F Prugnolle

Summary

Country: France

Publications

  1. ncbi The impact of clonalty on parasite population genetic structure
    F Prugnolle
    Laboratoire Genetics and Evolution of Infectious Disease, UMR CNRS IRD 2724, IRD Montpellier, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Parasite 15:455-7. 2008
  2. pmc A new malaria agent in African hominids
    Benjamin Ollomo
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS Pathog 5:e1000446. 2009
  3. pmc Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting
    Nitchakarn Noranate
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    BMC Microbiol 9:219. 2009
  4. pmc African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum
    Franck Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, Unité Mixte de Recherche 2724, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, Institut de Recherche pour le Développement Montpellier, 34394 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:1458-63. 2010
  5. ncbi Geographical variations in infectivity and susceptibility in the host-parasite system Schistosoma mansoni/Biomphalaria glabrata: no evidence for local adaptation
    F Prugnolle
    GEMI, Equipe ESS, UMR 2274 CNRS IRD, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Parasitology 133:313-9. 2006
  6. doi A comparison of Anopheles gambiae and Plasmodium falciparum genetic structure over space and time
    Franck Prugnolle
    Génétique et Evolution des Maladies Infectieuses, UMR 2274 IRD CNRS UMI, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Microbes Infect 10:269-75. 2008
  7. pmc Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
    Franck Prugnolle
    Laboratoire GEMI, UMR 2724 CNRS IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    BMC Evol Biol 8:223. 2008
  8. doi Infection and body odours: evolutionary and medical perspectives
    Franck Prugnolle
    GEMI, UMR CNRS IRD 2724, IRD, 911 av Agropolis BP 64501, 34394 Montpellier Cedex 5, France
    Infect Genet Evol 9:1006-9. 2009
  9. doi Effective size of the hierarchically structured populations of the agent of malaria: a coalescent-based model
    F Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, UMR 2724 CNRS IRD, IRD de Montpellier, Montpellier, Cedex 5, France
    Heredity (Edinb) 104:371-7. 2010
  10. doi Apparent high recombination rates in clonal parasitic organisms due to inappropriate sampling design
    F Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, Montpellier, Cedex 5, France
    Heredity (Edinb) 104:135-40. 2010

Collaborators

Detail Information

Publications30

  1. ncbi The impact of clonalty on parasite population genetic structure
    F Prugnolle
    Laboratoire Genetics and Evolution of Infectious Disease, UMR CNRS IRD 2724, IRD Montpellier, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Parasite 15:455-7. 2008
    ..The consequences of this mode of reproduction for the different kinds of parasite life-cycles are described. We here particularly focus on clonal diploids...
  2. pmc A new malaria agent in African hominids
    Benjamin Ollomo
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS Pathog 5:e1000446. 2009
    ..The risk of transfer and emergence of this new species in humans must be now seriously considered given that it was found in two chimpanzees living in contact with humans and its close relatedness to the most virulent agent of malaria...
  3. pmc Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting
    Nitchakarn Noranate
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    BMC Microbiol 9:219. 2009
    ..To address this question, population allelic polymorphism and sequence variant-specific antibody responses were studied in a single Senegalese rural community where malaria transmission is intense and perennial...
  4. pmc African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum
    Franck Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, Unité Mixte de Recherche 2724, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, Institut de Recherche pour le Développement Montpellier, 34394 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:1458-63. 2010
    ..falciparum, a species previously considered as strictly human specific. The continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens...
  5. ncbi Geographical variations in infectivity and susceptibility in the host-parasite system Schistosoma mansoni/Biomphalaria glabrata: no evidence for local adaptation
    F Prugnolle
    GEMI, Equipe ESS, UMR 2274 CNRS IRD, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Parasitology 133:313-9. 2006
    ..Our study constitutes the first cross-transplantation experiment concerning this host-parasite system of which both hosts and parasites came directly from the wild, excluding laboratory generations and experimental host passages...
  6. doi A comparison of Anopheles gambiae and Plasmodium falciparum genetic structure over space and time
    Franck Prugnolle
    Génétique et Evolution des Maladies Infectieuses, UMR 2274 IRD CNRS UMI, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Microbes Infect 10:269-75. 2008
    ..The small level of genetic differentiation observed between populations may explain the speed at which antimalarial drug resistance and insecticide resistance spread into the African continent...
  7. pmc Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
    Franck Prugnolle
    Laboratoire GEMI, UMR 2724 CNRS IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    BMC Evol Biol 8:223. 2008
    ..reichenowi) versus parasites infecting rodent hosts (P. yoelii yoelii, P. berghei, and P. chabaudi). Adaptation by the parasite to its host is likely highly critical to the evolution of these species...
  8. doi Infection and body odours: evolutionary and medical perspectives
    Franck Prugnolle
    GEMI, UMR CNRS IRD 2724, IRD, 911 av Agropolis BP 64501, 34394 Montpellier Cedex 5, France
    Infect Genet Evol 9:1006-9. 2009
    ....
  9. doi Effective size of the hierarchically structured populations of the agent of malaria: a coalescent-based model
    F Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, UMR 2724 CNRS IRD, IRD de Montpellier, Montpellier, Cedex 5, France
    Heredity (Edinb) 104:371-7. 2010
    ..The logic of the derivation of effective size presented in this study is applicable to any organism showing the same levels of subdivision...
  10. doi Apparent high recombination rates in clonal parasitic organisms due to inappropriate sampling design
    F Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, Montpellier, Cedex 5, France
    Heredity (Edinb) 104:135-40. 2010
    ....
  11. ncbi Test of pangamy by genetic analysis of Schistosoma mansoni pairs within its natural murine host in Guadeloupe
    Franck Prugnolle
    Centre d Etude du Polymorphisme des Micro organismes, Equipe ESS, UMR 9926 CNRS IRD, Institut de Recherche et Développement, 911 Avenue Agropolis, B P 64501, 34394 Montpellier 5, France
    J Parasitol 90:507-9. 2004
    ....
  12. ncbi Sex-specific genetic structure in Schistosoma mansoni: evolutionary and epidemiological implications
    F Prugnolle
    Centre d Etude du Polymorphisme des Micro organismes, UMR 9926 CNRS IRD, Institut de Recherche et Développement, 911 Avenue Agropolis, BP 5045, 34032 Montpellier, France
    Mol Ecol 11:1231-8. 2002
    ..These results change our view on the epidemiology of schistosomiasis, a serious disease affecting humans in African and American intertropical zones...
  13. ncbi Asexual reproduction: genetics and evolutionary aspects
    T de Meeus
    Génétique et Evolution des Maladies Infectieuses, Equipe Evolution des Systèmes Symbiotiques, UMR IRD CNRS 2724, BP 64501, 911 Av Agropolis, 34394, Montpellier Cedex 5, France
    Cell Mol Life Sci 64:1355-72. 2007
    ..An important question for evolutionary biologists as to why some organisms reproduce sexually, as opposed to asexually, is addressed. We also discuss the economic and medical importance of asexual organisms...
  14. pmc Genetic diversity and reproductive success in mandrills (Mandrillus sphinx)
    M Charpentier
    Centre d Ecologie Fonctionnelle et Evolutive, Unite Mixte de Recherche 5175, Centre National de la Recherche Scientifique, Montpellier, France
    Proc Natl Acad Sci U S A 102:16723-8. 2005
    ..Multilocus effects best explained the correlation between heterozygosity and reproductive success and tenure, indicating the occurrence of inbreeding depression in this mandrill colony...
  15. ncbi Inferring sex-biased dispersal from population genetic tools: a review
    F Prugnolle
    Centre d Etude du Polymorphisme des Micro organismes, UMR 9926 CNRS IRD, Institut de Recherche et Développement, 911 av Agropolis BP 5045, 34032 Montpellier Cedex 1, France
    Heredity (Edinb) 88:161-5. 2002
    ..Moreover, the relative power of these methods is not well known and requires further investigation...
  16. ncbi Host sex and parasite genetic diversity
    Damien Caillaud
    GEMI, Equipe ESS, UMR 2274 IRD CNRS, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Microbes Infect 8:2477-83. 2006
    ..This finding is the first empirical evidence that each host sex may play different roles in the maintenance of parasite genetic diversity and so in their evolutionary dynamics and epidemiology...
  17. ncbi Sex-specific genetic structure: new trends for dioecious parasites
    Franck Prugnolle
    Centre d Etude du Polymorphisme des Micro organismes, Equipe ESS, UMR 9926 CNRS IRD, Institut de Recherche et Développement, 911 Av Agropolis, BP 5045, 34032, Montpellier, France
    Trends Parasitol 19:171-4. 2003
    ..The proximate and ultimate factors that potentially generate a sex-specific genetic structure are discussed, as are evolutionary and epidemiological consequences for dioecious parasites and vectors...
  18. ncbi Sex-specific correlation between heterozygosity and clone size in the trematode Schistosoma mansoni
    Franck Prugnolle
    GEMI, Equipe ESS, UMR 2724 CNRS IRD, Centre IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Mol Ecol 13:2859-64. 2004
    ..This effect is however, sex-specific: only female clone size correlates with heterozygosity. We discuss this phenomenon in relation to the heterozygosity-fitness relationship and the sex-specific response to inbreeding depression...
  19. ncbi Population genetics of complex life-cycle parasites: an illustration with trematodes
    Franck Prugnolle
    Theoretical and Molecular Population Genetics Group, Department of Genetics, Cambridge CB2 3EH, England
    Int J Parasitol 35:255-63. 2005
    ..We hope that our model will encourage more empirical population genetics studies on monoecious trematodes and other organisms with similar life-cycles...
  20. pmc Geography predicts neutral genetic diversity of human populations
    Franck Prugnolle
    Theoretical and Molecular Population Genetics Group, Department of Genetics, University of Cambridge, Downing St, Cambridge CB2 3EH, UK
    Curr Biol 15:R159-60. 2005
  21. ncbi Dispersal in a parasitic worm and its two hosts: consequence for local adaptation
    Franck Prugnolle
    GEMI, Equipe ESS, UMR 2724 CNRS IRD, Centre IRD, 34394 Montpellier Cedex 5, France
    Evolution 59:296-303. 2005
    ..Models made about the evolution of local adaptation in function of the dispersal rates of hosts and parasites suggest that rats and mollusks should be locally adapted to their parasites...
  22. ncbi F-statistics under alternation of sexual and asexual reproduction: a model and data from schistosomes (platyhelminth parasites)
    Franck Prugnolle
    Equipe ESS, GEMI, UMR 2724, IRD de Montpellier, 911 Av Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Mol Ecol 14:1355-65. 2005
    ..g. all parasitic trematodes, many plants, and all aphididae), we finally confront some of these theoretical expectations to empirical data from Schistosoma mansoni infecting Rattus rattus in Guadeloupe...
  23. ncbi Pathogen-driven selection and worldwide HLA class I diversity
    Franck Prugnolle
    Theoretical and Molecular Population Genetics Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Curr Biol 15:1022-7. 2005
    ..This is in good agreement with both previous immunological and genetic data suggesting that HLA B could be under a higher selective pressure from pathogens...
  24. pmc Geography is a better determinant of human genetic differentiation than ethnicity
    Andrea Manica
    Evolutionary Ecology Group, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Hum Genet 118:366-71. 2005
    ..We conclude that the use of ethnicity alone will often be inadequate as a basis for medical treatment...
  25. ncbi Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans
    Anne Laure Bañuls
    Institut de Recherche pour le Developpement, UMR CNRS IRD 2724, Génétique et Evolution des Maladies Infectieuses, IRD Montpellier, 911 Avenue Agropolis, 34394 Montpellier Cedex 5, France
    Adv Parasitol 64:1-109. 2007
    ..It concludes by presenting a number of feasible ways of responding to these questions...
  26. pmc An African origin for the intimate association between humans and Helicobacter pylori
    Bodo Linz
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Nature 445:915-8. 2007
    ..pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since...
  27. ncbi Population genetics and molecular epidemiology or how to "débusquer la bête"
    Thierry de Meeus
    Génétique et Evolution des Maladies Infectieuses, Equipe Evolution des Systèmes Symbiotiques, UMR IRD CNRS 2724, BP 64501, 911 Av Agropolis, 34394 Montpellier Cedex 5, France
    Infect Genet Evol 7:308-32. 2007
    ..We conclude with relevant examples, most issued from our laboratory, to illustrate the pros and cons of such methods for the study of parasites, vectors, micropathogens and their hosts and briefly discuss future needs...
  28. pmc A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection
    Melany Jackson
    John Hughes Bennett Laboratory, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK
    BMC Genomics 7:212. 2006
    ..The rodent specific reproductive homeobox (Rhox) gene cluster on the X chromosome has been reported to contain twelve homeobox-containing genes, Rhox1-12...
  29. doi Genetic heterozygosity and sociality in a primate species
    Marie J E Charpentier
    Department of Biology, Duke University, Science Drive, Biological Bldg 020, PO 90338, Durham, NC 27708, USA
    Behav Genet 38:151-8. 2008
    ....
  30. pmc A geographically explicit genetic model of worldwide human-settlement history
    Hua Liu
    Theoretical and Molecular Population Genetics Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 79:230-7. 2006
    ..The general fit of the model with the data is excellent. This suggests that coupling analytical genetic models with explicit demography and geography provides a powerful tool for making inferences on human-settlement history...