Nathalie Rouas-Freiss

Summary

Country: France

Publications

  1. ncbi request reprint Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transplantation 84:S21-5. 2007
  2. ncbi request reprint Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses
    Nathalie Rouas-Freiss
    CEA, DSV, I2BM, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 avenue Claude Vellefaux, 75010 Paris, France
    Semin Cancer Biol 17:413-21. 2007
  3. ncbi request reprint Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/ regulatory T cells
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Direction des Sciences du Vivant, Departement de Recherche Medicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    J Immunol 176:3266-76. 2006
  4. ncbi request reprint Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients
    Caroline Creput
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1033-8. 2003
  5. ncbi request reprint MICA triggering signal for NK cell tumor lysis is counteracted by HLA-G1-mediated inhibitory signal
    Catherine Menier
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 100:63-70. 2002
  6. ncbi request reprint HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
  7. ncbi request reprint CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Commissariat à l energie atomique Direction des science, du vivant Departement de la recherche medical CEA DSV DRM, Hopital Saint Louis, Paris, France
    Blood 110:3936-48. 2007
  8. ncbi request reprint Exosomes bearing HLA-G are released by melanoma cells
    Beatrice Riteau
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1064-72. 2003
  9. ncbi request reprint Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation
    Caroline Creput
    Hemato immunology Research Institute, CEA Laboratory, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Saint Louis Hospital, 75010 Paris cedex 10, France
    J Hepatol 39:587-94. 2003
  10. ncbi request reprint Switch of HLA-G alternative splicing in a melanoma cell line causes loss of HLA-G1 expression and sensitivity to NK lysis
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Int J Cancer 117:114-22. 2005

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transplantation 84:S21-5. 2007
    ..In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance...
  2. ncbi request reprint Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses
    Nathalie Rouas-Freiss
    CEA, DSV, I2BM, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 avenue Claude Vellefaux, 75010 Paris, France
    Semin Cancer Biol 17:413-21. 2007
    ..These findings reinforce the role of HLA-G as one mechanism of tumor-driven immune evasion and provide potential targets for testing novel anticancer treatment strategies...
  3. ncbi request reprint Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/ regulatory T cells
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Direction des Sciences du Vivant, Departement de Recherche Medicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    J Immunol 176:3266-76. 2006
    ..These findings provide evidence supporting the tolerogenic properties of HLA-G and emphasize its potential application as a relevant therapeutic candidate capable of limiting allograft rejection...
  4. ncbi request reprint Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients
    Caroline Creput
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1033-8. 2003
    ....
  5. ncbi request reprint MICA triggering signal for NK cell tumor lysis is counteracted by HLA-G1-mediated inhibitory signal
    Catherine Menier
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 100:63-70. 2002
    ....
  6. ncbi request reprint HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
    ..We review these points, with special emphasis on the role of HLA-G in human pathologies, such as cancer, viral infection, and inflammatory diseases, as well as in organ transplantation...
  7. ncbi request reprint CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Commissariat à l energie atomique Direction des science, du vivant Departement de la recherche medical CEA DSV DRM, Hopital Saint Louis, Paris, France
    Blood 110:3936-48. 2007
    ..These data define novel immunosuppressive subpopulations of peripheral blood T cells induced by HLA-G with potent implications in peripheral tolerance...
  8. ncbi request reprint Exosomes bearing HLA-G are released by melanoma cells
    Beatrice Riteau
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1064-72. 2003
    ..Thus, the presence of tolerogenic HLA-G molecules on melanoma-derived exosomes may provide a novel way for tumors to modulate host's immune response...
  9. ncbi request reprint Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation
    Caroline Creput
    Hemato immunology Research Institute, CEA Laboratory, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Saint Louis Hospital, 75010 Paris cedex 10, France
    J Hepatol 39:587-94. 2003
    ..The HLA-G molecule is acknowledged to possess tolerogenic properties...
  10. ncbi request reprint Switch of HLA-G alternative splicing in a melanoma cell line causes loss of HLA-G1 expression and sensitivity to NK lysis
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Int J Cancer 117:114-22. 2005
    ..Modulating HLA-G at the mRNA splicing level would be an efficient way of lifting in vivo HLA-G-mediated tumor immune escape...
  11. doi request reprint Inhibition of human gamma delta [corrected] T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer
    Emilie Lesport
    CEAEA, I2BM, Service de Recherches en Hemato Immunologie, 75475 Paris, France
    Cell Mol Life Sci 68:3385-99. 2011
    ..These data demonstrate that HLA-G inhibits the anti-tumoral functions of Vγ9Vδ2 T cells and imply that treatments targeting HLA-G could optimize Vγ9Vδ2 T-cell-mediated immunotherapy of cancer...
  12. ncbi request reprint HLA-G in cancer: a way to turn off the immune system
    Nathalie Rouas-Freiss
    Senrvice de Recherches en Hémato Immunologie, CEA DSV DRM, Hopital Saint Louis, 1UH, 1 avenue Claude Vellefaux, 75475 Paris 10, France
    Semin Cancer Biol 13:325-36. 2003
    ....
  13. ncbi request reprint Viewpoint on the functionality of the human leukocyte antigen-G null allele at the fetal-maternal interface
    Philippe Moreau
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital St Louis, Institut Universitaire d Hematologie, 75475 Paris, Cedex 10, France
    Biol Reprod 67:1375-8. 2002
    ..In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses...
  14. ncbi request reprint Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules
    Catherine Menier
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:315-26. 2003
    ..These new mAbs represent valuable tools to study the expression of HLA-G and HLA-E molecules in cells and tissues under normal and pathologic conditions...
  15. doi request reprint Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17
    Sophie Agaugué
    Commissariat à l Énergie Atomique et aux Énergies Alternatives, Institut d Imagerie Biomédicale, Service de Recherches en Hemato Immunologie, Paris, France
    Blood 117:7021-31. 2011
    ..Finally, blocking HLA-G function by a specific Ab inhibits the in vivo development of the tumor, offering a new innovative therapeutic strategy in cancer...
  16. pmc Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Immunology 116:297-307. 2005
    ..IDO and HLA-G are thus complementary for inducing and maintaining immune tolerance in physiological (pregnancy) and pathological (tumour and allograft) situations...
  17. ncbi request reprint Immuno-tolerogenic functions of HLA-G: relevance in transplantation and oncology
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique DSV DRM, Hopital Saint Louis, 1, Avenue Claude Vellefaux 75010, Paris
    Autoimmun Rev 4:503-9. 2005
    ..We review here the functions of HLA-G from an immunological stand point, focusing on the recent advances in this field and on their potential impact in human pathologies, such as cancer and organ transplantation...
  18. doi request reprint HLA-G: from biology to clinical benefits
    Edgardo D Carosella
    Institut Universitaire d Hematologie, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 75010 Paris, France
    Trends Immunol 29:125-32. 2008
    ..These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels...
  19. doi request reprint The role of HLA-G in immunity and hematopoiesis
    Edgardo D Carosella
    CEA, I2BM, Service de Recherches en Hemato Immunologie, 75475 Paris, France
    Cell Mol Life Sci 68:353-68. 2011
    ..Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis...
  20. ncbi request reprint Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Hum Immunol 68:233-9. 2007
    ..Evidence to support such role in vivo was provided by the capacity of purified HLA-G5 from the plasma of the transplanted patient to suppress T-cell alloresponses...
  21. ncbi request reprint Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
    Catherine Menier
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75010 Paris, France
    Blood 104:3153-60. 2004
    ..This new marker, previously known by its immunotolerogeneic properties, may be involved in erythroid differentiation, angiogenesis, or both...
  22. ncbi request reprint HLA-G5 expression by trophoblast cells: the facts
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Mol Hum Reprod 11:719-22. 2005
  23. doi request reprint Beyond the increasing complexity of the immunomodulatory HLA-G molecule
    Edgardo D Carosella
    CEA, IBM, Service de Recherches en Hemato Immunologie, Paris, France
    Blood 111:4862-70. 2008
    ..We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant...
  24. ncbi request reprint Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Eur J Immunol 34:649-60. 2004
    ..The HLA-G-positive T cells we describe here may constitute a cellular source of HLA-G after allotransplantation and may be involved in the improved graft acceptance which is observed in HLA-G-positive transplanted patients...
  25. ncbi request reprint HLA-G gene activation in tumor cells involves cis-acting epigenetic changes
    Gael Mouillot
    Commissariat í l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 113:928-36. 2005
    ..2 kb. cis-acting epigenetic changes and the fact that demethylating agents activate HLA-G expression at least 5 days following treatment should be taken into account in epigenetic cancer therapies...
  26. ncbi request reprint HLA-G*0105N null allele encodes functional HLA-G isoforms
    Magali Le Discorde
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Institut d Hematologie, Hopital Saint Louis, Paris 75010, France
    Biol Reprod 73:280-8. 2005
    ....
  27. doi request reprint HLA-G1 and HLA-G5 active dimers are present in malignant cells and effusions: the influence of the tumor microenvironment
    Sonia Zilberman
    CEA, iMETI, Service de Recherches en Hemato Immunologie, Paris, France
    Eur J Immunol 42:1599-608. 2012
    ..In view of these results, the effect of the tumor microenvironment on upregulation of HLA-G function deserves particular attention when designing cancer immunotherapy protocols...
  28. ncbi request reprint HLA-G in transplantation: a relevant molecule for inhibition of graft rejection?
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Am J Transplant 3:11-6. 2003
    ....
  29. ncbi request reprint HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?
    Nathalie Rouas-Freiss
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Cancer Res 65:10139-44. 2005
    ....
  30. doi request reprint Human leukocyte antigen-G is expressed in advanced-stage ovarian carcinoma of high-grade histology
    Catherine Menier
    CEA, I2 BM, Service de Recherches en Hemato Immunologie, Paris, France
    Hum Immunol 70:1006-9. 2009
    ..For this purpose, we looked for HLA-G expression in ovarian carcinoma lesions from low to high grade and stage, and we showed that HLA-G is selectively expressed in advanced-stage disease of high-grade histology...
  31. ncbi request reprint Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytes
    Rajia Bahri
    Institut National de la Santé et de la Recherche Médicale Unité 542, Villejuif, France
    J Immunol 176:1331-9. 2006
    ..In contrast, it induced an accumulation of p27kip, but not p21cip, in activated T cells. HLA-G does not induce apoptosis of alloreactive T cells, but induces p27kip1 and inhibits cell cycle progression...
  32. ncbi request reprint Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule
    José M Lozano
    Service of Immunology, Reina Sofia University Hospital, University of Cordoba, School of Medicine, C Menendez Pidal s n, 14004 Cordoba, Spain
    AIDS 16:347-51. 2002
    ..To study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence of HIV-1 infection...
  33. ncbi request reprint Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    Zohair Selmani
    Institut National de la Santé et de la Recherche Médicale U645, IFR 133, Universite de Franche Comte, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Stem Cells 26:212-22. 2008
    ..Our results provide evidence that HLA-G5 secreted by MSCs is critical to the suppressive functions of MSCs and should contribute to improving clinical therapeutic trials that use MSCs to prevent GvHD...
  34. doi request reprint Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients
    Rohit Sheshgiri
    Heart Transplant Program, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 27:522-7. 2008
    ..We assessed myocardial HLA-G expression in adult heart transplant patients in an attempt to determine the value of this protein in identifying patients with a low risk of acute cellular rejection...
  35. pmc Modulation of HLA-G expression in human neural cells after neurotropic viral infections
    Monique Lafon
    Unité de Neuroimmunologie Virale, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:15226-37. 2005
    ..HLA-G may therefore be involved in the escape of certain viruses from the immune response in the nervous system...
  36. ncbi request reprint NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect
    Stephanie Nguyen
    Laboratoire d Immunologie Cellulaire et Tissulaire INSERM U543, Hopital Pitie Salpetriere, 83 Bvd de l Hôpital 75013 Paris, France
    Blood 105:4135-42. 2005
    ....
  37. ncbi request reprint Expression of functional soluble human leucocyte antigen-G molecules in lymphoproliferative disorders
    Yasmine Sebti
    UPRES Immunologie Hématologie, Universite de Rennes 1, Rennes, France
    Br J Haematol 138:202-12. 2007
    ..These results suggest that functional sHLA-G molecules are upregulated in lymphoproliferative disorders which can support their potential immunomodulatory role during this pathology...
  38. ncbi request reprint Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival
    Guillaume Monneret
    Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
    Crit Care Med 35:1942-7. 2007
    ..The main objective of the current study was to measure human leukocyte antigen-G (soluble and membrane proteins) in septic shock...
  39. ncbi request reprint Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections
    Françoise Mégret
    Laboratoire de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    Hum Immunol 68:294-302. 2007
    ..Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially...
  40. ncbi request reprint Implication of HLA-G in human embryo implantation
    Renato Fanchin
    Department of Obstetrics and Gynecology, Hopital Antoine Beclere, Clamart, France
    Hum Immunol 68:259-63. 2007
    ..In particular, studies investigating HLA-G expression on human preimplantation embryos and in the endometrium, as well as its levels in embryo culture supernatants and circulating maternal blood, are discussed...
  41. ncbi request reprint New aspect of immunosuppressive treatment in liver transplantation. How could you induce tolerance in liver transplantation?
    Severine Beaudreuil
    Department of Nephrology, IFRNT University Hospital of Kremlin Bicetre, 78 Avenue du General LeClerc, 94275 Le Kremlin Bicetre cedex, France
    Transpl Immunol 17:98-107. 2007
    ..We describe here current experience in liver and liver-kidney transplantation, the mechanism of tolerance and the immunosuppressive strategy used in liver transplantation...
  42. ncbi request reprint Report of the Wet Workshop for Quantification of Soluble HLA-G in Essen, 2004
    Vera Rebmann
    Institute of Immunology, University Hospital of Essen, Essen, Germany
    Hum Immunol 66:853-63. 2005
    ..Moreover, a novel soluble HLA-G structure can be predicted that is recognized by the mAb 5A6G7 + mAb W6/32 antibody combination, but not by the one of mAb MEM-G/9 + anti-beta2m...