Natalia Prevarskaya

Summary

Country: France

Publications

  1. pmc Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells
    Karine Vanoverberghe
    INSERM, U 1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    PLoS ONE 7:e45615. 2012
  2. pmc TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth
    V yacheslav Lehen'kyi
    INSERM, U 1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    PLoS ONE 6:e16856. 2011
  3. pmc Functional implications of calcium permeability of the channel formed by pannexin 1
    Fabien Vanden Abeele
    Institut National de la Sante et de la Recherche Medicale, U800, Equipe Labellisee par la Ligue Contre le Cancer, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq Cedex, F 59655 France
    J Cell Biol 174:535-46. 2006
  4. pmc Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells
    M Flourakis
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    Cell Death Dis 1:e75. 2010
  5. doi request reprint Targeting Ca²⁺ transport in cancer: close reality or long perspective?
    Natalia Prevarskaya
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe labellisée par Ligue contre Cancer, Villeneuve d Ascq, F 59650, France
    Expert Opin Ther Targets 17:225-41. 2013
  6. doi request reprint Ion channels and the hallmarks of cancer
    Natalia Prevarskaya
    INSERM, U800, Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, F 59650 France
    Trends Mol Med 16:107-21. 2010
  7. ncbi request reprint Ion channels in death and differentiation of prostate cancer cells
    N Prevarskaya
    Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, INSERM U800, Universite de Lille 1, Villeneuve d Ascq F 59650, France
    Cell Death Differ 14:1295-304. 2007
  8. doi request reprint Calcium in tumour metastasis: new roles for known actors
    Natalia Prevarskaya
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe labellise par la Ligue contre le cancer, Villeneuve dAscq, F59650, France
    Nat Rev Cancer 11:609-18. 2011
  9. ncbi request reprint Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells
    Fabien Vanden Abeele
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Bat SN3, 59655 Villeneuve d Ascq, France
    J Biol Chem 279:30326-37. 2004
  10. pmc Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
    Gabriel Bidaux
    INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    J Clin Invest 117:1647-57. 2007

Collaborators

Detail Information

Publications59

  1. pmc Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells
    Karine Vanoverberghe
    INSERM, U 1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    PLoS ONE 7:e45615. 2012
    ..Our data suggest that targeting cytoskeleton-induced pathways of malignant cells together with SOCE-involved channels may prove a useful strategy in the treatment of advanced prostate cancer...
  2. pmc TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth
    V yacheslav Lehen'kyi
    INSERM, U 1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    PLoS ONE 6:e16856. 2011
    ....
  3. pmc Functional implications of calcium permeability of the channel formed by pannexin 1
    Fabien Vanden Abeele
    Institut National de la Sante et de la Recherche Medicale, U800, Equipe Labellisee par la Ligue Contre le Cancer, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq Cedex, F 59655 France
    J Cell Biol 174:535-46. 2006
    ....
  4. pmc Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells
    M Flourakis
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    Cell Death Dis 1:e75. 2010
    ..Thus, Orai1 has a pivotal role in the triggering of apoptosis, irrespective of apoptosis-inducing stimuli, and in the establishment of an apoptosis-resistant phenotype in PCa cells...
  5. doi request reprint Targeting Ca²⁺ transport in cancer: close reality or long perspective?
    Natalia Prevarskaya
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe labellisée par Ligue contre Cancer, Villeneuve d Ascq, F 59650, France
    Expert Opin Ther Targets 17:225-41. 2013
    ....
  6. doi request reprint Ion channels and the hallmarks of cancer
    Natalia Prevarskaya
    INSERM, U800, Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, F 59650 France
    Trends Mol Med 16:107-21. 2010
    ..Therefore, to determine the importance of ion channels as targets for cancer diagnosis and treatment their expression, function and regulation must be assessed for each cancer...
  7. ncbi request reprint Ion channels in death and differentiation of prostate cancer cells
    N Prevarskaya
    Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, INSERM U800, Universite de Lille 1, Villeneuve d Ascq F 59650, France
    Cell Death Differ 14:1295-304. 2007
    ..The present review examines channel types expressed by PCa cells and their involvement in metastatic behaviors...
  8. doi request reprint Calcium in tumour metastasis: new roles for known actors
    Natalia Prevarskaya
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe labellise par la Ligue contre le cancer, Villeneuve dAscq, F59650, France
    Nat Rev Cancer 11:609-18. 2011
    ..We discuss how these developments have increased our understanding of the Ca²⁺ dependence of pro-metastatic behaviours...
  9. ncbi request reprint Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells
    Fabien Vanden Abeele
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Bat SN3, 59655 Villeneuve d Ascq, France
    J Biol Chem 279:30326-37. 2004
    ..These results provide new insight into the nature of SOCs and their representation in the single cell type as well as permit reconciliation of current SOC activation hypotheses...
  10. pmc Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
    Gabriel Bidaux
    INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    J Clin Invest 117:1647-57. 2007
    ....
  11. doi request reprint Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance
    Michael Monet
    Institut National de la Sante et de la Recherche Medicale, U 800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, France
    Cancer Res 70:1225-35. 2010
    ..Our findings establish a role for TRPV2 in PCa progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced PCa...
  12. doi request reprint CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells
    Florian Gackiere
    INSERM U800, Laboratoire de Physiologie Cellulaire, Equipe Labellisée par la Ligue contre le Cancer and Université des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    J Biol Chem 283:10162-73. 2008
    ....
  13. ncbi request reprint Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids
    Fabien Vanden Abeele
    INSERM U800, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq F 59650, France and Universite Lille 1, Villeneuve d Ascq F 59650, France
    J Biol Chem 281:40174-82. 2006
    ..This mechanism employs chemical rather than physical (temperature change) signaling and thus may be the main regulator of TRPM8 activation in organs not exposed to any essential temperature variations, as in the prostate gland...
  14. ncbi request reprint TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes
    Benjamin Beck
    Laboratoire de Physiologie Cellulaire, INSERM, U800, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, France
    J Invest Dermatol 126:1982-93. 2006
    ..We concluded that activation of both muscarinic and purinergic receptors via a common DAG-dependent link opens Ca(2+)-permeable TRPC7 channels...
  15. ncbi request reprint TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma
    Benjamin Beck
    Laboratoire de Physiologie Cellulaire, INSERM U800, USTL, Bat SN3, 59655 Villeneuve d Ascq cedex, France
    Cell Calcium 43:492-505. 2008
    ..In summary, our data demonstrate that TRPC1 and TRPC4 channels are key elements in keratinocyte Ca(2+) homeostasis and differentiation and may therefore be responsible for skin pathologies...
  16. ncbi request reprint Bcl-2-dependent modulation of swelling-activated Cl- current and ClC-3 expression in human prostate cancer epithelial cells
    Loic Lemonnier
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Batiment SN3, 59655 Villeneuve d Ascq, France
    Cancer Res 64:4841-8. 2004
    ....
  17. ncbi request reprint Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation
    Matthieu Flourakis
    Laboratoire de Physiologie Cellulaire, INSERM U800, Batiment SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    FASEB J 20:1215-7. 2006
    ..As the translocon is present in yeast and mammalian cells, our findings suggest that translocon-related calcium signaling is a common phenomenon...
  18. ncbi request reprint Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells
    Stephanie Thebault
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, USTL SN3, 59655 Villeneuve d Ascq, France
    J Biol Chem 280:39423-35. 2005
    ....
  19. ncbi request reprint Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells
    Stephanie Thebault
    Laboratoire de Physiologie Cellulaire, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Cancer Res 66:2038-47. 2006
    ..Our findings show that alpha1-AR signaling requires the coupled activation of TRPC6 channels and NFAT to promote proliferation of hPCE cells and thereby suggest TRPC6 as a novel potential therapeutic target...
  20. ncbi request reprint Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells
    Halima Ouadid-Ahidouch
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biochem Biophys Res Commun 316:244-51. 2004
    ..However, these K+ channels did not regulate the cell proliferation because of their minor role in the membrane potential...
  21. ncbi request reprint Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells
    Fabien Vanden Abeele
    Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, Universite des Sciences et Technologies de Lille, Batiment SN3, 59655 Villeneuve d Ascq cedex, France
    Cancer Cell 1:169-79. 2002
    ..Our data therefore suggest the pivotal role of SOCs in apoptosis and cancer progression...
  22. pmc Alpha1-adrenergic receptors activate Ca(2+)-permeable cationic channels in prostate cancer epithelial cells
    Stephanie Thebault
    Laboratoire de Physiologie Cellulaire, Institut National de la Santé et de la Recherche Médicale INSERM EMI 0228, Villeneuve d Ascq, France
    J Clin Invest 111:1691-701. 2003
    ..Collectively, our results suggest that alpha1-ARs play a role in promoting hPCE cell proliferation via TRP channels...
  23. ncbi request reprint Role of endoplasmic reticulum calcium content in prostate cancer cell growth regulation by IGF and TNFalpha
    Sandrine Humez
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, Cedex, France
    J Cell Physiol 201:201-13. 2004
    ..We thus identify [Ca(2+)](ER) and SERCA2b as a central targets for causing LNCaP PC cell life or death induced by growth modulators. Furthermore our results indicate that calcium pool contents can regulate cell growth...
  24. doi request reprint Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells
    Charbel El Boustany
    INSERM, U1003, IFR147, Univ Lille 1, F 59655 Villeneuve d Ascq, France
    Cell Calcium 47:350-9. 2010
    ..These observations reveal a tight relation between cell proliferation, calcium entry and Orai1 expression in HEK293 cells...
  25. ncbi request reprint TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes
    V yacheslav Lehen'kyi
    INSERM, U 800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite des Sciences et Technologies de Lille, F 59655 Villeneuve d Ascq, France
    J Biol Chem 282:22582-91. 2007
    ..Taken together, these data suggest that the TRPV6 channel is a key element in Ca(2+)/1,25-dihydroxyvitamin D3-induced differentiation of human keratinocytes...
  26. doi request reprint Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78
    Mehdi Hammadi
    Laboratoire de Physiologie Cellulaire Cellular Physiology Laboratory, Institut National de Santé et de Recherche Médicale INSERM U1003, Université Lille I, Villeneuve d Ascq, France
    FASEB J 27:1600-9. 2013
    ..The ability to modulate the ER Ca(2+) permeability and subsequent ER stress can lead to development of a novel therapeutic approach...
  27. pmc Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms
    Gabriel Bidaux
    Inserm U1003, Equipe Labellisée par la Ligue Nationale contre le Cancer and the Université des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    J Biol Chem 287:2948-62. 2012
    ..Our findings therefore uncover a new mode of regulation of the TRPM8 channel by its splice variants...
  28. doi request reprint Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium
    Charlotte Dubois
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite des Sciences et Technologies de Lille USTL, Villeneuve d Ascq, France Center for Membrane Pumps in Cells and Diseases, Danish Research Foundation, Aarhus, Denmark
    FEBS J 280:5430-40. 2013
    ....
  29. ncbi request reprint Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators
    Benjamin Beck
    INSERM, U800, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq F 59650, France
    Cell Calcium 41:285-94. 2007
    ..The high affinity of this new TRPM8 ligand and the possibility of incorporating a radiohalogen could thus be useful for diagnosis, monitoring and, perhaps, even therapy of prostate cancer...
  30. pmc TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion
    Agathe Oulidi
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    PLoS ONE 8:e64885. 2013
    ..In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level...
  31. doi request reprint Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation
    Charbel El Boustany
    Institut National de Santé et recherche Médicale INSERM, U800, IFR143, Université Sciences et Technologies Lille 1, F 59655, Villeneuve d Ascq, France
    Hepatology 47:2068-77. 2008
    ..Endothelial growth factor and hepatocyte growth factor increased TRPC6 expression and SOCE amplitude in Huh-7 cells, and cyclin D1 expression was decreased by STIM1, Orai1, and TRPC6 knockdowns...
  32. ncbi request reprint A role for voltage gated T-type calcium channels in mediating "capacitative" calcium entry?
    Florian Gackiere
    Laboratoire de Physiologie Cellulaire, INSERM EMI0228, Batiment SN3, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Cell Calcium 39:357-66. 2006
    ..On the contrary, we show that the action of mibefradil on capacitative calcium entry is due to an action on store-operated calcium channels...
  33. pmc Ca(2+)- and volume-sensitive chloride currents are differentially regulated by agonists and store-operated Ca2+ entry
    Alexander Zholos
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Université des Sciences et Technologie de Lille, 59655 Villeneuve d Ascq, France
    J Gen Physiol 125:197-211. 2005
    ..These results also suggest a novel function for SOCE, which can operate as a "selection" switch between closely localized channels...
  34. ncbi request reprint Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores
    Fabien Van Coppenolle
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite de Lille 1, Batiment SN3, 59655 Villeneuve d Ascq cedex, France
    J Cell Sci 117:4135-42. 2004
    ..This work reveals a new role for the translocon which is involved in the control of the [Ca(2+)](ER) and could therefore supervise many physiological processes, including gene expression and apoptosis...
  35. pmc Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells
    Maria Katsogiannou
    INSERM U800, Université Lille 1 Sciences et Technologies, Villeneuve d Ascq, France
    PLoS ONE 4:e7068. 2009
    ..Previous work has demonstrated that membrane lipid rafts associated with key signalling proteins mediate growth and survival signalling pathways in prostate cancer cells...
  36. pmc Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression
    Alexandre Crepin
    INSERM, U800, Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, F 59655 France
    Biochem J 401:49-55. 2007
    ..A small inter-fering RNA SERCA 2a/b, used to down-regulate endogenous SERCA 2b expression, reduced both PNT1A cell proliferation and [Ca2+]ER. We thus identify [Ca2+]ER and SERCA 2b as protagonists in PRL-induced proliferation...
  37. pmc Prolactin stimulates cell proliferation through a long form of prolactin receptor and K+ channel activation
    Fabien Van Coppenolle
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Bat SN3, 59655 Villeneuve d Ascq cedex, France
    Biochem J 377:569-78. 2004
    ..Thus, as K(+) channels are known to be involved in LNCaP cell proliferation, we suggest that K(+) channel modulation by PRL, via p59( fyn ) pathway, is the primary ionic event in PRL signal transduction, triggering cell proliferation...
  38. ncbi request reprint Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia
    Fabien Vanden Abeele
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Laboratory of Excellence, Ion Channels Science and Therapeutics Université des Sciences et Technologies de Lille USTL, Villeneuve d Ascq, France
    J Cell Sci 126:4479-89. 2013
    ..Thus, we propose TRPM8 as a new clinical target for diminishing common and serious complications of general anaesthesia...
  39. pmc ORAI1 calcium channel orchestrates skin homeostasis
    Matthieu Vandenberghe
    Institut National de la Santé et de la Recherche Médicale U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Laboratory of Excellence Ion Channel Science and Therapeutics, Universite des Sciences et Technologies de Lille, 59650 Villeneuve d Ascq, France
    Proc Natl Acad Sci U S A 110:E4839-48. 2013
    ..Our findings provide insight into the functions of the Orai1 channel in the maintenance of skin homeostasis. ..
  40. ncbi request reprint Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1
    Fabien Vanden Abeele
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Batiment SN3, USTL, 59655 Villeneuve d Ascq, France
    J Biol Chem 278:15381-9. 2003
    ....
  41. pmc The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway
    Alexis Bavencoffe
    INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite des Sciences et Technologies de Lille USTL, F59655 Villeneuve d Ascq, France
    J Biol Chem 285:9410-9. 2010
    ..We therefore propose that inhibition of TRPM8 through the alpha 2A-AR signaling cascade could constitute a new mechanism of modulation of thermosensation in both physiological and pathological conditions...
  42. pmc Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation
    Alexis Bavencoffe
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite des Sciences et Technologies de Lille, F59656 Villeneuve d Ascq, France
    J Biol Chem 286:9849-55. 2011
    ..We also summarize the existing TRPM8 regulations and discuss their physiological and pathological significance...
  43. ncbi request reprint Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression
    Halima Ouadid-Ahidouch
    Laboratoire de Physiologie Cellulaire, Universite des Sciences et Technologies de Lille, Cedex, France
    Am J Physiol Cell Physiol 287:C125-34. 2004
    ....
  44. ncbi request reprint Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line
    S Thebault
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, France
    J Cell Physiol 204:320-8. 2005
    ..It may be thus concluded that PS1 cells express TRPC3 and TRPC6 proteins which function as receptor- and store-operated Ca(2+) entry pathways...
  45. ncbi request reprint Opiates modulate thermosensation by internalizing cold receptor TRPM8
    George Shapovalov
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite de Sciences et Technologies de Lille USTL, 59655 Villeneuve d Ascq, France
    Cell Rep 4:504-15. 2013
    ..The proposed pathway represents a universal mechanism that is probably shared by regulatory pathways modulating general pain sensation in response to opioid treatment...
  46. ncbi request reprint Calcium channels and prostate cancer
    George Shapovalov
    Inserm U1003, USTL, F 59655 Villeneuve d Ascq, France
    Recent Pat Anticancer Drug Discov 8:18-26. 2013
    ....
  47. ncbi request reprint The role of intracellular pH in cell growth arrest induced by ATP
    Sandrine Humez
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Universite des Sciences et Technologies de Lille, Bat SN3, 59655 Villeneuve d Ascq cedex, France
    Am J Physiol Cell Physiol 287:C1733-46. 2004
    ..Taken together, our results suggest that ATP-induced acidification in DU-145 cells results from specific effect of mitochondrial function and is one of the major mechanisms leading to growth arrest induced by ATP...
  48. ncbi request reprint Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells
    Pascal Mariot
    Laboratoire de Physiologie Cellulaire, INSERM EPI9938, Batiment SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    J Biol Chem 277:10824-33. 2002
    ..This voltage-dependent calcium channel could be involved in the stimulation of mitogenic factor secretion and could therefore be a target for future therapeutic strategies...
  49. doi request reprint Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis
    V yacheslav Lehen'kyi
    Laboratory of Cell Physiology, Inserm U1003, Cite Scientifique, Villeneuve d Ascq, France
    Am J Physiol Cell Physiol 301:C1281-9. 2011
    ..This review focuses on the aspects of programmed cell death influenced by various ion channels and how dysfunctions and misregulations of these channels may affect the development and progression of different cancers...
  50. ncbi request reprint Ca2+ homeostasis in apoptotic resistance of prostate cancer cells
    Natalia Prevarskaya
    Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, USTL, Bat SN3, 59655 Villeneuve d Ascq cedex, France
    Biochem Biophys Res Commun 322:1326-35. 2004
    ..We show that the hallmark of such transformation is the inhibition of apoptosis pathway associated with endoplasmic reticulum Ca2+ store depletion...
  51. doi request reprint TRP channels in cell survival and cell death in normal and transformed cells
    George Shapovalov
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Universite de Sciences et Technologies de Lille USTL, F 59655 Villeneuve d Ascq, France
    Cell Calcium 50:295-302. 2011
    ..This review focuses on the aspects of TRP channel localization and function that affect the balance between cell survival and death and how various dysregulations of these channels may lead to perturbed balance and onset of cancer...
  52. ncbi request reprint Ca2+ modulation of volume-regulated anion channels: evidence for colocalization with store-operated channels
    Loic Lemonnier
    Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, Batiment SN3, USTL, 59655 Villeneuve d Ascq, France
    FASEB J 16:222-4. 2002
    ..Preferred access of SOC-transported Ca2+ to VRAC suggests colocalization of these channels in the cell membrane...
  53. pmc TRP channels in prostate cancer: the good, the bad and the ugly?
    Dimitra Gkika
    Inserm U1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    Asian J Androl 13:673-6. 2011
    ..The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed...
  54. doi request reprint Molecular mechanisms of TRP regulation in tumor growth and metastasis
    Dimitra Gkika
    INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, F59656 Villeneuve d Ascq, France
    Biochim Biophys Acta 1793:953-8. 2009
    ..This article mainly reviews the transcriptional mechanisms modulating TRP expression during tumorigenesis, involving hormones, growth factors, and alternative splicing...
  55. pmc The role of the TRPV6 channel in cancer
    V yacheslav Lehen'kyi
    INSERM, U 1003, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d Ascq, France
    J Physiol 590:1369-76. 2012
    ..Further studies are needed to confirm whether this channel does really have an oncogenic potential or is just the last hope for transformed cells/tissues to stop cancer...
  56. pmc Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?
    Natalia Prevarskaya
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, F 59650 France Laboratory of Excellence, Ion Channels Science and Therapeutics Universite de Lille 1, Villeneuve d Ascq, F 59650 France
    Philos Trans R Soc Lond B Biol Sci 369:20130097. 2014
    ....
  57. ncbi request reprint TRP channels in cancer
    Natalia Prevarskaya
    INSERM, U800, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq F 59650, France
    Biochim Biophys Acta 1772:937-46. 2007
    ....
  58. doi request reprint From urgency to frequency: facts and controversies of TRPs in the lower urinary tract
    Roman Skryma
    INSERM, U1003, Laboratoire de Physiologie Cellulaire, Equipe labelisée par la Ligue contre le cancer, Villeneuve d Ascq, F 59650 France
    Nat Rev Urol 8:617-30. 2011
    ..Further studies into these and other TRPs in the LUT will facilitate the development of improved therapeutic strategies to target these channels in LUT disorders...