Genomes and Genes
Location: Lyon, France
- Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodiesC Morris-Desbois
Laboratoire de Biologie Moleculaire et Cellulaire, UMR 5665 CNRS ENSL, Allee d Italie, France
J Cell Sci 112:3331-42. 1999..Int-6 and Rfp are co-localised in certain PML nuclear bodies in lymphocytes and transfection studies in HeLa cells strongly suggest that Rfp triggers translocation of Int-6 to nuclear bodies...
- The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response elementC Reynaud
Laboratoire de Biologie Moleculaire et Cellulaire, Unité Mixte de Recherche 5665, CNRS Ecole Normale Supérieure de Lyon, 46, Allee d Italie, 69364 Lyon Cedex 07, France
J Biol Chem 275:33962-8. 2000..These data show that the complex of active Rho with its effector rhotekin bound to TIP-1 produces in the cytoplasm a signal that triggers strong activation of the SRE...
- Identification of functional PDZ domain binding sites in several human proteinsS Fabre
, UMR 5665 CNRS ENSL, Lyon, France
Mol Biol Rep 27:217-24. 2000..The significance of the presence of a PDZ-BS in these various proteins is discussed with respect to their function...
- Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53Olivier D Lohez
, Grenoble Cedex 1, France
J Cell Biol 161:67-77. 2003..Our results thus establish that RB pocket proteins can be uniquely targeted for tumor chemotherapy...
- The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progressionCristiana Mollinari
Institut de Biologie Structurale J P Ebel, CEA CNRS, 41 rue Jules Horowitz, 38027 Cedex 1, Grenoble, France
Dev Cell 5:295-307. 2003..The latter is consistent with a TD-60 requirement for recruitment of the passenger proteins survivin and Aurora B, and suggests that like other passenger proteins, TD-60 is involved in regulation of cell cleavage...
- Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasomeArnaud Favre-Bonvin
Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, Ecole Normale Superieure de Lyon, Lyon, France
J Virol 79:4229-37. 2005..These results support the notion that HPV-18 E6 renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC...
- The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent modelCharbel Bouez
Laboratoire des Substituts Cutanés and Clinique dermatologique, Hopital E Herriot, Lyon Cedex, France
Clin Cancer Res 12:1463-9. 2006..Moreover, LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity...
- Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disordersCaroline Reynaud
IBCP, Institut de Biologie et Chimie des Proteines, Lyon, France
Matrix Biol 27:547-60. 2008..Taken together, these data reveal a role for Lox in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism...
- The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growthFloriane Pez
CNRS Centre National de la Recherche Scientifique, FRE3310 IFR128, IBCP, Lyon, France
Cancer Res 71:1647-57. 2011..Taken together, these findings provide compelling evidence that LOX and HIF-1 act in synergy to foster tumor formation, and they suggest that HIF-1/LOX mutual regulation is a pivotal mechanism in the adaptation of tumor cells to hypoxia...