 2007
    ..Whether PWV and AI are correlated and reflect CV risk in hypertensive men and women with metabolic syndrome (MS) remains unknown...
  20. ncbi request reprint Arterial stiffness and central hemodynamics in treated hypertensive subjects according to brachial blood pressure classification
    Michel E Safar
    AP HP Diagnosis Center, Hotel Dieu Hospital, Faculty of Medicine, Paris Descartes University, Paris, France michel safarhtd aphp fr
    J Hypertens 26:130-7. 2008
    ..Central BP has never been studied in relation to international guidelines for brachial BP classification...
  21. doi request reprint Predictive factors for all-cause mortality in the hospitalized elderly subject: the importance of arrhythmia
    Claire Vesin
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Atherosclerosis 207:507-13. 2009
    ..In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristics were associated with all-cause mortality...
  22. doi request reprint Pulse pressure amplification, pressure waveform calibration and clinical applications
    Davide Agnoletti
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, 1, Place du Parvis Notre Dame, 75004 Paris, France
    Atherosclerosis 224:108-12. 2012
    ..We also suggest that the alteration of amplification in each arterial territory might be considered as a signal of clinical/subclinical damage...
  23. ncbi request reprint Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: effect of eplerenone
    Johnny Nehme
    INSERM U572, Paris, France
    J Renin Angiotensin Aldosterone Syst 7:31-9. 2006
    ..Our aim was to determine in vivo the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on simultaneous changes in cardiac and arterial structure and function and their interactions...
  24. ncbi request reprint Large-artery stiffness, hypertension and cardiovascular risk in older patients
    Jacques Blacher
    Diagnosis Center, Hopital Hotel Dieu, Paris, France
    Nat Clin Pract Cardiovasc Med 2:450-5. 2005
    ..Here we discuss the structural and functional factors that influence arterial stiffness, wave reflections and pulse pressure in hypertension, as well as their related roles in cardiovascular risk...
  25. ncbi request reprint From 'optimal' to 'borderline' blood pressure in subjects under chronic antihypertensive therapy
    Anne Claire Vergnaud
    U557 INSERM UMR INSERM INRA CNAM, CRNH Ile de France, Paris, France
    J Hypertens 26:138-44. 2008
    ..Differences between these groups in arterial stiffness, pressure wave reflections and central blood pressure, which are all predictors of cardiovascular risk independently of peripheral blood pressure, have never been studied...
  26. doi request reprint Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study
    Michel E Safar
    Universite Paris Descartes, Paris, France
    Hypertens Res 34:91-7. 2011
    ..This new aspect of the MetS might modify clinical management leading to earlier drug treatment, particularly in regard to both endothelial dysfunction and increased arterial stiffness...
  27. ncbi request reprint Angiotensin-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Arterioscler Thromb Vasc Biol 24:782-6. 2004
    ....
  28. ncbi request reprint Determinants of hypertension control in a large French population of treated hypertensive subjects
    Olivier Roux
    Centre de Diagnostic, Hopital Hotel Dieu, AP HP, Universite Paris 5, Paris, France
    Blood Press 15:6-13. 2006
    ..In conclusion, this study has shown poor blood pressure control in a primary care-recruited population, especially in males and in the elderly...
  29. ncbi request reprint Aortic stiffness, kidney disease, and renal transplantation
    Sola Aoun Bahous
    Diagnosis and Therapeutic Center, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Curr Hypertens Rep 11:98-103. 2009
    ..This alteration potentially initiates renal damage and favors CV events. In subjects with end-stage renal disease and high CV risk, pharmacologic modulation of the renin-angiotensin system might prevent CKD progression and CV events...
  30. doi request reprint Cardiovascular risk as defined in the 2003 European blood pressure classification: the assessment of an additional predictive value of pulse pressure on mortality
    Frederique Thomas
    Centre d Investigations Préventives et Cliniques, Hotel Dieu Hospital, AP HP, University Paris 5, Paris, France
    J Hypertens 26:1072-7. 2008
    ..This study determines the predictive value of brachial pulse pressure for cardiovascular stroke and coronary mortality in a large population categorized by blood pressure level...
  31. ncbi request reprint Age-related increase of pulse pressure and gene polymorphisms in essential hypertension: a preliminary study
    Jean Jacques Mourad
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    J Renin Angiotensin Aldosterone Syst 3:109-15. 2002
    ..In subjects with essential hypertension, genes may modulate the age-mediated increase of PP. This finding gives new insights in the interactions between genes, mechanical factors and cardiovascular risk...
  32. ncbi request reprint Prognostic significance of arterial stiffness measurements in end-stage renal disease patients
    Jacques Blacher
    Department of Internal Medicine, Broussais Hospital, AP HP, Paris, France
    Curr Opin Nephrol Hypertens 11:629-34. 2002
    ....
  33. doi request reprint Effect of antihypertensive agents on blood pressure variability: the Natrilix SR versus candesartan and amlodipine in the reduction of systolic blood pressure in hypertensive patients (X-CELLENT) study
    Yi Zhang
    Centre de Diagnostic et de Thérapeutique, Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Hypertension 58:155-60. 2011
    ..The combination of the 2 agents might help to optimize such properties...
  34. ncbi request reprint Large artery stiffness and antihypertensive agents
    Jacques Blacher
    Hypertension and Cardiovascular Prevention Unit, Centre de Diagnostic, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    Curr Pharm Des 11:3317-26. 2005
    ....
  35. ncbi request reprint Improvement of impaired coronary vasodilator reserve in hypertensive patients by low-dose ACE inhibitor/diuretic therapy: a pilot PET study
    Jean Jacques Mourad
    St Michel Hospital, Paris, France
    J Renin Angiotensin Aldosterone Syst 4:94-5. 2003
  36. ncbi request reprint Dissociation between central augmentation index and carotid-femoral pulse-wave velocity: when and why?
    Athanase D Protogerou
    Diagnosis Center, Faculty of Medicine, Paris Descartes University, Hotel Dieu Hospital, Paris, France
    Am J Hypertens 20:648-9. 2007
  37. ncbi request reprint Is there any additional prognostic value of central blood pressure wave forms beyond peripheral blood pressure?
    Miso Sabovic
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Curr Pharm Des 15:254-66. 2009
    ..Crucially, we will review data supporting the view that improvement of central blood pressure can result in reduction of cardiovascular events. Lastly, the future perspectives in this exciting and promising field will be presented...
  38. ncbi request reprint Central blood pressures: do we need them in the management of cardiovascular disease? Is it a feasible therapeutic target?
    Athanase D Protogerou
    Diagnostic and Therapeutic Center, Hotel Dieu Hospital, Paris, France
    J Hypertens 25:265-72. 2007
    ....
  39. doi request reprint Pulsatile hemodynamics and cardiovascular risk factors in very old patients: background, sex aspects and implications
    Michel E Safar
    Paris Descartes University, Faculty of Medicine Hôtel Dieu Hospital AP HP, Diagnosis Center, Paris, France
    J Hypertens 31:848-57. 2013
    ..Such focus deflected attention from primary ageing changes, represented by stiffening and dilation of the proximal aorta...
  40. doi request reprint Impact of country of birth on arterial function in subjects living in France
    Frederique Thomas
    Centre d Investigations Préventives et Cliniques, Paris, France
    J Am Soc Hypertens 6:405-13. 2012
    ....
  41. doi request reprint Blood pressure variability in relation to autonomic nervous system dysregulation: the X-CELLENT study
    Yi Zhang
    Paris Descartes University, Paris, France
    Hypertens Res 35:399-403. 2012
    ..In summary, autonomic nervous system dysfunction was associated with a heightened day-night SBP gradient and more variable SBP over 24 h in patients with essential hypertension...
  42. doi request reprint Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus
    Bernard I Levy
    Centre de Recherche Cardiovasculaire de Lariboisière, INSERM U689, Service d Explorations Fonctionnelles, Hopital Lariboisiere, Paris, France
    Circulation 118:968-76. 2008
  43. doi request reprint Prevalence and prognosis of left ventricular diastolic dysfunction in the elderly: The PROTEGER Study
    Yi Zhang
    Paris Descartes University, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    Am Heart J 160:471-8. 2010
    ..Left ventricular diastolic dysfunction (LVDD) was reported as a significant predictor of mortality, mainly in patients with heart failure. However, prospective data are scarce in the hospitalized elderly population...
  44. doi request reprint Central blood pressure and hypertension: role in cardiovascular risk assessment
    Michel E Safar
    Diagnosis Center, Paris Descartes University, Hotel Dieu Hospital, Paris, France
    Clin Sci (Lond) 116:273-82. 2009
    ....
  45. ncbi request reprint Mechanism(s) of systolic blood pressure reduction and drug therapy in hypertension
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, AP HP, Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Hypertension 50:167-71. 2007
  46. ncbi request reprint Pulse pressure, heart rate, and drug treatment of hypertension
    Michel E Safar
    Centre de Diagnostic, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris 04, France
    Curr Hypertens Rep 6:190-4. 2004
    ....
  47. ncbi request reprint Carotid intima-media thickness and carotid and/or iliofemoral plaques: comparison of two markers of cardiovascular risk in hypertensive patients
    Jean Michel Tartiere
    Department of Internal Medicine, Broussais Hospital, AP HP, Paris, France
    J Hypertens 21:739-46. 2003
    ....
  48. doi request reprint Pulse pressure, arterial stiffness, and end-organ damage
    Michel E Safar
    Paris Descartes University AP HP Diagnosis and Therapeutic Center, Hotel Dieu, 1, Place du Parvis Notre Dame, 75181, Paris Cedex 04, France
    Curr Hypertens Rep 14:339-44. 2012
    ..For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly...
  49. doi request reprint Cardiac and arterial calcifications and all-cause mortality in the elderly: the PROTEGER Study
    Yi Zhang
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    Atherosclerosis 213:622-6. 2010
    ..To investigate the association of overall mortality with the presence and extent of cardiovascular calcifications...
  50. ncbi request reprint Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage
    Michel E Safar
    Faculty of Medicine, Paris Descartes University, Paris, France
    Am J Physiol Heart Circ Physiol 293:H1-7. 2007
    ....
  51. ncbi request reprint Relation of plasma total homocysteine to cardiovascular mortality in a French population
    Jacques Blacher
    Department of Internal Medicine, Broussais Hospital and Centre d Investigations Préventives et Cliniques, Paris, France
    Am J Cardiol 90:591-5. 2002
    ..Thus, HCY is an independent risk predictor for CV mortality. Because of extensive adjustment procedures, the present study provides additional epidemiologic evidence for a causal relation between HCY and CV disease...
  52. ncbi request reprint Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
    Paul Milliez
    Department of Cardiology, Lariboisiere Hospital, Paris, France
    J Am Coll Cardiol 45:1243-8. 2005
    ..The aim of this report was to show that the rate of cardiovascular events is increased in patients with either subtype of primary aldosteronism (PA)...
  53. ncbi request reprint Blood pressure components in clinical hypertension
    Michel E Safar
    Hopital Hotel Dieu, Paris, France
    J Clin Hypertens (Greenwich) 8:659-66. 2006
    ....
  54. ncbi request reprint Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure
    Michel E Safar
    Medecine Interne 1, Hopital Broussais, Paris, France
    J Hypertens 20:1653-61. 2002
    ..A low-dose combination of perindopril (Per) and indapamide (Ind) has been shown to reduce more SBP than atenolol for the same DBP reduction. However, the possible influence of gender on this finding has never been tested...
  55. ncbi request reprint [New goals in hypertension management: target-organ protection beyond blood pressure lowering]
    Michel E Safar
    Service de Medecine Interne, Hopital Broussais, Paris, France
    Drugs 63:45-7. 2003
    ....
  56. ncbi request reprint Central pulse pressure and mortality in end-stage renal disease
    Michel E Safar
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 39:735-8. 2002
    ..These results provide the first direct evidence that in patients with ESRD, the carotid PP level and, mostly, the disappearance of PP amplification are strong independent predictors of all-cause (including cardiovascular) mortality...
  57. doi request reprint The Data from an Epidemiologic Study on the Insulin Resistance Syndrome Study: the change and the rate of change of the age-blood pressure relationship
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, Hotel Dieu Hospital, France
    J Hypertens 26:1903-11. 2008
    ..Whether the rates of change of SBP and DBP with age exhibit a similar dissociation has never been investigated...
  58. doi request reprint Radial late-SBP as a surrogate for central SBP
    Yi Zhang
    Diagnosis and Therapeutic Center, AP HP, Paris Descartes University, Hotel Dieu, Paris, France
    J Hypertens 29:676-81. 2011
    ..The objective of the present study was, therefore, to investigate whether rSBP2, from commercially available noninvasive devices, could practically indicate central SBP in current clinical care...
  59. ncbi request reprint Factors influencing arterial stiffness in systolic hypertension in the elderly: role of sodium and the renin-angiotensin system
    Michel E Safar
    Department of Internal Medicine MES, Broussais Hospital, Paris, France
    Am J Hypertens 16:249-58. 2003
    ....
  60. doi request reprint Hypertension, systolic blood pressure, and large arteries
    Michel E Safar
    Assistance Publique Hopitaux de Paris, Hotel Dieu, Centre de Diagnostic et de Thérapeutique, Universite Paris Descartes, Paris Cedex 04, Paris, France
    Med Clin North Am 93:605-19, Table of Contents. 2009
    ....
  61. ncbi request reprint Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases
    Michel E Safar
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Circulation 107:2864-9. 2003
  62. ncbi request reprint Spironolactone improves carotid artery fibrosis and distensibility in rat post-ischaemic heart failure
    Johnny A Nehme
    Cardiovascular Research Center Lariboisiere Inserm U689, Paris, France
    J Mol Cell Cardiol 39:511-9. 2005
    ..Only spironolactone reduced the stiffness of carotid wall material independently of blood pressure and WS...
  63. ncbi request reprint Hypertension in women
    Michel E Safar
    Hopital Broussais, Paris, France
    Am J Hypertens 17:82-7. 2004
    ....
  64. ncbi request reprint Arterial aging--hemodynamic changes and therapeutic options
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Nat Rev Cardiol 7:442-9. 2010
    ..Consistent reductions in cardiovascular outcomes obtained using these agents can be predicted through noninvasive measurements of central systolic blood pressure and pulse pressure...
  65. doi request reprint Pulse pressure, arterial stiffness and wave reflections (augmentation index) as cardiovascular risk factors in hypertension
    Michel E Safar
    Paris Descartes University 5, Centre de Diagnostic, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    Ther Adv Cardiovasc Dis 2:13-24. 2008
    ..Nowadays, it is largely admitted that the BP curve should be characterized from pulsatile arterial hemodynamics, thus leading to the definition of novel indices in CV epidemiology. The present chapter details these new aspects...
  66. doi request reprint Pulse pressure and dual angiotensin blockade
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, Hotel Dieu Hospital, Diagnosis Center, Paris, France
    Am J Hypertens 21:133. 2008
  67. ncbi request reprint Systolic hypertension in the elderly: arterial wall mechanical properties and the renin-angiotensin-aldosterone system
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    J Hypertens 23:673-81. 2005
    ..The mechanisms for such alterations remain largely unknown...
  68. ncbi request reprint Aortic pulse wave velocity: an independent marker of cardiovascular risk
    Michel E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, 75674 Paris, France
    Am J Geriatr Cardiol 11:295-8. 2002
    ..Since aortic pulse wave velocity is dominantly influenced by age, this finding may be of major importance for the evaluation of cardiovascular risk in geriatric populations...
  69. ncbi request reprint Arterial stiffness and kidney function
    Michel E Safar
    Department of Internal Medicine, Hopital Broussais, 96 rue Didot, 75674, Paris Cedex 14, France
    Hypertension 43:163-8. 2004
    ..Whether sodium, divalent ionic species (calcium, phosphates), and the renin-angiotensin-aldosterone system play a role in such alterations remains to be elucidated...
  70. ncbi request reprint Relations between large artery structure and function and aldosterone
    Michel E Safar
    Universite Paris Descartes, Paris, France
    J Hypertens 29:1676-83. 2011
    ..This finding is observed mainly with the CC genotype and not the TT or the TC genotype of the aldosterone synthase gene polymorphism. Early identification of individuals presenting this genotype could be important to detect hypertension...
  71. ncbi request reprint Relationship between arterial distensibility and low-frequency power spectrum of blood pressure in spontaneously hypertensive rats
    Hubert Dabire
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Cardiovasc Pharmacol 39:98-106. 2002
    ....
  72. ncbi request reprint The heart, macrocirculation and microcirculation in hypertension: a unifying hypothesis
    Harry A J Struijker Boudier
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Hypertens Suppl 21:S19-23. 2003
    ..For correct understanding of the pathophysiology of hypertensive disease, its risks for target-organ damage and its effective treatment, both the pulsatile and steady components of the blood pressure curve must be considered...
  73. ncbi request reprint C-reactive protein elevation predicts pulse pressure reduction in hypertensive subjects
    Jacques Amar
    Department of Internal Medicine and Hypertension, CHU Purpan, Toulouse Cedex 9, France
    Hypertension 46:151-5. 2005
    ..This effect is significantly associated with a more effective PP reduction in patients with baseline CRP >3 mg/L...
  74. ncbi request reprint Pulse pressure and arterial stiffness in rats: comparison with humans
    Michel E Safar
    Am J Physiol Heart Circ Physiol 285:H1363-9. 2003
  75. ncbi request reprint Peripheral pulse pressure, large arteries, and microvessels
    Michel E Safar
    Hypertension 44:121-2. 2004
  76. ncbi request reprint Aortic pulse pressure and extent of coronary artery disease in percutaneous transluminal coronary angioplasty candidates
    Francois Philippe
    Departement de Cardiologie, Institut Mutualiste Montsouris, Paris France
    Am J Hypertens 15:672-7. 2002
    ..Pulse pressure and aortic stiffness are both predictors of coronary artery disease. Whether these parameters are directly related to coronary structural alterations has never been studied...
  77. ncbi request reprint Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/indapamide in hypertensive subjects: comparison with atenolol
    Gerard M London
    Hopital Manhes, Fleury Merogis, France
    J Am Coll Cardiol 43:92-9. 2004
    ....
  78. ncbi request reprint Aldosterone antagonism and arterial stiffness
    Michel E Safar
    Hypertension 43:e3; author reply e3. 2004
  79. ncbi request reprint Aortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats
    Emmanuel Cosson
    INSERM Unité 660, ENVA Bâtiment Ferrando, 7 Avenue du General de Gaulle, Maisons Alfort F 94704, France
    Am J Physiol Heart Circ Physiol 292:H2506-12. 2007
    ..An intervention study should consider in the objectives systolic BP and PP amplifications measured in conscious animals, central control of body weight, and autonomic nervous system...
  80. ncbi request reprint Regression of left ventricular mass in hypertensive patients treated with perindopril/indapamide as a first-line combination: the REASON echocardiography study
    Nicola De Luca
    Clinica Medica, Napoli, Italy
    Am J Hypertens 17:660-7. 2004
    ..The aim of this study was to compare the effects of perindopril (2 mg)/indapamide (0.625 mg) first-line combination with atenolol (50 mg) on LVM reduction in hypertensive patients...
  81. ncbi request reprint Influence of lifestyle modification on arterial stiffness and wave reflections
    Hirofumi Tanaka
    Department of Kinesiology and Health Education, University of Texas, Austin, Texas, USA
    Am J Hypertens 18:137-44. 2005
    ..However, more information is needed for a full understanding and optimal use of lifestyle modifications in the management of arterial stiffening...
  82. ncbi request reprint Elevated pulse pressure is associated with low renal function in elderly patients with isolated systolic hypertension
    Jacobien C Verhave
    Department of Internal Medicine, CHU Montpellier, France
    Hypertension 45:586-91. 2005
    ....
  83. ncbi request reprint Letter by Safar and Fournier regarding article, "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study"
    Michel E Safar
    Circulation 114:e539; author reply e540-1. 2006
  84. ncbi request reprint Pulse pressure and antihypertensive agents
    Michel E Safar
    Hypertension 46:e6; author reply e6-7. 2005
  85. ncbi request reprint Obesity is associated with increased arterial stiffness from adolescence until old age
    Pantelis E Zebekakis
    The Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens 23:1839-46. 2005
    ..We therefore investigated whether the relationship between arterial stiffness and body mass index (BMI) was consistent across an age range from 10 to 86 years...
  86. ncbi request reprint Aortic stiffness, living donors, and renal transplantation
    Sola Aoun Bahous
    Nephrology and Transplantation Center, Rizk Hopsital, Beirut, Lebanon
    Hypertension 47:216-21. 2006
    ..Assessment of cause-effect relationships and implication of biochemical and/or genetic factors warrant additional studies...
  87. ncbi request reprint Increased pulse pressure amplification in treated hypertensive subjects with metabolic syndrome
    Athanase D Protogerou
    Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece
    Am J Hypertens 20:127-33. 2007
    ..The objective of this study was to investigate whether PP amplification is affected by MS and is related to cardiovascular (CV) risk...
  88. ncbi request reprint [Blood pressure profile along the arterial tree and genetics of hypertension]
    Luiz Aparecido Bortolotto
    Instituto do Coracao, Hospital das Clinicas, FMUSP, Sao Paulo, SP
    Arq Bras Cardiol 86:166-9. 2006
  89. ncbi request reprint Sodium, arterial stiffness, and cardiovascular mortality in hypertensive rats
    Nathalie Mercier
    INSERM, U684, Nancy, France Université Henri Poincaré, UFR Medecine, Nancy, France
    Am J Hypertens 20:319-25. 2007
    ..We examined the effects of early high salt diet (HSD) and angiotensin II type 1 (AT1) receptor antagonist valsartan (Val) on mortality and carotid distensibility in surviving spontaneously hypertensive rats (SHRs)...
  90. ncbi request reprint Twenty-four-hour ambulatory blood pressure monitoring efficacy of perindopril/indapamide first-line combination in hypertensive patients: the REASON study
    Jean Michel Mallion
    Cardiologie et Hypertension Arterielle, Service de Médecine Interne et Cardiologie, Hopital A Michallon CHU, BP 217, 38043 Grenoble Cedex, France
    Am J Hypertens 17:245-51. 2004
    ..The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0.625 mg versus atenolol 50 mg on BP parameters and variability over 24 h in patients with hypertension...
  91. doi request reprint Methods for transfer function assessment
    Michael F O'Rourke
    J Hypertens 26:377-8; author reply 378-9. 2008
  92. doi request reprint A preliminary evaluation of the mean arterial pressure as measured by cuff oscillometry
    Harold Smulyan
    Department of Medicine, Upstate Medical University, State University of New York, Syracuse, New York, USA
    Am J Hypertens 21:166-71. 2008
    ..The oscillometric brachial MBP could therefore serve as a surrogate for aortic MBP and might be a valuable non-invasive risk predictor...
  93. ncbi request reprint Proximal aortic diameter and aortic pressure-flow relationship in systolic hypertension
    Michael F O'Rourke
    Circulation 109:e227-8; author reply e227-8. 2004
  94. ncbi request reprint Pulse pressure amplification, adiposity and metabolic syndrome in subjects under chronic antihypertensive therapy: the role of heart rate
    Anne Claire Vergnaud
    INSERM U557, INRA U1125CNAM EA3200, Iniv Paris 13, CRNH IdF, Bobigny, F 93017 France
    Atherosclerosis 199:222-9. 2008
    ..However, the relationships of BMI, WC and metabolic syndrome (MS) with central wave reflections and pulse pressure (PP) amplification have never been investigated...
  95. ncbi request reprint Central blood pressure measurements and antihypertensive therapy: a consensus document
    Enrico Agabiti-Rosei
    Clinica Medica and Department of Medicine, University Hospital, Brescia, Italy
    Hypertension 50:154-60. 2007
  96. ncbi request reprint Selective reduction of cardiac mass and central blood pressure on low-dose combination perindopril/indapamide in hypertensive subjects
    Nicola De Luca
    Universita degli Studi Federico II, Naples, Italy
    J Hypertens 22:1623-30. 2004
    ..The objective was to determine whether changes in LVM under drug treatment was preferentially associated with changes in central or brachial SBP and PP...
  97. ncbi request reprint Selective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats
    Pierre Albaladejo
    Department of Anesthesiology, Beaujon Hospital, Clichy, France
    J Hypertens 22:1739-45. 2004
    ..The heart rate (HR) reduction obtained by ivabradine is associated in rats with a decrease in diastolic blood pressure (DBP) and mean blood pressure (MBP), and with an increased pulsatile carotid arterial diameter...
  98. ncbi request reprint The X-cellent Study
    Michel E Safar
    Am J Hypertens 19:8-9. 2006