Research Topics
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Publications
Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritisStephane Pallu
UMR S658 INSERM, Hôpital Porte Madeleine, 1 rue Porte Madeleine, BP 2439, 45032 Orleans, France
Arthritis Res Ther 12:R112. 2010....
Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular productionN Presle
Faculte de Medecine, UMR CNRS UHP 7561, avenue de la Forêt de Haye, BP 184, 54505 Vandoeuvre les Nancy, France
Osteoarthritis Cartilage 14:690-5. 2006..The active free form of leptin was also examined by evaluating the level of the soluble leptin receptor (sOb-R)...
Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolismE Nedelec
Laboratoire de Pharmacologie et UMR CNRS UHP 7561, Faculte de Medecine de Nancy, avenue de la Forêt de Haye, BP184, F 54505, Vandoeuvre les Nancy, France
Biochem Pharmacol 61:965-78. 2001....
The role of 3D-microscopy in the study of chondrocyte-matrix interaction (alginate bead or sponge, rat femoral head cap, human osteoarthritic cartilage) and pharmacological applicationD Dumas
UMR CNRS UHP INPL 7563 LEMTA, Faculte de Medecine, Vandoeuvre les Nancy, France
Biorheology 37:165-76. 2000..This high resolution light microscopy gave complementary information that could be important for a better understanding of the interaction of chondrocytes with the extracellular matrix in a variety of culture devices...
Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritisH Dumond
Laboratoire de Pharmacologie et Physiopathologie articulaires, UMR CNRS-UHP 7561, , , BP 184, , France
Osteoarthritis Cartilage 12:284-95. 2004..Increased susceptibility to MIA in weight-bearing areas of cartilage further indicate that MIA-induced experimental OA is a relevant model to study not only metabolical but also biomechanical aspects of human OA...
Effect of dimethicone (polysilane gel) on the stereoselective pharmacokinetics of ketoprofenN Presle
Laboratoire de Pharmacologie UMR 7561 CNRS UHP Nancy 1, Faculte de Medecine, Vandoeuvre les Nancy, France
Eur J Clin Pharmacol 54:351-4. 1998....
[Is leptin the missing link between osteoarthritis and obesity?]B Terlain
Laboratoire de Pharmacologie, UMR 7561 CNRS UHP, Faculté de Médecine de Nancy Université Henri Poincaré Nancy 1, Vandoeuvre lès Nacy Cedex
Ann Pharm Fr 63:186-93. 2005..In conclusion, leptin may be a link between osteoarthritis and obesity, and may play a key role in cartilage metabolism. Leptin may contribute to the pathophysiology of OA...
Obesity and osteoarthritis: more complex than predicted!P Pottie
Ann Rheum Dis 65:1403-5. 2006
