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Publications
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocationRenaud Dentin
Departement d Endocrinologie, Institut Cochin, INSERM U567 CNRS UMR8104, Universite Rene Descartes, Paris, France
J Clin Invest 115:2843-54. 2005....
ChREBP, a transcriptional regulator of glucose and lipid metabolismCatherine Postic
Departement d Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Annu Rev Nutr 27:179-92. 2007..Here, we review some of the studies that have begun to elucidate the regulation and function of this key transcription factor in liver...- Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceCatherine Postic
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
J Clin Invest 118:829-38. 2008..This review discusses recent advances in the field... - Mouse models of insulin resistance and type 2 diabetesC Postic
, Institut Cochin, INSERM U567, , 24, rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Endocrinol (Paris) 65:51-9. 2004 - Role of the liver in the control of carbohydrate and lipid homeostasisC Postic
Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR 8104, université Paris V René Descartes, Paris, France
Diabetes Metab 30:398-408. 2004..In addition, since the possibility of controlling hepatic glucose utilization as a treatment of type 2 diabetes has been explored we will review some of the strategies proved to be valuable for improving the hyperglycemic phenotype... - Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob miceRenaud Dentin
Departement d Endocrinologie, Institut Cochin, Métabolisme et Cancer, 24 rue du Faubourg St Jacques, Paris 75014, France
Diabetes 55:2159-70. 2006..Taken together, our results demonstrate that ChREBP is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice... - Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expressionRenaud Dentin
Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
J Biol Chem 279:20314-26. 2004..Together these results support a model whereby both SREBP-1c and glucose metabolism, acting via ChREBP, are necessary for the dietary induction of glycolytic and lipogenic gene expression in liver... - The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathwaysAnaïs Perilhou
Department of Endocrinology, Metabolism, and Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Mol Cell Biol 28:6568-79. 2008..We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism... - ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liverPierre Damien Denechaud
Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
J Clin Invest 118:956-64. 2008..Taken together, our results demonstrate that glucose is required for ChREBP functional activity and that LXRs are not necessary for the induction of glucose-regulated genes in liver... - Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBPRenaud Dentin
Institut Cochin, INSERM U567 CNRS UMR8104, , , , Paris, France
J Nutr 136:1145-9. 2006.... 
[Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP]Celine Robichon
Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Med Sci (Paris) 24:841-6. 2008..Although its implication in human disease has not yet been demonstrated, ChRepsilonBP could be an interesting therapeutic target against metabolic syndrome components...- [The regulation of gene expression by glucose]Jean Girard
INSERM U567, CNRS UMR 8104, Universite Paris Descartes, Departement d Endocrinologie, Métabolisme et Cancer, Faculté de Médecine Cochin, 24, rue du Faubourg Saint Jacques, 75014 Paris
J Soc Biol 201:159-64. 2007..Finally, the possible implication of ChREBP in the physiopathology of obesity and type 2 diabetes are discussed... - Role of ChREBP in hepatic steatosis and insulin resistancePierre Damien Denechaud
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Departement d Endocrinologie, Métabolisme et Cancer, 24 rue du Faubourg Saint Jacques, Paris, France
FEBS Lett 582:68-73. 2008..In this mini-review, we will focus on the importance of ChREBP in the physiopathology of hepatic steatosis and insulin resistance by discussing the physiological and metabolic consequences of ChREBP knockdown in liver of ob/ob mice... - O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liverCéline Guinez
INSERM, U1016, Institut Cochin, Paris, France
Diabetes 60:1399-413. 2011.... - The role of the lipogenic pathway in the development of hepatic steatosisC Postic
Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, Paris, France
Diabetes Metab 34:643-8. 2008..This review describes the models that have provided evidence implicating lipogenesis in the development and/or prevention of hepatic steatosis... - Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liverRenaud Dentin
, Institut Cochin, INSERM U567, CNRS UMR8104, , 24, rue du Faubourg Saint Jacques, 75014 Paris, France
Biochimie 87:81-6. 2005.... - Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymesLoubna Erraji-Benchekroun
Department of Immunology, Institut Cochin, Institut National de la Sante et de la Recherche Medicale, Paris, France
Am J Physiol Endocrinol Metab 288:E715-22. 2005..These transgenic mice open new perspectives for studying in vivo the hepatic beta2-AR system physiopathology and for testing the effects of beta-AR ligands on liver metabolism... - Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout miceBertrand Cariou
Department of Endocrinology, Institut National de la Sante et de la Recherche Medicale, Unité 567 Centre National de la Recherche Scientifique, Paris, France
Endocrinology 145:1926-32. 2004..The MIRKO mouse confirms the importance of WAT plasticity in the maintenance of whole body insulin sensitivity and represents an interesting model to search for new secreted molecules that positively alter adipose tissue biology... - Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storageClaude Knauf
UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
J Clin Invest 115:3554-63. 2005..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state... - Carbohydrate responsive element binding protein and lipid homeostasisPierre Damien Denechaud
Cochin Institute, Department of Endocrinology, Metabolism and Cancer, Paris Descartes University, CNRS UMR 8104, Paris, France
Curr Opin Lipidol 19:301-6. 2008..Recently, the transcription factor carbohydrate responsive element binding protein has emerged as the hepatic glucose sensor required for the induction of lipogenic genes in response to glucose...