Research Topics
Species | E RenardSummaryCountry: France Publications
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Publications
Towards an artificial pancreas at homeE Renard
Department of Endocrinology, Diabetes, Nutrition, University Hospital of Montpellier, France
Diabetes Metab 37:S94-8. 2011..To review the recent clinical research related to the development of an artificial pancreas and the current perspectives for its home use...
Systems medicine and integrated care to combat chronic noncommunicable diseasesJean Bousquet
Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
Genome Med 3:43. 2011..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...- Lower rate of initial failures and reduced occurrence of adverse events with a new catheter model for continuous subcutaneous insulin infusion: prospective, two-period, observational, multicenter studyEric Renard
Endocrinology Department, Montpellier University Hospital, Montpellier, France
Diabetes Technol Ther 12:769-73. 2010..No recent clinical data on the incidence of catheter-related adverse events under insulin pump therapy have been reported... 
[From external to implantable insulin pump, can we close the loop?]E Renard
Service des Maladies Endocriniennes, Hopital Lapeyronie, 34295 Montpellier Cedex 5, France
Diabetes Metab 28:2S19-2S25. 2002....- [Insulin substitution: new insulins, new modes of delivery]Eric Renard
Service des Maladies Endocriniennes, Hopital Lapeyronie, F34295 Montpellier Cedex 5, France
J Soc Biol 201:141-8. 2007.... - Bariatric surgery in patients with late-stage type 2 diabetes: expected beneficial effects on risk ratio and outcomesE Renard
Endocrinology Department, Centre Hospitalier Universitaire de Montpellier, and UMR CNRS 5232, University of Montpellier I, Montpellier, France
Diabetes Metab 35:564-8. 2009..The objective of this review was to assess the safety and efficacy of bariatric surgery in patients with severe obesity and late-stage type 2 diabetes (T2D)... - Implantable insulin pumps. A position statement about their clinical useE Renard
Service des Maladies Endocriniennes, Hopital Lapeyronie, 34295 Montpellier cedex 05, France
Diabetes Metab 33:158-66. 2007..To review clinical use of implantable insulin pumps and to suggest indications for this therapy... - Implantable continuous glucose sensorsEric Renard
Endocrinology Department, Lapeyronie Hospital, F34295 Montpellier Cedex 5, France
Curr Diabetes Rev 4:169-74. 2008..These data could open a favourable perspective for IGMS after improvement of biointerface conditions and if compatible with an affordable cost... - Artificial beta-cell: clinical experience toward an implantable closed-loop insulin delivery systemE Renard
Endocrinology Department, Lapeyronie Hospital, Montpellier, France
Diabetes Metab 32:497-502. 2006..The possibility of implantation of the three crucial components of such a system (insulin delivery device, glucose sensor and controller) is analyzed... - Intensive insulin therapy today: 'basal-bolus' using multiple daily injections or CSII?E Renard
Endocrinology Department, Lapeyronie Hospital, Montpellier, France
Diabetes Metab 31:4S40-4S44. 2005..Nevertheless, individual factors seem to be decisional in the choice between CSII and MDI using long-acting analogues, among which patient ability and will to use an insulin pump are critical... - Insulin pump use in EuropeEric Renard
Endocrinology Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
Diabetes Technol Ther 12:S29-32. 2010..More sophisticated technologies connected to pump therapy, such as continuous glucose monitoring or telemedicine, will need specific cost coverage for a true implementation in diabetes care in Europe... - Non-inferiority of insulin glargine versus insulin detemir on blood glucose variability in type 1 diabetes patients: a multicenter, randomized, crossover studyEric Renard
Department of Endocrinology, Diabetes and Nutrition, Montpellier University Hospital and INSERM Clinical Investigation Centre 1001, Lapeyronie University Hospital 191, avenue Doyen Gaston Giraud, Montpellier Cedex 5, France
Diabetes Technol Ther 13:1213-8. 2011..This study compared the effects of insulin glargine and insulin detemir on blood glucose variability under clinical practice conditions in patients with type 1 diabetes (T1D) using glulisine as the mealtime insulin... - Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern FranceR Attaoua
IURC, Molecular Endocrinology Laboratory UMR 204, Montpellier Cedex 5, France
Diabetes Metab 35:476-83. 2009..The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene... - [Insulin therapy in type 1 diabetes for and during pregnancy: by which means and for which objectives?]E Renard
Service des Maladies Endocriniennes, Hopital Lapeyronie, 34295 Montpellier, France
Diabetes Metab 27:S61-6. 2001..Labor and delivery, cesarean section, fetal maturation by corticosteroids and use of i.v. betamimetic drugs require continuous i.v. insulin delivery. The continuation of intensive insulin management in post-partum is encouraged... - [Insulin sensitivity and polycystic ovarian syndrome]J Bringer
Service des Maladies Endocriniennes, , 34295 Montpellier Cedex 5, France
Diabetes Metab 27:239-45. 2001..Nutritional education and regular physical exercice are the necessary approaches. The efficacy and indications of metformin and thiazolidinediones have to be further evaluated... - Accuracy of continuous subcutaneous glucose monitoring with the GlucoDay in type 1 diabetic patients treated by subcutaneous insulin infusion during exercise of low versus high intensityC Fayolle
, , Montpellier, France
Diabetes Metab 32:313-20. 2006..Reduction of probe fragility and confirmed sensor accuracy in hypoglycaemia would further support applicability of GlucoDay at exercise... - Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndromeS A El Mkadem
Molecular Endocrinology Laboratory, Institut Universitaire de Recherche Cilnique, Montpellier, France
Diabetes 50:2164-8. 2001..0085, OR 1.7, 95% CI 1.09-2.99). We conclude that polymorphic alleles of both IRS-1 and IRS-2, alone or in combination, may have a functional impact on the insulin-resistant component of PCOS... - Continuous glucose monitoring as a tool to identify hyperglycaemia in non-diabetic patients with acute coronary syndromesR P Radermecker
Endocrinology Department, CHU Montpellier, Universite Montpellier, Montpellier, France
Diabet Med 26:167-70. 2009..To explore the occurrence and the distribution of glucose excursions > 7.8 mmol/l by continuous glucose monitoring (CGM) in non-diabetic patients admitted with acute coronary syndrome (ACS)... - Clinical experience with an implanted closed-loop insulin delivery systemEric Renard
Endocrinology Department, Lapeyronie Hospital, Montpellier, France
Arq Bras Endocrinol Metabol 52:349-54. 2008..To report the first clinical experience with a prototype of implanted artificial beta-cell... - [Insulin therapy by insulin pump: continuous or conventional self-blood glucose monitoring? ]E Renard
Service des Maladies Endocriniennes, Hopital Lapeyronie, 34295 Montpellier Cedex 5, France
Diabetes Metab 29:S54-62. 2003..Pump control by the sensor signal is conceivable if it corresponds to a direct, continuous, real time measurement of blood glucose, and subject to a simultaneous improvement of insulin infusion modes... - [Long-term risks of polycystic ovaries syndrome]P Lefebvre
Service des Maladies Endocriniennes, Hopital Lapeyronie, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
Gynecol Obstet Fertil 32:193-8. 2004..The latter begin to be better understood. Some studies suggest that PCOS may increase the risk for several conditions, including type 2 diabetes, dyslipidemia, hypertension, cardiovascular disease and some cancers... - Syndrome of body fat redistribution in HIV-1-infected patients: relationships to cortisol and catecholaminesE Renard
The Department of Endocrinology, Lapeyronie Hospital, Montpellier, France
Clin Endocrinol (Oxf) 51:223-30. 1999..Alterations of body fat distribution have been recently reported in HIV-infected patients. We aimed to investigate whether the hormones modulating adipose tissue metabolism could be implicated... - [Which contraception to choose for the diabetic woman?]J Bringer
Service des Maladies Endocriniennes, Hopital Lapeyronie, 34295 Montpellier
Diabetes Metab 27:S35-41. 2001..Macroprogestative contraception is a adequate choice for women within forties. For multiparous diabetic women, intra-uterine devices represent the first choice... - Optimizing the outcome of pregnancy in obese women: from pregestational to long-term managementF Galtier
Inserm CIC 0001, Clinical Investigation Centre, St Eloi hospital, Montpellier University Hospital, 80, avenue Augustin Fliche, 34295 Montpellier cedex 05, France
Diabetes Metab 34:19-25. 2008.... - Dupuytren's disease, carpal tunnel syndrome, trigger finger, and diabetes mellitusM Chammas
Department of Endocrinology, Lapeyronie University Hospital, Montpellier, France
J Hand Surg Am 20:109-14. 1995..All these hand changes were more marked in insulin-dependent diabetics and they showed a positive correlation with increasing age of the patient, duration of the diabetes, and the presence of a microangiopathy... - Myocardial perfusion imaging and cardiac events in a cohort of asymptomatic patients with diabetes living in southern FranceA Sultan
Metabolic Diseases Department, Montpellier University Hospital, Montpellier, France
Diabet Med 23:410-8. 2006..Randomized studies of cardiac heart disease screening are required in asymptomatic subjects with diabetes to determine the effectiveness of this intervention... - Resting energy expenditure and fuel metabolism following laparoscopic adjustable gastric banding in severely obese women: relationships with excess weight lostF Galtier
centre d investigation clinique, Hopital St Eloi, Montpellier Cedex, France
Int J Obes (Lond) 30:1104-10. 2006.... - Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreasEric Renard
Endocrinology Department, Le Centre Hospitalier Universitaire Montpellier, Montpellier, France
Diabetes Care 33:121-7. 2010..We tested closed-loop intraperitoneal insulin infusion from an implanted pump driven by an subcutaneous glucose sensor via a proportional-integral-derivative (PID) algorithm... - A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjectsHugues Chevassus
centre d investigation clinique, Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France
Eur J Clin Pharmacol 66:449-55. 2010..The aim of our study was to investigate the effects of a repeated administration of a fenugreek seed extract on the eating behaviour of overweight subjects... - The Southern French registry of genetic hemochromatosis: a tool for determining clinical prevalence of the disorder and genotype penetrancePatricia Aguilar-Martinez
CHU of Montpellier Laboratory of Hematology, Hopital Saint Eloi, avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
Haematologica 95:551-6. 2010..Despite great progress in understanding the mechanisms underlying genetic hemochromatosis, data on the prevalence and the penetrance of the disorder are conflicting... - Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapyEric Renard
Department of Endocrinology, Lapeyronie Hospital, 34295, Cedex 5, Montpellier, France
Curr Opin Pharmacol 2:708-16. 2002..Preliminary investigations of intravascular enzymatic sensors demonstrate their clinical acceptability and accuracy and the possibility of developing closed-loop insulin delivery by combination with implantable pumps... - Implantable insulin pumps: infections most likely due to seeding from skin flora determine severe outcomes of pump-pocket seromasE Renard
Department of Endocrinology, Lapeyronie Hospital, Montpellier, France
Diabetes Metab 27:62-5. 2001..We recommend that bacterial investigations of pump-pocket seromas should be systematically performed, while prophylactic measures might include antibiotic cover for each puncture of the pump-pocket... - Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemiaG J Thöni
UPRES EA 2991, Sports, Performance, Health Laboratory, Faculty of Sport Sciences, Montpellier, France
Diabetes Metab 28:397-404. 2002..The management of abdominal fat accumulation and metabolic disorders in HIV1-infected patients, by an aerobic training program, is considered... - Monitoring glycemic control: the importance of self-monitoring of blood glucoseEric Renard
Department of Endocrinology, Diabetes, and Metabolism, Montpellier I University, Montpellier, France
Am J Med 118:12S-19S. 2005..SMBG should be implemented for all patients as part of an overall diabetes management plan that includes specific instruction on how, when, and why to test... - [Cowden syndrome, or multiple hamartomatous tumor syndrome, in clinical endocrinology]M Sardinoux
Service des Maladies Endocriniennes, Hopital Lapeyronie, CHRU de Montpellier, 371, avenue du Doyen Gaston Giraud, 34925 Montpellier cedex 05, France
Ann Endocrinol (Paris) 71:264-73. 2010..The development of antineoplastic agents targeting PI3K/Akt/mTOR pathway, such as rapamycin, may be the opportunity of treatment in PHTS and CS patients, for whom no specific medical treatment exist... - Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteersHugues Chevassus
Section of Clinical Pharmacology, Clinical Investigation Center, Saint-Eloi University Hospital, and Research Unit UPRES EA 1677, Faculty of Medicine, Montpellier, France
Br J Clin Pharmacol 53:641-3. 2002..485, P=0.049). Glucose tolerance was not affected. CONCLUSIONS: Oral (L)-glutamate enhances glucose-induced insulin secretion in healthy volunteers in a concentration-dependent manner... - Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trialsP Y Benhamou
Department of Endocrinology, Centre Hospitalier Universitaire de Grenoble, Pôle DigiDUNE, Clinique d Endocrinologie, BP 217X, Grenoble 38043, France
Diabet Med 26:617-21. 2009..Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation... - Identification of two novel insulin receptor mutations, Asp59Gly and Leu62Pro, in type A syndrome of extreme insulin resistanceM Rouard
Laboratoire d Endocrinologie Moléculaire, Institut Universitaire de Recherche Clinique and Centre de Recherche de Biochimie Macromoléculaire, ERS 155 CNRS, Montpellier, France
Biochem Biophys Res Commun 234:764-8. 1997.... - Risk factors for silent myocardial ischemia in high-risk type 1 diabetic patientsAriane Sultan
Metabolic Diseases Department, Montpellier University Hospital, Montpellier, France
Diabetes Care 27:1745-7. 2004 - Global sequencing approach for characterizing the molecular background of hereditary iron disordersSeverine Cunat
Laboratory of Haematology, CHU of Montpellier, Montpellier, France
Clin Chem 53:2060-9. 2007..This study aimed to develop a rapid automated method for sequencing the main genes involved... - Implantable pump therapy restores metabolic control and quality of life in type 1 diabetic patients with Buschke's nonsystemic sclerodermaSabine Baillot-Rudoni
Diabetes Care 29:1710. 2006 - Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trialLionel Badet
Department of Urology, University Hospital, Lyon, France
Transplantation 84:89-96. 2007.... - [Treatment of insulin-dependent diabetes: new therapy by electromagnetic replacement: towards an artificial pancreas]Jacques Bringer
,
Bull Acad Natl Med 187:1285-94; discussion 1295. 2003..This most physiological restoration of insulin function is feasible and appears to represent a possibility for long term treatment of diabetics... - Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetesJohn C Pickup
Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
Diabetes Care 31:S140-5. 2008..It is possible that CSII will be beneficial in selected patient groups with type 2 diabetes, but this requires further study... - Naltrexone improves blood glucose control in type 1 diabetic women with severe and chronic eating disordersIsabelle Raingeard
Diabetes Care 27:847-8. 2004 - Aseptic peritonitis revealed through recurrent catheter obstructions in type 1 diabetic patients treated with continuous peritoneal insulin infusionEric Renard
Diabetes Care 27:276-7. 2004 - French multicentric survey of outcome of pregnancy in women with pregestational diabetesPierre Boulot
Diabetes Care 26:2990-3. 2003..Despite knowledge of the importance of intensified glycemic control before pregnancy, reaching the St. Vincent's target needs further implementation in France... - Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantationMarie-Claude Kempf
Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transplantation 79:1200-5. 2005..CONCLUSIONS.: A high rate of pancreas offers, successful isolation, and islet transplantation can be achieved in multicenter networks such as GRAGIL. Such an approach can expand both the donor pool and the recipient population... - Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutationCorinne Lautier
Molecular Endocrinology Laboratory, University Institute of Clinical Research, Faculty of Medicine, 641 Avenue du Doyen Gaston Giraud, 34093, Montpellier Cedex 5, France
Hum Genet 113:34-43. 2003....