Didier Raoult

Summary

Country: France

Publications

  1. ncbi Q fever during pregnancy: diagnosis, treatment, and follow-up
    Didier Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, CNRS UMR 6020, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Arch Intern Med 162:701-4. 2002
  2. ncbi Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 29:434-6. 1999
  3. ncbi What does the future hold for clinical microbiology?
    Didier Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Nat Rev Microbiol 2:151-9. 2004
  4. ncbi Naming of Rickettsiae and rickettsial diseases
    Didier Raoult
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 1063:1-12. 2005
  5. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
  6. pmc Bartonella quintana in domestic cat
    Vu Dang La
    Université de la Méditerranée Unité des Rickettsies, CNRS UMR 6020, IFR 48, Marseille, France
    Emerg Infect Dis 11:1287-9. 2005
  7. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
  8. pmc Zoonotic focus of plague, Algeria
    Idir Bitam
    Institute Pasteur d Algérie, Algiers, Algeria
    Emerg Infect Dis 12:1975-7. 2006
  9. pmc Histologic features and immunodetection of African tick-bite fever eschar
    Hubert Lepidi
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:1332-7. 2006
  10. pmc Bacterial zoonoses and infective endocarditis, Algeria
    Akila Benslimani
    Service de Biologie Clinique, Alger, Algerie
    Emerg Infect Dis 11:216-24. 2005

Collaborators

Detail Information

Publications235 found, 100 shown here

  1. ncbi Q fever during pregnancy: diagnosis, treatment, and follow-up
    Didier Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, CNRS UMR 6020, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Arch Intern Med 162:701-4. 2002
    ..Q fever, caused by Coxiella burnetii, may result in abortions, premature deliveries, and stillbirths in infected pregnant women...
  2. ncbi Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 29:434-6. 1999
    ..quintana DNA was amplified from lice. Epidemic typhus remains extant in the area, and B. quintana infections were encountered and documented for the first time in South America...
  3. ncbi What does the future hold for clinical microbiology?
    Didier Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Nat Rev Microbiol 2:151-9. 2004
    ....
  4. ncbi Naming of Rickettsiae and rickettsial diseases
    Didier Raoult
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 1063:1-12. 2005
    ..In this paper, we review taxonomic rules and appropriate approaches to valid naming of rickettsial species and the diseases they cause...
  5. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
    ..We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis. These data show that only Orientalis type caused the 3 plague pandemics...
  6. pmc Bartonella quintana in domestic cat
    Vu Dang La
    Université de la Méditerranée Unité des Rickettsies, CNRS UMR 6020, IFR 48, Marseille, France
    Emerg Infect Dis 11:1287-9. 2005
    ..This study, the first to detect B. quintana in a nonhuman mammal, changes our understanding of the epidemiology of this infection and proposes that cats may be an emerging source of human infection...
  7. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
    ..pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains...
  8. pmc Zoonotic focus of plague, Algeria
    Idir Bitam
    Institute Pasteur d Algérie, Algiers, Algeria
    Emerg Infect Dis 12:1975-7. 2006
    ..Nine fleas were definitively confirmed to be infected with Y. pestis biovar orientalis. Our results demonstrate the persistence of a zoonotic focus of Y. pestis in Algeria...
  9. pmc Histologic features and immunodetection of African tick-bite fever eschar
    Hubert Lepidi
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:1332-7. 2006
    ..Neutrophils in ATBF are a notable component of the host reaction, perhaps because ATBF is a milder disease than the other rickettsioses. Immunohistochemical detection of rickettsial antigens may be useful in diagnosing ATBF...
  10. pmc Bacterial zoonoses and infective endocarditis, Algeria
    Akila Benslimani
    Service de Biologie Clinique, Alger, Algerie
    Emerg Infect Dis 11:216-24. 2005
    ..Our data underline the high prevalence of infective endocarditis caused by Bartonella quintana in northern Africa and the role of serologic and molecular tools for the diagnosis of blood culture-negative endocarditis...
  11. pmc Rickettsia prowazekii and real-time polymerase chain reaction
    Sanela Svraka
    Universite de la Mediterranee, Marseilles, France
    Emerg Infect Dis 12:428-32. 2006
    ..Because our assay is highly standardized and easily adaptable, it could improve epidemic typhus surveillance in public health programs, especially for countries with underdiagnosed or unrecognized human cases...
  12. pmc Lymph node biopsy specimens and diagnosis of cat-scratch disease
    Jean Marc Rolain
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:1338-44. 2006
    ..Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis...
  13. pmc Coxiella burnetii genotyping
    Olga Glazunova
    Unite des Rickettsies, Faculte de Medecine, CNRS UMR 6020, IFR48, Marseille, France
    Emerg Infect Dis 11:1211-7. 2005
    ..Phylogenic analysis showed 3 major clusters. MST allows easy comparison and exchange of results obtained in different laboratories and could be a useful tool for identifying bacterial strains...
  14. pmc Novel chikungunya virus variant in travelers returning from Indian Ocean islands
    Philippe Parola
    Hopital Nord, Marseilles, France
    Emerg Infect Dis 12:1493-9. 2006
    ..High viral loads in patients returning from Indian Ocean islands to countries where Ae. albopictus is prevalent may be a source of epidemics...
  15. pmc Questions on Mediterranean spotted fever a century after its discovery
    Clarisse Rovery
    Unite des Rickettsies, CNRS UMR6020, Marseille, France
    Emerg Infect Dis 14:1360-7. 2008
    ..Moreover, MSF has become more severe than RMSF; the mortality rate was as high as 32% in Portugal in 1997. Whether Rhipicephalus sanguineus is the only vector and reservoir for R. conorii conorii is a question not yet answered...
  16. pmc Bartonella quintana characteristics and clinical management
    Cedric Foucault
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:217-23. 2006
    ..Recent characterization of its genome allowed the development of modern diagnosis and typing methods. Guidelines for the treatment of B. quintana infections are presented...
  17. pmc Ameba-associated microorganisms and diagnosis of nosocomial pneumonia
    Pierre Berger
    Centre Hospitalier Universitaire La Timone, Marseille, France
    Emerg Infect Dis 12:248-55. 2006
    ..This finding suggested its clinical relevance. Therefore, AAM might cause nosocomial pneumonia and should be suspected when conventional microbiologic results are negative...
  18. pmc Wind in November, Q fever in December
    Hervé Tissot-Dupont
    Unite des Rickettsies, CNRS, Faculte de Medecine, Marseille, France
    Emerg Infect Dis 10:1264-9. 2004
    ..These data confirm that wind plays a role in C. burnetii transmission, a factor that can be monitored but not prevented. Further studies are needed to identify and confirm preventable individual behavioral risk factors for Q fever...
  19. pmc Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model
    Yassina Bechah
    Unit for Research on Emergent and Tropical Infectious Diseases URMITE, CNRS IRD UMR 6236, Faculty of Medicine, University of the Mediterranean, Marseille, France
    PLoS ONE 5:e8547. 2010
    ..In vitro, R. prowazekii rickettsiae infected and replicated in the murine adipocyte cell line 3T3-L1. Collectively these data suggest a role for adipose tissue as a potential reservoir for dormant infections with R. prowazekii...
  20. pmc Ameobal pathogen mimivirus infects macrophages through phagocytosis
    Eric Ghigo
    URMITE CNRS UMR 6236 IRD 3R198, Universite de la Mediterranee, Marseille, France
    PLoS Pathog 4:e1000087. 2008
    ..Altogether, our data demonstrated that APMV enters macrophages through phagocytosis, a new pathway for virus entry in cells. This reinforces the paradigm that intra-amoebal pathogens have the potential to infect macrophages...
  21. pmc Parachlamydiaceae: potential emerging pathogens
    Gilbert Greub
    Unite des Rickettsies, Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 8:625-30. 2002
    ..The recent identification of a 16S rRNA gene sequence of a Parachlamydiaceae from bronchoalveolar lavage is additional evidence supporting potential for pathogenicity...
  22. pmc Rickettsia slovaca infection, France
    Frédérique Gouriet
    Emerg Infect Dis 12:521-3. 2006
  23. pmc "Candidatus Rickettsia kellyi," India
    Jean Marc Rolain
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:483-5. 2006
    ..The diagnosis was made by serologic testing, polymerase chain reaction detection, and immunohistochemical testing of the organism from a skin biopsy specimen...
  24. pmc Rickettsia massiliae human isolation
    Giustina Vitale
    Emerg Infect Dis 12:174-5. 2006
  25. pmc Bartonella henselae in Ixodes ricinus ticks (Acari: Ixodida) removed from humans, Belluno province, Italy
    Yibayiri O Sanogo
    Faculte de Medecine, Marseille, France
    Emerg Infect Dis 9:329-32. 2003
    ..henselae is the first human-infecting Bartonella identified from Ixodes ricinus, a common European tick and the vector of various tickborne pathogens. The role of ticks in the transmission of bartonellosis should be further investigated...
  26. pmc Rickettsia felis infection, Tunisia
    Abir Znazen
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 12:138-40. 2006
    ..aeschlimannii infections acquired in Tunisia from 1998 to 2003. We found that most patients with antibodies against both R. conorii and R. typhi had serologic evidence of R. felis infection...
  27. pmc Emerging rickettsioses of the Thai-Myanmar border
    Philippe Parola
    Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    Emerg Infect Dis 9:592-5. 2003
    ..Four patients had murine typhus, three patients had scrub typhus, and eight patients had spotted fever group rickettsioses, including the first case of Rickettsia felis infection reported in Asia...
  28. pmc Molecular detection of Bartonella quintana, B. koehlerae, B. henselae, B. clarridgeiae, Rickettsia felis, and Wolbachia pipientis in cat fleas, France
    Jean Marc Rolain
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 9:338-42. 2003
    ..quintana from fleas and the first description of B. koehlerae in fleas from an area outside the United States. Cat fleas may be more important vectors of human diseases than previously reported...
  29. pmc Parachlamydiaceae as rare agents of pneumonia
    Gilbert Greub
    Emerg Infect Dis 9:755-6. 2003
  30. pmc First isolation of Rickettsia slovaca from a patient, France
    C Cazorla
    Emerg Infect Dis 9:135. 2003
  31. pmc Alistipes finegoldii in blood cultures from colon cancer patients
    Lukas Fenner
    Emerg Infect Dis 13:1260-2. 2007
  32. pmc Rickettsioses in South Korea, materials and methods
    Pierre Edouard Fournier
    Emerg Infect Dis 12:531. 2006
  33. pmc Mimivirus in pneumonia patients
    Bernard La Scola
    Universite de la Mediterranee, 13385 Marseille, France
    Emerg Infect Dis 11:449-52. 2005
    ..Mimivirus DNA was found in respiratory samples of a patient with hospital-acquired pneumonia...
  34. pmc Cost-effectiveness of blood agar for isolation of mycobacteria
    Michel Drancourt
    Fédération de Microbiologie Clinique, Assistance Publique Hopitaux de Marseille, Marseille, France
    PLoS Negl Trop Dis 1:e83. 2007
    ..Preliminary data suggested that versatile blood agar may be also used for mycobacterial culture...
  35. pmc Bartonella quintana and Rickettsia felis in Gabon
    Jean Marc Rolain
    Ricksettias Unit, Faculty of Medicine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Emerg Infect Dis 11:1742-4. 2005
    ..This is the first report of B. quintana in the human flea...
  36. pmc Bartonella australis sp. nov. from kangaroos, Australia
    Pierre Edouard Fournier
    Emerg Infect Dis 13:1961-2. 2007
  37. pmc Human infection caused by Leptospira fainei
    Jean Pierre Arzouni
    Unité de Rickettsies, Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 8:865-8. 2002
    ..Leptospira fainei was identified by sequencing the 16S rDNA gene, which had been amplified by polymerase chain reaction. This case confirms the role of L. fainei as a human pathogen and extends its distribution to southern Europe...
  38. pmc Murine typhus, Algeria
    Nadjet Mouffok
    Emerg Infect Dis 14:676-8. 2008
  39. pmc African tick-bite fever in French travelers
    Paul H Consigny
    Emerg Infect Dis 11:1804-6. 2005
  40. pmc Amoeba-resisting bacteria and ventilator-associated pneumonia
    Bernard La Scola
    Unite des Rickettsies, Marseille, France
    Emerg Infect Dis 9:815-21. 2003
    ..Amoeba-associated bacteria might be a cause of VAP in ICUs, especially when microbiologic investigations are negative...
  41. pmc Human Rickettsia felis infection, Canary Islands, Spain
    José Luis Pérez-Arellano
    Hospital Universitario Insular de Las Palmas, Canary Islands, Spain
    Emerg Infect Dis 11:1961-4. 2005
    ..Antibodies against R. felis were found in 5 adsorbed serum samples from 44 patients with clinically suspected rickettsiosis by Western blot serology. Fleas from 1 patient's dog were positive for R. felis by polymerase chain reaction...
  42. pmc Traditional and molecular techniques for the study of emerging bacterial diseases: one laboratory's perspective
    Pierre Houpikian
    Unite des Rickettsies, Faculte de Medecine de Marseille, France
    Emerg Infect Dis 8:122-31. 2002
    ....
  43. doi Human rickettsioses in the Batna area, eastern Algeria
    Khamsa Mokrani
    Department of Infectious Diseases, Batna Hospital, Algeria
    Ticks Tick Borne Dis 3:364-6. 2012
    ..In addition, we emphasize the high incidence of typhus group rickettioses, including epidemic typhus, in this area...
  44. pmc Molecular evidence of Bartonella infection in domestic dogs from Algeria, North Africa, by polymerase chain reaction (PCR)
    Tahar Kernif
    Département de zoologie, Institut National d Agronomie, El Harrach, Algiers, Algeria
    Am J Trop Med Hyg 83:298-300. 2010
    ..berkhoffii, Bartonella clarridgeiae, and Bartonells elizabethae were detected infecting Algerian dogs. To our knowledge, this study is the first report of detection by PCR amplification of Bartonella in dogs in North Africa...
  45. doi Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria
    Tahar Kernif
    Service d Ecologie et des Systèmes Vectoriels, Institut Pasteur d Algerie, Algiers, Algeria
    Ticks Tick Borne Dis 3:377-9. 2012
    ..To date, R. africae has been associated mainly with Amblyomma spp. The role of H. dromedarii in the epidemiology of R. africae requires further investigation...
  46. pmc Proteomics paves the way for Q fever diagnostics
    Malgorzata Kowalczewska
    URMITE, CNRS UMR 6236 IRD 198, Universite de la Mediterranee, Faculte de Medecine, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Genome Med 3:50. 2011
    ..In this review, we highlight advances in the field of C. burnetii proteomics, focusing mainly on the contribution of these technologies to the development and improvement of Q fever diagnostics...
  47. pmc A new example of viral intein in Mimivirus
    Hiroyuki Ogata
    Information Genomique et Structurale, UPR2589 CNRS, IBSM, IFR88, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Virol J 2:8. 2005
    ..After their discovery, inteins have been quickly identified in all domains of life, but only once to date in the genome of a eukaryote-infecting virus...
  48. pmc HIV-2 Protease resistance defined in yeast cells
    Najoua Ben M'Barek
    Unite des Rickettsies, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, Pathologies Transmissibles et Pathologies Infectieuses Tropicales, IFR48, France
    Retrovirology 3:58. 2006
    ..In order to be able to define the specific mutations in the Protease that confer loss of susceptibility to Protease Inhibitors, we set up an experimental model system based in the expression of the viral protein in yeast...
  49. pmc Microarray for serotyping of Bartonella species
    Cyrille J Bonhomme
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine de Marseille, Marseille Cedex 05, France
    BMC Microbiol 7:59. 2007
    ..Bacteria of the genus Bartonella are responsible for a large variety of human and animal diseases. Serological typing of Bartonella is a method that can be used for differentiation and identification of Bartonella subspecies...
  50. pmc SVARAP and aSVARAP: simple tools for quantitative analysis of nucleotide and amino acid variability and primer selection for clinical microbiology
    Philippe Colson
    Laboratoire de Virologie, Fédération Hospitalière de Bactériologie VirologieClinique et d Hygiène, CHRU Timone, 264 rue Saint Pierre 13385, Marseille Cedex 05, France
    BMC Microbiol 6:21. 2006
    ..Our aim was therefore to test easy and cost-free tools (SVARAP and aSVARAP) that require short hands-on work, little expertise, and which allow visual interpretation and statistical analysis of results...
  51. pmc Detection of "Rickettsia sp. strain Uilenbergi" and "Rickettsia sp. strain Davousti" in Amblyomma tholloni ticks from elephants in Africa
    Kotaro Matsumoto
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Marseille, France
    BMC Microbiol 7:74. 2007
    ..To date, 6 tick-borne rickettsiae pathogenic for humans are known to occur in Africa and 4 of them were first identified in ticks before being recognized as human pathogens...
  52. pmc Multi-pathogens sequence containing plasmids as positive controls for universal detection of potential agents of bioterrorism
    Remy N Charrel
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Marseille, France
    BMC Microbiol 4:21. 2004
    ..burnetii using constructed plasmids as positive controls...
  53. pmc Sca1, a previously undescribed paralog from autotransporter protein-encoding genes in Rickettsia species
    Maxime Ngwamidiba
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    BMC Microbiol 6:12. 2006
    ....
  54. pmc False positive PCR detection of Tropheryma whipplei in the saliva of healthy people
    Jean Marc Rolain
    Universite de la Mediterranee, Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Marseille Cedex 05, France
    BMC Microbiol 7:48. 2007
    ..whipplei in a series of 57 saliva from healthy people...
  55. pmc From cat scratch disease to endocarditis, the possible natural history of Bartonella henselae infection
    Frédérique Gouriet
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
    BMC Infect Dis 7:30. 2007
    ..To date, none of the reported patients have had a history of typical cat scratch disease (CSD) which is also a manifestation of infection with B. henselae...
  56. pmc Prosthetic valve endocarditis caused by Pseudomonas luteola
    Jean Paul Casalta
    Laboratoire de Microbiologie, IFR 48, Centre Hospitalier Universitaire de la Timone, 264 rue Saint Pierre, Marseille, France
    BMC Infect Dis 5:82. 2005
    ..Pseudomonas luteola has been recognized as an uncommon cause of bacteremia and of infections in patients with underlying medical disorders...
  57. pmc Comparative genomic analysis of Tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the WiSP proteins
    My Van La
    Unite des Rickettsies, CNRS UMR6020, IFR48, Faculte de Medecine, 27 Bd Jean Moulin, Marseille, F13385, France
    BMC Genomics 8:349. 2007
    ..whipplei Twist strain. For each isolate, the genes were defined as either present or absent/divergent using the GACK analysis software. Genomic changes were then further characterized by PCR and sequencing...
  58. pmc First isolation of Bartonella alsatica from a valve of a patient with endocarditis
    Didier Raoult
    Universite de la Mediterranee, Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Marseille, France
    J Clin Microbiol 44:278-9. 2006
    ..B. alsatica was identified by serology and culture and by PCR of an aortic valve specimen. B. alsatica should be added to the list of zoonotic agents of blood culture-negative endocarditis...
  59. ncbi A pedagogical farm as a source of Q fever in a French city
    Hervé Tissot-Dupont
    Faculte de Medecine, Unite des Rickettsies, CNRS UMR 6020, Marseille, France
    Eur J Epidemiol 20:957-61. 2005
    ..These farms require a drastic hygiene and control. Q fever, as a public health problem, still requires further studies to identify and confirm individual behavioral risk factors...
  60. ncbi Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
    ..Advances in understanding the pathophysiology and natural history of Q fever are reviewed...
  61. ncbi The 1.2-megabase genome sequence of Mimivirus
    Didier Raoult
    Unite des Rickettsies, Faculte de Medecine, CNRS UMR6020, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Science 306:1344-50. 2004
    ..This new sequence data might help shed a new light on the origin of DNA viruses and their role in the early evolution of eukaryotes...
  62. pmc Contribution of systematic serological testing in diagnosis of infective endocarditis
    D Raoult
    Unite des Rickettsies, Hopital de la Timone, Faculte de Medicine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    J Clin Microbiol 43:5238-42. 2005
    ..9%) possible cases of IE as definite cases. Systematic serological testing improved the performance of the modified Duke criteria and was instrumental in establishing the etiologic diagnosis in 8% (34/427) cases of IE...
  63. ncbi Evidence for louse-transmitted diseases in soldiers of Napoleon's Grand Army in Vilnius
    Didier Raoult
    Unite des Rickettsies, Centre National de la Recherche Scientifique CNRS Unite Mixte de Recherche UMR 6020, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    J Infect Dis 193:112-20. 2006
    ..Because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by Rickettsia prowazekii), were common...
  64. ncbi Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticks
    Didier Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Infect Dis 34:1331-6. 2002
    ..Immunofluorescence and/or Western blot analysis detected antibodies in 50% of tested patients. Three Dermacentor ticks obtained from patients revealed R. slovaca by PCR...
  65. ncbi Lack of correlation between Bartonella DNA detection within fleas, serological results, and results of blood culture in a Bartonella-infected stray cat population
    B La Scola
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Marseille, France
    Clin Microbiol Infect 8:345-51. 2002
    ..To correlate the presence of different Bartonella species in the blood of a stray cat population trapped on a French military base with specific antibodies and species detected in cat fleas...
  66. ncbi Q fever 1985-1998. Clinical and epidemiologic features of 1,383 infections
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Marseille, France
    Medicine (Baltimore) 79:109-23. 2000
    ..Our data confirm that chronic Q fever is mainly determined by host factors and demonstrate for the first time that host factors may also play a role in the clinical expression of acute Q fever...
  67. ncbi Cultivation of the bacillus of Whipple's disease
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, Marseilles, France
    N Engl J Med 342:620-5. 2000
    ..Whipple's disease is a systemic bacterial infection, but to date no isolate of the bacterium has been established in subculture, and no strain of this bacterium has been available for study...
  68. pmc Nanobacteria are mineralo fetuin complexes
    Didier Raoult
    Unite des Rickettsies, Centre National de la Recherche Scientifique UMR 6020, IFR 48, Faculte de Medecine, Marseille, France
    PLoS Pathog 4:e41. 2008
    ..The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor...
  69. ncbi Infections in the homeless
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, and Hĵpital Nord Service des Maladies Infectieuses et Tropicales, Marseille, France
    Lancet Infect Dis 1:77-84. 2001
    ..Patients with serious and contagious illnesses should be hospitalised. Physicians should be aware of these specific issues to enhance care...
  70. ncbi The body louse as a vector of reemerging human diseases
    D Raoult
    Universite de la Mediterranee, Faculte de Medecine, Centre National de la Recherche Scientifique, Unité Propre de Recherche de l Enseignement Superieur Associée 6020, Marseille, France
    Clin Infect Dis 29:888-911. 1999
    ..A small outbreak was also reported in Russia in 1997. Louse infestation appears to become more prevalent worldwide, associated with a decline in social and hygienic conditions provoked by civil unrest and economic instability...
  71. ncbi Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Université de la Mediterranée CNRS, Marseille, France
    Arch Intern Med 159:167-73. 1999
    ..Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a long-term tetracycline and quinolone regimen for at least 4 years is recommended, although relapses are frequent...
  72. pmc Purification of Encephalitozoon cultures contaminated by mycoplasmas by murine intraperitoneal inoculation
    O Ridoux
    Unité des Rickettsies CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Clin Microbiol 36:2380-2. 1998
    ..Mycoplasma-free microsporidia were isolated from the brains and spleens of inoculated mice 24 h postinoculation by using the centrifugation shell vial system. Identification was confirmed by direct sequencing of PCR-amplified 16S rRNA...
  73. ncbi Outcome and treatment of Bartonella endocarditis
    Didier Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Arch Intern Med 163:226-30. 2003
    ..Endocarditis caused by Bartonella species is a potentially lethal infection characterized by a subacute evolution and severe valvular lesions...
  74. pmc A flea-associated Rickettsia pathogenic for humans
    D Raoult
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Emerg Infect Dis 7:73-81. 2001
    ..Our successful isolation of this rickettsia makes it available for use in serologic tests to determine its clinical spectrum, prevalence, and distribution...
  75. ncbi Molecular genetic methods for the diagnosis of fastidious microorganisms
    Florence Fenollar
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    APMIS 112:785-807. 2004
    ..Ehrlichia spp., Coxiella burnetii, Bartonella spp., Tropheryma whipplei and Yersinia pestis...
  76. pmc Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities
    Yassina Bechah
    Unit for Research on Emergent and Tropical Infectious Diseases URMITE, Faculty of Medicine, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, University of the Mediterranean, 13005 Marseille, France
    Genome Res 20:655-63. 2010
    ..An area of genomic plasticity appears to determine virulence in R. prowazekii and represents an example of adaptive mutation for this pathogen...
  77. pmc Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens
    Hiroyuki Ogata
    Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique UPR 2589, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
    PLoS Genet 2:e76. 2006
    ....
  78. ncbi Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticks
    Pierre Edouard Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Syst Evol Microbiol 56:1673-5. 2006
    ..Such genotypic and phenotypic characteristics warrant its classification as a representative of a novel species, for which the name Rickettsia tamurae sp. nov. is proposed, with the type strain AT-1(T) (=CSUR R1(T))...
  79. ncbi rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
    Int J Syst Evol Microbiol 56:133-43. 2006
    ....
  80. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
    ..Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts...
  81. pmc Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage
    Jean Marc Rolain
    URMITE CNRS IRD UMR 6236, Faculte de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Biol Direct 4:1. 2009
    ..We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution...
  82. pmc Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction
    Pierre Edouard Fournier
    Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
    BMC Genomics 10:166. 2009
    ..prowazekii, which causes epidemic typhus and kills its arthropod host, to the mild pathogen R. africae, the agent of African tick-bite fever, which does not affect the fitness of its tick vector...
  83. pmc Rapid comparative genomic analysis for clinical microbiology: the Francisella tularensis paradigm
    Bernard La Scola
    Unite des Rickettsies CNRS UMR 6020, IFR 48, Faculte de Medecine de Marseille, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Genome Res 18:742-50. 2008
    ..In the bioterrorism context, it allows the rapid detection of strain manipulation, including intentionally added virulence genes and genes that support antibiotic resistance...
  84. doi Soluble squalamine tablets for the rapid disinfection of home nebulizers of cystic fibrosis patients
    Lamia Djouhri-Bouktab
    Unité de Recherche des Maladies Infectieuses et Tropicales Emergentes UMR 6236 CNRS Méditerranée Infection, Faculte de Medecine et de Pharmacie, Aix Marseille Universite, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Cyst Fibros 11:555-9. 2012
    ..The bacterial contamination of nebulizers represents a major problem for cystic fibrosis (CF) patients that can lead to reduced nebulizer performance and increase the risk of patient reinfection by the contaminating bacteria...
  85. doi Staphylococcus massiliensis sp. nov., isolated from a human brain abscess
    Mouhamad Al Masalma
    Laboratoire de Bacteriologie virologie, Hopital de la Timone, URMITE CNRS IRD UMR 6236, IFR48, 264 rue Saint Pierre, 13385 Marseille, Cedex 05, France
    Int J Syst Evol Microbiol 60:1066-72. 2010
    ..8 %). On the basis of phenotypic and genotypic data, this isolate represents a novel species for which the name Staphylococcus massiliensis sp. nov. is proposed (type strain 5402776(T)=CCUG 55927(T)=CSUR P23(T))...
  86. pmc Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis
    Soraya Meghari
    Unite des Rickettsies, CNRS UMR 6020, Institut Federatif de Recherche 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    PLoS Pathog 4:e23. 2008
    ..To our knowledge, this is the first efficient model for chronic Q fever pathogenesis...
  87. pmc Detection of a rickettsia closely related to Rickettsia aeschlimannii, "Rickettsia heilongjiangensis," Rickettsia sp. strain RpA4, and Ehrlichia muris in ticks collected in Russia and Kazakhstan
    Stanislav Shpynov
    Unite des Rickettsies, IFR48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    J Clin Microbiol 42:2221-3. 2004
    ..In Kazakhstan, we detected Rickettsia sp. strain RpA4 and a rickettsia closely related to Rickettsia aeschlimannii. These agents should be considered in a differential diagnosis of tick-borne infections in these areas...
  88. pmc Reductive genome evolution from the mother of Rickettsia
    Guillaume Blanc
    Structural and Genomic Information Laboratory, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
    PLoS Genet 3:e14. 2007
    ....
  89. ncbi Molecular detection of Bartonella spp. in the dental pulp of stray cats buried for a year
    Gerard Aboudharam
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27, Boulevard Jean Moulin, Marseille Cedex 05 13385, France
    Microb Pathog 38:47-51. 2005
    ..grahamii (one cat). Our study indicates that dental pulp from the teeth of cats, especially the canine teeth, may be used for the PCR detection of Bartonella in animals buried for a year...
  90. pmc Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009
    Antoine Nougairede
    Unité Mixte de Recherche 190 Unité des Virus Emergents, Université de la Méditerranée et Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 5:e9214. 2010
    ..In April 2009, the first cases of pandemic (H1N1)-2009 influenza [H1N1sw] virus were detected in France. Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones...
  91. pmc Outbreak of Corynebacterium pseudodiphtheriticum infection in cystic fibrosis patients, France
    Fadi Bittar
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 16:1231-6. 2010
    ..Our study reemphasizes the conclusion that correctly identifying bacteria at the species level facilitates detection of an outbreak of new or emerging infections in humans...
  92. doi Finegoldia magna, an early post-operative cause of infectious endocarditis: report of two cases and review of the literature
    Pierre Edouard Fournier
    Fédération de Microbiologie, Hopital de la Timone, Marseille Hôpital de la Timone, rue Saint Pierre, 13385 Marseille Cedex 5, France
    Anaerobe 14:310-2. 2008
    ..Our report highlights the potential role of F. magna in early post-surgical endocarditis on prosthetic valves...
  93. pmc Multispacer typing to study the genotypic distribution of Bartonella henselae populations
    Wenjun Li
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Clin Microbiol 44:2499-506. 2006
    ..Finally, we provide a free-access MST-Rick online software program (http://ifr48.timone.univ-mrs.fr/MST_BHenselae/mst) that investigators may use to compare their own MST sequences to our database...
  94. doi Monocyte responses in the context of Q fever: from a static polarized model to a kinetic model of activation
    Vikram Mehraj
    Aix Marseille University, URMITE, CNRS UMR 7278, IRD 198, INSERM 1095, Marseille, France
    J Infect Dis 208:942-51. 2013
    ..Q fever is caused by Coxiella burnetii, a bacterium that persists in M2-polarized macrophages. We wondered whether the concept of M1/M2 polarization is applicable to Q fever patients...
  95. doi Prediction of symptomatic embolism in infective endocarditis: construction and validation of a risk calculator in a multicenter cohort
    Sandrine Hubert
    Département de Cardiologie Hôpital Universitaire de la Timone, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, Marseille, France Service de Chirurgie Cardiaque, Hôpital Universitaire de La Timone, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, Marseille, France
    J Am Coll Cardiol 62:1384-92. 2013
    ..The aim of this study was to develop and validate a simple calculator to quantify the embolic risk (ER) at admission of patients with infective endocarditis...
  96. ncbi A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus
    Yassina Bechah
    Unite des Rickettsies, CNRS UMR 6020, Universite de la Mediterranee, Faculte de Medecine, 27 Bld J Moulin, 13385 Marseille Cedex 05, France
    Microbes Infect 9:898-906. 2007
    ..We concluded that the BALB/c mouse strain provides a useful model for studying the pathogenic mechanisms of epidemic typhus and its control by the immune system...
  97. ncbi Identification of two putative rickettsial adhesins by proteomic analysis
    Patricia Renesto
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Res Microbiol 157:605-12. 2006
    ..Both proteins are highly conserved within the Rickettsia genus and might play a critical role in their pathogenicity. These data may have important implications for the development of future vaccines against rickettsial infections...
  98. ncbi Emended description of Rickettsia felis (Bouyer et al. 2001), a temperature-dependent cultured bacterium
    Bernard La Scola
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille 05, France
    Int J Syst Evol Microbiol 52:2035-41. 2002
    ..felis and those observed for the isolate in this study indicated some differences, although concurrent analysis of the two was not possible as no extant isolates of the first isolate of R. felis exist...
  99. doi The rhizome of the multidrug-resistant Enterobacter aerogenes genome reveals how new "killer bugs" are created because of a sympatric lifestyle
    Seydina M Diene
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents URMITE, UMR7278 CNRS IRD INSERM, IHU Méditerranée Infection, Aix Marseille Universite, Marseille, France
    Mol Biol Evol 30:369-83. 2013
    ..found in his genome; and "usage" to have the ability to translate these sequences including those from rare codons to serve as a translator of foreign languages...
  100. doi Detection of Acinetobacter baumannii in human head and body lice from Ethiopia and identification of new genotypes
    Marie Kempf
    URMITE, UMR IRD 198 CNRS 6236, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Infect Dis 16:e680-3. 2012
    ..The objectives of this study were to determine the presence of this bacterium in head and body lice collected from healthy individuals in Ethiopia by molecular methods and to characterize the genotype...