D Raoult

Summary

Country: France

Publications

  1. doi request reprint Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach
    Z Sekeyova
    Faculte de Medecine, Universite de la Mediterranee, URMITE 6236 IRD, IFR 48, 27 Boulevard Jean Moulin, 05 13385 Marseille Cedex, France
    Eur J Clin Microbiol Infect Dis 28:287-95. 2009
  2. pmc Rickettsioses as paradigms of new or emerging infectious diseases
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRESA 6020, Marseille, France
    Clin Microbiol Rev 10:694-719. 1997
  3. pmc Genetic classification of "Rickettsia heilongjiangii" and "Rickettsia hulinii," two Chinese spotted fever group rickettsiae
    J Z Zhang
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRES A6020, 13385 Marseille Cedex 05, France
    J Clin Microbiol 38:3498-501. 2000
  4. ncbi request reprint Outbreak of epidemic typhus associated with trench fever in Burundi
    D Raoult
    WHO Reference Centre for Rickettsial Diseases, Universite de la Mediterranee, Marseille, France
    Lancet 352:353-8. 1998
  5. ncbi request reprint Cultivation of the bacillus of Whipple's disease
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, Marseilles, France
    N Engl J Med 342:620-5. 2000
  6. pmc Body lice as tools for diagnosis and surveillance of reemerging diseases
    V Roux
    , CNRS UPRES A 6020, , 13385 Marseille, France
    J Clin Microbiol 37:596-9. 1999
  7. ncbi request reprint Q fever 1985-1998. Clinical and epidemiologic features of 1,383 infections
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Marseille, France
    Medicine (Baltimore) 79:109-23. 2000
  8. ncbi request reprint Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand
    P E Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:168-73. 2008
  9. ncbi request reprint Echocardiography predicts embolic events in infective endocarditis
    G Di Salvo
    Department of Cardiology, La Timone Hospital, Marseille, France
    J Am Coll Cardiol 37:1069-76. 2001
  10. ncbi request reprint Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases
    H Tissot Dupont
    , , Marseille, France
    Am J Med 93:427-34. 1992

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. doi request reprint Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach
    Z Sekeyova
    Faculte de Medecine, Universite de la Mediterranee, URMITE 6236 IRD, IFR 48, 27 Boulevard Jean Moulin, 05 13385 Marseille Cedex, France
    Eur J Clin Microbiol Infect Dis 28:287-95. 2009
    ..Two proteins, arginine repressor and OmpH, were recognised exclusively by the sera of patients with Q fever endocarditis. These proteins are promising candidates for the development of serodiagnostic assays for Q fever endocarditis...
  2. pmc Rickettsioses as paradigms of new or emerging infectious diseases
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRESA 6020, Marseille, France
    Clin Microbiol Rev 10:694-719. 1997
    ..We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses...
  3. pmc Genetic classification of "Rickettsia heilongjiangii" and "Rickettsia hulinii," two Chinese spotted fever group rickettsiae
    J Z Zhang
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRES A6020, 13385 Marseille Cedex 05, France
    J Clin Microbiol 38:3498-501. 2000
    ....
  4. ncbi request reprint Outbreak of epidemic typhus associated with trench fever in Burundi
    D Raoult
    WHO Reference Centre for Rickettsial Diseases, Universite de la Mediterranee, Marseille, France
    Lancet 352:353-8. 1998
    ..Reports of sutama among the civilian population date back to late 1995 and, in association with body-louse infestation, the disease has subsequently swept across the higher and colder regions of the country...
  5. ncbi request reprint Cultivation of the bacillus of Whipple's disease
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, Marseilles, France
    N Engl J Med 342:620-5. 2000
    ..Whipple's disease is a systemic bacterial infection, but to date no isolate of the bacterium has been established in subculture, and no strain of this bacterium has been available for study...
  6. pmc Body lice as tools for diagnosis and surveillance of reemerging diseases
    V Roux
    , CNRS UPRES A 6020, , 13385 Marseille, France
    J Clin Microbiol 37:596-9. 1999
    ....
  7. ncbi request reprint Q fever 1985-1998. Clinical and epidemiologic features of 1,383 infections
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Marseille, France
    Medicine (Baltimore) 79:109-23. 2000
    ..Our data confirm that chronic Q fever is mainly determined by host factors and demonstrate for the first time that host factors may also play a role in the clinical expression of acute Q fever...
  8. ncbi request reprint Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand
    P E Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:168-73. 2008
    ..Other genotypes formed two other clusters that may also be associated with undescribed serotypes...
  9. ncbi request reprint Echocardiography predicts embolic events in infective endocarditis
    G Di Salvo
    Department of Cardiology, La Timone Hospital, Marseille, France
    J Am Coll Cardiol 37:1069-76. 2001
    ..It also suggests that early operation may be recommended in patients with vegetations > 15 mm and high mobility, irrespective of the degree of valve destruction, heart failure and response to antibiotic therapy...
  10. ncbi request reprint Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases
    H Tissot Dupont
    , , Marseille, France
    Am J Med 93:427-34. 1992
    ..CONCLUSION: Our results indicate that many cases of acute Q fever are undiagnosed. A greater awareness of the disease and more extensive serologic testing of patients with symptoms compatible with Q fever may improve the situation...
  11. doi request reprint Comparison of the new InoDiag automated fluorescence multiplexed antigen microarray to the reference technique in the serodiagnosis of atypical bacterial pneumonia
    F Gouriet
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:1119-27. 2008
    ..The performance of this serological assay was comparable to that of other assays reported in the literature. This preliminary study shows that the automatic InoDiag assay opens the way to immunofluorescence assay standardization...
  12. doi request reprint Multiplexed whole bacterial antigen microarray, a new format for the automation of serodiagnosis: the culture-negative endocarditis paradigm
    F Gouriet
    Unite des Rickettsies, CNRS UMR, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:1112-8. 2008
    ..These results were confirmed by two other assays, one using triplicate testing and one blind testing performed by another centre. This multiplexed test is therefore a valuable tool for the rapid diagnosis of blood-culture negative IE...
  13. pmc Detection and identification of spotted fever group Rickettsiae and Ehrlichiae in African ticks
    P Parola
    Unite des Rickettsies, CNRS UMR 6020, Marseille, France
    Emerg Infect Dis 7:1014-7. 2001
    ..mongolotimonae" was identified for the first time in Africa. Rickettsiae of unknown pathogenicity and two new ehrlichiae of the Ehrlichia canis group were identified in ticks from Mali and Niger...
  14. pmc Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis
    P Y Levy
    Centre National de Reference des Rickettsioses, Centre Hospitalier Universitaire La Timone, Marseille, France
    Antimicrob Agents Chemother 35:533-7. 1991
    ..We advise a minimum duration of treatment of 3 years with therapy combining quinolones and doxycycline...
  15. ncbi request reprint Culture and immunological detection of Tropheryma whippelii from the duodenum of a patient with Whipple disease
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Université des la Méditerranée CNRS, 27 Boulevard Jean Moulin, UPRESA 6020, 13385 Marseille Cedex 05, France
    JAMA 285:1039-43. 2001
    ..Molecular-based diagnostic techniques, although highly sensitive, may be less specific. New diagnostic tools involving isolation of bacteria from contaminated intestinal biopsies and immunohistological detection need to be developed...
  16. pmc Contribution of systematic serological testing in diagnosis of infective endocarditis
    D Raoult
    Unite des Rickettsies, Hopital de la Timone, Faculte de Medicine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    J Clin Microbiol 43:5238-42. 2005
    ..9%) possible cases of IE as definite cases. Systematic serological testing improved the performance of the modified Duke criteria and was instrumental in establishing the etiologic diagnosis in 8% (34/427) cases of IE...
  17. ncbi request reprint Preliminary transcriptional analysis of spoT gene family and of membrane proteins in Rickettsia conorii and Rickettsia felis
    C Rovery
    Unite des Rickettsies, CNRS UMR 6020, IFR48, Faculte de Medecine, 13 385 Marseille, France
    Ann N Y Acad Sci 1063:79-82. 2005
    ..We hypothesized that multiple copies of genes in bacteria with reduced genomes might account for such a process. Transcription of spoT and sca paralogs was thus analyzed in R. conorii and R. felis...
  18. doi request reprint [Bartonella henselae, an ubiquitous agent of proteiform zoonotic disease]
    S Edouard
    CNRS, UMR6236, IRD 198, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Centre National de Reference des Rickettsies, Bartonella et Coxiella, Faculte de Medecine, Universite de la Mediterranee, Boulevard Jean Moulin, Marseille Cedex 5, France
    Med Mal Infect 40:319-30. 2010
    ..No treatment is required for the benign form of cat scratch disease. For more severe clinical presentations, the treatment must be adapted to every clinical presentation...
  19. ncbi request reprint Prevalence of Rickettsia spp. in Dermacentor marginatus ticks removed from game pigs (Sus scrofa) in southern France
    Y O Sanogo
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Marseilles, France
    Ann N Y Acad Sci 990:191-5. 2003
    ..Moreover, a new Rickettsia genotype was detected in one specimen (1.4%). The pathogenic role of this new rickettsia has yet to be demonstrated...
  20. pmc Multispacer typing technique for sequence-based typing of Bartonella quintana
    C Foucault
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine de Marseille, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Clin Microbiol 43:41-8. 2005
    ..Direct typing of natural samples allowed the identification of a fifth genotype in the DNA extracted from a human body louse collected in Burundi. We have named the typing technique herein described multispacer typing...
  21. ncbi request reprint Rickettsia africae, a tick-borne pathogen in travelers to sub-Saharan Africa
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseilles, France
    N Engl J Med 344:1504-10. 2001
    ..African tick-bite fever occurs after contact with ticks that carry Rickettsia africae and that parasitize cattle and game. Sporadic reports suggest that this infection has specific clinical and epidemiologic features...
  22. ncbi request reprint Characterization of a new spotted fever group rickettsia detected in Ixodes ricinus (Acari: Ixodidae) collected in Slovakia
    Z Sekeyova
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRES, Marseille, France
    J Med Entomol 37:707-13. 2000
    ....
  23. ncbi request reprint Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus
    B La Scola
    Unite des Rickettsies, , , CNRS UPRESA 6020, Marseille, France
    Int J Syst Evol Microbiol 51:1471-9. 2001
    ..Strain Twist-MarseilleT (= CNCM I-2202T) is proposed as the type strain of a new species within a new genus, Tropheryma whipplei gen. nov., sp. nov., that was provisionally created solely on the basis of 16S rRNA gene sequence data...
  24. ncbi request reprint Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 29:434-6. 1999
    ..quintana DNA was amplified from lice. Epidemic typhus remains extant in the area, and B. quintana infections were encountered and documented for the first time in South America...
  25. pmc Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever
    C Foucault
    Unite des Rickettsies, CNRS UMR 6020, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Clin Microbiol 42:4904-6. 2004
    ..B. quintana has been retrieved in erythrocytes in large clusters and in erythroblasts. Direct immunofluorescence of blood smears allows a rapid diagnosis...
  26. pmc Detection by immunofluorescence assay of Bartonella henselae in lymph nodes from patients with cat scratch disease
    J M Rolain
    Unite des Rickettsies, CNRS UMR 6020A, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 10:686-91. 2003
    ..4% if one of the two tests was positive. Since PCR-based detection with biopsy samples is available only in reference laboratories, we suggest using IFD coupled with the commercial serology test for the diagnosis of CSD...
  27. ncbi request reprint Whipple's endocarditis: review of the literature and comparisons with Q fever, Bartonella infection, and blood culture-positive endocarditis
    F Fenollar
    , Centre Nationale de Recherche Scientifique, , Marseille, France
    Clin Infect Dis 33:1309-16. 2001
    ..Treatment is not well established. Whipple's endocarditis is a specific entity involving minor inflammatory reactions and negative blood cultures, and its incidence is probably underestimated...
  28. ncbi request reprint Genetic diversity of bacterial agents detected in ticks removed from asymptomatic patients in northeastern Italy
    Y O Sanogo
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Marseilles, France
    Ann N Y Acad Sci 990:182-90. 2003
    ..Anaplasma phagocytophilum, the agent of human granulocytic ehrlichiosis, was identified in 1 specimen of I. ricinus. A new Ehrlichia sp. ("Candidatus Ehrlichia walkerii", sp. nov.) was identified in 10 I. ricinus specimens...
  29. ncbi request reprint Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
    E Botelho-Nevers
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 26:635-40. 2007
    ..01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections...
  30. ncbi request reprint Q fever osteoarticular infection: four new cases and a review of the literature
    C Landais
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385, Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 26:341-7. 2007
    ..Culture-negative osteoarticular samples with granulomatous presentation upon histological examination should raise suspicion of Q fever...
  31. ncbi request reprint Diagnosis of endocarditis in acute Q-fever by immunofluorescence serology
    D Raoult
    Centre National de Reference des Rickettsies, CHU La Timone, Marseille, France
    Acta Virol 32:70-4. 1988
    ..The positive predictive value of these tests was 100% and 94.1%, respectively...
  32. pmc Detection and culture of Bartonella quintana, Serratia marcescens, and Acinetobacter spp. from decontaminated human body lice
    B La Scola
    , CNRS UPRESA 6020, , 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France
    J Clin Microbiol 39:1707-9. 2001
    ..The sensitivities of PCR and culture of B. quintana were 98 and 36%, respectively. These procedures may be useful for epidemiologic studies of trench fever and for the recovery of strains for characterization and comparison...
  33. ncbi request reprint Molecular detection of Bartonella quintana DNA in the dental pulp of a homeless patient
    G Aboudharam
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 23:920-2. 2004
    ..Using PCR with two specific gene targets, Bartonella quintana DNA was detected in the dental pulp extracted from the tooth of a homeless patient. The patient had been bacteremic 6 months previously but was not when the tooth was sampled...
  34. ncbi request reprint Real-time PCR for universal antibiotic susceptibility testing
    J M Rolain
    Didier Raoult, Unite des Rickettsies, Faculte de Medecine, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Antimicrob Chemother 54:538-41. 2004
    ..In this study, we developed a universal 16S rRNA and rpoB quantitative PCR assay for susceptibility testing of bacteria commonly isolated in clinical microbiology laboratories...
  35. pmc Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection
    F Fenollar
    Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Clin Microbiol 42:4919-24. 2004
    ..004). In patient samples with titers below 1:25,600 tested prospectively, sensitivity was 100% (7 of 7). The LCN-PCR assay may be helpful in establishing an early diagnosis of chronic Q fever...
  36. pmc A flea-associated Rickettsia pathogenic for humans
    D Raoult
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Emerg Infect Dis 7:73-81. 2001
    ..Our successful isolation of this rickettsia makes it available for use in serologic tests to determine its clinical spectrum, prevalence, and distribution...
  37. pmc Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR
    S Branger
    Unite des Rickettsies, CNRS UMR 6020A, Faculte de Medecine, Marseille, France
    Antimicrob Agents Chemother 48:4822-8. 2004
    ..Our study confirms previous reports that quantitative PCR is a reliable method for determining antibiotic susceptibility; therefore, it might be useful for screening new drugs...
  38. ncbi request reprint Molecular phylogeny of the genus Bartonella: what is the current knowledge?
    P Houpikian
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine de Marseille, 27, Boulevard Jean Moulin, 13385 Marseille Cedex, France
    FEMS Microbiol Lett 200:1-7. 2001
    ..Lack of host specificity, however, seems to be frequent and may reflect the influence of vector specificity. Host or vector specificity may also explain the current geographic distribution of Bartonella species...
  39. ncbi request reprint Concomitant or consecutive infection with Coxiella burnetii and tickborne diseases
    J M Rolain
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 40:82-8. 2005
    ..In this study, we describe 6 patients with Q fever who were infected with 1 of the following tickborne pathogens: Rickettsia conorii (2 patients), Rickettsia slovaca (2), Rickettsia africae (1), and Francisella tularensis (1)...
  40. ncbi request reprint Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Université de la Mediterranée CNRS, Marseille, France
    Arch Intern Med 159:167-73. 1999
    ..Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a long-term tetracycline and quinolone regimen for at least 4 years is recommended, although relapses are frequent...
  41. doi request reprint Evaluation of the LightCycler SeptiFast test in the rapid etiologic diagnostic of infectious endocarditis
    J P Casalta
    Laboratoire de Microbiologie, IFR 48, Centre Hospitalier Universitaire de la Timone, 264 rue Saint Pierre, Marseille, France
    Eur J Clin Microbiol Infect Dis 28:569-73. 2009
    ..03). However, bacteria were detected from three IE treated by antibiotics, with blood culture negative on admission. The SeptiFast test may be useful in cases of IE in patients treated with antibiotics before admission...
  42. ncbi request reprint Subtyping of uncultured bartonellae using sequence comparison of 16 S/23 S rRNA intergenic spacer regions amplified directly from infected blood
    R J Birtles
    Unite des Rickettsies, UPRESA 6020, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille Cedex 5, 13385, France
    Mol Cell Probes 14:79-87. 2000
    ....
  43. ncbi request reprint Antibiotic susceptibility of rickettsia and treatment of rickettsioses
    D Raoult
    Centre National de Reference des Rickettsioses, WHO collaborative center for diagnosis and research CHU la Timone, Marseille, France
    Eur J Epidemiol 5:432-5. 1989
    ..In Q fever, according to the new biological data, an association of tetracyclines and Rifampin or Quinolones is suggested...
  44. ncbi request reprint Species-specific BALB/c mouse antibodies to rickettsiae studied by western blotting
    L Beati
    Unite des Rickettsies, Faculte de Medecine, Marseilles, France
    FEMS Microbiol Lett 119:339-44. 1994
    ..Our findings suggest that the intraperitoneal route of inoculation of BALB/c mice can be used for the differentiation of spotted fever group rickettsiae...
  45. pmc Use of rpoB gene analysis for detection and identification of Bartonella species
    P Renesto
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille, France
    J Clin Microbiol 39:430-7. 2001
    ..In all cases, our results were in accordance with those of the reference method. Moreover, conserved regions of DNA were chosen as suitable primer targets for PCR amplification of a 439-bp fragment which can be easily sequenced...
  46. pmc Diagnosis of granulocytic ehrlichiosis in humans by immunofluorescence assay
    P Brouqui
    Unite des Rickettsies, WHO Collaborative Center for Rickettsial Reference and Research, CNRS UPRES A 6020, Faculte de Medecine, 13385 Marseille Cedex 5 France
    Clin Diagn Lab Immunol 8:199-202. 2001
    ..Immunofluorescence assay (IFA) with this antigen is as efficient as with the MRL kit and allows a one-step IFA with other cell-free antigens that is useful when testing sera from patients bitten by ticks...
  47. pmc First case of osteomyelitis due to Shewanella algae
    E Botelho-Nevers
    Service de Maladies Infectieuses et Tropicales, Hopital Nord, Marseille, France
    J Clin Microbiol 43:5388-90. 2005
    ..This bacterium, at first misidentified by phenotypic tests as Shewanella putrefaciens, was subsequently identified correctly as S. algae by 16S rRNA gene sequence analysis...
  48. ncbi request reprint 'Candidatus Odyssella thessalonicensis' gen. nov., sp. nov., an obligate intracellular parasite of Acanthamoeba species
    R J Birtles
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Marseille, France
    Int J Syst Evol Microbiol 50:63-72. 2000
    ..L13 is therefore proposed as 'Candidatus Odyssella thessalonicensis' gen. nov., sp. nov...
  49. ncbi request reprint Value and limitations of the Duke criteria for the diagnosis of infective endocarditis
    G Habib
    Department of Cardiology, La Timone Hospital, Marseille, France
    J Am Coll Cardiol 33:2023-9. 1999
    ..The purpose of this study was to assess the value and limitations of Duke criteria for the diagnosis of infective endocarditis (IE)...
  50. ncbi request reprint [Molecular tools in the epidemiology of tick-borne bacterial diseases]
    P Parola
    , CNRS UMR 6020, , 27, Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Ann Biol Clin (Paris) 59:177-82. 2001
    ..Anaplasma marginale the agent of bovine anaplasmosis was detected in Mali. Rickettsiae of unknown pathogenicity were detected in Mali and Niger...
  51. ncbi request reprint Update on tick-borne bacterial diseases in Europe
    C Socolovschi
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes URMITE, UMR CNRS IRD 6236 198, WHO Collaborative Center for Rickettsial diseases and other arthropod borne bacterial diseases, Faculte de Medecine, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Parasite 16:259-73. 2009
    ..We focus on the epidemiological and clinical aspects of tick-borne rickettsioses and give an overview of other tick-borne illnesses as well as the emergence and re-emergence of these diseases...
  52. ncbi request reprint Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium
    A Boulos
    Unite des Rickettsies, CNRS UMR 6020, IFR48, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Antimicrob Chemother 55:178-81. 2005
    ..In this study, we have evaluated the antibiotic susceptibility of three strains of T. whipplei grown in axenic medium using the same assay...
  53. pmc Recommendations for treatment of human infections caused by Bartonella species
    J M Rolain
    Unite des Rickettsies, Faculte de Medecine, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Antimicrob Agents Chemother 48:1921-33. 2004
  54. pmc Comparison of in-house and commercial slides for detection by immunofluorescence of immunoglobulins G and M against Bartonella henselae and Bartonella quintana
    M Maurin
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 9:1004-9. 2002
    ..7% of serum samples with the FT test (P = 0.004). Since each test has advantages over the other, the serological diagnosis of Bartonella infections would benefit if both tests were used concurrently...
  55. pmc Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia
    C Foucault
    Unite des Rickettsies, CNRS UMR 6020, IFR48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Antimicrob Agents Chemother 47:2204-7. 2003
    ..003). This study demonstrates the efficiency of the combination of doxycycline and gentamicin in eradicating B. quintana bacteremia...
  56. pmc Molecular evaluation of antibiotic susceptibility: Tropheryma whipplei paradigm
    F Masselot
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Antimicrob Agents Chemother 47:1658-64. 2003
    ..whipplei is naturally relatively resistant to fluoroquinolones...
  57. ncbi request reprint Rickettsia aeschlimannii in Hyalomma ticks from Corsica
    K Matsumoto
    Unite des Rickettsies, Faculte de Medecine, WHO Collaborative Center for Rickettsial Reference and Research, CNRS UMR 6020 IFR 48, 27 Bd Jean Moulin, Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 23:732-4. 2004
  58. ncbi request reprint Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis
    J M Rolain
    Unite des Rickettsies, Centre National de Recherche Scientifique, Unite Mixte de Recherche 6020, Institut Federatif de Recherche 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Infect Dis 188:1322-5. 2003
    ..29+/-1.75 vs. 3.14+/-1.40 microg/mL; P=.003). We recommend adjusting the posology of doxycycline to achieve a serum concentration of at least 5 microg/mL...
  59. pmc Characterization of and application of monoclonal antibodies against Rickettsia africae, a newly recognized species of spotted fever group rickettsia
    W Xu
    Unite des Rickettsies, Faculte de Medecine, Marseille, France
    J Clin Microbiol 35:64-70. 1997
    ..africae and the other SFG rickettsiae on the basis of Jaccard coefficients and unweighted pair group method with arithmetic mean analysis. The relatedness was generally consistent with that obtained by other methods of comparison...
  60. doi request reprint Q fever and pregnancy: disease, prevention, and strain specificity
    E Angelakis
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, CNRS UMR 7278, IRD 198, Aix Marseille Universite, 27 Bd Jean Moulin, 13005 Marseille, France
    Eur J Clin Microbiol Infect Dis 32:361-8. 2013
    ..burnetii relative to different geographical areas could be related to strain specificity, possibly based on differences in plasmid sequences, or to a failure of public health authorities to detect early miscarriages...
  61. ncbi request reprint Real-time laboratory surveillance of sexually-transmissible infections in Marseille University hospitals reveals rise of gonorrhoea, syphilis and human immunodeficiency virus seroconversions in 2012
    P Colson
    Fédération de Bactériologie Hygiène Virologie, University Hospital Centre Timone, Institut Hospitalo Universitaire IHU Mediterranee Infection, Assistance Publique Hopitaux de Marseille, Marseille, France
    Euro Surveill 18:4. 2013
    ..Our system allowed timely identification of an increase in sexually-transmitted infections in Marseille for the whole year of 2012...
  62. pmc Predominant immunoglobulin A response to phase II antigen of Coxiella burnetii in acute Q fever
    P E Fournier
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 6:173-7. 1999
    ....
  63. doi request reprint Infective endocarditis incidentally discovered by pathological examination
    H Lepidi
    Unite des Rickettsies et des Pathogenes Emergents, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Clin Pathol 61:233-4. 2008
    ..Pathological examination of cardiac valves remains the gold standard for the diagnosis of infective endocarditis, and it should be routinely performed even without suspicion of infectious process...
  64. ncbi request reprint Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA
    P E Fournier
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Int J Syst Bacteriol 48:839-49. 1998
    ....
  65. ncbi request reprint Determination of the rpoB gene sequences of Bartonella henselae and Bartonella quintana for phylogenic analysis
    P Renesto
    Unite des Rickettsies, CNRS UPRES A 6020, Universite de la Mediterranee, Marseille, France
    Res Microbiol 151:831-6. 2000
    ..Based on the bootstrap values derived from rpoB phylogenic analysis, we believe that this molecule should contribute to better understanding the evolutionary process...
  66. pmc Endocarditis due to rare and fastidious bacteria
    P Brouqui
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, 13385 Marseille Cedex 5, France
    Clin Microbiol Rev 14:177-207. 2001
    ..Pathologic examination of the valve using special staining, such as Warthin-Starry, Gimenez, and PAS, and broad-spectrum PCR should be performed systematically when no etiologic diagnosis is evident through routine laboratory evaluation...
  67. pmc Immunofluorescent detection of intraerythrocytic Bartonella henselae in naturally infected cats
    J M Rolain
    , CNRS UMR 6020, , 13385 Marseille Cedex 05, France
    J Clin Microbiol 39:2978-80. 2001
    ..Three cats that were positive by blood culture were also positive by direct immunofluorescence, and laser confocal microscopy confirmed the intraerythrocytic location of B. henselae...
  68. ncbi request reprint The body louse as a vector of reemerging human diseases
    D Raoult
    Universite de la Mediterranee, Faculte de Medecine, Centre National de la Recherche Scientifique, Unité Propre de Recherche de l Enseignement Superieur Associée 6020, Marseille, France
    Clin Infect Dis 29:888-911. 1999
    ..A small outbreak was also reported in Russia in 1997. Louse infestation appears to become more prevalent worldwide, associated with a decline in social and hygienic conditions provoked by civil unrest and economic instability...
  69. pmc Bactericidal effect of doxycycline associated with lysosomotropic agents on Coxiella burnetii in P388D1 cells
    D Raoult
    Centre National de Reference des Rickettsies, Centre Hospitalier Universitaire de la Timone, Marseille, France
    Antimicrob Agents Chemother 34:1512-4. 1990
    ..burnetii is located inhibit antibiotic activity. This inhibition can be reversed in vitro when lysosomotropic alkalinizing agents are used...
  70. doi request reprint [Q fever: current diagnosis and treatment options]
    M Million
    CNRS, UMR 6236, IRD 198, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Med Mal Infect 39:82-94. 2009
    ..The treatment is effective and well tolerated, but must be adapted to the acute or chronic pattern, the presence of a heart valve disease, an aneurysm or a vascular prosthesis, an immunodeficiency and the specific problem of pregnancy...
  71. ncbi request reprint Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae
    V Roux
    Unite des Rickettsies, Centre National de la Recherche Scientifique, EPJ 0054, Faculte de Medecine, Marseille, France
    Int J Syst Bacteriol 47:252-61. 1997
    ....
  72. ncbi request reprint Rickettsial antibody in southern France: antibodies to Rickettsia conorii and Coxiella burnetii among urban, suburban and semi-rural blood donors
    D Raoult
    Laboratoire de Bacteriologie, C H U la Timone, Marseille, France
    Trans R Soc Trop Med Hyg 81:80-1. 1987
    ..This supports the view that in the south of France the highest prevalence of Mediterranean Spotted Fever is suburban. 5% of the sera had antibodies to Coxiella burnetti in this area, in which Q fever is endemic...
  73. ncbi request reprint Infections in the homeless
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, and Hĵpital Nord Service des Maladies Infectieuses et Tropicales, Marseille, France
    Lancet Infect Dis 1:77-84. 2001
    ..Patients with serious and contagious illnesses should be hospitalised. Physicians should be aware of these specific issues to enhance care...
  74. ncbi request reprint Prevalence of rickettsia-like organisms and spotted fever group rickettsiae in ticks (Acari: Ixodidae) from Zimbabwe
    L Beati
    Unite des Rickettsies, Faculte de Medecine, Marseille, France
    J Med Entomol 32:787-92. 1995
    ....
  75. pmc Sequence-based identification of new bacteria: a proposition for creation of an orphan bacterium repository
    M Drancourt
    Unite des Rickettsies, Faculte de Medecine, Marseille, France
    J Clin Microbiol 43:4311-5. 2005
  76. ncbi request reprint Ticks and tickborne bacterial diseases in humans: an emerging infectious threat
    P Parola
    , CNRS UMR 6020, , , Marseille, France
    Clin Infect Dis 32:897-928. 2001
    ..Methods are described for the detection and isolation of bacteria from ticks and advice is given on how tick bites may be prevented and how clinicians should deal with patients who have been bitten by ticks...
  77. ncbi request reprint Phylogeny of Rickettsia spp. inferred by comparing sequences of 'gene D', which encodes an intracytoplasmic protein
    Z Sekeyova
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRES A, Universite de la Mediterranee, Marseille, France
    Int J Syst Evol Microbiol 51:1353-60. 2001
    ..As significant bootstrap values were obtained for most of the nodes, sequence comparison of 'gene D' should be considered as a complementary approach in phylogenetic studies of rickettsiae...
  78. pmc Interleukin-10 stimulates Coxiella burnetii replication in human monocytes through tumor necrosis factor down-modulation: role in microbicidal defect of Q fever
    E Ghigo
    , CNRS UMR 6020, , Marseille, France
    Infect Immun 69:2345-52. 2001
    ..These results suggest that interleukin-10 enables monocytes to support C. burnetii replication and to favor the development of chronic Q fever...
  79. ncbi request reprint Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer-membrane protein rOmpB (ompB)
    V Roux
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Marseille, France
    Int J Syst Evol Microbiol 50:1449-55. 2000
    ..Integration of phenotypic, genotypic and phylogenetic data will contribute to the definition of a polyphasic taxonomy as has been done for other bacterial genera...
  80. ncbi request reprint IFN-gamma-mediated control of Coxiella burnetii survival in monocytes: the role of cell apoptosis and TNF
    J Dellacasagrande
    Unite des Rickettsies, Universite de la Mediterranee, Centre National de la Recherche Scientifique, Faculte de Medecine, Marseille, France
    J Immunol 162:2259-65. 1999
    ..burnetii and cell death. These results suggest that IFN-gamma promotes the killing of C. burnetii in monocytes through an apoptotic mechanism mediated in part by TNF...
  81. pmc New Rickettsiae in ticks collected in territories of the former soviet union
    E Rydkina
    Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 5:811-4. 1999
    ..conorii (8%), and the Astrakhan fever agent (3%), respectively. Three new Rickettsiae of the R. massiliae genogroup were identified in ticks by 16S rDNA, gltA, and ompA sequencing...
  82. doi request reprint Evidence of circulation of an epidemic strain of Francisella tularensis in France by multispacer typing
    W Li
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, CNRS IRD UMR 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Eur J Clin Microbiol Infect Dis 30:1135-8. 2011
    ..Incorporating 79 Swedish F. tularensis strains, phylogenetic analysis demonstrated that although tularemia appears as a sporadic disease in France, it is caused by an epidemic cluster of strains...
  83. doi request reprint [From Whipple's disease to Tropheryma whipplei infections]
    J C Lagier
    URMITE CNRS IRD UMR 6236, Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Med Mal Infect 40:371-82. 2010
    ..In addition to histological analyses, molecular tools help the clinician to prove these difficult diagnoses. Failure and relapse data and antibiotic susceptibility tests have allowed to determine a rational treatment...
  84. pmc rpoB sequence analysis of cultured Tropheryma whippelii
    M Drancourt
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Clin Microbiol 39:2425-30. 2001
    ..This study underscores that a method involving isolation and then propagation of emerging bacteria is a useful way to quickly achieve extensive molecular knowledge of these pathogens...
  85. ncbi request reprint Proposed tests for the routine identification of Rochalimaea species
    M Drancourt
    Unité des Rickettsie, Centre National de Référence, Faculte de Medecine, Marseille, France
    Eur J Clin Microbiol Infect Dis 12:710-3. 1993
    ..Further studies are needed to confirm the validity of these tests for identification of Rochalimaea species...
  86. doi request reprint Serological microarray for a paradoxical diagnostic of Whipple's disease
    C J Bonhomme
    Unite des Rickettsies, CNRS UMR 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13005, Marseille, France
    Eur J Clin Microbiol Infect Dis 27:959-68. 2008
    ..If confirmed, this serological test will distinguish between carriers and patients in people with positive PCR of the stool...
  87. ncbi request reprint [Lice and lice-borne diseases in humans]
    L Houhamdi
    L Unité des Rickettsies, CNRS UMR 6020, Marseille, France
    Med Trop (Mars) 65:13-23. 2005
    ..Recently, a forth human pathogen, Acinetobacter baumannii, has been associated to the body louse...
  88. pmc Jail fever (epidemic typhus) outbreak in Burundi
    D Raoult
    , , Marsaille, France
    Emerg Infect Dis 3:357-60. 1997
    ..The jail-associated outbreak predates an extensive ongoing outbreak of louse-borne typhus in central eastern Africa after civil war and in refugee camps in Rwanda, Burundi (1), and Zaire...
  89. pmc Production of Bartonella genus-specific monoclonal antibodies
    Z Liang
    , CNRS UPRES-A 6020, , , , France
    Clin Diagn Lab Immunol 8:847-9. 2001
    ..Moreover, these MAbs allow all Bartonella species to be identified to the genus level...
  90. ncbi request reprint Survival of Coxiella burnetii within free-living amoeba Acanthamoeba castellanii
    B La Scola
    , UPRESA 6020, , , 27 Boulevard Jean Moulin, France
    Clin Microbiol Infect 7:75-9. 2001
    ..CONCLUSION: These results indicate that free-living amoebae could provide an intracellular niche for the spore formation and survival of C. burnetii in the environment...
  91. ncbi request reprint Detection of R. felis and R. typhi in fleas using monoclonal antibodies
    R Fang
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculté de Méedecine, 13385 Marseilles, France
    Ann N Y Acad Sci 990:213-20. 2003
    ..typhi but, in contrast, was 97% for R. felis. Thus, our method appears to be useful for surveillance in R. felis infections, but requires further studies for the detection of R. typhi...
  92. pmc Simplified serological diagnosis of endocarditis due to Coxiella burnetii and Bartonella
    J M Rolain
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 10:1147-8. 2003
    ..This assay should be considered as a possible commercial test for the diagnosis of BCNE...
  93. ncbi request reprint Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
    ..Advances in understanding the pathophysiology and natural history of Q fever are reviewed...
  94. ncbi request reprint Genomic and evolutionary aspects of Mimivirus
    M Suzan-Monti
    Unité des Rickettsies et pathogènes émergents, Faculte de Medecine, IFR 48, CNRS UMR 6020, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Virus Res 117:145-55. 2006
    ..This paper reviews our current knowledge on Mimivirus structure, life cycle and genome analysis and discusses its putative evolutionary origin in the tree of species of the three domains of life...
  95. ncbi request reprint Characterization of antigens for Q fever serodiagnostics
    Z Sekeyova
    Unite des Rickettsies, CNRS UMR IRD 6236, IFR 48, Faculte de Medecine, Marseille, France
    Acta Virol 54:173-80. 2010
    ..The recombinant protein CBU_0937 with unknown biological function proved to be a more applicable diagnostic tool for Q fever ELISA as compared to the Com1 protein...
  96. ncbi request reprint Interactions between Mycobacterium xenopi, amoeba and human cells
    M Drancourt
    Rickettsia Unit, Faculty of Medicine, Mediterranean University, Marseille, France
    J Hosp Infect 65:138-42. 2007
    ..xenopi is a facultative intra-amoebal and intracellular pathogen. Testing intra-amoebal M. xenopi might be necessary to properly evaluate decontamination procedures for hospital water supply systems in order to achieve eradication...
  97. pmc Differentiation of spotted fever group rickettsiae by sequencing and analysis of restriction fragment length polymorphism of PCR-amplified DNA of the gene encoding the protein rOmpA
    V Roux
    Unite des Rickettsies, Faculte de Medecine, Centre National de la Recherche Scientifique EPJ 0054, Marseille, France
    J Clin Microbiol 34:2058-65. 1996
    ..R. africae and strain S were differentiated by AvaII digestion. Thus, using a single PCR amplification, we were able to differentiate all of the SFG rickettsiae whose ompA gene was amplified by PCR...
  98. ncbi request reprint Candidatus Ehrlichia walkerii: a new Ehrlichia detected in Ixodes ricinus tick collected from asymptomatic humans in Northern Italy
    P Brouqui
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, 13385 Marseille Cedex 5 France
    Ann N Y Acad Sci 990:134-40. 2003
    ..Comparison of the 16S rRNA and the gltA gene sequences showed the organism is most closely related to Ehrlichia ruminantium. We propose this new Ehrlichia be named "candidatus Ehrlichia walkerii."..
  99. ncbi request reprint Lack of correlation between Bartonella DNA detection within fleas, serological results, and results of blood culture in a Bartonella-infected stray cat population
    B La Scola
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Marseille, France
    Clin Microbiol Infect 8:345-51. 2002
    ..To correlate the presence of different Bartonella species in the blood of a stray cat population trapped on a French military base with specific antibodies and species detected in cat fleas...
  100. ncbi request reprint Causative organisms of infective endocarditis according to host status
    K Barrau
    Unite des Rickettsies, CNRS UPRESA 6020, Universite de la Mediterranee, Faculte de Medecine, Marseilles, France
    Clin Microbiol Infect 10:302-8. 2004
    ..The basic host status of IE patients has been linked to specific microorganisms, and this may be of value when empirical treatment is needed in patients who have received previous antibiotic therapy and whose blood cultures are negative...
  101. ncbi request reprint From genes to proteins: in vitro expression of rickettsial proteins
    P Renesto
    Unite des Rickettsies, CNRS UMRA 6020, Faculte de Medecine, 13480 Marseille, France
    Ann N Y Acad Sci 990:642-52. 2003
    ..Moreover, this system is able to overcome some of the limitations encountered with rickettsial proteins highly toxic for E. coli or insect cells...