- Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson diseaseMaria Joao Ribeiro
URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91401 Orsay, Cedex, France
Arch Neurol 59:580-6. 2002..The latter might be assessed using newly developed ligands of the membrane dopamine transporter...
- Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic systemPhilippe Remy
CNRS CEA URA2210, Service Hospitalier Frederic Joliot, CHU Henri Mondor et Faculté de Médecine Paris 12, France
Brain 128:1314-22. 2005..These results suggest that depression and anxiety in Parkinson's disease might be associated with a specific loss of dopamine and noradrenaline innervation in the limbic system...
- Primary somatosensory cortex activation is not altered in patients with ventroposterior thalamic lesions: a PET studyP Remy
CEA, Service Hospitalier Frederic Joliot, Orsay, France
Stroke 30:2651-8. 1999..We know remarkably little about the mechanisms underlying cortical activation. Such mechanisms might be better understood by studying the effect of well-localized lesions on the cortical activations in simple paradigms...
- The role of dopamine in cognition: evidence from functional imaging studiesPhilippe Remy
URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, Orsay, France
Curr Opin Neurol 16:S37-41. 2003..This paper reviews recent evidence provided by studies in healthy individuals and patients with Parkinson's disease or schizophrenia supporting the role of dopamine in normal and pathological cognitive processes...
- [Is functional imaging useful in the clinical evaluation of Parkinson's disease?]Ph Remy
URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, Orsay
Rev Neurol (Paris) 159:3S57-61. 2003..However, there has been no prospective study to confirm this hypothesis and functional imaging is only performed to exclude patients with atypical parkinsonism from the waiting list for neurosurgical treatments...
- Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET studyAlan L Whone
Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
Ann Neurol 54:93-101. 2003..1%; levodopa, -22.9%; 95% CI, 4.24-13.3), but the decrease was significantly lower with ropinirole compared with levodopa (p < 0.001). Ropinirole is associated with slower progression of PD than levodopa as assessed by (18)F-dopa PET...
- Functional recovery in a primate model of Parkinson's disease following motor cortex stimulationXavier Drouot
URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, 91401 Orsay, France
Neuron 44:769-78. 2004..Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery...
- Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT imagesAurélie Kas
URA Centre National de la Recherche Scientifique, Commissariat à l Energie Atomique 2210, Service Hospitalier Frederic Joliot, 4 Place du General Leclerc, 91401 Orsay, France
J Nucl Med 48:1459-67. 2007..Next, we hypothesized that this customized template could be used by different SPECT centers without affecting the outcomes of imaging analyses...
- A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter studyAlan L Whone
Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
J Nucl Med 45:1135-45. 2004..To our knowledge, this is the first time such a centralized approach has been employed with (18)F-DOPA PET and this descriptive basic science article outlines the methods used...
- Young-onset Parkinson disease with and without parkin gene mutations: a fluorodopa F 18 positron emission tomography studyStephane Thobois
Service de Neurologie D and Cycloton Unit, CERMEP, Hopital Neurologique Pierre Wertheimer, Lyon, France
Arch Neurol 60:713-8. 2003..Mutations of the parkin gene are frequently encountered in patients with young-onset Parkinson disease (YOPD), but the effects of this mutation on the nigrostriatal dopaminergic degeneration are not well established...
- 18F-FDG PET in neurodegenerative Langerhans cell histiocytosis : results and potential interest for an early diagnosis of the diseaseMaria Joao Ribeiro
Service Hospitalier Frederic Joliot, DRM DSV, CEA 4, place du General Leclerc, 91406 Orsay, France
J Neurol 255:575-80. 2008..MRI is the gold standard to investigate CNS lesions of ND-LCH but little is known about functional changes observed in this disease...
- Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissueValerie Cochen
Unité de Recherche Associée Commissariat à l Energie Atomique CEA Centre National de la Recherche Scientifique CNRS 2210, Orsay, France
Mov Disord 18:928-32. 2003..Further analysis showed that the clinical and [(18)F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation...
- Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behaviorLuc Mallet
Institut National de la Santé et de la Recherche Médicale AVENIR Group, Behavior, Emotion, and Basal Ganglia, 75013 Paris, France
Proc Natl Acad Sci U S A 104:10661-6. 2007....
- Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up studyAnne Catherine Bachoud-Lévi
INSERM U 421, Faculte de Medecine, Creteil, France
Lancet Neurol 5:303-9. 2006..We undertook long-term follow-up of previously reported patients with the disease to ascertain the nature and extent of any secondary decline after grafting...
- Psychogenic parkinsonism: a combination of clinical, electrophysiological, and [(123)I]-FP-CIT SPECT scan explorations improves diagnostic accuracySandrine Benaderette
Department of Neurology, Saint Antoine Hospital, Paris, France
Mov Disord 21:310-7. 2006..A combination of clinical, electrophysiological, and [(123)I]-FP-CIT SPECT scan explorations improves diagnostic accuracy in order to distinguish PP from PP + PD...
- Executive function deficits in early Alzheimer's disease and their relations with episodic memorySophie Baudic
INSERM UPVM Unite 421, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Arch Clin Neuropsychol 21:15-21. 2006..With the progression of the disease, additional deficit is observed in abstract thinking. In mild AD, memory failure is also related to executive impairment...
- Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson diseasePierre Payoux
Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France
Arch Neurol 61:1307-13. 2004....
- Striatal neural grafting improves cortical metabolism in Huntington's disease patientsVéronique Gaura
URA CEA CNRS 2210, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Brain 127:65-72. 2004..Our results demonstrate the usefulness of PET measurements of brain glucose metabolism in understanding the effects of foetal grafts in patients with Huntington's disease...
- Language processing within the striatum: evidence from a PET correlation study in Huntington's diseaseMarc Teichmann
INSERM U841, Equipe 1, Neuropsychologie Interventionnelle, IM3 Paris XII, Creteil, France
Brain 131:1046-56. 2008....