Frank M Ruemmele

Summary

Country: France

Publications

  1. doi request reprint Pediatric inflammatory bowel diseases: coming of age
    Frank M Ruemmele
    Universite Paris Descartes, INSERM U989 and Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Gastroenterol 26:332-6. 2010
  2. ncbi request reprint Characteristics of inflammatory bowel disease with onset during the first year of life
    Frank M Ruemmele
    Paediatric Gastroenterology Unit, Department of Paediatrics, Hopital Necker Enfants Malades, National Center for Rare Digestive Diseases INSERM EMI U793, University Rene Descartes, Paris, France
    J Pediatr Gastroenterol Nutr 43:603-9. 2006
  3. doi request reprint Immunomodulation with methotrexate: underused and undervalued?
    Frank M Ruemmele
    University Paris Descartes, Faculty of Medicine, INSERM U793, Hopital Necker Enfants Malades, Paediatric Gastroenterology, FR 75015Paris, France
    Dig Dis 27:312-4. 2009
  4. doi request reprint Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease
    F M Ruemmele
    Department of Paediatric Gastroenterology, APHP Hôpital Necker Enfants Malades, 149 rue de Sévres 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 2 rue de l École de Médecine, 75006 Paris, France Inserm U989, Institut Imagine, 24 Bd Montparnasse, 75015 Paris, France Electronic address
    J Crohns Colitis 8:1179-207. 2014
  5. pmc Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease
    Natalie Frede
    Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Engesser Straße 4, 79108 Freiburg, Germany
    BMC Immunol 15:10. 2014
  6. doi request reprint Differences in the management of pediatric and adult onset ulcerative colitis--lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis
    Frank M Ruemmele
    Université Sorbonne Paris Cité, Paris Descartes, Paris, France APHP, Hopital Necker Enfants Malades, Service de Gastroenterologie, Pediatric IBD Program, Paris, France Electronic address
    J Crohns Colitis 8:1-4. 2014
  7. doi request reprint Why are genetics important for nutrition? Lessons from epigenetic research
    Frank M Ruemmele
    Service de Gastroentérologie pédiatrique, Hopital Necker Enfants Malades, INSERM U989, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Ann Nutr Metab 60:38-43. 2012
  8. doi request reprint Bacterial mucosa cross-talk and pathophysiology of inflammation
    Frank M Ruemmele
    University Paris Descartes, Faculty of Medicine, INSERM U793, Paris, France
    J Pediatr Gastroenterol Nutr 48:S49-51. 2009
  9. doi request reprint Clinical evidence for immunomodulatory effects of probiotic bacteria
    F M Ruemmele
    Department of Pediatrics, Hopital Necker Enfants Malades, Paris, France
    J Pediatr Gastroenterol Nutr 48:126-41. 2009
  10. doi request reprint Clinical and molecular aspects of autoimmune enteropathy and immune dysregulation, polyendocrinopathy autoimmune enteropathy X-linked syndrome
    Frank M Ruemmele
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology Unit, France
    Curr Opin Gastroenterol 24:742-8. 2008

Collaborators

Detail Information

Publications34

  1. doi request reprint Pediatric inflammatory bowel diseases: coming of age
    Frank M Ruemmele
    Universite Paris Descartes, INSERM U989 and Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Gastroenterol 26:332-6. 2010
    ..Inflammatory bowel diseases (IBD) comprise a heterogeneous group of distinct intestinal disorders. Here, we discuss the concept of childhood-onset IBD as separate disease forms within a larger multifactorial disease category...
  2. ncbi request reprint Characteristics of inflammatory bowel disease with onset during the first year of life
    Frank M Ruemmele
    Paediatric Gastroenterology Unit, Department of Paediatrics, Hopital Necker Enfants Malades, National Center for Rare Digestive Diseases INSERM EMI U793, University Rene Descartes, Paris, France
    J Pediatr Gastroenterol Nutr 43:603-9. 2006
    ..We were particularly interested in the relationship between bacterial infections and the use of antibiotics before the onset of IBD...
  3. doi request reprint Immunomodulation with methotrexate: underused and undervalued?
    Frank M Ruemmele
    University Paris Descartes, Faculty of Medicine, INSERM U793, Hopital Necker Enfants Malades, Paediatric Gastroenterology, FR 75015Paris, France
    Dig Dis 27:312-4. 2009
    ..Taken together, there are first data indicating that MTX might play a role comparable to AZA in the treatment of CD; however, to date it seems to be underused in the routine care of IBD patients...
  4. doi request reprint Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease
    F M Ruemmele
    Department of Paediatric Gastroenterology, APHP Hôpital Necker Enfants Malades, 149 rue de Sévres 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 2 rue de l École de Médecine, 75006 Paris, France Inserm U989, Institut Imagine, 24 Bd Montparnasse, 75015 Paris, France Electronic address
    J Crohns Colitis 8:1179-207. 2014
    ....
  5. pmc Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease
    Natalie Frede
    Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Engesser Straße 4, 79108 Freiburg, Germany
    BMC Immunol 15:10. 2014
    ..Our study aimed at investigating the existence of inhibitory autoantibodies against IL-10 and IL-10R in IBD patients capable of down-modulating IL-10 signalling thereby mimicking IL-10 or IL-10R deficiency...
  6. doi request reprint Differences in the management of pediatric and adult onset ulcerative colitis--lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis
    Frank M Ruemmele
    Université Sorbonne Paris Cité, Paris Descartes, Paris, France APHP, Hopital Necker Enfants Malades, Service de Gastroenterologie, Pediatric IBD Program, Paris, France Electronic address
    J Crohns Colitis 8:1-4. 2014
    ..The acute and on-going management of pediatric UC should be guided by evidence- and consensus-based balanced decisions, reflecting a vision of long-term treatment goals. ..
  7. doi request reprint Why are genetics important for nutrition? Lessons from epigenetic research
    Frank M Ruemmele
    Service de Gastroentérologie pédiatrique, Hopital Necker Enfants Malades, INSERM U989, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Ann Nutr Metab 60:38-43. 2012
    ..It is anticipated that within the next few years, major advances will be made to translate this knowledge of nutritional intervention on gene regulation and expression into health preventive programs...
  8. doi request reprint Bacterial mucosa cross-talk and pathophysiology of inflammation
    Frank M Ruemmele
    University Paris Descartes, Faculty of Medicine, INSERM U793, Paris, France
    J Pediatr Gastroenterol Nutr 48:S49-51. 2009
    ....
  9. doi request reprint Clinical evidence for immunomodulatory effects of probiotic bacteria
    F M Ruemmele
    Department of Pediatrics, Hopital Necker Enfants Malades, Paris, France
    J Pediatr Gastroenterol Nutr 48:126-41. 2009
    ....
  10. doi request reprint Clinical and molecular aspects of autoimmune enteropathy and immune dysregulation, polyendocrinopathy autoimmune enteropathy X-linked syndrome
    Frank M Ruemmele
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology Unit, France
    Curr Opin Gastroenterol 24:742-8. 2008
    ..Recent research data allowed us to gain a first insight in the pathogenesis of AIE. On the basis of this data, we will discuss new aspects of AIE emphasizing new diagnostic and therapeutic possibilities...
  11. doi request reprint Efficacy of infliximab in pediatric Crohn's disease: a randomized multicenter open-label trial comparing scheduled to on demand maintenance therapy
    Frank M Ruemmele
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Paris, France
    Inflamm Bowel Dis 15:388-94. 2009
    ..The present study aimed to evaluate in a prospective manner the efficacy and safety of IFX as maintenance therapy of severe pediatric CD comparing scheduled and "on demand" treatment strategies...
  12. doi request reprint Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease
    Bernadette Begue
    INSERM U989, Paris, France
    Am J Gastroenterol 106:1544-55. 2011
    ..Thus, we aimed to further elaborate the hypothesis of defective anti-inflammatory responses in patients with IBD...
  13. doi request reprint Tolerance and efficacy of azathioprine in pediatric Crohn's disease
    Laura Riello
    Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paediatric Gastroenterology Unit, Paris, France
    Inflamm Bowel Dis 17:2138-43. 2011
    ..In the present study we analyzed the tolerance and efficacy of azathioprine (AZA) to maintain remission in a homogenous single-center observational cohort of children with CD...
  14. doi request reprint Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    Nicolette Moes
    Universite Paris Descartes, Paris, France
    Gastroenterology 139:770-8. 2010
    ..We analyzed the molecular basis of neonatal or early postnatal AIE using clinical, genetic, and functional immunological studies...
  15. doi request reprint 12-month follow-up after successful infliximab therapy in pediatric crohn disease
    Jan Wynands
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology, Paris, France
    J Pediatr Gastroenterol Nutr 46:293-8. 2008
    ..Given the increasing safety concerns about the concomitant and prolonged use of IFX and azathioprine in CD, we wanted to address the clinical outcome in pediatric CD patients who responded to IFX medication, once IFX was stopped...
  16. doi request reprint Transforming growth factor and intestinal inflammation: the role of nutrition
    Frank M Ruemmele
    Université Sorbonne Paris Cité, Universite Paris Descartes, INSERM U989, Hopital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Paris, France
    Nestle Nutr Inst Workshop Ser 77:91-8. 2013
    ....
  17. doi request reprint Microvillous inclusion disease: how to improve the prognosis of a severe congenital enterocyte disorder
    Ugur Halac
    Pediatric Gastroenterology, Hepatology and Nutrition Unit, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, France
    J Pediatr Gastroenterol Nutr 52:460-5. 2011
    ....
  18. doi request reprint Pediatric ulcerative colitis associated with autoimmune diseases: a distinct form of inflammatory bowel disease?
    Felipe Ordonez
    Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Paris, France
    Inflamm Bowel Dis 18:1809-17. 2012
    ..The aim of this study was to describe these features, in order to differentiate a subgroup of colitis associated with autoimmunity (CAI) from CUC...
  19. pmc Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms
    Camille Jung
    Universite Paris Diderot, UMR843, Paris, France
    PLoS ONE 7:e52223. 2012
    ..However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms...
  20. pmc Microvillous inclusion disease (microvillous atrophy)
    Frank M Ruemmele
    INSERM EMI 0212, Pediatric Gastroenterology, Hepatology and Nutrition, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Orphanet J Rare Dis 1:22. 2006
    ..Early small bowel transplantation resulting in intestinal autonomy gives new hope for disease management and outcome...
  21. doi request reprint Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model
    Frank M Ruemmele
    Universite Paris Descartes, Faculte Necker, INSERM U793, Paris, France
    Hum Mutat 31:544-51. 2010
    ....
  22. doi request reprint Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group
    Benedicte Pigneur
    Universite Paris Descartes, Sorbonne Paris Cité, Institut Imagine, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Paris, France Department of Pediatric Gastroenterology, ErasmusMC Sophia Children s Hospital, Rotterdam, The Netherlands Department of Gastroenterology, Great Ormond Street Hospital for Sick Children and Institute of Child Health, London, United Kingdom Pediatric Gastroenterology Unit, Centro Hospitalar do Porto, Porto, Portugal Marienhospital, Bonn, Germany Department of Gastroenterology, Hepatology and Feeding Disorders, The Children s Memorial Health Institute, Warsaw, Poland Gastroenterologia, Endoscopia Digestiva, Epatologia e Cura del Bambino con Trapianto di Fegato, Dipartimento Salute della Donna e del Bambino, Padova, Italy Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service d Anatomopathologie, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service de Radiologie, Paris, France Inserm U989, Paris, Turkey
    Inflamm Bowel Dis 19:2820-8. 2013
    ..We set up the GENetically determined ImmUne-mediated enteropathieS (GENIUS) network and collected infants with a proven defect of the IL10 axis for accurate phenotyping of disease presentation and evolution...
  23. doi request reprint A soluble form of IL-27Rα is a natural IL-27 antagonist
    Céline Dietrich
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Universite Paris Descartes, Sorbonne Paris Cité, 75 015 Paris, France Institut Necker Enfants Malades, INSERM U1151, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8253, 75 015 Paris, France
    J Immunol 192:5382-9. 2014
    ..These findings suggest that sIL-27Rα may play important immunoregulatory functions under normal and pathological conditions...
  24. ncbi request reprint New perspectives for children with microvillous inclusion disease: early small bowel transplantation
    Frank M Ruemmele
    Combined Program of Liver and Intestinal Transplantation, Hopital Necker Enfants Malades, Paris, France
    Transplantation 77:1024-8. 2004
    ..Despite long-term total parenteral nutrition, life expectancy is extremely reduced because of metabolic or septic complications or liver failure...
  25. doi request reprint Natural history of Crohn's disease: comparison between childhood- and adult-onset disease
    Benedicte Pigneur
    gastroentérologie et nutrition pédiatrique, Hopital d Enfants Armand Trousseau, AP HP, Paris, France
    Inflamm Bowel Dis 16:953-61. 2010
    ..Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD...
  26. ncbi request reprint Chronic enteropathy: molecular basis
    Frank M Ruemmele
    Pediatric Gastroenterology, Hepatology and Nutrition, INSERM U793, Hopital Necker Enfants Malades, 149 rue de Sevres, FR 75743 Paris Cedex 15, France
    Nestle Nutr Workshop Ser Pediatr Program 59:73-85; discussion 85-8. 2007
    ..With the increasing understanding of the molecular basis of these distinct diarrheal disorders, new treatment strategies will emerge within the next years, giving new hope to these critically ill children and their families...
  27. doi request reprint Celiac disease in children
    Hélène Garnier-Lengliné
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France AP HP, Hopital Necker Enfants Malades, Service de Gastroenterologie, Hépatologie et Nutrition Pédiatriques, 149, rue de Sevres, 75743 Paris Cedex 15, France Unité Inserm UMR_S1163, Institut Imagine, Paris, France Electronic address
    Clin Res Hepatol Gastroenterol 39:544-51. 2015
    ..Gluten-free diet is useful to obtain clinical assessment, but also to prevent long-term complications of celiac disease, mainly osteoporosis, other autoimmune diseases, decreased fertility and cancers...
  28. doi request reprint Enteral nutrition as treatment option for Crohn's disease: in kids only?
    Frank M Ruemmele
    Université Sorbonne Paris Cité, Universite Paris Descartes, INSERM U989, Service de Gastroentérologie pédiatrique, Hopital Necker Enfants Malades, Paris, France
    Nestle Nutr Inst Workshop Ser 79:115-23. 2014
    ..These observations give a first basis for the understanding of the impact of EEN on dysbiosis in patients with CD...
  29. pmc Specific IgG response against Mycobacterium avium paratuberculosis in children and adults with Crohn's disease
    Julien Verdier
    Institut National de la Sante et de la Recherche Medicale INSERM, UMR989, Paris, France
    PLoS ONE 8:e62780. 2013
    ..In the present work, we assessed antibody reactivity of serum and intestinal fluid against four distinct MAP-antigens, including the recently identified MAP-specific lipopentapeptide (L5P)...
  30. ncbi request reprint Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions
    Bernadette Begue
    INSERM U793, Faculte de Medecine Necker, Universite Paris V, Paris, France
    Gastroenterology 130:1962-74. 2006
    ..In this work, we analyzed the potential implication of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) in these inflammatory lesions...
  31. doi request reprint Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells
    Lúcia Moreira-Teixeira
    Universite Paris Descartes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Hopital Necker Enfants Malades, 75015 Paris, France
    J Immunol 186:5758-65. 2011
    ..In conclusion, IL-17 production by human iNKT cells depends on two critical parameters, namely an intrinsic program and a proinflammatory environment...
  32. doi request reprint Use of Biosimilars in Paediatric Inflammatory Bowel Disease: A Position Statement of the ESPGHAN Paediatric IBD Porto Group
    Lissy de Ridder
    Paediatric Gastroenterology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands Department of Gastroenterology, Inflammatory Bowel Diseases Service, Rambam Health Care Campus, Haifa Institute of Paediatric Gastroenterology, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel Department of Paediatrics, University Hospital Motol, Prague, Czech Republic Department of Paediatrics and Adolescence Medicine, GPGE Educational Center of Paediatric Gastroenterology, Medical University of Graz, Austria Pediatric Gastroeneterology Department, Hospital Sao Joa, Porto, Portugal Department of Woman, Child, and General and Specialized Surgery, Second University of Naples, Naples, Italy Université Paris Descartes Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Inserm U1163, Institute Imagine, Paris, France Paediatric Gastroenterology Unit, Wolfson Medical Center, Tel Aviv University, Israel Department of Neuroscience, Psychology, Pharmacology and Child s Health, University of Florence, Meyer Hospital, USA
    J Pediatr Gastroenterol Nutr 61:503-8. 2015
    ..Postmarketing surveillance programs for efficacy, safety, and immunogenicity should become mandatory in children with IBD using biosimilars, as for all biological drugs. ..
  33. doi request reprint Molecular mechanisms and cell targets of Th17 cells in the gastrointestinal tract: an innate sense of adaptivity
    Julien Verdier
    Institut National de la Sante et de la Recherche Medicale INSERM, UMR989, Paris, France
    Int Rev Immunol 32:475-92. 2013
    ....
  34. ncbi request reprint Regulation of intestinal epithelial cell apoptosis and the pathogenesis of inflammatory bowel disorders
    Frank M Ruemmele
    Laboratory of Intestinal Immunology, Children s Hospital Medical Center, Department of Pediatrics, University of Bonn, Germany
    J Pediatr Gastroenterol Nutr 34:254-60. 2002