Anne Puel

Summary

Country: France

Publications

  1. pmc Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
    Luyan Liu
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale U980 and University Paris Descartes, 75015 Paris, France
    J Exp Med 208:1635-48. 2011
  2. pmc Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale INSERM, U550, 75015 Paris, France
    J Exp Med 207:291-7. 2010
  3. pmc Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, University Paris Descartes, Necker Medical School, Paris, France, EU
    Curr Opin Immunol 22:467-74. 2010
  4. pmc Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France
    Science 332:65-8. 2011
  5. doi request reprint Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de Santé et de Recherche Médicale, U550, Paris, France, EU
    Immunol Rev 226:29-40. 2008
  6. ncbi request reprint Heritable defects of the human TLR signalling pathways
    Anne Puel
    University of Paris INSERM U550, Necker Medical School, Paris, France
    J Endotoxin Res 11:220-4. 2005
  7. ncbi request reprint TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
  8. pmc Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells
    Ludovic de Beaucoudrey
    Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    J Exp Med 205:1543-50. 2008
  9. ncbi request reprint Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases
    Jacinta Bustamante
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, INSERM U550, Paris 75015, France, EU
    Curr Opin Immunol 20:39-48. 2008
  10. ncbi request reprint Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France, EU
    Immunol Rev 220:225-36. 2007

Detail Information

Publications45

  1. pmc Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
    Luyan Liu
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale U980 and University Paris Descartes, 75015 Paris, France
    J Exp Med 208:1635-48. 2011
    ..Gain-of-function STAT1 alleles therefore cause AD CMCD by impairing IL-17 immunity...
  2. pmc Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale INSERM, U550, 75015 Paris, France
    J Exp Med 207:291-7. 2010
    ..These findings suggest that auto-Abs against IL-17A, IL-17F, and IL-22 may cause CMC in patients with APS-I...
  3. pmc Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, University Paris Descartes, Necker Medical School, Paris, France, EU
    Curr Opin Immunol 22:467-74. 2010
    ..albicans. They also suggest that the distinct syndrome of isolated CMC, without auto-immunity or other infections, may be caused by inborn errors of IL-17 immunity...
  4. pmc Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France
    Science 332:65-8. 2011
    ..These experiments of nature indicate that human IL-17A and IL-17F are essential for mucocutaneous immunity against C. albicans, but otherwise largely redundant...
  5. doi request reprint Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de Santé et de Recherche Médicale, U550, Paris, France, EU
    Immunol Rev 226:29-40. 2008
    ..Future studies in humans aim to define the specific roles of IFN-alpha/beta and IFN-lambda types and individual molecules in host defense in natura...
  6. ncbi request reprint Heritable defects of the human TLR signalling pathways
    Anne Puel
    University of Paris INSERM U550, Necker Medical School, Paris, France
    J Endotoxin Res 11:220-4. 2005
    ..These data, therefore, suggest that TLRs play a critical role in host defence against pyogenic bacteria, but may be dispensable or redundant for immunity to most other infectious agents in humans...
  7. ncbi request reprint TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
    ..Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3...
  8. pmc Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells
    Ludovic de Beaucoudrey
    Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    J Exp Med 205:1543-50. 2008
    ..These data suggest that IL-12Rbeta1- and STAT-3--dependent signals play a key role in the differentiation and/or expansion of human IL-17-producing T cell populations in vivo...
  9. ncbi request reprint Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases
    Jacinta Bustamante
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, INSERM U550, Paris 75015, France, EU
    Curr Opin Immunol 20:39-48. 2008
    ....
  10. ncbi request reprint Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France, EU
    Immunol Rev 220:225-36. 2007
    ....
  11. ncbi request reprint Inherited disorders of human Toll-like receptor signaling: immunological implications
    Cheng Lung Ku
    Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, INSERM U550, Necker Medical School, Paris, France
    Immunol Rev 203:10-20. 2005
    ..Paradoxically, these experiments of nature raise the possibility that the entire set of human TLRs is largely redundant in protective immunity in vivo...
  12. pmc IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients
    Sandra Weller
    INSERM U783, Développement du Système Immunitaire, Faculté de Médecine Site Necker Enfants Malades, Universite Paris Descartes, Paris, France
    Blood 120:4992-5001. 2012
    ..Hence, we propose a role for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenance of IgM(+)IgD(+)CD27(+) B cells in humans...
  13. pmc IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease
    Cheng Lung Ku
    Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, University of Paris Rene Descartes, Paris, France
    J Med Genet 44:16-23. 2007
    ..About 2% of childhood episodes of invasive pneumococcal disease (IPD) are recurrent, and most remain unexplained...
  14. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
    ..Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3...
  15. pmc Pyogenic bacterial infections in humans with MyD88 deficiency
    Horst von Bernuth
    Human Genetics of Infectious Diseases, INSERM U550, Paris, France
    Science 321:691-6. 2008
    ..The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections...
  16. pmc Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
    Cheng Lung Ku
    Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    J Exp Med 204:2407-22. 2007
    ..Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria...
  17. ncbi request reprint Inherited human IRAK-4 deficiency: an update
    Capucine Picard
    Centre d Etude des Déficits Immunitaires, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, 75015, France, EU
    Immunol Res 38:347-52. 2007
    ..We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular...
  18. ncbi request reprint Human primary immunodeficiencies of type I interferons
    Emmanuelle Jouanguy
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
    Biochimie 89:878-83. 2007
    ..These novel inherited disorders strongly suggest that type I IFN-mediated immunity is essential for protection against natural infections caused by several viruses in humans...
  19. ncbi request reprint Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6
    Anne Puel
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, Paris, France
    J Immunol 180:647-54. 2008
    ..Patients with severe bacterial infections and low serum CRP concentrations should be tested for anti-IL-6 autoantibodies, especially in the presence of other clinical and biological signs of inflammation...
  20. ncbi request reprint Septicemia without sepsis: inherited disorders of nuclear factor-kappa B-mediated inflammation
    Horst von Bernuth
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, Paris, France
    Clin Infect Dis 41:S436-9. 2005
    ..An underlying defect in NF- kappa B activation should be suspected in children with bacterial septicemia accompanied by mild signs of inflammation...
  21. ncbi request reprint Herpes simplex virus encephalitis in human UNC-93B deficiency
    Armanda Casrouge
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, INSERM, U550, Faculte de Medecine Necker, Paris 75015, France
    Science 314:308-12. 2006
    ..HSE can result from a single-gene immunodeficiency that does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Other severe infectious diseases may also reflect monogenic disorders of immunity...
  22. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  23. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    ..Thus, CD14(dim) cells are bona fide monocytes involved in the innate local surveillance of tissues and the pathogenesis of autoimmune diseases...
  24. pmc Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency
    Capucine Picard
    Study Center of Primary Immunodeficiencies, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 89:403-25. 2010
    ..Prophylactic measures in childhood are beneficial, until spontaneous improvement occurs in adolescence...
  25. ncbi request reprint Inherited disorders of NF-kappaB-mediated immunity in man
    Anne Puel
    Université de Paris René Descartes, Institut National de la Santé et de la Recherche Médicale U550, Faculte de Medecine Necker, 75015 Paris, France
    Curr Opin Immunol 16:34-41. 2004
    ..The description of the infectious phenotypes associated with these genetic defects has initiated the forward genetic dissection of NF-kappaB-mediated immunity in man...
  26. ncbi request reprint Primary immunodeficiencies associated with pneumococcal disease
    Capucine Picard
    Pediatric Immunology Hematology Unit, Necker Enfants Malades Hospital, University of Paris Rene Descartes, Paris, France, EU
    Curr Opin Allergy Clin Immunol 3:451-9. 2003
    ..We thus reviewed the medical literature on cases of S. pneumoniae infection in patients with primary immunodeficiency diseases, with a particular emphasis on invasive pneumococcal disease...
  27. pmc The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation
    Anne Puel
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
    Am J Hum Genet 78:691-701. 2006
    ..The residual production of an NH(2)-truncated NEMO protein was sufficient for normal fetal development and for the subsequent normal development of skin appendages but was insufficient for the development of protective immune responses...
  28. pmc New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein
    Marjorie Hubeau
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Paris, France
    Blood 118:926-35. 2011
    ..They also demonstrate that the normal expression and folding of NEMO do not exclude a pathogenic role for NEMO mutations in patients with EDA-ID...
  29. ncbi request reprint Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    Kun Yang
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
    Immunity 23:465-78. 2005
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
  30. ncbi request reprint A fast procedure for the detection of defects in Toll-like receptor signaling
    Horst von Bernuth
    Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, Institut National de la Santé et de la Recherche Médicale U550, Necker Medical School, Paris, France
    Pediatrics 118:2498-503. 2006
    ..We, therefore, aimed to develop a cheap and fast test for the detection of defects in Toll-like receptor signaling...
  31. pmc Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980 and University Paris Descartes, Necker Medical School, Paris Sorbonne Cité, Paris, France
    Curr Opin Allergy Clin Immunol 12:616-22. 2012
    ..Patients with isolated CMC (CMCD) rarely display any other severe disease. We review here recent progress in the genetic dissection of these three types of inherited CMC...
  32. pmc Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes
    Stéphanie Boisson-Dupuis
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
    Curr Opin Immunol 24:364-78. 2012
    ..These experiments of Nature neatly highlight the clinical and immunological impact of the human genetic dissection of infectious phenotypes...
  33. pmc Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
    Vanessa Sancho-Shimizu
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, Necker Medical School, Paris, France
    J Clin Invest 121:4889-902. 2011
    ..They further demonstrate the importance of TRIF for the TLR3-dependent production of antiviral IFNs in the CNS during primary infection with HSV-1 in childhood...
  34. pmc X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production
    Orchidée Filipe-Santos
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes Institut National de la Santé et de la Recherche Médicale INSERM U 550, Necker Medical School, Paris, France
    J Exp Med 203:1745-59. 2006
    ..They also demonstrate the importance of the T cell- and CD40L-triggered, CD40-, and NEMO/NF-kappaB/c-Rel-mediated induction of IL-12 by monocyte-derived cells for protective immunity to mycobacteria in humans...
  35. ncbi request reprint Successful allogeneic hemopoietic stem cell transplantation in a child who had anhidrotic ectodermal dysplasia with immunodeficiency
    Sophie Dupuis-Girod
    Unité d Immunologie et d Hématologie Pédiatriques, Institut National de la Santé et de la Recherche Médicale U429, Hopital Necker Enfants Malades, Paris, France
    Pediatrics 118:e205-11. 2006
    ..Hematopoietic stem cell transplantation is well tolerated and efficiently cures the profound immunodeficiency associated with autosomal-dominant anhidrotic ectodermal dysplasia with immunodeficiency...
  36. doi request reprint Primary immunodeficiencies underlying fungal infections
    Fanny Lanternier
    aLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980 Necker Medical School, Imagine Institute and Paris Descartes University, Sorbonne Paris Cité bInfectious Diseases and Tropical Medicine Unit, Necker Enfants Malades Hospital, AP HP and Paris Descartes University cPasteur Institute, National Reference Center of Invasive Mycoses and Antifungals, Paris, France dSt Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA eStudy Center for Immunodeficiency fPediatric Hematology Immunology Unit, Necker Enfants Malades Hospital, AP HP, and Paris Descartes University, Sorbonne Paris Cité, Paris, France
    Curr Opin Pediatr 25:736-47. 2013
    ..Finally, we suggest that other fungal infections may also result from hitherto unknown inborn errors of immunity, at least in some patients with no known risk factors...
  37. ncbi request reprint Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes
    Celine Eidenschenk
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM Unité 550, Faculte de Medecine Necker, 156 rue de Vaugirard, 75015 Paris, France, European Union EU
    J Immunol 177:8835-43. 2006
    ..Impaired cytokine-mediated lymphocyte survival is likely to be the pathogenic mechanism underlying this novel form of inherited and selective NK deficiency in humans...
  38. pmc Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease
    Jacinta Bustamante
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, Paris, France
    Nat Immunol 12:213-21. 2011
    ..This 'experiment of nature' indicates that CYBB is associated with MSMD and demonstrates that the respiratory burst in human macrophages is a crucial mechanism for protective immunity to tuberculous mycobacteria...
  39. ncbi request reprint Autosomal-dominant primary immunodeficiencies
    Tatiana Lawrence
    Laboratory of Human Genetics of Infectious Diseases, University of Paris, René Descartes INSERM U550, Paris, France
    Curr Opin Hematol 12:22-30. 2005
    ..These recent data suggest that many more autosomal-dominant PIDs are likely to be identified in the near future...
  40. pmc A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency
    Gilles Courtois
    Unité de Biologie Moléculaire de l Expression Génique, Centre National de la Recherche Scientifique URA 2582, Institut Pasteur, Paris, France
    J Clin Invest 112:1108-15. 2003
    ..Our report highlights both the diversity of genotypes associated with EDA-ID and the diversity of immunologic phenotypes associated with mutations in different components of the NF-kappaB signaling pathway...
  41. pmc Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency
    Capucine Picard
    Study Center of Primary Immunodeficiencies, Assistance Publique Hoˆpitaux de Paris, Necker Hospital, France
    Clin Microbiol Rev 24:490-7. 2011
    ..These disorders were initially thought to be rare but have now been diagnosed in over 170 patients worldwide. We review here the infectious diseases affecting patients with inborn errors of NF-κB-dependent TLR and IL-1R immunity...
  42. doi request reprint Isolated congenital asplenia: a French nationwide retrospective survey of 20 cases
    Nizar Mahlaoui
    Pediatric Immunology Hematology Unit, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, University Paris Descartes, Paris, France
    J Pediatr 158:142-8, 148.e1. 2011
    ..To better describe the natural history, mode of inheritance, and the epidemiological and clinical features of isolated congenital asplenia, a rare and poorly understood primary immunodeficiency...
  43. ncbi request reprint Pyogenic bacterial infections in humans with IRAK-4 deficiency
    Capucine Picard
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université René Descartes INSERM U550, Faculte Necker, 156 rue de Vaugirard, 75015 Paris, France
    Science 299:2076-9. 2003
    ..These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms...
  44. ncbi request reprint Invasive pneumococcal disease in children can reveal a primary immunodeficiency
    Jean Gaschignard
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR1163 University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France Groupe de Pathologie Infectieuse Pédiatrique, France
    Clin Infect Dis 59:244-51. 2014
    ..Some primary immunodeficiencies (PIDs) are known to confer predisposition to IPD. However, a systematic search for these PIDs has never been carried out in children presenting with IPD...
  45. ncbi request reprint Autoantibodies against cytokines: back to human genetics
    Anne Puel
    Inserm U980, University Paris Descartes, France
    Blood 121:1246-7. 2013
    ..In this issue of Blood, Chi et al have discovered that the occurrence of autoantibodies against IFN-γ, which trigger mycobacterial diseases and mimic inborn errors of IFN-γ immunity, is genetically determined.(1)..