Pierre Francois Pradat

Summary

Country: France

Publications

  1. doi request reprint Biomarkers in amyotrophic lateral sclerosis: facts and future horizons
    Pierre Francois Pradat
    Assistance Publique Hopitaux de Paris, Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, Paris, France
    Mol Diagn Ther 13:115-25. 2009
  2. ncbi request reprint [SBMA: a rare disease but a classic ALS mimic syndrome]
    Pierre Francois Pradat
    AP HP, Groupe Hospitalier Pitie Salpetriere, Département des Maladies du Système Nerveux, 47, Boulevard de l Hopital, 75651 Paris Cedex, France Sorbonne Universités, UPMC Universite Paris 06, INSERM, CNRS, Laboratoire d Imagerie Biomédicale, 75006 Paris, France Electronic address
    Presse Med 43:580-6. 2014
  3. ncbi request reprint [ALS treatment: state of the art in 2014 and perspectives]
    Pierre Francois Pradat
    AP HP, Hopital de la Pitie Salpetriere, Département des Maladies du Système Nerveux, 75013 Paris, France Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Laboratoire d Imagerie Biomédicale, 75005 Paris, France Electronic address
    Presse Med 43:595-602. 2014
  4. doi request reprint Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient
    Aurelio Hernandez Lain
    Fédération des Maladies du Système Nerveux, Bat Paul Castaigne, Hopital Pitie Salpetriere, 83 bd de l hopital, 75013 Paris, France
    J Neurol Neurosurg Psychiatry 82:1414-6. 2011
  5. doi request reprint Late radiation injury to peripheral nerves
    Pierre Francois Pradat
    Département des Maladies du Système Nerveux, Hopital Pitie Salpetriere, Paris, France Electronic address
    Handb Clin Neurol 115:743-58. 2013
  6. doi request reprint [Radiation-induced neuropathies: collateral damage of improved cancer prognosis]
    P F Pradat
    Département des Maladies du Système Nerveux, Hopital Pitie Salpetriere, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Rev Neurol (Paris) 168:939-50. 2012
  7. doi request reprint [New biological and radiological markers in amyotrophic lateral sclerosis]
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, APHP, Hopital de la Pitie Salpetriere, F 75651 Paris Cedex 13, France
    Presse Med 38:1843-51. 2009
  8. ncbi request reprint Sciatic nerve moneuropathy: an unusual late effect of radiotherapy
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitie Salpetriere, APHP, 47 83, Boulevard de l Hopital, 75651 Paris, France
    Muscle Nerve 40:872-4. 2009
  9. doi request reprint Extrapyramidal stiffness in patients with amyotrophic lateral sclerosis
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Hopital de la Pitie Salpetriere, AP HP, Paris, France
    Mov Disord 24:2143-8. 2009
  10. doi request reprint Impaired glucose tolerance in patients with amyotrophic lateral sclerosis
    Pierre Francois Pradat
    APHP, Hopital de la Pitie Salpetriere, Fédération des Maladies du Système Nerveux, Paris, France
    Amyotroph Lateral Scler 11:166-71. 2010

Collaborators

Detail Information

Publications44

  1. doi request reprint Biomarkers in amyotrophic lateral sclerosis: facts and future horizons
    Pierre Francois Pradat
    Assistance Publique Hopitaux de Paris, Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, Paris, France
    Mol Diagn Ther 13:115-25. 2009
    ..This article provides an overview of recently described biologic and radiologic markers of the disease...
  2. ncbi request reprint [SBMA: a rare disease but a classic ALS mimic syndrome]
    Pierre Francois Pradat
    AP HP, Groupe Hospitalier Pitie Salpetriere, Département des Maladies du Système Nerveux, 47, Boulevard de l Hopital, 75651 Paris Cedex, France Sorbonne Universités, UPMC Universite Paris 06, INSERM, CNRS, Laboratoire d Imagerie Biomédicale, 75006 Paris, France Electronic address
    Presse Med 43:580-6. 2014
    ..The diminution of sensory potential at electroneuromyogram is a major criteria discriminating between SBMA and ALS. Diagnostic confirmation is based on genetic testing...
  3. ncbi request reprint [ALS treatment: state of the art in 2014 and perspectives]
    Pierre Francois Pradat
    AP HP, Hopital de la Pitie Salpetriere, Département des Maladies du Système Nerveux, 75013 Paris, France Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Laboratoire d Imagerie Biomédicale, 75005 Paris, France Electronic address
    Presse Med 43:595-602. 2014
    ..Recent progress in the genetic of ALS may lead to new therapeutic strategies. Results of therapeutic trials with drugs or nutritional intervention are expected in 2014. ..
  4. doi request reprint Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient
    Aurelio Hernandez Lain
    Fédération des Maladies du Système Nerveux, Bat Paul Castaigne, Hopital Pitie Salpetriere, 83 bd de l hopital, 75013 Paris, France
    J Neurol Neurosurg Psychiatry 82:1414-6. 2011
  5. doi request reprint Late radiation injury to peripheral nerves
    Pierre Francois Pradat
    Département des Maladies du Système Nerveux, Hopital Pitie Salpetriere, Paris, France Electronic address
    Handb Clin Neurol 115:743-58. 2013
    ..Recent developments show promising strategies for the prevention and treatment of these complications, which have a considerable impact on a patient's quality of life. ..
  6. doi request reprint [Radiation-induced neuropathies: collateral damage of improved cancer prognosis]
    P F Pradat
    Département des Maladies du Système Nerveux, Hopital Pitie Salpetriere, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Rev Neurol (Paris) 168:939-50. 2012
    ..However, radiation-induced neuropathies have not been the focus of great attention. The objective of this paper is to provide an updated review about the radiation-induced lesions of the peripheral nerve system...
  7. doi request reprint [New biological and radiological markers in amyotrophic lateral sclerosis]
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, APHP, Hopital de la Pitie Salpetriere, F 75651 Paris Cedex 13, France
    Presse Med 38:1843-51. 2009
    ..In the future, a combination of biological, radiological and electrophysiological markers, rather than a single marker, may provide diagnostic tool for the diagnosis and follow-up of ALS patients...
  8. ncbi request reprint Sciatic nerve moneuropathy: an unusual late effect of radiotherapy
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitie Salpetriere, APHP, 47 83, Boulevard de l Hopital, 75651 Paris, France
    Muscle Nerve 40:872-4. 2009
    ..Our observation suggests that the risk of late mononeuropathy should be considered when large-volume and high-dose radiotherapy includes a nerve trunk...
  9. doi request reprint Extrapyramidal stiffness in patients with amyotrophic lateral sclerosis
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Hopital de la Pitie Salpetriere, AP HP, Paris, France
    Mov Disord 24:2143-8. 2009
    ..Both were correlated with balance and posture impairment (UPDRS and Berg's scale, P < 0.001). This study suggests that extrapyramidal involvement plays a role in stiffness and balance impairment in a subset of ALS patients...
  10. doi request reprint Impaired glucose tolerance in patients with amyotrophic lateral sclerosis
    Pierre Francois Pradat
    APHP, Hopital de la Pitie Salpetriere, Fédération des Maladies du Système Nerveux, Paris, France
    Amyotroph Lateral Scler 11:166-71. 2010
    ..The origin of glucose homeostasis abnormalities in ALS may be multifactorial and deserves further investigation...
  11. doi request reprint Abnormalities of satellite cells function in amyotrophic lateral sclerosis
    Pierre Francois Pradat
    Assistance Publique Hopitaux de Paris, Département des Maladies du Système Nerveux, Centre de référence maladies rares SLA, Hopital Pitie Salpetriere, France
    Amyotroph Lateral Scler 12:264-71. 2011
    ..Our study suggests that SC function is altered in ALS. This could limit the efficacy of compensatory processes and therefore could contribute to the progression of muscle atrophy and weakness...
  12. doi request reprint Mutations in UBQLN2 are rare in French amyotrophic lateral sclerosis
    Stephanie Millecamps
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, Paris, France
    Neurobiol Aging 33:839.e1-3. 2012
    ..This variant did not segregate with the disease in the corresponding family and was also detected in 1/380 control subject. Our results suggest that UBQLN2 gene mutations are rare in French ALS...
  13. doi request reprint Radiation therapy for hypersalivation: a prospective study in 50 amyotrophic lateral sclerosis patients
    Avi Assouline
    Department of Radiation Oncology, Centre Clinique de la Porte de Saint Cloud, Boulogne Billancourt, France Department of Radiation Oncology, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris APHP, Paris, France Electronic address
    Int J Radiat Oncol Biol Phys 88:589-95. 2014
    ..This study aimed to evaluate the efficiency and the tolerance of radiation therapy (RT) on salivary glands in a large series of amyotrophic lateral sclerosis (ALS) patients with hypersalivation...
  14. ncbi request reprint Improving survival in a large French ALS center cohort
    Paul H Gordon
    INSERM, Unité U708, F 75013, Neuroépidémiologie, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    J Neurol 259:1788-92. 2012
    ..At this large ALS center, survival improved after 2006. Because more aggressive use of NIV was the principal therapeutic adaptation, our data suggest that better survival resulted from improved respiratory care...
  15. ncbi request reprint Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes
    Pierre Francois Pradat
    Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris, France
    Ann Neurol 62:15-20. 2007
    ..Muscle expression of Nogo-A is a new candidate marker of ALS. We tested whether detection of Nogo-A in a muscle biopsy from patients with LMNS predicts progression to ALS...
  16. ncbi request reprint Genetic analysis of SS18L1 in French amyotrophic lateral sclerosis
    Elisa Teyssou
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie UPMC Paris 6, Hopital Pitie Salpetriere, Paris, France
    Neurobiol Aging 35:1213.e9-1213.e12. 2014
    ..Ala264Thr in a patient carrying a p.Arg96Leu variant in the OPTN gene. As these variants were not found in Single Nucleotide Polymorphism databases and were absent from 180 controls they could be new SS18L1 mutations causing ALS. ..
  17. doi request reprint Predicting survival of patients with amyotrophic lateral sclerosis at presentation: a 15-year experience
    Paul H Gordon
    UMR_S 708, UPMC Universite Paris 06, Paris, France
    Neurodegener Dis 12:81-90. 2013
    ..To describe the clinical features at first evaluation that best predict survival of the amyotrophic lateral sclerosis (ALS) population from the Salpêtrière Hospital between 1995 and 2009...
  18. doi request reprint Radiation-induced neuropathy in cancer survivors
    Sylvie Delanian
    Oncologie radiothérapie, Hopital Saint Louis, APHP, Paris, France
    Radiother Oncol 105:273-82. 2012
    ..Promising treatments via the antioxidant pathway for radiation-induced fibrosis suggest a way to improve the everyday quality of life of these long-term cancer survivors...
  19. doi request reprint Phenotype difference between ALS patients with expanded repeats in C9ORF72 and patients with mutations in other ALS-related genes
    Stephanie Millecamps
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, INSERMUMR_S975, CNRS UMR7225, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    J Med Genet 49:258-63. 2012
    ....
  20. doi request reprint Muscle gene expression is a marker of amyotrophic lateral sclerosis severity
    Pierre Francois Pradat
    Assistance Publique Hopitaux de Paris, Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, Paris, France
    Neurodegener Dis 9:38-52. 2012
    ..The lack of molecular markers of the progression of disease is detrimental to clinical practice and therapeutic trials...
  21. doi request reprint Progression in ALS is not linear but is curvilinear
    Paul H Gordon
    Fédération des Maladies du Système Nerveux, AP HP, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651, Paris, France
    J Neurol 257:1713-7. 2010
    ..Older age and bulbar signs are associated with a steeper decline, and along with more rapid initial rate of decline, but not current functional status, also predict survival...
  22. ncbi request reprint SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations
    Stephanie Millecamps
    Centre de Recherche de l Institut du Cerveau et de la Moelle épinière INSERM UMR_S975, CNRS UMR7225, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    J Med Genet 47:554-60. 2010
    ..Mutations in SOD1, ANG, VAPB, TARDBP and FUS genes have been identified in amyotrophic lateral sclerosis (ALS)...
  23. doi request reprint Fronto-temporal lobar degeneration: neuropathology in 60 cases
    Danielle Seilhean
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Groupe Hospitalier Pitie Salpetriere, AP HP and UPMC Sorbonne Universités, Paris, France
    J Neural Transm 118:753-64. 2011
    ..The prevalence of the different types of FTD is tightly linked to the recruitment. This series was enriched in motor neuron disease (explaining the overall predominance of type 2 TDP inclusions)...
  24. ncbi request reprint Causes of death in a post-mortem series of ALS patients
    Philippe Corcia
    Fédération des Maladies du Système Nerveux, Centre référent SLA, AP HP, Paris, France
    Amyotroph Lateral Scler 9:59-62. 2008
    ..An effort has to be made for a better understanding of the causes of deterioration of ALS patients. A more proactive attitude to treat respiratory infections could have a significant impact on survival...
  25. doi request reprint Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration
    Julien Cohen-Adad
    UMR 678, Inserm UPMC, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Amyotroph Lateral Scler Frontotemporal Degener 14:30-8. 2013
    ..Our data also demonstrate an association between muscle deficits and local spinal cord atrophy, suggesting that atrophy is a sensitive biomarker for lower motor neurons degeneration...
  26. ncbi request reprint Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease
    Helene Blasco
    From UMR Inserm U930 H B, L N D, C A, C V D, S M, P E, C R A, P C, Tours Université François Rabelais H B, L N D, C A, C V D, S M, P E, C R A, P C, Tours Laboratoire de Biochimie et Biologie Moléculaire H B, C A, P E, C R A, CHRU de Tours PPF ASB L N D, P E, Universite Francois Rabelais, Tours Fédération des Maladies du Système Nerveux P F P, P H G, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, Paris Service de Neurologie C M, D D, CHRU de Lille and Centre SLA P C, Service de Neurologie, CHRU Bretonneau
    Neurology 82:1167-74. 2014
    ..To develop a CSF metabolomics signature for motor neuron disease (MND) using (1)H-NMR spectroscopy and to evaluate the predictive value of the profile in a separate cohort...
  27. ncbi request reprint Association of chorea and motor neuron disease
    Pierre Francois Pradat
    Fédération de Neurologie Mazarin, Hopital de la Pitie Salpetriere, Paris, France
    Mov Disord 17:419-20. 2002
    ..1 We report on a patient who was primarily diagnosed as typical ALS and developed chorea 10 years after the onset of motor neuron signs...
  28. ncbi request reprint Psychopathology in amyotrophic lateral sclerosis: a preliminary study with 27 ALS patients
    Catherine Bungener
    Laboratory of Clinical Psychology and Psychopathology, University Paris Descartes, F 92774 Boulogne Billancourt, Paris, France
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:221-5. 2005
    ..The results show that it is useful to continue the affective evaluation of these patients and to undertake longitudinal studies starting at the time of diagnosis disclosure...
  29. doi request reprint [Nutritional management in amyotrophic lateral sclerosis: A medical and ethical stake]
    Guillaume Lehéricey
    AP HP, Groupe Hospitalier Pitie Salpetriere, Service de diététique, 75651 Paris Cedex 13, France
    Presse Med 41:560-74. 2012
    ..The criteria leading to artificial nutrition indication are medical, mainly based on percentage of weight loss, but also psychological and ethical...
  30. ncbi request reprint Neuropsychological changes in patients with primary lateral sclerosis
    Ambre Piquard
    Fédération des Maladies du Système Nerveux, Hopital de la Pitie Salpetriere, Paris
    Amyotroph Lateral Scler 7:150-60. 2006
    ..Our results suggest a patchy distribution of cortical involvement in PLS but it remains difficult to draw any definite conclusion as to the spatio-temporal progression of the disease into the different regions of the frontal lobe...
  31. doi request reprint Safety of home parenteral nutrition in patients with amyotrophic lateral sclerosis: a French national survey
    Maya Abdelnour-Mallet
    APHP, Hopital de la Pitie Salpetriere, Département des Maladies du Système Nerveux, Centre SLA de Paris
    Amyotroph Lateral Scler 12:178-84. 2011
    ..The relation of CVC and RIG placement timing and the complications' occurrence should also be investigated...
  32. doi request reprint Screening of OPTN in French familial amyotrophic lateral sclerosis
    Stephanie Millecamps
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Neurobiol Aging 32:557.e11-3. 2011
    ..Western blot experiments on the patients' lymphoblasts showed that the former variant led to a loss of function and the latter did not cause protein accumulation. Our results do not confirm the contribution of OPTN in ALS...
  33. ncbi request reprint Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis
    Mohamed Mounir El Mendili
    Sorbonne Universités, UPMC Univ Paris 06, UM CR 2, Laboratoire d Imagerie Biomédicale, Paris, Ile de France, France CNRS, UMR 7371, Laboratoire d Imagerie Biomédicale, Paris, Ile de France, France INSERM, U 1146, Laboratoire d Imagerie Biomédicale, Paris, Ile de France, France
    PLoS ONE 9:e95516. 2014
    ..To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients...
  34. ncbi request reprint [SLA: a long way since Charcot]
    Pierre Francois Pradat
    Centre de référence national pour la SLA, Fédération de Neurologie Mazarin, groupe hospitalier La Pitié La Salpêtrière, 47, Bd de l Hopital, 75651 Paris
    Rev Prat 53:1861-3. 2003
  35. doi request reprint Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression
    Gaelle Bruneteau
    APHP, Hopital Pitie Salpetriere, Departement de Neurologie, Centre référent SLA, Paris Cedex 13, France
    Brain 136:2359-68. 2013
    ..Specific histone deacetylase 4 inhibitors may then constitute a therapeutic approach to enhancing motor performance and slowing disease progression in amyotrophic lateral sclerosis. ..
  36. doi request reprint Diaphragm pacing improves sleep in patients with amyotrophic lateral sclerosis
    Jesus Gonzalez-Bermejo
    Service de Pneumologie et Reanimation, Groupe Hospitalier Pitie Salpetriere, 47 83 Bd de l Hopital, Paris, France
    Amyotroph Lateral Scler 13:44-54. 2012
    ..In conclusion, in these severe patients not expected to experience spontaneous improvements, diaphragm conditioning improved sleep and there were hints at diaphragm function changes...
  37. doi request reprint Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo)
    Sylvie Delanian
    Oncologie radiothérapie, Hôpital Saint Louis APHP, Paris, France
    J Neurol Sci 275:164-6. 2008
    ....
  38. doi request reprint The range and clinical impact of cognitive impairment in French patients with ALS: a cross-sectional study of neuropsychological test performance
    Paul H Gordon
    AP HP, Centre référent maladies rares SLA, Departement de Neurologie
    Amyotroph Lateral Scler 12:372-8. 2011
    ..As in other causes of dementia, higher education attainment may protect against clinical cognitive deterioration in ALS. French patients with severe cognitive impairment have shorter survival time...
  39. doi request reprint Validation of robust tools to measure sialorrhea in amyotrophic lateral sclerosis: a study in a large French cohort
    Maya Abdelnour-Mallet
    Département des Maladies du Système Nerveux, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Amyotroph Lateral Scler Frontotemporal Degener 14:302-7. 2013
    ..Because of the wide range of salivation degrees, SSS may be more sensitive as a tool to evaluate treatments in patients with severe hypersialorrhea...
  40. pmc Postradiation lumbosacral radiculopathy with spinal root cavernomas mimicking carcinomatous meningitis
    François Ducray
    Service de Neurologie Mazarin, APHP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Neuro Oncol 10:1035-9. 2008
    ..Its diagnosis is important in order to avoid inappropriate treatment and useless or dangerous spinal root biopsies...
  41. ncbi request reprint Gene transfer into the central and peripheral nervous system: applications for the treatment of neurodegenerative diseases and peripheral neuropathies
    Pierre Francois Pradat
    Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs LGN, UMR C9923, Centre National de la Recherche Scientifique, Hopital de la Pitie Salpetriere, 47 83 boulevard de l Hopital, 75013 Paris, France
    Biotechnol Genet Eng Rev 20:49-76. 2003
  42. pmc Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability
    Lionel Thivard
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, 75013, Paris, France
    J Neurol Neurosurg Psychiatry 78:889-92. 2007
    ..In ALS patients, our results show that subcortical lesions extend beyond the corticospinal tract and are clinically relevant...
  43. ncbi request reprint Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial
    Vincent Meininger
    Département des Maladies du Système Nerveux, Assistance Publique Hopitaux de Paris, Centre de référence maladies rares SLA, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 9:e97803. 2014
    ..In conclusion, single and repeat dose ozanezumab treatment was well tolerated and demonstrated co-localization at the site of action. These findings support future studies with ozanezumab in ALS...
  44. doi request reprint Selective disruption of acetylcholine synthesis in subsets of motor neurons: a new model of late-onset motor neuron disease
    Marie José Lecomte
    CRicm, CNRS UMR 7225, Paris, France UPMC Univ Paris 06, UMR 7225, Paris, France INSERM, UMR_S975, Paris, France
    Neurobiol Dis 65:102-11. 2014
    ..They also offer the opportunity to explore fundamental issues of motor neuron biology. ..