D Ricquier

Summary

Country: France

Publications

  1. ncbi Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4
    A M Cassard
    Centre de Recherche sur la Nutrition, CNRS, Meudon, France
    J Cell Biochem 43:255-64. 1990
  2. pmc The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    D Ricquier
    Centre de Recherche sur l Endocrinologie Moléculaire et le Développement CEREMOD, Centre National de la recherche Scientifique CNRS Unit 9078, 9 rue Jules Hetzel, 92190 Meudon, France
    Biochem J 345:161-79. 2000
  3. ncbi [To burn or to store]
    D Ricquier
    CNRS UPR 9078, Institut de Recherche Necker Enfants Malades 9, rue Jules Hetzel 92190 Meudon
    Ann Endocrinol (Paris) 63:S7-14. 2002
  4. ncbi Contributions of studies on uncoupling proteins to research on metabolic diseases
    D Ricquier
    Centre National de la Recherche Scientifique, Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Meudon, France
    J Intern Med 245:637-42. 1999
  5. ncbi Uncoupling protein-2 (UCP2): molecular and genetic studies
    D Ricquier
    CEREMOD, CRNS, Meudon, France
    Int J Obes Relat Metab Disord 23:S38-42. 1999
  6. ncbi Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain
    M Larose
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, Centre National de la Recherche Scientifique, 92190 Meudon, France
    J Biol Chem 271:31533-42. 1996
  7. ncbi Contribution to the identification and analysis of the mitochondrial uncoupling proteins
    D Ricquier
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Centre National de la Recherche Scientifique Unit 9078, Meudon, France
    J Bioenerg Biomembr 31:407-18. 1999
  8. ncbi Endocrine regulation of uncoupling proteins and energy expenditure
    D Ricquier
    Centre National de la Recherche Scientifique Unité 9078, Meudon, France
    Int J Obes Relat Metab Disord 24:S86-8. 2000
  9. pmc Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
    D Ricquier
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Centre National de la Recherche Scientifique, Meudon 92190, France
    J Physiol 529:3-10. 2000
  10. ncbi Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene
    C Pecqueur
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, UPR 9078 CNRS, 9 rue Jules Hetzel, Meudon, 92190, France
    Biochem Biophys Res Commun 255:40-6. 1999

Collaborators

Detail Information

Publications35

  1. ncbi Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4
    A M Cassard
    Centre de Recherche sur la Nutrition, CNRS, Meudon, France
    J Cell Biochem 43:255-64. 1990
    ..Interestingly, the T1 gene encoding the heart-skeletal muscle ADP/ATP carrier has recently been shown to be on the same chromosome (Li et al. Biol Chem 264:13998, 1989)...
  2. pmc The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    D Ricquier
    Centre de Recherche sur l Endocrinologie Moléculaire et le Développement CEREMOD, Centre National de la recherche Scientifique CNRS Unit 9078, 9 rue Jules Hetzel, 92190 Meudon, France
    Biochem J 345:161-79. 2000
    ..Other aims will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body...
  3. ncbi [To burn or to store]
    D Ricquier
    CNRS UPR 9078, Institut de Recherche Necker Enfants Malades 9, rue Jules Hetzel 92190 Meudon
    Ann Endocrinol (Paris) 63:S7-14. 2002
    ..In other respects, analysis of molecular mechanisms controlling respiration uncoupling may contribute to new strategies of treatment of metabolic disorders such as obesity...
  4. ncbi Contributions of studies on uncoupling proteins to research on metabolic diseases
    D Ricquier
    Centre National de la Recherche Scientifique, Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Meudon, France
    J Intern Med 245:637-42. 1999
    ..Their biological importance should be studied. They also represent new putative targets for drugs against metabolic diseases such as obesity...
  5. ncbi Uncoupling protein-2 (UCP2): molecular and genetic studies
    D Ricquier
    CEREMOD, CRNS, Meudon, France
    Int J Obes Relat Metab Disord 23:S38-42. 1999
    ..Recent genetic, biochemical and physiological studies suggest that these novel UCP2 contribute to resting metabolic rate, fat oxidation and may represent new targets for anti-obesity compounds...
  6. ncbi Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain
    M Larose
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, Centre National de la Recherche Scientifique, 92190 Meudon, France
    J Biol Chem 271:31533-42. 1996
    ..This response was obtained with a larger DNA fragment (bp -2489 to -2398) constituting a complex RA response domain...
  7. ncbi Contribution to the identification and analysis of the mitochondrial uncoupling proteins
    D Ricquier
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Centre National de la Recherche Scientifique Unit 9078, Meudon, France
    J Bioenerg Biomembr 31:407-18. 1999
    ..Although the biochemical activities and physiological roles of the novel UCPs are not well understood, these recent data stimulate research on mitochondrial carriers, mitochondrial bioenergetics, and energy expenditure...
  8. ncbi Endocrine regulation of uncoupling proteins and energy expenditure
    D Ricquier
    Centre National de la Recherche Scientifique Unité 9078, Meudon, France
    Int J Obes Relat Metab Disord 24:S86-8. 2000
    ..Activity and expression of the three UCP's are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin...
  9. pmc Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
    D Ricquier
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, Centre National de la Recherche Scientifique, Meudon 92190, France
    J Physiol 529:3-10. 2000
    ..However, very recent data suggest an important role for the UCPs in the control of production of free radicals by mitochondria, and in response to oxidants...
  10. ncbi Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene
    C Pecqueur
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, UPR 9078 CNRS, 9 rue Jules Hetzel, Meudon, 92190, France
    Biochem Biophys Res Commun 255:40-6. 1999
    ..Analysis of several genomic clones encompassing UCP2 and/or UCP3 genes demonstrated that the 2 genes are adjacent, the human UCP2 gene being located 7 kb downstream of the UCP3 gene...
  11. ncbi Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
    C Fleury
    CNRS CEREMOD, Meudon, France
    Nat Genet 15:269-72. 1997
    ..Our findings suggest that UCP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli...
  12. ncbi A new polymorphic site located in the human UCP1 gene controls the in vitro binding of CREB-like factor
    S Rousset
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, CNRS, Meudon, France
    Int J Obes Relat Metab Disord 26:735-8. 2002
    ..However, we postulate that the C/A substitution, in human, may contribute to a minor defect in the regulation of hUCP1 transcription and that would explain fat gain over time...
  13. ncbi Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation
    C Pecqueur
    CEREMOD (UPR 9078 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
    J Biol Chem 276:8705-12. 2001
    ..This further level of regulation of the ucp2 gene provides a mechanism by which expression can be strongly and rapidly induced under stress conditions...
  14. ncbi BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
    D Sanchis
    Centre National de la Recherche Scientifique, Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, 9 rue Jules Hetzel 92190 Meudon, France
    J Biol Chem 273:34611-5. 1998
    ....
  15. ncbi The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research
    M del Mar Gonzalez-Barroso
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
    Obes Rev 1:61-72. 2000
    ....
  16. ncbi Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis
    C Pecqueur
    Centre National de la Recherche Scientifique UPR 9078, CEREMOD, Meudon, France
    J Mol Med 79:48-56. 2001
    ..However, several physiological studies question such a role. Importantly, UCP2 and UCP3 seem to be able to control the activity of mitochondria in response to oxidants...
  17. ncbi Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe
    F Bouillaud
    Centre de Recherche sur la Nutrition, Centre National de la Recherche Scientifique, Meudon, France
    Clin Sci (Lond) 75:21-7. 1988
    ..8 kb mRNA in human brown adipose tissue obtained from six patients with phaeochromocytoma and from one patient with a hibernoma. This molecular probe is a new, sensitive and reliable tool with which to study human brown adipocytes...
  18. ncbi Respiration under control of uncoupling proteins: Clinical perspective
    T Nubel
    Centre National de la Recherche Scientifique, Unit 9078, Faculty of Medicine René Descartes Paris 5, Paris, France
    Horm Res 65:300-10. 2006
    ..This lively awaited information may be the basis for potential pharmacological targeting of the UCPs in future...
  19. pmc The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins
    B Miroux
    Centre de Recherches en Endocrinologie Moléculaire et Développement CEREMOD, CNRS, Meudon, France
    EMBO J 12:3739-45. 1993
    ..This topological study together with previous data on the UCP provides an experimental basis for the predicted structure of the UCP and for other homologous carrier proteins...
  20. ncbi Regulation of UCP gene expression in brown adipocytes differentiated in primary culture. Effects of a new beta-adrenoceptor agonist
    O Champigny
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS, Meudon Bellevue, France
    Mol Cell Endocrinol 86:73-82. 1992
    ..It was concluded that the drug could affect the brown adipose cells through a beta 3-pathway. It could clearly modulate the expression of UCP in brown adipocytes differentiated in vitro, but was not able by itself to turn on the gene...
  21. pmc An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds
    S Raimbault
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, CNRS, 9 rue Jules Hetzel, F 92190 Meudon, France
    Biochem J 353:441-4. 2001
    ..6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure...
  22. pmc Nucleotide sequence of a cDNA encoding bovine brown fat uncoupling protein. Homology with ADP binding site of ADP/ATP carrier
    L Casteilla
    Centre de Recherche sur la Nutrition, CNRS, Meudon, France
    Nucleic Acids Res 17:2131. 1989
  23. pmc Expression of beta 1- and beta 3-adrenergic-receptor messages and adenylate cyclase beta-adrenergic response in bovine perirenal adipose tissue during its transformation from brown into white fat
    L Casteilla
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS, Meudon, France
    Biochem J 297:93-7. 1994
    ..The bovine might represent a good model to understand the transition from brown to white fat in the human...
  24. ncbi DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
    J M Oppert
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 18:526-31. 1994
    ..3-kb allele was found in individuals who gained more body fat over time...
  25. ncbi Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle
    R Vettor
    Internal Medicine, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Int J Obes Relat Metab Disord 26:838-47. 2002
    ....
  26. ncbi Mitochondrial respiratory chain deficiency revealed by hypothermia
    F Cholley
    Service de Neurologie, , , Rennes, France
    Neuropediatrics 32:104-6. 2001
    ..Moreover, UCP3 mRNA expression in muscle was decreased...
  27. ncbi The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons
    F Bouillaud
    Centre de Recherches sur la Nutrition, CNRS, Meudon Bellevue, France
    Biochem Biophys Res Commun 157:783-92. 1988
    ..Evidence for homology between Uncoupling Protein and Neurospora crassa ADP/ATP carrier at the gene level was also noticed...
  28. ncbi Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
    K Clement
    Department de Nutrition, Hotel Dieu, Paris, France
    Int J Obes Relat Metab Disord 20:1062-6. 1996
    ....
  29. ncbi Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    D Arsenijevic
    Centre de Recherche de Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique, Universite Laval, Quebec, Canada
    Nat Genet 26:435-9. 2000
    ..001 ), which was absent in the presence of a quencher of reactive oxygen species (ROS). Our results indicate a role for Ucp2 in the limitation of ROS and macrophage-mediated immunity...
  30. ncbi Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein
    F Bouillaud
    J Biol Chem 261:1487-90. 1986
    ..We found a significant sequence homology between the uncoupling protein and the ADP/ATP carrier and propose that the nucleotide binding site of the uncoupling protein is localized at the C-terminal end...
  31. ncbi In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis?
    S Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    FEBS Lett 440:348-50. 1998
    ..The results suggest a possible role for UCP2 and UCP3 in the increase of energy expenditure associated with cytokine treatment...
  32. ncbi Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation
    A V Medvedev
    Departments of Psychiatry and Behavioral Sciences and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:10817-23. 2001
    ..Taken together, these data indicate that PPARgamma activates the UCP2 gene indirectly by altering the activity or expression of other transcription factors that bind to the UCP2 promoter...
  33. ncbi Seasonal acclimation of bank voles and wood mice: nonshivering thermogenesis and thermogenic properties of brown adipose tissue mitochondria
    S Klaus
    Fachbereich Biologie, , Marburg, Federal Republic of Germany
    J Comp Physiol B 158:157-64. 1988
    ..It is concluded that seasonal improvements of in vivo and in vitro thermogenesis are very similar in these species, although the physiological basis for this improvement is different in Clethrionomys and Apodemus...
  34. ncbi Protective role of uncoupling protein 2 in atherosclerosis
    J Blanc
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, and Université Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 107:388-90. 2003
    ..Uncoupling protein 2 (UCP2) regulates the production of reactive oxygen species in macrophages. However, its role in atherosclerosis is unknown...
  35. pmc Tissue distribution of beta 3-adrenergic receptor mRNA in man
    S Krief
    Centre National de la Recherche Scientifíque Unité Propre de Recherche 0415, Paris, France
    J Clin Invest 91:344-9. 1993
    ..beta 3-AR may thus be involved in the control of lipid metabolism, possibly from fat assimilation in the digestive tract, to triglyceride storage and mobilization in adipose tissues...