Research Topics
| Yves RollandSummaryCountry: France Publications
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Detail Information
Publications
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectivesY Rolland
INSERM U558, F 31073Toulouse, France
J Nutr Health Aging 12:433-50. 2008..On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people...
Vitamin d supplementation in older adults: searching for specific guidelines in nursing homesY Rolland
Y Rolland Gérontopôle de Toulouse, Pavillon Junot, 170 avenue de Casselardit Hôpital La Grave Casselardit, 31300 Toulouse, FranceTelephone 33 0 5 61 77 64 06 Fax 33 0 5 61 49 71 09 Email
J Nutr Health Aging 17:402-12. 2013..The clinical relevance and cost effectiveness of this proposal should be assessed under NH real-world conditions to establish its feasibility...- Multidisciplinary team meetings (MDTM) in detection of Alzheimer's disease: data from the IDEM studyY Rolland
Gérontopôle de Toulouse, Departement de Medecine Interne et Gerontologie Clinique, centre hospitalo universitaire de Toulouse, Toulouse, France
J Nutr Health Aging 17:137-41. 2013..The HAS proposes in particular that continuation of these drugs for longer than one year should be decided in multidisciplinary team meetings (MDTM)... - Psychotropic drug consumption at admission and discharge of nursing home residentsYves Rolland
INSERM, Toulouse, France
J Am Med Dir Assoc 13:407.e7-12. 2012..To quantify transitions of residents into or out of nursing homes (NHs) and to describe psychotropic drug prescription at admission and discharge and with regard to dementia diagnosis... - Screening older people at risk of malnutrition or malnourished using the Simplified Nutritional Appetite Questionnaire (SNAQ): a comparison with the Mini-Nutritional Assessment (MNA) toolYves Rolland
Gérontopôle of Toulouse, CHU Purpan, Toulouse, France
J Am Med Dir Assoc 13:31-4. 2012..Our objective was to assess whether the SNAQ is related to the MNA and can screen older people at risk of malnutrition or malnourishment... - Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) StudyYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
Am J Clin Nutr 89:1895-900. 2009..In elders, decreased muscle mass (sarcopenia) and increased fat mass (obesity) may contribute to difficulties with physical function... - Cachexia versus sarcopeniaYves Rolland
INSERM U558, University of Toulouse III, France
Curr Opin Clin Nutr Metab Care 14:15-21. 2011..The review summarizes and discusses the proposed new definitions for sarcopenia and cachexia. It also highlights the overlapping of both conditions and the fact that these conditions frequently occur in elderly patients... - Validated treatments and therapeutic perspectives regarding physical activitiesY Rolland
INSERM U558, University of Toulouse III, Toulouse, France
J Nutr Health Aging 13:742-5. 2009..Impact of resistance training on muscle and mass and function as well as its interaction with other factors associated with sarcopenia such as denervation, hormones modification and protein intake will be discussed... - Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectivesY Rolland
INSERM U558, F 31073, Universite de Toulouse III, France
J Nutr Health Aging 12:335-46. 2008..It also sets out to heighten awareness of the need for management of osteoporosis in the frail elderly... - Physical activity and Alzheimer's disease: from prevention to therapeutic perspectivesYves Rolland
INSERM, Toulouse, France University of Toulouse III, Toulouse, France
J Am Med Dir Assoc 9:390-405. 2008..In the future, the prevention of Alzheimer's disease may be based on rules governing lifestyle habits such as diet, cognitive activity, and physical activity... - Descriptive study of nursing home residents from the REHPA networkY Rolland
Gérontopôle de Toulouse, Service de Medecine Interne et de Gerontologie Clinique, Pavillon Junot, 170 avenue de Casselardit, Hopital La Grave Casselardit, 31300 Toulouse, France
J Nutr Health Aging 13:679-83. 2009.... - Strontium ranelate and risk of vertebral fractures in frail osteoporotic womenYves Rolland
INSERM U558, F 31073, Avenue Jules Guesdes, University of Toulouse III, F 31073, France
Bone 48:332-8. 2011..Our study determined and compared the risk of vertebral fractures in frail, intermediate and robust older patients being treated with strontium ranelate vs. placebo... - [Sarcopenia]Y Rolland
Service de médecine interne et gérontologie clinique, Hopital La Grave Casselardit, Gérontopôle de Toulouse, Pavillon Junot, 170, avenue de Casselardit, 31300 Toulouse, France
Rev Med Interne 30:150-60. 2009..The endpoint prevention of mobility disability should be added to the well-established outcomes of treatment of the loss of muscular mass, muscle strength or muscle quality... - An abnormal "one-leg balance" test predicts cognitive decline during Alzheimer's diseaseYves Rolland
INSERM, U558, Toulouse, France
J Alzheimers Dis 16:525-31. 2009..8 (0.3) points at two years (p < 0.001). An abnormal one-leg balance test is a marker of more advanced dementia and predicts a higher rate of cognitive decline... - Healthy brain aging: role of exercise and physical activityYves Rolland
INSERM U558, Avenue J Guesdes, F 31073 Toulouse, France
Clin Geriatr Med 26:75-87. 2010..Future prevention of Alzheimer disease may depend on lifestyle habits such as physical activity... - Treatment strategies for sarcopenia and frailtyYves Rolland
INSERM U1027, F 31073, Avenue Jules Guesdes, University of Toulouse III, F 31073, France
Med Clin North Am 95:427-38, ix. 2011..The quality of amino acids in the diet is an important factor for stimulating protein synthesis. Vitamin D deficiency should be treated, and new pharmacologic approaches for sarcopenia are currently assessed... - Current and future pharmacologic treatment of sarcopeniaYves Rolland
INSERM U1027, University of Toulouse III, Avenue Jules Guesdes, France
Clin Geriatr Med 27:423-47. 2011..Therefore, new pharmacologic agents may substantially reduce the functional decline in older people. This article reviews the new pharmacologic agents currently being assessed for treating sarcopenia... - Prognosis of an abnormal one-leg balance in community-dwelling patients with Alzheimer's disease: a 2-year prospective study in 686 patients of the REAL.FR studySandrine Sourdet
Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
J Am Med Dir Assoc 13:407.e1-6. 2012..The aim of this study was to explore the predictive value of an abnormal one-leg balance (OLB) test for functional decline, nursing home admission, and mortality in community-dwelling patients affected with Alzheimer's disease (AD)... - Weight loss and rapid cognitive decline in community-dwelling patients with Alzheimer's diseaseMaria E Soto
Alzheimer s Disease Research and Clinical Centre, Department of Geriatric Medicine, Gerontopole, Toulouse University Hospital, Toulouse, France
J Alzheimers Dis 28:647-54. 2012..50, 95% CI = 1.04-2.17). In conclusion, weight loss predicted RCD in this cohort. Whether the prevention of weight loss (by improving nutritional status) impacts cognitive decline remains an open question... - Wandering behavior and Alzheimer disease. The REAL.FR prospective studyYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Pavillon Junot, Hopital La Grave Casselardit, 170 avenue de Casselardit, Toulouse, France
Alzheimer Dis Assoc Disord 21:31-8. 2007..Risk for undernutrition and death are not increased in wanderers. Their higher risk of ADL disabilities and institutionalization are partly explained by their baseline characteristics... - Sarcopenia, calf circumference, and physical function of elderly women: a cross-sectional studyYves Rolland
Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
J Am Geriatr Soc 51:1120-4. 2003..To determine whether calf circumference (CC), related to appendicular skeletal muscle mass, can be used as a measure of sarcopenia and is related to physical function... - Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional studyYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
Am J Clin Nutr 79:552-7. 2004..Muscle strength (MS) may be impaired in obese persons, and this impairment may be a consequence of both obesity and low physical fitness... - Cardiovascular disease risk factors and progression of Alzheimer's diseaseGabor Abellan van Kan
INSERM U558, Department of Geriatric Medicine, CHU Toulouse, Toulouse, France
Dement Geriatr Cogn Disord 27:240-6. 2009..To assess if cardiovascular disease risk factors (CVDRF) are predictive factors for poorer evolution of Alzheimer's disease (AD) patients in terms of cognitive decline... - Gait speed, body composition, and dementia. The EPIDOS-Toulouse cohortGabor Abellan van Kan
Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
J Gerontol A Biol Sci Med Sci 67:425-32. 2012..The aim of the study was to evaluate whether GS, TLM, and TFM were associated factors with an increased risk for subsequent dementia in community-dwelling older women... - The assessment of frailty in older adultsGabor Abellan van Kan
Gérontopôle de Toulouse, Department of Geriatric Medicine, Pavillon JP Junod, University Hospital Toulouse, CHU Toulouse, 170 avenue de Casselardit, TSA 40031, 31059 Toulouse Cedex 9, France
Clin Geriatr Med 26:275-86. 2010..The evaluation of gait speed over a short distance emerges from the literature as a tool with the capacity to identify frail older adults, and slow gait speed has been proven to be a strong predictor for frailty-adverse outcomes... - Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trialYves Rolland
Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
J Am Geriatr Soc 55:158-65. 2007.... - Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohortGabor Abellan van Kan
Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, 170, avenue de Casselardit, Toulouse 31059, France
Age Ageing 42:196-202. 2013..common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment... - Physical performance measures as predictors of mortality in a cohort of community-dwelling older French womenYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, 31300, Toulouse, France
Eur J Epidemiol 21:113-22. 2006..Increased risk of death was partly explained by baseline health status and was absent in the healthiest elderly... - Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional studyPhilipe de Souto Barreto
Gérontopôle de Toulouse, Institut du vieillissement, Centre Hospitalo Universitaire de Toulouse CHU Toulouse, Toulouse, France UMR7268 Aix Marseille University, Laboratoire d Anthropologie Bioculturelle, Droit, Ethique et Santé, Marseille, France Electronic address
J Am Med Dir Assoc 14:265-9. 2013..Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents... - Associated factors with antipsychotic use in assisted living facilities: a cross-sectional study of 4367 residentsAgnes Larrayadieu
Department of Geriatric Medicine, Toulouse University Hospital Gérontopôle, 170, avenue de Casselardit, Toulouse 31059, France
Age Ageing 40:368-75. 2011..Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence... - Gait and balance impairments in Alzheimer disease patientsVirginia Mazoteras Muñoz
Department of Geriatric Medicine, Univ Toulouse III, Toulouse, France
Alzheimer Dis Assoc Disord 24:79-84. 2010..To describe the characteristics and associated factors of Alzheimer disease (AD) patients with balance and gait impairments... - Nutritional intake and recreational physical activity in healthy elderly women living in the communityY Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hôpital Casselardit, Pavillon Junod, 31300 Toulouse, France
J Nutr Health Aging 9:397-402. 2005..Recreational physical activity, which increases energy expenditure, may help to maintain proper food intake. To compare the nutritional intake of inactive, active and very active healthy elderly women... - Patterns of dementia treatment use in assisted living facilities: a cross-sectional study of 1975 demented residentsNadège Barro-Belaygues
Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
J Am Med Dir Assoc 12:648-54. 2011..To report the associated factors with the nonuse of cholinesterase-inhibitors and memantine in residents from assisted living (AL) facilities suffering from dementia... - [Pastel in the urine bag]Lucie Cantaloube
Gérontopôle de Toulouse, Universite de Toulouse III, CHU Purpan, Toulouse
Geriatr Psychol Neuropsychiatr Vieil 10:5-8. 2012..Both of whom were diagnosed with indwelling urinary bacterial colonization, with Escherichia coli and Pseudomonas aeruginosa respectively... - Rehabilitation outcome of elderly patients with hip fracture and cognitive impairmentYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
Disabil Rehabil 26:425-31. 2004..To assess the association between cognitive status and functional gain during a rehabilitation programme for elderly patients with hip fracture... - Determination of appendicular muscle mass by dual energy X-ray absorptiometry method in women with sarcopenia and Alzheimer's diseaseS Gillette-Guyonnet
Department of Gerontology and Internal Medicine, Purpan University Hospital, Toulouse, France
J Nutr Health Aging 4:165-9. 2000..To study appendicular muscle mass in women with Alzheimer's disease (AD) to investigate the association between sarcopenia and AD. To examine the AD associated changes in body fat distribution... - A SPECT study of wandering behavior in Alzheimer's diseaseYves Rolland
Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, 170 avenue de Casselardit, 31300 Toulouse, France
Int J Geriatr Psychiatry 20:816-20. 2005..The aim of this study was to examine whether wandering during AD was associated with cerebral perfusion patterns measured by (99 m)Tc-labeled bicisate (ECD) brain SPECT... - Clinical trials on sarcopenia: methodological issues regarding phase 3 trialsGabor Abellan van Kan
Gerontopole, Department of Geriatric Medicine, Toulouse University Hospital, France
Clin Geriatr Med 27:471-82. 2011..The challenges to conduct phase 3 trials in the elderly should not offset the opportunities for the development of new strategies to counteract sarcopenia and prevent late-life disability... - Alzheimer's disease progression in the oldest old compared to younger elderly patient: data from the REAL.FR studyFati Nourhashemi
Gérontopôle Toulouse, France
Int J Geriatr Psychiatry 24:149-55. 2009..The aim of this study is to describe the progression of Alzheimer's disease (AD) in the oldest old (>or=85 years) and to compare it with the younger elderly... - The I.A.N.A Task Force on frailty assessment of older people in clinical practiceG Abellan Van Kan
Department of Geriatric Medicine, Pavillon J P Junod, CHU Toulouse, 170 avenue de Casselardit, TSA40031, 31059 Toulouse Cedex 9, France
J Nutr Health Aging 12:29-37. 2008.... - Nutrition assessment in the elderlyB Vellas
Department of Internal Medicine and Clinical Gerontology, University of Toulouse, France
Curr Opin Clin Nutr Metab Care 4:5-8. 2001..If malnutrition is suggested by such screening tests, then they should be supplemented by conventional nutritional assessment before treatment is planned... - Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task ForceG Abellan Van Kan
Gerontopole, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
J Nutr Health Aging 13:881-9. 2009.... - PUFA for prevention and treatment of dementia?I Carrie
Gerontopole, CHU Toulouse, Department of Geriatric Medicine, Toulouse, France
Curr Pharm Des 15:4173-85. 2009..In this review, we summarize preclinical and clinical research suggesting that DHA exerts beneficial effects on cognitive function with ageing... - IANA task force on nutrition and cognitive decline with agingS Gillette Guyonnet
Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
J Nutr Health Aging 11:132-52. 2007..These studies must control for the greatest number of known confounding factors and take into account the impact of the standard social determinants of food habits, such as the regional cultures, social status, and educational level... - Overview of the MNA--Its history and challengesB Vellas
INSERM U 558, Department of Geriatrics, Toulouse University Hospital, Toulouse, France
J Nutr Health Aging 10:456-63; discussion 463-5. 2006..A short screening version (MNA-SF) has been developed, which, if positive, indicates the need to complete the full MNA. It takes less than 4 minutes to administer the MNA-SF and between 10 and 15 minutes for the full MNA... - A randomized trial of the impact of a specific care plan in 1120 Alzheimer's patients (PLASA Study) over a two-year period: design and baseline dataF Nourhashemi
Hôpital Casselardit, Service de Medecine Interne et de Gerontologie Clinique, 31059 Toulouse, France
J Nutr Health Aging 12:263-71. 2008..The study is designed to evaluate the effect of PLASA in AD primarily looking at change in functional capacity... - The geriatric minimum data set for clinical trials (GMDS)G Abellan Van Kan
Inserum U558, Department of Geriatric Medicine, CHU Toulouse, France
J Nutr Health Aging 12:197-200. 2008..This will lead to uniform nomenclature and to the standardisation of the assessment tools. Our primary objective was to develop a Geriatric Minimum Data Set (GMDS) for clinical research... - Carla Task Force on Sarcopenia: propositions for clinical trialsG Abellan Van Kan
Gerontopole, INSERM U558, University of Toulouse III, Toulouse, France
J Nutr Health Aging 13:700-7. 2009..Through this report, the reader will appreciate the determination to find conclusions on the various issues and further studies to be developed to determine the best multidisciplinary approach needed... - Indicators of benzodiazepine use in nursing home residents in France: a cross-sectional studyPhilipe de Souto Barreto
Gérontopôle de Toulouse, Institut du vieillissement, Centre Hospitalo Universitaire de Toulouse CHU Toulouse, Toulouse, France
J Am Med Dir Assoc 14:29-33. 2013..Little information is available about associations between nursing home (NH) structural and organizational aspects and benzodiazepine prescriptions, particularly for long-acting drugs. This study addressed this knowledge gap... 
Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on SarcopeniaMatteo Cesari
Gerontopôle and INSERM Unit 1027, Universite de Toulouse, Toulouse, France
J Cachexia Sarcopenia Muscle 3:181-90. 2012..However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject...- [Wandering and Alzheimer's type disease. Descriptive study. REAL.FR research program on Alzheimer's disease and management]Y Rolland
Service de médecine interne et gérontologie clinique, CHU Purpan, Pavillon Junod, 170, avenue de Casselardit, 31300 Toulouse, France
Rev Med Interne 24:333s-338s. 2003..Few studies have examined this problematic behaviour in the community. The aim of the present study was to increase our understanding of wandering during Alzheimer's disease in subjects living in the community... - FrailtyJohn E Morley
Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, MO 63104, USA
Med Clin North Am 90:837-47. 2006..In people who have frailty aggressive health promotion and disease prevention techniques can lead to an inhibition of the downward spiral to disability... - Office management of weight loss in older personsYves Rolland
Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
Am J Med 119:1019-26. 2006..Early screening for anorexia can be undertaken in the physician's office utilizing the Simplified Nutritional Assessment Questionnaire. An algorithmic approach to the office management of weight loss is provided...