C Postic

Summary

Country: France

Publications

  1. pmc Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, INSERM U567 CNRS UMR8104, Universite Rene Descartes, Paris, France
    J Clin Invest 115:2843-54. 2005
  2. ncbi ChREBP, a transcriptional regulator of glucose and lipid metabolism
    Catherine Postic
    Departement d Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Annu Rev Nutr 27:179-92. 2007
  3. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
  4. ncbi Mouse models of insulin resistance and type 2 diabetes
    C Postic
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104 Université Paris V René Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Endocrinol (Paris) 65:51-9. 2004
  5. ncbi Role of the liver in the control of carbohydrate and lipid homeostasis
    C Postic
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR 8104, université Paris V René Descartes, Paris, France
    Diabetes Metab 30:398-408. 2004
  6. ncbi Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, Métabolisme et Cancer, 24 rue du Faubourg St Jacques, Paris 75014, France
    Diabetes 55:2159-70. 2006
  7. ncbi Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 279:20314-26. 2004
  8. pmc The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways
    Anaïs Perilhou
    Department of Endocrinology, Metabolism, and Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mol Cell Biol 28:6568-79. 2008
  9. pmc ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
    Pierre Damien Denechaud
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    J Clin Invest 118:956-64. 2008
  10. ncbi Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP
    Renaud Dentin
    Institut Cochin, INSERM U567 CNRS UMR8104, Universite Rene Descartes, Departement d Endocrinologie, Métabolisme et Cancer, Paris, France
    J Nutr 136:1145-9. 2006

Collaborators

Detail Information

Publications20

  1. pmc Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, INSERM U567 CNRS UMR8104, Universite Rene Descartes, Paris, France
    J Clin Invest 115:2843-54. 2005
    ....
  2. ncbi ChREBP, a transcriptional regulator of glucose and lipid metabolism
    Catherine Postic
    Departement d Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Annu Rev Nutr 27:179-92. 2007
    ..Here, we review some of the studies that have begun to elucidate the regulation and function of this key transcription factor in liver...
  3. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
    ..This review discusses recent advances in the field...
  4. ncbi Mouse models of insulin resistance and type 2 diabetes
    C Postic
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104 Université Paris V René Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Endocrinol (Paris) 65:51-9. 2004
  5. ncbi Role of the liver in the control of carbohydrate and lipid homeostasis
    C Postic
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR 8104, université Paris V René Descartes, Paris, France
    Diabetes Metab 30:398-408. 2004
    ..In addition, since the possibility of controlling hepatic glucose utilization as a treatment of type 2 diabetes has been explored we will review some of the strategies proved to be valuable for improving the hyperglycemic phenotype...
  6. ncbi Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, Métabolisme et Cancer, 24 rue du Faubourg St Jacques, Paris 75014, France
    Diabetes 55:2159-70. 2006
    ..Taken together, our results demonstrate that ChREBP is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice...
  7. ncbi Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 279:20314-26. 2004
    ..Together these results support a model whereby both SREBP-1c and glucose metabolism, acting via ChREBP, are necessary for the dietary induction of glycolytic and lipogenic gene expression in liver...
  8. pmc The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways
    Anaïs Perilhou
    Department of Endocrinology, Metabolism, and Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mol Cell Biol 28:6568-79. 2008
    ..We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism...
  9. pmc ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
    Pierre Damien Denechaud
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    J Clin Invest 118:956-64. 2008
    ..Taken together, our results demonstrate that glucose is required for ChREBP functional activity and that LXRs are not necessary for the induction of glucose-regulated genes in liver...
  10. ncbi Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP
    Renaud Dentin
    Institut Cochin, INSERM U567 CNRS UMR8104, Universite Rene Descartes, Departement d Endocrinologie, Métabolisme et Cancer, Paris, France
    J Nutr 136:1145-9. 2006
    ....
  11. ncbi [Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP]
    Celine Robichon
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Med Sci (Paris) 24:841-6. 2008
    ..Although its implication in human disease has not yet been demonstrated, ChRepsilonBP could be an interesting therapeutic target against metabolic syndrome components...
  12. ncbi [The regulation of gene expression by glucose]
    Jean Girard
    INSERM U567, CNRS UMR 8104, Universite Paris Descartes, Departement d Endocrinologie, Métabolisme et Cancer, Faculté de Médecine Cochin, 24, rue du Faubourg Saint Jacques, 75014 Paris
    J Soc Biol 201:159-64. 2007
    ..Finally, the possible implication of ChREBP in the physiopathology of obesity and type 2 diabetes are discussed...
  13. ncbi Role of ChREBP in hepatic steatosis and insulin resistance
    Pierre Damien Denechaud
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Departement d Endocrinologie, Métabolisme et Cancer, 24 rue du Faubourg Saint Jacques, Paris, France
    FEBS Lett 582:68-73. 2008
    ..In this mini-review, we will focus on the importance of ChREBP in the physiopathology of hepatic steatosis and insulin resistance by discussing the physiological and metabolic consequences of ChREBP knockdown in liver of ob/ob mice...
  14. pmc O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
    Céline Guinez
    INSERM, U1016, Institut Cochin, Paris, France
    Diabetes 60:1399-413. 2011
    ....
  15. doi The role of the lipogenic pathway in the development of hepatic steatosis
    C Postic
    Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, Paris, France
    Diabetes Metab 34:643-8. 2008
    ..This review describes the models that have provided evidence implicating lipogenesis in the development and/or prevention of hepatic steatosis...
  16. ncbi Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS UMR8104, université Paris V René Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    Biochimie 87:81-6. 2005
    ....
  17. ncbi Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes
    Loubna Erraji-Benchekroun
    Department of Immunology, Institut Cochin, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Am J Physiol Endocrinol Metab 288:E715-22. 2005
    ..These transgenic mice open new perspectives for studying in vivo the hepatic beta2-AR system physiopathology and for testing the effects of beta-AR ligands on liver metabolism...
  18. ncbi Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice
    Bertrand Cariou
    Department of Endocrinology, Institut National de la Sante et de la Recherche Medicale, Unité 567 Centre National de la Recherche Scientifique, Paris, France
    Endocrinology 145:1926-32. 2004
    ..The MIRKO mouse confirms the importance of WAT plasticity in the maintenance of whole body insulin sensitivity and represents an interesting model to search for new secreted molecules that positively alter adipose tissue biology...
  19. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state...
  20. ncbi Carbohydrate responsive element binding protein and lipid homeostasis
    Pierre Damien Denechaud
    Cochin Institute, Department of Endocrinology, Metabolism and Cancer, Paris Descartes University, CNRS UMR 8104, Paris, France
    Curr Opin Lipidol 19:301-6. 2008
    ..Recently, the transcription factor carbohydrate responsive element binding protein has emerged as the hepatic glucose sensor required for the induction of lipogenic genes in response to glucose...