Frederic Rieux-Laucat

Summary

Country: France

Publications

  1. pmc Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome
    F Rieux-Laucat
    Unité INSERM 429, Hopital Necker Enfants Malades, 75743 Paris, Cedex 15, France
    J Clin Invest 102:312-21. 1998
  2. ncbi request reprint [Autoimmune lymphoproliferative syndrome: an inherited or a somatic defect of apoptosis]
    Frederic Rieux-Laucat
    Inserm U768, Universite Paris V, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 22:645-50. 2006
  3. ncbi request reprint Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency
    Frederic Rieux-Laucat
    INSERM Unité 768, Hopital Necker, Paris, France
    N Engl J Med 354:1913-21. 2006
  4. ncbi request reprint Inherited and acquired death receptor defects in human Autoimmune Lymphoproliferative Syndrome
    Frederic Rieux-Laucat
    Unité INSERM 429, Universite Paris V, Hopital Necker Enfants Malades, Paris, France
    Curr Dir Autoimmun 9:18-36. 2006
  5. ncbi request reprint Cell-death signaling and human disease
    Frederic Rieux-Laucat
    Institut National de la Santé et de la Recherche Médicale U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Curr Opin Immunol 15:325-31. 2003
  6. ncbi request reprint Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways
    F Rieux-Laucat
    Hôpital Necker INSERM U429, Paris, France
    Cell Death Differ 10:124-33. 2003
  7. ncbi request reprint Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations
    F Rieux-Laucat
    Department of Pediatric Immunology, Unit INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Blood 94:2575-82. 1999
  8. ncbi request reprint Autoimmune lymphoproliferative syndrome with somatic Fas mutations
    Eliska Holzelova
    INSERM Unité 429, Hopital Necker Enfants Malades, Paris
    N Engl J Med 351:1409-18. 2004
  9. ncbi request reprint Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells
    Anne Bristeau-Leprince
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    J Immunol 181:440-8. 2008
  10. ncbi request reprint Differential sensitivity of Jurkat and primary T cells to caspase-independent cell death triggered upon Fas stimulation
    Cedric Vonarbourg
    INSERM U429, Developpement Normal et Pathologique du Systeme Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 32:2376-84. 2002

Collaborators

Detail Information

Publications31

  1. pmc Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome
    F Rieux-Laucat
    Unité INSERM 429, Hopital Necker Enfants Malades, 75743 Paris, Cedex 15, France
    J Clin Invest 102:312-21. 1998
    ..These results suggest that the oligoclonal expansion of T cells observed in Omenn's syndrome could be the consequence of autoimmune proliferation generated by a profound defect in lymphocyte development...
  2. ncbi request reprint [Autoimmune lymphoproliferative syndrome: an inherited or a somatic defect of apoptosis]
    Frederic Rieux-Laucat
    Inserm U768, Universite Paris V, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 22:645-50. 2006
    ..These findings might have important implications in deciphering the pathophysiological bases of other autoimmune diseases...
  3. ncbi request reprint Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency
    Frederic Rieux-Laucat
    INSERM Unité 768, Hopital Necker, Paris, France
    N Engl J Med 354:1913-21. 2006
    ....
  4. ncbi request reprint Inherited and acquired death receptor defects in human Autoimmune Lymphoproliferative Syndrome
    Frederic Rieux-Laucat
    Unité INSERM 429, Universite Paris V, Hopital Necker Enfants Malades, Paris, France
    Curr Dir Autoimmun 9:18-36. 2006
    ..Consequences of this finding will be discussed in terms of functional and molecular diagnosis as well as in the understanding of the pathophysiological basis of ALPS...
  5. ncbi request reprint Cell-death signaling and human disease
    Frederic Rieux-Laucat
    Institut National de la Santé et de la Recherche Médicale U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Curr Opin Immunol 15:325-31. 2003
    ....
  6. ncbi request reprint Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways
    F Rieux-Laucat
    Hôpital Necker INSERM U429, Paris, France
    Cell Death Differ 10:124-33. 2003
    ..This review will discuss the main findings provided by the study of mouse models and human conditions...
  7. ncbi request reprint Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations
    F Rieux-Laucat
    Department of Pediatric Immunology, Unit INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Blood 94:2575-82. 1999
    ..This observation suggests that Fas-mediated apoptosis plays a more important role in lymphocyte homeostasis in early childhood than later on in life...
  8. ncbi request reprint Autoimmune lymphoproliferative syndrome with somatic Fas mutations
    Eliska Holzelova
    INSERM Unité 429, Hopital Necker Enfants Malades, Paris
    N Engl J Med 351:1409-18. 2004
    ..We studied six children with ALPS whose lymphocytes had normal sensitivity to Fas-induced apoptosis in vitro...
  9. ncbi request reprint Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells
    Anne Bristeau-Leprince
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    J Immunol 181:440-8. 2008
    ..CDR3 sequencing of matching clonotypes revealed a significant sharing of CDR3 sequences from selected Vbeta-Jbeta transcripts between DN and CD8+ T cells. Altogether, these data strongly argue for a CD8 origin of DN T cells in ALPS...
  10. ncbi request reprint Differential sensitivity of Jurkat and primary T cells to caspase-independent cell death triggered upon Fas stimulation
    Cedric Vonarbourg
    INSERM U429, Developpement Normal et Pathologique du Systeme Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 32:2376-84. 2002
    ..Indeed, in this setting, Fas-induced cell death was always substantially inhibited by Z-VAD-fmk, suggesting that caspase activation is an absolute requirement in the Fas-induced death of primary human T lymphocytes...
  11. ncbi request reprint Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes
    Véronique Mateo
    INSERM, U768, Paris, France
    Blood 110:4285-92. 2007
    ..Furthermore, they identified a novel AICD pathway as a unique alternative to Fas apoptosis in human peripheral T lymphocytes...
  12. doi request reprint Somatic loss of heterozygosity, but not haploinsufficiency alone, leads to full-blown autoimmune lymphoproliferative syndrome in 1 of 12 family members with FAS start codon mutation
    Fabian Hauck
    Inserm U768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Clin Immunol 147:61-8. 2013
    ..FAS surface expression on DN T cells should be assessed routinely and FAS haploinsufficient patients should be followed as its potential for lymphomagenesis is not well defined and a second hit might occur later on...
  13. doi request reprint Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    Nicolette Moes
    Universite Paris Descartes, Paris, France
    Gastroenterology 139:770-8. 2010
    ..We analyzed the molecular basis of neonatal or early postnatal AIE using clinical, genetic, and functional immunological studies...
  14. pmc Efficacy of gene therapy for X-linked severe combined immunodeficiency
    Salima Hacein-Bey-Abina
    Department of Biotherapy, Necker Enfants Malades Hospital, Paris, France
    N Engl J Med 363:355-64. 2010
    ..We reviewed long-term outcomes after gene therapy in nine patients with X-linked severe combined immunodeficiency (SCID-X1), which is characterized by the absence of the cytokine receptor common gamma chain...
  15. doi request reprint Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease
    Bernadette Begue
    INSERM U989, Paris, France
    Am J Gastroenterol 106:1544-55. 2011
    ..Thus, we aimed to further elaborate the hypothesis of defective anti-inflammatory responses in patients with IBD...
  16. pmc STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity
    Capucine Picard
    Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris
    N Engl J Med 360:1971-80. 2009
    ..Two of these patients have a homozygous nonsense mutation in STIM1 that abrogates expression of STIM1 and Ca(2+) influx...
  17. pmc Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation
    Aude Magerus-Chatinet
    Unité Inserm 768, Hopital Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 131:486-90. 2013
    ..Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphoproliferation, accumulation of double-negative T cells, hypergammaglobulinemia G and A, and autoimmune cytopenia...
  18. doi request reprint A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
    Benedicte Neven
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:4798-807. 2011
    ..We also noted a significantly greater occurrence of disease-related symptoms in male than in female patients...
  19. pmc Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation
    Aude Magerus-Chatinet
    Inserm U768, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    J Clin Invest 121:106-12. 2011
    ..This observation provides the molecular bases of a nonmalignant autoimmune disease development in humans and may shed light on the mechanism underlying the occurrence of other autoimmune diseases...
  20. doi request reprint A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
    Benedicte Neven
    Unité d Immuno Hématologie Pédiatrique, Hopital Necker Enfant Malades, Assistance publique des Hôpitaux de Paris APHP, Paris, France
    Blood 122:3713-22. 2013
    ..Hence, IL-10R deficiency is associated with a high risk of developing B-cell lymphoma. Our results revealed an unexpected role of the IL-10R pathway in lymphomagenesis. ..
  21. doi request reprint Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
    Fabian Hauck
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 130:1144-1152.e11. 2012
    ..The T lymphocyte-specific protein tyrosine kinase (Lck) is a key component of the TCR signaling machinery. On the basis of its function, we considered LCK a candidate gene in patients with combined immunodeficiency...
  22. doi request reprint FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function
    Aude Magerus-Chatinet
    Inserm U768, Paris, France
    Blood 113:3027-30. 2009
    ..Overall, we showed that determination of the FAS-L represents, together with the IL-10 concentration and the DNT cell percentage, a reliable tool for the diagnosis of ALPS...
  23. doi request reprint Digestive histopathological presentation of IPEX syndrome
    Natacha Patey-Mariaud de Serre
    Department of Pathology, Necker Enfants Malades, Universite Rene Descartes Paris V, tumorothèque, Paris, France
    Mod Pathol 22:95-102. 2009
    ....
  24. doi request reprint Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity
    Capucine Picard
    Centre d Etude des Déficits Immunitaires, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, EU, Paris, France
    Eur J Immunol 39:1966-76. 2009
    ..This report extends the phenotype spectrum of ZAP70 deficiency with a residual function of ZAP70...
  25. pmc MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
    Nadine T Nehme
    Inserm U768, Paris, France
    Blood 119:3458-68. 2012
    ..Our results characterize a new mechanism in primary T-cell immunodeficiencies and highlight a role of the MST1/FOXO1 pathway in controlling the death of human naive T cells...
  26. doi request reprint Accessory spleen: differential diagnosis for lymphoma in autoimmune lymphoproliferative syndrome
    Sophie Georgin-Lavialle
    Department of Adult Hematology, Hopital Necker, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Paris, France
    Pediatr Blood Cancer 54:1020-2. 2010
    ..This observation highlights the lymphoma's differential diagnosis in this context...
  27. ncbi request reprint XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
    Stéphanie Rigaud
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Univ René Descartes, Paris, F 75015, France
    Nature 444:110-4. 2006
    ..Furthermore, by identifying an XLP immunodeficiency that is caused by mutations in XIAP, we show that XIAP is a potent regulator of lymphocyte homeostasis in vivo...
  28. doi request reprint Clinical and molecular aspects of autoimmune enteropathy and immune dysregulation, polyendocrinopathy autoimmune enteropathy X-linked syndrome
    Frank M Ruemmele
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology Unit, France
    Curr Opin Gastroenterol 24:742-8. 2008
    ..Recent research data allowed us to gain a first insight in the pathogenesis of AIE. On the basis of this data, we will discuss new aspects of AIE emphasizing new diagnostic and therapeutic possibilities...
  29. ncbi request reprint Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity
    Chantal Lagresle-Peyrou
    Universite Paris Descartes, Faculte de Medecine, INSERM Unit 429, Site Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex15, France
    Blood 107:63-72. 2006
    ....
  30. doi request reprint Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group
    Benedicte Pigneur
    Universite Paris Descartes, Sorbonne Paris Cité, Institut Imagine, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Paris, France Department of Pediatric Gastroenterology, ErasmusMC Sophia Children s Hospital, Rotterdam, The Netherlands Department of Gastroenterology, Great Ormond Street Hospital for Sick Children and Institute of Child Health, London, United Kingdom Pediatric Gastroenterology Unit, Centro Hospitalar do Porto, Porto, Portugal Marienhospital, Bonn, Germany Department of Gastroenterology, Hepatology and Feeding Disorders, The Children s Memorial Health Institute, Warsaw, Poland Gastroenterologia, Endoscopia Digestiva, Epatologia e Cura del Bambino con Trapianto di Fegato, Dipartimento Salute della Donna e del Bambino, Padova, Italy Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service d Anatomopathologie, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Service de Radiologie, Paris, France Inserm U989, Paris, Turkey
    Inflamm Bowel Dis 19:2820-8. 2013
    ..We set up the GENetically determined ImmUne-mediated enteropathieS (GENIUS) network and collected infants with a proven defect of the IL10 axis for accurate phenotyping of disease presentation and evolution...
  31. pmc Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness
    Chantal Lagresle-Peyrou
    Research Laboratory on Normal and Pathologic Development of the Immune System, U768, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    Nat Genet 41:106-11. 2009
    ..These results identify a previously unknown mechanism involved in regulation of hematopoietic cell differentiation and in one of the most severe human immunodeficiency syndromes...