D Saadoun

Summary

Country: France

Publications

  1. doi request reprint Azathioprine in severe uveitis of Behçet's disease
    D Saadoun
    Hôpital Pitié Salpétrière and Pierre et Marie Curie Paris VI University, Paris, France
    Arthritis Care Res (Hoboken) 62:1733-8. 2010
  2. doi request reprint Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24
    David Saadoun
    Department of Internal Medicine, Service de Medecine Interne, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Ann Rheum Dis 73:831-7. 2014
  3. doi request reprint Ethnicity and association with disease manifestations and mortality in Behçet's disease
    Lea Savey
    Department of Internal Medicine and Clinical Immunology, Centre de référence des maladies autoimmunes et systémiques rares, AP HP, Hopital Pitie Salpetriere, Paris, France
    Orphanet J Rare Dis 9:42. 2014
  4. doi request reprint Biotherapies in inflammatory ocular disorders: Interferons, immunoglobulins, monoclonal antibodies
    D Saadoun
    Service de médecine interne 2, AP HP, Groupe Hospitalier Pitie Salpetriere, Centre de référence des maladies autoimmunes rares, Universite Pierre et Marie Curie, Paris VI, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié Salpêtrière Paris, F 75013 France
    Autoimmun Rev 12:774-83. 2013
  5. doi request reprint Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation
    D Saadoun
    CNRS UMR 7211, INSERM U959, Groupe Hospitalier Pitie Salpetriere, and Universite Pierre et Marie Curie, Paris 6, Paris, France
    Arthritis Rheum 65:1085-96. 2013
  6. doi request reprint Using rituximab plus fludarabine and cyclophosphamide as a treatment for refractory mixed cryoglobulinemia associated with lymphoma
    D Saadoun
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Arthritis Care Res (Hoboken) 65:643-7. 2013
  7. pmc Behçet's disease
    David Saadoun
    Service de médecine interne 2, Centre de Référence Maladies Autoimmunes rares, CHU Pitie Salpetriere, 83 bd de l hopital, 75013, Paris, France
    Orphanet J Rare Dis 7:20. 2012
  8. doi request reprint Pseudotumoural presentation of neuro-Behcet's disease: case series and review of literature
    Nicolas Noel
    Service de Medecine Interne, AP HP, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris F 75013, France
    Rheumatology (Oxford) 51:1216-25. 2012
  9. doi request reprint [Management of antiphospholipid syndrome]
    D Saadoun
    Service de Medecine Interne, centre de référence national pour le lupus et le syndrome des antiphospholipides, CHU Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie Paris 6, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Med Interne 33:217-22. 2012
  10. doi request reprint Retrospective analysis of surgery versus endovascular intervention in Takayasu arteritis: a multicenter experience
    David Saadoun
    Service de médecine interne 2, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, Paris, France
    Circulation 125:813-9. 2012

Collaborators

Detail Information

Publications41

  1. doi request reprint Azathioprine in severe uveitis of Behçet's disease
    D Saadoun
    Hôpital Pitié Salpétrière and Pierre et Marie Curie Paris VI University, Paris, France
    Arthritis Care Res (Hoboken) 62:1733-8. 2010
    ..To investigate the efficacy and tolerance of azathioprine in severe uveitis related to Behçet's disease (BD)...
  2. doi request reprint Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24
    David Saadoun
    Department of Internal Medicine, Service de Medecine Interne, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Ann Rheum Dis 73:831-7. 2014
    ..About 30-40% of patients are non-responders or relapsers to such combination...
  3. doi request reprint Ethnicity and association with disease manifestations and mortality in Behçet's disease
    Lea Savey
    Department of Internal Medicine and Clinical Immunology, Centre de référence des maladies autoimmunes et systémiques rares, AP HP, Hopital Pitie Salpetriere, Paris, France
    Orphanet J Rare Dis 9:42. 2014
    ..Behçet's disease (BD) significantly increases morbidity and mortality. BD mainly affects young adults with a peculiar geographical distribution. It has been suggested that BD varies in its phenotypic expression in different ethnic groups...
  4. doi request reprint Biotherapies in inflammatory ocular disorders: Interferons, immunoglobulins, monoclonal antibodies
    D Saadoun
    Service de médecine interne 2, AP HP, Groupe Hospitalier Pitie Salpetriere, Centre de référence des maladies autoimmunes rares, Universite Pierre et Marie Curie, Paris VI, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié Salpêtrière Paris, F 75013 France
    Autoimmun Rev 12:774-83. 2013
    ..Its safety profile is good and with a quick action that could be interesting for the treatment of severe uveitis...
  5. doi request reprint Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation
    D Saadoun
    CNRS UMR 7211, INSERM U959, Groupe Hospitalier Pitie Salpetriere, and Universite Pierre et Marie Curie, Paris 6, Paris, France
    Arthritis Rheum 65:1085-96. 2013
    ..Primary Sjögren's syndrome (SS) is an autoimmune disease associated with a high risk of developing non-Hodgkin's lymphoma. This study was undertaken to determine the nature of B cells driving lymphoproliferation in primary SS...
  6. doi request reprint Using rituximab plus fludarabine and cyclophosphamide as a treatment for refractory mixed cryoglobulinemia associated with lymphoma
    D Saadoun
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Arthritis Care Res (Hoboken) 65:643-7. 2013
    ..We first report the safety and efficacy of FCR treatment in severe and refractory MC vasculitis associated with lymphoma...
  7. pmc Behçet's disease
    David Saadoun
    Service de médecine interne 2, Centre de Référence Maladies Autoimmunes rares, CHU Pitie Salpetriere, 83 bd de l hopital, 75013, Paris, France
    Orphanet J Rare Dis 7:20. 2012
    ..DEFINITION OF THE DISEASE: Behçet disease (BD) is a chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations...
  8. doi request reprint Pseudotumoural presentation of neuro-Behcet's disease: case series and review of literature
    Nicolas Noel
    Service de Medecine Interne, AP HP, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris F 75013, France
    Rheumatology (Oxford) 51:1216-25. 2012
    ..To describe the pseudotumoural presentation of neuro-Behçet's disease (NBD)...
  9. doi request reprint [Management of antiphospholipid syndrome]
    D Saadoun
    Service de Medecine Interne, centre de référence national pour le lupus et le syndrome des antiphospholipides, CHU Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie Paris 6, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Med Interne 33:217-22. 2012
    ..5. The possible occurrence of relapse despite anticoagulation in the therapeutic target may lead to the addition of aspirin. The development of new anti-thrombotic agents might change the management of APS in the coming years...
  10. doi request reprint Retrospective analysis of surgery versus endovascular intervention in Takayasu arteritis: a multicenter experience
    David Saadoun
    Service de médecine interne 2, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, Paris, France
    Circulation 125:813-9. 2012
    ..However, data came from case reports or small series, and the long-term outcome has not been reported. The incidence of potential vascular complications after surgery or endovascular treatment is still to be determined...
  11. doi request reprint Long-term outcome of arterial lesions in Behçet disease: a series of 101 patients
    David Saadoun
    Department of Internal Medicine, UMR CNRS 7211, INSERM U959, France
    Medicine (Baltimore) 91:18-24. 2012
    ..0001). In conclusion, the long-term outcome of arterial lesions in BD is poor, especially in the case of occlusive lesions and associated venous involvement. The use of immunosuppressants improved the prognosis...
  12. ncbi request reprint Interleukin-25: key regulator of inflammatory and autoimmune diseases
    David Saadoun
    Laboratory I3 Immunology, Immunopathology, immunotherapy UMR 7211 INSERM U959, and Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris 6, France
    Curr Pharm Des 17:3781-5. 2011
    ..In this article, we review the dual roles of IL-25 in immune responses, the molecular basis for these effects, and the potential therapeutic implications...
  13. doi request reprint [Cryofibrinogenemia]
    D Saadoun
    UMR 7211 Inserm U959, centre de références maladies auto immunes, Service de Médecine Interne II, Hopital Pitie Salpetriere, 75013 Paris, France
    Rev Med Interne 32:287-91. 2011
    ..In this article, we review the clinical presentation, pathogenesis and treatment of CF...
  14. doi request reprint Mortality in Behçet's disease
    D Saadoun
    Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and Université Pierre et Marie Curie Paris 6, Paris, France
    Arthritis Rheum 62:2806-12. 2010
    ..To report the long-term mortality in patients with Behçet's disease (BD)...
  15. doi request reprint [Ocular manifestations of Behçet's disease]
    D Saadoun
    CNRS UMR 7087, Service de Medecine Interne, Hopital de la Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 31:545-50. 2010
    ..Controlled clinical trials are mandatory to define the place of these new immunomodulatory agents in the therapeutic strategy, and especially their use as first-line therapy...
  16. doi request reprint Cerebral venous thrombosis in Behçet's disease
    D Saadoun
    Hôpital Pitié Salpétrière and Pierre et Marie Curie Paris VI University, Paris, France
    Arthritis Rheum 61:518-26. 2009
    ..To analyze the clinical findings, treatment, outcome, and prevalence of cerebral venous thrombosis (CVT) in a large cohort of patients with Behçet's disease (BD) from a single center...
  17. doi request reprint Immunosuppressants reduce venous thrombosis relapse in Behçet's disease
    A C Desbois
    UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitie Salpetriere, AP HP, and Université Pierre et Marie Curie Paris 6, Paris, France
    Arthritis Rheum 64:2753-60. 2012
    ..To investigate and describe the long-term outcome of venous thrombosis in patients with Behçet's disease (BD)...
  18. doi request reprint [Vitamin D and autoimmunity. Second part: Clinical aspects]
    Y Schoindre
    Service de Medecine Interne, Université Versailles Saint Quentin en Yvelines, Hopital Foch, 40, rue Worth, 92151 Suresnes Cedex, France
    Rev Med Interne 33:87-93. 2012
    ....
  19. doi request reprint Serum-free light chain assessment in hepatitis C virus-related lymphoproliferative disorders
    B Terrier
    Department of Internal Medicine, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    Ann Rheum Dis 68:89-93. 2009
    ..To evaluate the relevance of serum-free light chain (FLC) assessment in hepatitis C virus (HCV)-related lymphoproliferative disorders, including mixed cryoglobulinemia (MC) and B cell non-Hodgkin lymphoma (B-NHL)...
  20. doi request reprint Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab
    G Geri
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    J Viral Hepat 19:497-500. 2012
    ..No beneficial effects of RTX were evidenced on liver fibrosis progression, but we found interesting correlations with the serum albumin level, FibroTest values and B-cell count...
  21. doi request reprint [Cryoglobulinemia]
    P Cacoub
    Service de Médecine Interne II, hôpital La Pitié Salpêtrière, AP HP, 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Med Interne 29:200-8. 2008
    ..Cryoglobulin may be an isolated biological abnormality or may induce clinical manifestations of a systemic vasculitis, involving the skin, the joints, the peripheral nerve system and the kidneys...
  22. doi request reprint The B lymphocyte stimulator receptor-ligand system in hepatitis C virus-induced B cell clonal disorders
    D A Landau
    Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Centre National de la Recherche Sientifique, Universite Pierre et Marrie Curie UMR 7087, Paris, France
    Ann Rheum Dis 68:337-44. 2009
    ..The study aim was to examine the B lymphocyte stimulator (BLyS) receptor-ligand system in hepatitis C virus (HCV)-induced B lymphocyte clonal disorders...
  23. doi request reprint Hepatitis C virus-associated polyarteritis nodosa
    D Saadoun
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Arthritis Care Res (Hoboken) 63:427-35. 2011
    ..To analyze the main characteristics and outcome of polyarteritis nodosa (PAN)-type vasculitis associated with hepatitis C virus (HCV)...
  24. doi request reprint [Catastrophic antiphospholipid syndrome]
    N Costedoat-Chalumeau
    Service de Medecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, faculté Paris 6, Hopital Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 33:194-9. 2012
    ..The prevention of CAPS is based upon the adequate management of the perioperative period when surgery cannot be avoided, the prompt treatment of infections and the education of patients with antiphospholipid syndrome...
  25. doi request reprint Antimyeloperoxidase antibodies are a useful marker of disease activity in antineutrophil cytoplasmic antibody-associated vasculitides
    B Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Ann Rheum Dis 68:1564-71. 2009
    ..To evaluate the relevance of monitoring antimyeloperoxidase antibody levels in the management of antimyeloperoxidase-associated vasculitides...
  26. doi request reprint Rituximab combined with Peg-interferon-ribavirin in refractory hepatitis C virus-associated cryoglobulinaemia vasculitis
    D Saadoun
    Pierre et Marie Curie Paris 6, University 1, CNRS, UMR 7087, Paris, F 75013 France
    Ann Rheum Dis 67:1431-6. 2008
    ..To report the results of a pilot study using rituximab combined with Peg-interferon (IFN) alpha2b-ribavirin in severe refractory hepatitis C virus (HCV) related mixed cryoglobulinaemia (MC) vasculitis...
  27. doi request reprint [Vitamin D and autoimmunity. First part: Fundamental aspects]
    Y Schoindre
    Service de Medecine Interne, Université Versailles Saint Quentin en Yvelines, Hopital Foch, 40, rue Worth, 92151 Suresnes Cedex, France
    Rev Med Interne 33:80-6. 2012
    ..The authors present their actions on myeloid dendritic cells, T cells, B cells, as well as on the synthesis of antimicrobial peptides and autophagy, and the potential beneficial effects in autoimmune and inflammatory diseases...
  28. pmc Anti-C1q antibodies in hepatitis C virus infection
    D Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, 75651 Cedex 13 Paris, France
    Clin Exp Immunol 145:308-12. 2006
    ..Anti-C1q antibodies were associated with low C4 levels. No association was found between anti-C1q antibodies and HCV-MC vasculitis, nor between anti-C1q antibodies and cryoglobulinaemia...
  29. ncbi request reprint [Update in Hepatitis C virus associated extrahepatic manifestations]
    D Sene
    Service de Medecine Interne, Hopital de la Pitie Salpetriere, 91, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Med Interne 28:388-93. 2007
    ..The use of anti-CD20 antibodies in the treatment of cryoglobulinemic vasculitis is also under investigation...
  30. doi request reprint [Cardiovascular involvement in Behçet's disease]
    A C Desbois
    Service de Medecine Interne, Centre de référence des maladies autoimmunes rares, Groupe Hospitalier Pitie Salpetriere, 75013 Paris, France DHU i2B, Immunopathologie, Inflammation, biothérapie, Universite Pierre et Marie Curie, Paris 6, AP HP, 75013 Paris, France
    Rev Med Interne 35:103-11. 2014
    ..Coronary lesions complicated to myocardial infarction are the most severe cardiac complications. Treatment is based on corticosteroids and immunosuppressive drugs. The use of anticoagulation in venous thrombosis is still controversial. ..
  31. ncbi request reprint Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?
    P Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Ann Rheum Dis 67:283-7. 2008
    ..A relapse of cryoglobulinemia vasculitis was frequently noted. Randomised controlled trials with long-term study are needed to form definitive conclusions on the benefit/risk ratio of rituximab therapy in such patients...
  32. doi request reprint [Necrotizing folliculitis in Behçet's disease]
    S Trad
    Service de Medecine Interne, CHU de la Pitié Salpêtrière, Universite Pierre et Marie Curie Paris VI, 75651 Paris Cedex 13, France
    Rev Med Interne 30:268-70. 2009
    ..Bacteriological analysis should be mandatory in the absence of specific criteria for the diagnosis of Behcet's disease...
  33. doi request reprint [Neurological manifestations of Behçet's disease]
    N Noel
    Service de médecine interne 2, Centre de référence des maladies autoimmunes rares, DHU i2B, Immunopathologie, Inflammation, biothérapie, Universite Pierre et Marie Curie, Paris 6, Groupe Hospitalier Pitie Salpetriere, AP HP, 75013 Paris, France
    Rev Med Interne 35:112-20. 2014
    ..e. multiple sclerosis and sarcoidosis). A prompt recognition of NBS should lead to initiate adequate therapies in order to limit the risk of sequelae, relapses or death. ..
  34. doi request reprint The association of systemic lupus erythematosus and myasthenia gravis: a series of 17 cases, with a special focus on hydroxychloroquine use and a review of the literature
    M Jallouli
    Centre Hospitalier Universitaire Pitie Salpetriere, Universite Paris 6, AP HP, Paris, France
    J Neurol 259:1290-7. 2012
    ..Hydroxychloroquine treatment appears to be safe in this setting...
  35. ncbi request reprint Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation
    D Saadoun
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Rheumatology (Oxford) 46:1234-42. 2007
    ..This review will focus on recent advances in our understanding of the clinical course, complications, pathophysiology and treatment of those immune-mediated disorders...
  36. ncbi request reprint Hepatitis C virus-associated B-cell proliferation--the role of serum B lymphocyte stimulator (BLyS/BAFF)
    D Sene
    Department of Internal Medicine, La Pitié Salpêtrière, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Rheumatology (Oxford) 46:65-9. 2007
    ..We assessed BLyS serum levels in HCV-infected patients and in various forms of HCV-associated BCP [i.e. mixed cryoglobulin (MC), rheumatoid factor (RF) and systemic vasculitis]...
  37. doi request reprint [Treatment of Behçet's disease]
    C Comarmond
    Service de Médecine Interne et d Immunologie Clinique, Centre de référence des maladies autoimmunes rares, DHU i2B, Inflammation, Immunopathologie, biothérapie, Universite Pierre et Marie Curie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris 6, Paris, France
    Rev Med Interne 35:126-38. 2014
    ..Novel targeted immunosuppressive therapies might be used in the future for BD. ..
  38. doi request reprint [Ocular manifestations in Behçet's disease]
    H Zeghidi
    Service d Ophtalmologie, DHU vision et handicaps, Hopital de la Pitie Salpetriere, Universite Pierre et Marie Curie, AP HP, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 35:97-102. 2014
    ..New therapeutic strategies such as interferon alpha and TNF alpha blockers have dramatically improved the visual prognosis of patients with intraocular inflammation related to this chronic and potentially blinding condition. ..
  39. doi request reprint [The pulmonary-renal syndrome: a diagnostic and therapeutic emergency for the internist and the intensivist]
    M Hie
    Service de médecine interne 2, Hopital Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France Electronic address
    Rev Med Interne 34:679-86. 2013
    ..Initial treatment usually associates systemic corticosteroid, cyclophosphamide and plasma exchange. The role of biotherapy as first line therapy remains to be determined. ..
  40. doi request reprint [Liver involvement in systemic diseases]
    G Geri
    Service de Médecine Interne II, Hopital Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 32:486-93. 2011
    ..In the latter, the outcome is generally favourable with immunosuppressive treatment...
  41. ncbi request reprint Tuberculosis in HIV-infected patients: a comprehensive review
    L Aaron
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Clin Microbiol Infect 10:388-98. 2004
    ..Finally, immune restoration induced by highly active anti-retroviral therapy (HAART) in developed countries may be responsible for a paradoxical worsening of TB manifestations...