Cecile Rochette-Egly

Summary

Country: France

Publications

  1. ncbi request reprint The AF-1 and AF-2 activating domains of retinoic acid receptor-alpha (RARalpha) and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes
    C Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, CU de Strasbourg
    Mol Endocrinol 14:1398-410. 2000
  2. ncbi request reprint F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling
    C Rochette-Egly
    Institute of Genetic and Cellular and Molecular Biology, CNRS INSERM ULP College of France, Illkirch
    Histol Histopathol 16:909-22. 2001
  3. ncbi request reprint Nuclear receptors: integration of multiple signalling pathways through phosphorylation
    Cecile Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, France
    Cell Signal 15:355-66. 2003
  4. ncbi request reprint Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity
    Nathalie Bruck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, France
    Cell Signal 17:1229-39. 2005
  5. ncbi request reprint The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers
    Maurizio Gianni
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, UMR 7104, BP 10142, 67404 Illkirch Cedex, France
    J Biol Chem 278:34458-66. 2003
  6. ncbi request reprint Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription
    Gaétan Bour
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, 67404 Illkirch Cedex, France
    J Biol Chem 280:17027-37. 2005
  7. pmc Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    EMBO J 21:3760-9. 2002
  8. ncbi request reprint The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
  9. pmc Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7
    Gaétan Bour
    Département de Biologie Cellulaire et de Transduction du Signal, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, UMR 7104, Illkirch, France
    Proc Natl Acad Sci U S A 102:16608-13. 2005
  10. pmc Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7
    Emilie Gaillard
    Département de Biologie Cellulaire et de Transduction du Signal, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, Unite Mixte de Recherche 7104, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:9548-53. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The AF-1 and AF-2 activating domains of retinoic acid receptor-alpha (RARalpha) and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes
    C Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, CU de Strasbourg
    Mol Endocrinol 14:1398-410. 2000
    ..We also show that the RARalpha AF-1 and AF-2 activation functions, but not their phosphorylation sites, are involved in the induction of RA-responsive genes in a differential promoter context-dependent manner...
  2. ncbi request reprint F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling
    C Rochette-Egly
    Institute of Genetic and Cellular and Molecular Biology, CNRS INSERM ULP College of France, Illkirch
    Histol Histopathol 16:909-22. 2001
    ..Thus, retinoid receptors are sophisticated signal integrators that transduce not only the effects of their cognate ligands, but also those of ligands that bind to membrane receptors...
  3. ncbi request reprint Nuclear receptors: integration of multiple signalling pathways through phosphorylation
    Cecile Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, France
    Cell Signal 15:355-66. 2003
    ..These different modes of regulation reveal an unexpected complexity of the dynamics of NR-mediated transcription. In addition, deregulation of NR phosphorylation may impact their action in certain diseases or cancers...
  4. ncbi request reprint Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity
    Nathalie Bruck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, France
    Cell Signal 17:1229-39. 2005
    ....
  5. ncbi request reprint The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers
    Maurizio Gianni
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, UMR 7104, BP 10142, 67404 Illkirch Cedex, France
    J Biol Chem 278:34458-66. 2003
    ..Our results underline that the AF-1 and AF-2 domains of each heterodimer partner cooperate with one other and that this cooperation is relevant for both the transcription and degradation processes...
  6. ncbi request reprint Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription
    Gaétan Bour
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, 67404 Illkirch Cedex, France
    J Biol Chem 280:17027-37. 2005
    ..We propose a model in which phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta...
  7. pmc Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    EMBO J 21:3760-9. 2002
    ..Blocking RAR gamma 2 degradation through inhibition of either the p38MAPK pathway or the 26S proteasome function impairs its RA-induced transactivation activity. Thus, the turnover of RAR gamma 2 is linked to transactivation...
  8. ncbi request reprint The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
    ..Ser(22) is also indispensable for the antiproliferative effect of RA and necessary for the RA-induced down-regulation of p21(CIP) and p27(KIP) CKIs proteins that are known to be involved in the control of cell cycle progression...
  9. pmc Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7
    Gaétan Bour
    Département de Biologie Cellulaire et de Transduction du Signal, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, UMR 7104, Illkirch, France
    Proc Natl Acad Sci U S A 102:16608-13. 2005
    ..To our knowledge, this study provides the first example of a cooperation between the AF-2 and AF-1 domains of RARs through a kinase complex...
  10. pmc Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7
    Emilie Gaillard
    Département de Biologie Cellulaire et de Transduction du Signal, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, Unite Mixte de Recherche 7104, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:9548-53. 2006
    ..Finally, it results in higher DNA-binding efficiency, providing an explanation for how cAMP synergizes with retinoic acid for transcription...
  11. ncbi request reprint Nuclear retinoid receptors and the transcription of retinoid-target genes
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, 1 rue Laurent Fries, BP 10142, Illkirch Cedex 67404, France
    Gene 328:1-16. 2004
    ..These different modes of regulation reveal unexpected levels of complexity in the dynamics of retinoid-dependent transcription...
  12. ncbi request reprint Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha
    Anne Tarrade
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, France
    Oncogene 24:2277-88. 2005
    ..Finally, we demonstrate that As2O3 also abrogates the transactivation of RA-target genes...
  13. ncbi request reprint XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha
    Anne Keriel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U, Strasbourg, France
    Cell 109:125-35. 2002
    ..Thus, we demonstrate that the cdk7 kinase of TFIIH phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes...
  14. pmc SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3
    Christine Ferry
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, Boite Postale 10142, Illkirch 67404 Cedex, CU de Strasbourg, France
    J Biol Chem 284:8127-35. 2009
    ..This study provides new insights into how SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3...
  15. pmc Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response
    Christine Ferry
    Department of Functional Genomics and Cancer, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7104, Universite de Strasbourg, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 108:20603-8. 2011
    ..Finally, phosphorylation, ubiquitination, and degradation of SRC-3 cooperate to control the dynamics of transcription. In all, this process participates to the antiproliferative effect of RA...
  16. doi request reprint Vinexinß, an atypical "sensor" of retinoic acid receptor gamma signaling: union and sequestration, separation, and phosphorylation
    Sébastien Lalevée
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Sante et de la Recherche Medicale INSERM, U596, Illkirch, France
    FASEB J 24:4523-34. 2010
    ..This separation allows RARγ to occupy promoters. This is the first report of an RAR corepressor association/dissociation out of promoters and regulated by phosphorylation...
  17. pmc Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics
    Yassmine Chebaro
    Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France
    PLoS Comput Biol 9:e1003012. 2013
    ..This results in changes in conformation and flexibility of the latter. The high conservation of the residues implicated in this signal transduction suggests a mechanism that could be applied to other nuclear receptor proteins...
  18. ncbi request reprint Dynamic combinatorial networks in nuclear receptor-mediated transcription
    Cecile Rochette-Egly
    Department of Cell Biology and Signal Transduction, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, BP 10142, 67404 Illkirch Cedex, France
    J Biol Chem 280:32565-8. 2005
  19. ncbi request reprint Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors
    Gaétan Bour
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Cell Biology and Signal Transduction, BP10142 Inserm, U596 CNRS, UMR7104, Illkirch, France
    Trends Cell Biol 17:302-9. 2007
    ..Here, we review new insights into how N-terminal domain and the proteasome pathway can influence the dynamics of RAR transcriptional activity...
  20. ncbi request reprint TIF2 mediates the synergy between RARalpha 1 activation functions AF-1 and AF-2
    Martin Bommer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, France
    J Biol Chem 277:37961-6. 2002
    ..Because another p160 coactivator, SRC-1, has no effect, this is also the first demonstration of a difference between the members of this coactivator family...
  21. doi request reprint Evolution of nuclear retinoic acid receptor alpha (RARα) phosphorylation sites. Serine gain provides fine-tuned regulation
    Eric Samarut
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de Sante et de Recherche Medicale INSERM, U596, Centre National de Recherche Scientifique CNRS, UMR7104, Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Mol Biol Evol 28:2125-37. 2011
    ..In contrast, S(NTD) is conserved, indicating that the phosphorylation of this functional site has been under ancient high selection constraint. This suggests that, during evolution, different regulatory circuits control RARα activity...
  22. pmc A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters
    Nathalie Bruck
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U596, CNRS UMR7104, Universite Louis Pasteur de Strasbourg, CU de Strasbourg, France
    EMBO J 28:34-47. 2009
    ..Cancer cells characterized by a deregulated p38MAPK/MSK1 pathway, do not respond to RA, outlining the essential contribution of the RA-triggered phosphorylation cascade in RA signalling...
  23. ncbi request reprint Phosphorylation of the retinoic acid receptor RARγ2 is crucial for the neuronal differentiation of mouse embryonic stem cells
    Ziad Al Tanoury
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, U596, CNRS, UMR7104, Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    J Cell Sci 127:2095-105. 2014
    ..These new findings suggest an important role for RARγ phosphorylation during cell differentiation and pave the way for further investigations during embryonic development. ..
  24. doi request reprint The molecular physiology of nuclear retinoic acid receptors. From health to disease
    Vanessa Duong
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, U596, CNRS, UMR7104, Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Biochim Biophys Acta 1812:1023-31. 2011
    ..This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease...
  25. ncbi request reprint Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:24859-62. 2002
    ..Altogether these data indicate that the PI3K/Akt pathway plays an important role in retinoic acid signaling...
  26. ncbi request reprint Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis
    Nadège Vernet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Université Louis Pasteur de Strasbourg ULP Collège de France, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Endocrinology 147:96-110. 2006
    ..Our data also suggest that the involvement of RA in testis development starts when primary spermatogonia first appear...
  27. ncbi request reprint Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamm
    Edoardo Parrella
    Institut de Genetique et Biologie Moleculaire, Illkirch, France
    Mol Pharmacol 70:909-24. 2006
    ....
  28. ncbi request reprint Retinoic-acid receptor beta expression in melanocytes
    Nelly Boehm
    Institut d Histologie, Faculte de Medecine, 4 rue Kirschleger 67085, Strasbourg, France
    Eur J Dermatol 14:19-23. 2004
    ..These results indicate that melanoma are characterised by simultaneous decrease of RARbeta and absence of RXRalpha that may be responsible for the RA-resistance of most melanoma cell lines...
  29. doi request reprint Production and characterization of a retinoic acid receptor RARγ construction encompassing the DNA binding domain and the disordered N-terminal proline rich domain
    Denise Martinez-Zapien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Université de Strasbourg CNRS UMR 7104 INSERM U964, 1 rue Laurent Fries, 67404 Illkirch, France
    Protein Expr Purif 95:113-20. 2014
    ..These studies showed that PRD extension of RARγ is disordered in solution, a state that is compatible with modifications such as phosphorylation. ..
  30. doi request reprint Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts
    Ziad Al Tanoury
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, U964, CNRS, UMR7104, Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    J Cell Sci 127:521-33. 2014
    ..Our results increase the repertoire of genes that are regulated by RARs and highlight the complexity and diversity of the transcriptional programs regulated by RARs, depending on the gene. ..
  31. doi request reprint Nuclear retinoic acid receptors: conductors of the retinoic acid symphony during development
    Eric Samarut
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM, U596 CNRS, UMR7104 Université de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Mol Cell Endocrinol 348:348-60. 2012
    ..It appears that RARs are the conductors of the RA signaling symphony through controlling the dynamics and the coordination of the different players and development steps...
  32. pmc Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
    Cecile Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, INSERM U596, CNRS UMR7104, Universite Louis Pasteur de Strasbourg, Strasbourg, France
    Nucl Recept Signal 7:e005. 2009
    ..Here we will review these mechanisms, focusing on how kinase signaling and the proteasome pathway cooperate to influence the dynamics of RAR transcriptional activity...
  33. pmc Vitamin A and retinoid signaling: genomic and nongenomic effects
    Ziad Al Tanoury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Sante et de la Recherche Medicale INSERM, U964, CNRS, UMR7104, Universite de Strasbourg, 67404 Illkirch Cedex, France
    J Lipid Res 54:1761-75. 2013
    ..However, vitamin A itself proved recently to be active and RARs to be present in the cytosol to regulate translation and cell plasticity. These new concepts expand the scope of the biologic functions of vitamin A and RA...