M E Safar

Summary

Country: France

Publications

  1. ncbi request reprint Gender influence on metabolic syndrome's effects on arterial stiffness and pressure wave reflections in treated hypertensive subjects
    Athanase D Protogerou
    Diagnosis and Therapeutic Center, Hotel Dieu Hospital, Paris, France
    Atherosclerosis 193:151-8. 2007
  2. doi request reprint Can antihypertensive treatment reverse large-artery stiffening?
    Michel E Safar
    Centre de Diagnostic et de Thérapeutique, Hôtel Dieu 1 Place du Parvis Notre Dame, Paris Cedex 04, France
    Curr Hypertens Rep 12:47-51. 2010
  3. doi request reprint Relations between large artery structure and function and aldosterone
    Michel E Safar
    Universite Paris Descartes, Paris, France
    J Hypertens 29:1676-83. 2011
  4. doi request reprint Pulsatile hemodynamics and cardiovascular risk factors in very old patients: background, sex aspects and implications
    Michel E Safar
    Paris Descartes University, Faculty of Medicine Hôtel Dieu Hospital AP HP, Diagnosis Center, Paris, France
    J Hypertens 31:848-57. 2013
  5. doi request reprint Hypertension and vascular dynamics in men and women with metabolic syndrome
    Michel E Safar
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    J Am Coll Cardiol 61:12-9. 2013
  6. pmc Effect of angiotensin II blockade on central blood pressure and arterial stiffness in subjects with hypertension
    Michel E Safar
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hôtel Dieu Centre de Diagnostic et de Thérapeutique, Paris, France
    Int J Nephrol Renovasc Dis 3:167-73. 2010
  7. doi request reprint Pulse pressure, arterial stiffness, and end-organ damage
    Michel E Safar
    Paris Descartes University AP HP Diagnosis and Therapeutic Center, Hotel Dieu, 1, Place du Parvis Notre Dame, 75181, Paris Cedex 04, France
    Curr Hypertens Rep 14:339-44. 2012
  8. doi request reprint Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness
    Sola Aoun Bahous
    Division of Nephrology and Hypertension, Centre Hospitalier du Nord, Zgharta, Lebanon
    Nephrol Dial Transplant 27:2095-100. 2012
  9. doi request reprint Antihypertensive therapy and de-stiffening of the arteries
    Michel E Safar
    Centre de Diagnostic et de Thérapeutique, Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris Cedex 04 France
    Expert Opin Pharmacother 11:2625-34. 2010
  10. doi request reprint Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study
    Michel E Safar
    Universite Paris Descartes, Paris, France
    Hypertens Res 34:91-7. 2011

Collaborators

Detail Information

Publications145 found, 100 shown here

  1. ncbi request reprint Gender influence on metabolic syndrome's effects on arterial stiffness and pressure wave reflections in treated hypertensive subjects
    Athanase D Protogerou
    Diagnosis and Therapeutic Center, Hotel Dieu Hospital, Paris, France
    Atherosclerosis 193:151-8. 2007
    ..Whether PWV and AI are correlated and reflect CV risk in hypertensive men and women with metabolic syndrome (MS) remains unknown...
  2. doi request reprint Can antihypertensive treatment reverse large-artery stiffening?
    Michel E Safar
    Centre de Diagnostic et de Thérapeutique, Hôtel Dieu 1 Place du Parvis Notre Dame, Paris Cedex 04, France
    Curr Hypertens Rep 12:47-51. 2010
    ..Cardiovascular outcomes have been significantly improved when compared with controls, but most of them have been treated with beta blockers. Such "de-stiffening" therapies are important to consider and require additional trials...
  3. doi request reprint Relations between large artery structure and function and aldosterone
    Michel E Safar
    Universite Paris Descartes, Paris, France
    J Hypertens 29:1676-83. 2011
    ..This finding is observed mainly with the CC genotype and not the TT or the TC genotype of the aldosterone synthase gene polymorphism. Early identification of individuals presenting this genotype could be important to detect hypertension...
  4. doi request reprint Pulsatile hemodynamics and cardiovascular risk factors in very old patients: background, sex aspects and implications
    Michel E Safar
    Paris Descartes University, Faculty of Medicine Hôtel Dieu Hospital AP HP, Diagnosis Center, Paris, France
    J Hypertens 31:848-57. 2013
    ..Such focus deflected attention from primary ageing changes, represented by stiffening and dilation of the proximal aorta...
  5. doi request reprint Hypertension and vascular dynamics in men and women with metabolic syndrome
    Michel E Safar
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    J Am Coll Cardiol 61:12-9. 2013
    ..This pulsatile hemodynamic abnormality contributes independently to increase age- and sex-mediated CV risk, justifying new research regarding Framingham scores and drug treatment...
  6. pmc Effect of angiotensin II blockade on central blood pressure and arterial stiffness in subjects with hypertension
    Michel E Safar
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hôtel Dieu Centre de Diagnostic et de Thérapeutique, Paris, France
    Int J Nephrol Renovasc Dis 3:167-73. 2010
    ....
  7. doi request reprint Pulse pressure, arterial stiffness, and end-organ damage
    Michel E Safar
    Paris Descartes University AP HP Diagnosis and Therapeutic Center, Hotel Dieu, 1, Place du Parvis Notre Dame, 75181, Paris Cedex 04, France
    Curr Hypertens Rep 14:339-44. 2012
    ..For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly...
  8. doi request reprint Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness
    Sola Aoun Bahous
    Division of Nephrology and Hypertension, Centre Hospitalier du Nord, Zgharta, Lebanon
    Nephrol Dial Transplant 27:2095-100. 2012
    ..This risk is attributed mostly to recipient-related risk factors. Donor vascular characteristics, such as arterial stiffness, have been poorly investigated in this regard...
  9. doi request reprint Antihypertensive therapy and de-stiffening of the arteries
    Michel E Safar
    Centre de Diagnostic et de Thérapeutique, Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris Cedex 04 France
    Expert Opin Pharmacother 11:2625-34. 2010
    ..Systolic blood pressure and pulse pressure in the ascending aorta exceeds brachial systolic and pulse pressure significantly...
  10. doi request reprint Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study
    Michel E Safar
    Universite Paris Descartes, Paris, France
    Hypertens Res 34:91-7. 2011
    ..This new aspect of the MetS might modify clinical management leading to earlier drug treatment, particularly in regard to both endothelial dysfunction and increased arterial stiffness...
  11. doi request reprint Arterial aging--hemodynamic changes and therapeutic options
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Nat Rev Cardiol 7:442-9. 2010
    ..Consistent reductions in cardiovascular outcomes obtained using these agents can be predicted through noninvasive measurements of central systolic blood pressure and pulse pressure...
  12. doi request reprint Central blood pressure and hypertension: role in cardiovascular risk assessment
    Michel E Safar
    Diagnosis Center, Paris Descartes University, Hotel Dieu Hospital, Paris, France
    Clin Sci (Lond) 116:273-82. 2009
    ....
  13. doi request reprint Hypertension, systolic blood pressure, and large arteries
    Michel E Safar
    Assistance Publique Hopitaux de Paris, Hotel Dieu, Centre de Diagnostic et de Thérapeutique, Universite Paris Descartes, Paris Cedex 04, Paris, France
    Med Clin North Am 93:605-19, Table of Contents. 2009
    ....
  14. doi request reprint Pulse pressure, arterial stiffness and wave reflections (augmentation index) as cardiovascular risk factors in hypertension
    Michel E Safar
    Paris Descartes University 5, Centre de Diagnostic, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    Ther Adv Cardiovasc Dis 2:13-24. 2008
    ..Nowadays, it is largely admitted that the BP curve should be characterized from pulsatile arterial hemodynamics, thus leading to the definition of novel indices in CV epidemiology. The present chapter details these new aspects...
  15. doi request reprint Arterial stiffness, pulse pressure, and cardiovascular disease-is it possible to break the vicious circle?
    Michel E Safar
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Centre de Diagnostic et de Thérapeutique, Paris Cedex 04, France
    Atherosclerosis 218:263-71. 2011
    ..These protocols were evaluated in randomized controlled trials and showed significant reduction in cardiovascular risk, particularly in comparison with beta-blockers...
  16. doi request reprint Pulse pressure and dual angiotensin blockade
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, Hotel Dieu Hospital, Diagnosis Center, Paris, France
    Am J Hypertens 21:133. 2008
  17. doi request reprint Cross-talk between macro- and microcirculation
    M E Safar
    Paris Descartes University, Paris, France
    Acta Physiol (Oxf) 198:417-30. 2010
    ..The purpose of this paper is to review the cross-talk between the micro- and macrocirculation. We shall discuss this cross-talk from the perspective of the development, physiology and pathology of the entire arterial tree...
  18. ncbi request reprint Mechanism(s) of systolic blood pressure reduction and drug therapy in hypertension
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, AP HP, Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Hypertension 50:167-71. 2007
  19. ncbi request reprint Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage
    Michel E Safar
    Faculty of Medicine, Paris Descartes University, Paris, France
    Am J Physiol Heart Circ Physiol 293:H1-7. 2007
    ....
  20. ncbi request reprint Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol
    R G Asmar
    , Paris, France
    Hypertension 38:922-6. 2001
    ....
  21. doi request reprint Aortic stiffness, inflammation, denutrition and prognosis in the oldest people
    J Blacher
    Paris Descartes University, AP HP, Diagnosis and Therapeutic Center, Hotel Dieu, Paris, France
    J Hum Hypertens 26:518-24. 2012
    ..In conclusion, although marginally significant in crude analysis, PWV is a powerful determinant of prognosis in the oldest people taking into account inflammation and denutrition...
  22. ncbi request reprint Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension
    J J Mourad
    , , Paris, France
    Kidney Int 59:1834-41. 2001
    ....
  23. ncbi request reprint Arterial stiffness and wave reflections following acute calcium blockade in essential hypertension
    B M Pannier
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 7:168-76. 1994
    ..abstract truncated at 250 words)..
  24. ncbi request reprint Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure
    A P Guerin
    , , , , , Paris, France
    Circulation 103:987-92. 2001
    ....
  25. ncbi request reprint Stiffness of carotid artery wall material and blood pressure in humans: application to antihypertensive therapy and stroke prevention
    M E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Stroke 31:782-90. 2000
    ....
  26. doi request reprint Aortic stiffness, inflammation, denutrition and type 2 diabetes in the elderly
    J Blacher
    HTA Unit, Diagnosis and Therapeutic Center, Paris Descartes University, Paris 5, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    Diabetes Metab 38:68-75. 2012
    ....
  27. ncbi request reprint Effects of valsartan on mechanical properties of the carotid artery in spontaneously hypertensive rats under high-salt diet
    C Labat
    INSERM U337, Paris, France
    Hypertension 38:439-43. 2001
    ..Despite a reduction in mean arterial pressure in HSD rats, AT(1) blockade was not able to prevent the effects of a HSD on pulse pressure, carotid artery stiffness, and hypertrophy...
  28. ncbi request reprint Remodeling of heart and arteries by chronic converting enzyme inhibition in spontaneously hypertensive rats
    B I Levy
    , Paris, France
    Am J Hypertens 4:240S-245S. 1991
    ..Dissociation between cardiac and arterial changes may be observed...
  29. doi request reprint Preferential association of aldosterone synthase gene polymorphism with central blood pressure and wave reflections in hypertensive individuals
    J Blacher
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    J Hum Hypertens 24:291-9. 2010
    ..The result was observed only for CC and TC genotypes. Such findings are observed when central, but not brachial, haemodynamic measurements are performed...
  30. ncbi request reprint Amelioration of arterial properties with a perindopril-indapamide very-low-dose combination
    R G Asmar
    L'Institut CardioVasculaire, Paris, France
    J Hypertens Suppl 19:S15-20. 2001
    ....
  31. ncbi request reprint Assessment of vascular aging and atherosclerosis in hypertensive subjects: second derivative of photoplethysmogram versus pulse wave velocity
    L A Bortolotto
    Department of Internal Medicine and Inserm U 337, Broussais Hospital, Paris, France
    Am J Hypertens 13:165-71. 2000
    ..However, the SDPTG AI may be useful for evaluation of vascular aging in hypertensives...
  32. ncbi request reprint Pressure-independent contribution of sodium to large artery structure and function in hypertension
    M E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Cardiovasc Res 46:269-76. 2000
    ..Sodium sensitivity is usually studied in terms of change of blood pressure (BP) but the specific effects on conduit arteries have not been addressed...
  33. doi request reprint [Pressure wave shape comparison between two non-invasive tonometric devices]
    D Agnoletti
    Centre de Diagnostic et de Thérapeutique, Paris Descartes University, Hotel Dieu, AP HP, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Ann Cardiol Angeiol (Paris) 62:193-9. 2013
    ..The aim of our study was to further quantify differences on radial and carotid signals from the two devices...
  34. ncbi request reprint Influence of sex and body weight on forearm hemodynamics in patients with sustained essential hypertension
    J H Raison
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 4:820-6. 1991
    ..This study provides evidence that body composition and body mass index evolve as determinants of arterial blood velocity whereas the gender of the patient seems to influence the arterial diameter...
  35. doi request reprint Cardiovascular prevention: relationships between arterial aging and chronic drug treatment
    A Lieber
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hotel Dieu, Centre de Diagnostic et de Thérapeutique, Paris, France
    J Hum Hypertens 25:524-31. 2011
    ..Treatment of CV prevention involves alterations of the arterial wall depending on drug class. β-Blocking agents and insulin are associated with the higher increases of central PP...
  36. ncbi request reprint Arterial structural changes with verapamil in spontaneously hypertensive rats
    I Koffi
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Am J Hypertens 12:732-8. 1999
    ....
  37. ncbi request reprint Distension capacity of the carotid artery and ambulatory blood pressure monitoring. Effects of age and hypertension
    R S Cunha
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 8:343-52. 1995
    ..Thus, in addition to the level of blood pressure, carotid artery distension is specifically influenced by two factors independently implicated in the epidemiologic cardiovascular risk: pulse pressure and heart rate...
  38. ncbi request reprint Life survival and cardiovascular structures following selective beta-blockade in spontaneously hypertensive rats
    A Benetos
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 7:186-92. 1994
    ..These results provide evidence that 2 months of selective beta-blockade in adult SHR has an important antihypertrophic cardiac and vascular effect.(ABSTRACT TRUNCATED AT 250 WORDS)..
  39. ncbi request reprint Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations
    R Asmar
    L'Institut CardioVasculaire, Paris, France
    Am J Hypertens 14:91-7. 2001
    ..00; 95% confidence intervals: 0.99-1.01). CONCLUSION: In cross-sectional hypertensive populations, PP and PWV, but not CAI, are significantly and independently associated with cardiovascular amplications...
  40. ncbi request reprint Pulse pressure, arterial stiffness, and cardiovascular risk
    M E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Curr Opin Cardiol 15:258-63. 2000
    ....
  41. pmc Influence of graded changes in vasomotor tone on the carotid arterial mechanics in live spontaneously hypertensive rats
    P Lacolley
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Br J Pharmacol 115:1235-44. 1995
    ....
  42. ncbi request reprint Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors
    M E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Curr Opin Nephrol Hypertens 10:257-61. 2001
    ..The solution of this important question requires the development of specific intervention trials...
  43. doi request reprint Aortic wave reflection in women and men
    Ari Lieber
    Paris Descartes University, Assistance Publique Hopitaux de Paris, Diagnosis and Therapeutic Center, 1 Place du Parvis Notre Dame, Paris Cedex 04, France
    Am J Physiol Heart Circ Physiol 299:H236-42. 2010
    ..This finding relates to sex differences in body size and mostly brachial-carotid PP amplification, a parameter highly related to the sex difference of cardiovascular risk...
  44. ncbi request reprint Should diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women
    A Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    J Am Coll Cardiol 37:163-8. 2001
    ..The goal of this study was to evaluate the role of diastolic blood pressure (DBP) in cardiovascular mortality for different systolic blood pressure (SBP) levels in middle-aged men and women...
  45. ncbi request reprint Renal hemodynamics in patients with sustained essential hypertension and in patients with unilateral stenosis of the renal artery
    G M London
    Diagnostic Center, Broussais Hospital, Paris, France
    Am J Hypertens 2:244-52. 1989
    ..001). The Cin was positively correlated with CPAH in all kidneys in RVH or in EH.(ABSTRACT TRUNCATED AT 250 WORDS)..
  46. doi request reprint Peripheral arterial disease and isolated systolic hypertension: the ATTEST study
    M E Safar
    Faculte de Medecine, Hotel Dieu Hospital, Universite Paris Descartes, Paris, France
    J Hum Hypertens 23:182-7. 2009
    ..Finally, one of the predominant goals of secondary prevention in subjects with PAD should be the treatment of isolated systolic hypertension...
  47. ncbi request reprint Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension
    J Blacher
    Department of Internal Medicine and INSERM (U 337, Broussais Hospital, Paris, France
    Am J Hypertens 10:1326-34. 1997
    ..Taken together, these findings strongly suggest that significant interactions exist between aldosterone and central conduit arteries and that aldosterone might modulate arterial function in subjects with essential hypertension...
  48. ncbi request reprint Enhanced brachial artery compliance following perindopril in essential hypertension
    R G Asmar
    Diagnosis Center, Broussais Hospital, Paris, France
    Am J Hypertens 1:103S-105S. 1988
    ....
  49. ncbi request reprint Diastolic blood pressure and mortality in the elderly with cardiovascular disease
    Athanase D Protogerou
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Hypertension 50:172-80. 2007
    ....
  50. ncbi request reprint Large-artery stiffness, hypertension and cardiovascular risk in older patients
    Jacques Blacher
    Diagnosis Center, Hopital Hotel Dieu, Paris, France
    Nat Clin Pract Cardiovasc Med 2:450-5. 2005
    ..Here we discuss the structural and functional factors that influence arterial stiffness, wave reflections and pulse pressure in hypertension, as well as their related roles in cardiovascular risk...
  51. ncbi request reprint Renal and systemic hemodynamics in borderline hypertension
    G M London
    Diagnosis Center, Broussais Hospital, Paris, France
    Am J Hypertens 1:127S-130S. 1988
    ..No significant changes in glomerular filtration rate and renal filtration fraction were observed. The study clearly demonstrated that renal ischemia was absent in young patients with borderline hypertension...
  52. ncbi request reprint Influence of diuretics on brachial artery diameter and distensibility in hypertensive patients
    S Laurent
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Fundam Clin Pharmacol 4:685-93. 1990
    ..The study indicates that, in hypertensive patients of middle age, diuretics did not change brachial artery diameter and distensibility, whether the drug caused an increase or a decrease in plasma potassium levels...
  53. ncbi request reprint Vascular effects of intravenous infusion of the angiotensin converting enzyme inhibitor perindoprilat
    A Benetos
    Department of Internal Medicine, Broussais Hospital, Paris, France
    J Hypertens 8:819-26. 1990
    ..01).(abstract truncated at 250 words)..
  54. ncbi request reprint Role of adrenergic tone in mechanical and functional properties of carotid artery during aging
    A Benetos
    Institut National de la Santé et de la Recherche Médicale U 337, Paris, France
    Am J Physiol 265:H1132-8. 1993
    ..We suggest that with aging there is an increased vasoconstricting effect of alpha-agonists and a decreased vasodilatative action of alpha-blockade.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi request reprint Is there any additional prognostic value of central blood pressure wave forms beyond peripheral blood pressure?
    Miso Sabovic
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Curr Pharm Des 15:254-66. 2009
    ..Crucially, we will review data supporting the view that improvement of central blood pressure can result in reduction of cardiovascular events. Lastly, the future perspectives in this exciting and promising field will be presented...
  56. ncbi request reprint Arterial stiffness and central hemodynamics in treated hypertensive subjects according to brachial blood pressure classification
    Michel E Safar
    AP HP Diagnosis Center, Hotel Dieu Hospital, Faculty of Medicine, Paris Descartes University, Paris, France michel safarhtd aphp fr
    J Hypertens 26:130-7. 2008
    ..Central BP has never been studied in relation to international guidelines for brachial BP classification...
  57. ncbi request reprint From 'optimal' to 'borderline' blood pressure in subjects under chronic antihypertensive therapy
    Anne Claire Vergnaud
    U557 INSERM UMR INSERM INRA CNAM, CRNH Ile de France, Paris, France
    J Hypertens 26:138-44. 2008
    ..Differences between these groups in arterial stiffness, pressure wave reflections and central blood pressure, which are all predictors of cardiovascular risk independently of peripheral blood pressure, have never been studied...
  58. ncbi request reprint Vascular development, pulse pressure, and the mechanisms of hypertension
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Hypertension 46:205-9. 2005
    ..We suggest that hypertension results from early developmental vascular mechanisms that direct BP toward the higher percentiles of the Gaussian distribution curve...
  59. ncbi request reprint Heart rate and pulse pressure amplification in hypertensive subjects
    Pierre Laurent
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 16:363-70. 2003
    ..Amplification of PP is known to be influenced by heart rate (HR), but the impact of this alteration has never been tested in patients with hypertension...
  60. ncbi request reprint [New goals in hypertension management: target-organ protection beyond blood pressure lowering]
    Michel E Safar
    Service de Medecine Interne, Hopital Broussais, Paris, France
    Drugs 63:45-7. 2003
    ....
  61. ncbi request reprint Difference in response of vascular resistance to orthostasis in patients with borderline and sustained essential hypertension
    G M London
    Diagnosis Center, Broussais Hospital, Paris, France
    Am J Hypertens 1:110S-112S. 1988
    ..The latter result suggests an abnormality in the autonomic nervous control in patients with borderline hypertension, possibly mediated by cardiopulmonary mechanoreceptors in the low pressure system...
  62. doi request reprint [Focus on beta-blockers for vascular specialists in 2012]
    S Mairesse
    Unité d hypertension artérielle, prévention et thérapeutique cardiovasculaires, Centre de Diagnostic et de Thérapeutique, Universite Paris Descartes, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    J Mal Vasc 36:339-47. 2011
    ..Finally, except for patients with critical ischemia of the lower limbs, presence of peripheral artery disease should probably be considered as a condition favoring their prescription...
  63. ncbi request reprint Therapeutic studies and arterial stiffness in hypertension: recommendations of the European Society of Hypertension. The Clinical Committee of Arterial Structure and Function. Working Group on Vascular Structure and Function of the European Society of Hyp
    M E Safar
    Department of Internal Medicine, Hospital Broussais, Paris, France
    J Hypertens 18:1527-35. 2000
    ..Under conventional treatment, normalization of DBP (< or = 90 mmHg) is not consistently associated with normalization of SBP (< or = 140 mmHg)...
  64. ncbi request reprint Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study
    J Raison
    Department of Internal Medicine, Broussaia Hospital, Paris, France
    J Hum Hypertens 16:705-10. 2002
    ....
  65. ncbi request reprint Response to the cold pressor test in normotensive and hypertensive patients
    A Benetos
    Hypertension Department, Broussais Hospital, Paris, France
    Am J Hypertens 4:627-9. 1991
    ..Therefore it is unlikely that CPT may be used as a predictor test of future hypertension in this population.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi request reprint Hemodynamic changes in elderly hypertensive patients
    M E Safar
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 6:20S-23S. 1993
    ....
  67. ncbi request reprint Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases
    Michel E Safar
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Circulation 107:2864-9. 2003
  68. ncbi request reprint Arterial stiffness: a simplified overview in vascular medicine
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:1-18. 2007
    ..Arterial elasticity is a common index of medical semiology, easier to understand than blood pressure measurement. This chapter summarizes the most classical aspects which are important to understand in vascular medicine...
  69. ncbi request reprint Large artery stiffness and antihypertensive agents
    Jacques Blacher
    Hypertension and Cardiovascular Prevention Unit, Centre de Diagnostic, Hotel Dieu, AP HP, Place du Parvis Notre Dame, 75004 Paris, France
    Curr Pharm Des 11:3317-26. 2005
    ....
  70. ncbi request reprint Metabolic syndrome and age-related progression of aortic stiffness
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    J Am Coll Cardiol 47:72-5. 2006
    ..Metabolic syndrome involves an increased progression of arterial stiffness with age and, thus, favors premature senescence...
  71. ncbi request reprint Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
    ....
  72. ncbi request reprint Pulse pressure: a help in medical semiology for metabolic syndrome
    Michel E Safar
    Paris Descartes University AP HP, Hotel Dieu Hospital, Diagnosis Center, Paris, France
    Am J Hypertens 20:204-5. 2007
  73. ncbi request reprint Pulse pressure monitoring of open antihypertensive therapy
    Michel E Safar
    Diagnostic Center, Hopital Hotel Dieu, 75181 Paris, France
    Am J Hypertens 17:1088-94. 2004
    ..Pulse pressure (PP) >60 mm Hg is an independent predictor of cardiovascular (CV) risk. Controlled studies showed that, unlike systolic and diastolic blood pressure (BP), PP responds minimally to placebo or no treatment...
  74. ncbi request reprint Central blood pressures: do we need them in the management of cardiovascular disease? Is it a feasible therapeutic target?
    Athanase D Protogerou
    Diagnostic and Therapeutic Center, Hotel Dieu Hospital, Paris, France
    J Hypertens 25:265-72. 2007
    ....
  75. ncbi request reprint Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure
    Michel E Safar
    Medecine Interne 1, Hopital Broussais, Paris, France
    J Hypertens 20:1653-61. 2002
    ..A low-dose combination of perindopril (Per) and indapamide (Ind) has been shown to reduce more SBP than atenolol for the same DBP reduction. However, the possible influence of gender on this finding has never been tested...
  76. ncbi request reprint Blood pressure components in clinical hypertension
    Michel E Safar
    Hopital Hotel Dieu, Paris, France
    J Clin Hypertens (Greenwich) 8:659-66. 2006
    ....
  77. doi request reprint Urinary aldosterone-to-active-renin ratio: a useful tool for predicting resolution of hypertension after adrenalectomy in patients with aldosterone-producing adenomas
    Jean Jacques Mourad
    Hypertension Unit, Avicenne Hospital, AP HP, Paris XIII University EA 3412, Paris, France
    Am J Hypertens 21:742-7. 2008
    ..The purpose of this study was to determine the preoperative clinical and biological factors that predict the clinical outcomes after surgery, in subjects with aldosterone-producing adenomas (APAs)...
  78. ncbi request reprint Dissociation between central augmentation index and carotid-femoral pulse-wave velocity: when and why?
    Athanase D Protogerou
    Diagnosis Center, Faculty of Medicine, Paris Descartes University, Hotel Dieu Hospital, Paris, France
    Am J Hypertens 20:648-9. 2007
  79. ncbi request reprint Systolic hypertension in elderly patients
    Michel E Safar
    Diagnosis Center, Hopital Hotel Dieu, Paris, France
    Semin Cardiothorac Vasc Anesth 10:203-5. 2006
    ..In older subjects, systolic blood pressure and pulse pressure are higher, whereas diastolic blood pressure is lower than in younger subjects...
  80. ncbi request reprint Atherosclerosis, arterial stiffness and antihypertensive drug therapy
    Michel E Safar
    The Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Adv Cardiol 44:331-51. 2007
    ....
  81. ncbi request reprint Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: effect of eplerenone
    Johnny Nehme
    INSERM U572, Paris, France
    J Renin Angiotensin Aldosterone Syst 7:31-9. 2006
    ..Our aim was to determine in vivo the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on simultaneous changes in cardiac and arterial structure and function and their interactions...
  82. ncbi request reprint Obesity, arterial stiffness, and cardiovascular risk
    Michel E Safar
    Hypertension and Cardiovascular Prevention Unit, Diagnosis Center, Hotel Dieu Hospital, 75181 Paris Cedex 04, France
    J Am Soc Nephrol 17:S109-11. 2006
    ..This report focuses on the role of arterial stiffness in individuals with obesity and on the association between this hemodynamic feature and cardiovascular risk...
  83. ncbi request reprint Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension
    Annie Rudnichi
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Am J Hypertens 17:321-7. 2004
    ..Few studies have examined to what extent genes might modulate the changes of systolic and diastolic blood pressure (BP) with age although, in older populations, systolic BP and diastolic BP vary with age in opposite directions...
  84. ncbi request reprint Pulse pressure, heart rate, and drug treatment of hypertension
    Michel E Safar
    Centre de Diagnostic, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris 04, France
    Curr Hypertens Rep 6:190-4. 2004
    ....
  85. ncbi request reprint Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension
    Michel E Safar
    Diagnosis Centre, Hotel Dieu Hospital, Paris, France
    J Hypertens 23:1159-66. 2005
    ..Whether the aldosterone synthase gene polymorphism (ASGP) CYP11B2 influences the age-related changes in blood pressure (BP) and arterial stiffness in hypertensive subjects has never been investigated...
  86. doi request reprint Macro and microvasculature in hypertension: therapeutic aspects
    M E Safar
    Faculty of Medicine, Diagnosis and Therapeutic Center, AP HP, Hotel Dieu Hospital, Paris Descartes University, Paris, France
    J Hum Hypertens 22:590-5. 2008
    ....
  87. ncbi request reprint Structural and functional arterial properties in patients with obstructive sleep apnoea syndrome and cardiovascular comorbidities
    A D Protogerou
    Diagnostic Center, Hotel Dieu Hospital, Paris, France
    J Hum Hypertens 22:415-22. 2008
    ..In conclusion, arterial stiffening and thickening are modulated by the severity of OSAS, independently from age and cardiovascular risk factors...
  88. ncbi request reprint Hemodynamic effects of the anti-hypertensive agent ketanserin in hypertension in man
    Y A Weiss
    Diagnosis Center, Broussais Hospital, Paris
    Acta Cardiol 42:329-37. 1987
    ....
  89. ncbi request reprint Homocysteine, folic acid, B vitamins and cardiovascular risk
    J Blacher
    Department of Internal Medicine, Broussais Hospital, APHP, Paris, France
    J Nutr Health Aging 5:196-9. 2001
    ..Several interventional trials are underway and the answer of whether there is a cardiovascular benefit through folic acid plus B vitamins supplementation in different populations will be available in the years to come...
  90. ncbi request reprint Hypertension in women
    Michel E Safar
    Hopital Broussais, Paris, France
    Am J Hypertens 17:82-7. 2004
    ....
  91. ncbi request reprint Improvement of impaired coronary vasodilator reserve in hypertensive patients by low-dose ACE inhibitor/diuretic therapy: a pilot PET study
    Jean Jacques Mourad
    St Michel Hospital, Paris, France
    J Renin Angiotensin Aldosterone Syst 4:94-5. 2003
  92. ncbi request reprint Aortic pulse wave velocity index and mortality in end-stage renal disease
    Jacques Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Kidney Int 63:1852-60. 2003
    ..Nevertheless, because age, blood pressure, heart rate, and gender are strong determinants of both arterial stiffness and mortality, the individual relevance of PWV measurements remains controversial...
  93. ncbi request reprint Factors influencing arterial stiffness in systolic hypertension in the elderly: role of sodium and the renin-angiotensin system
    Michel E Safar
    Department of Internal Medicine MES, Broussais Hospital, Paris, France
    Am J Hypertens 16:249-58. 2003
    ....
  94. doi request reprint The Data from an Epidemiologic Study on the Insulin Resistance Syndrome Study: the change and the rate of change of the age-blood pressure relationship
    Michel E Safar
    Paris Descartes University, Faculty of Medicine, Hotel Dieu Hospital, France
    J Hypertens 26:1903-11. 2008
    ..Whether the rates of change of SBP and DBP with age exhibit a similar dissociation has never been investigated...
  95. doi request reprint Cardiovascular risk as defined in the 2003 European blood pressure classification: the assessment of an additional predictive value of pulse pressure on mortality
    Frederique Thomas
    Centre d Investigations Préventives et Cliniques, Hotel Dieu Hospital, AP HP, University Paris 5, Paris, France
    J Hypertens 26:1072-7. 2008
    ..This study determines the predictive value of brachial pulse pressure for cardiovascular stroke and coronary mortality in a large population categorized by blood pressure level...
  96. ncbi request reprint Age-related increase of pulse pressure and gene polymorphisms in essential hypertension: a preliminary study
    Jean Jacques Mourad
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    J Renin Angiotensin Aldosterone Syst 3:109-15. 2002
    ..In subjects with essential hypertension, genes may modulate the age-mediated increase of PP. This finding gives new insights in the interactions between genes, mechanical factors and cardiovascular risk...
  97. ncbi request reprint Angiotensin-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Arterioscler Thromb Vasc Biol 24:782-6. 2004
    ....
  98. ncbi request reprint Aortic stiffness, kidney disease, and renal transplantation
    Sola Aoun Bahous
    Diagnosis and Therapeutic Center, Hopital Hotel Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Curr Hypertens Rep 11:98-103. 2009
    ..This alteration potentially initiates renal damage and favors CV events. In subjects with end-stage renal disease and high CV risk, pharmacologic modulation of the renin-angiotensin system might prevent CKD progression and CV events...
  99. ncbi request reprint Determinants of hypertension control in a large French population of treated hypertensive subjects
    Olivier Roux
    Centre de Diagnostic, Hopital Hotel Dieu, AP HP, Universite Paris 5, Paris, France
    Blood Press 15:6-13. 2006
    ..In conclusion, this study has shown poor blood pressure control in a primary care-recruited population, especially in males and in the elderly...
  100. ncbi request reprint Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
    Paul Milliez
    Department of Cardiology, Lariboisiere Hospital, Paris, France
    J Am Coll Cardiol 45:1243-8. 2005
    ..The aim of this report was to show that the rate of cardiovascular events is increased in patients with either subtype of primary aldosteronism (PA)...
  101. doi request reprint Predictive factors for all-cause mortality in the hospitalized elderly subject: the importance of arrhythmia
    Claire Vesin
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Atherosclerosis 207:507-13. 2009
    ..In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristics were associated with all-cause mortality...