Bernard Portha

Summary

Country: France

Publications

  1. ncbi request reprint beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony
    B Portha
    Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Université D Diderot, Paris, France
    Diabetes 50:S89-93. 2001
  2. ncbi request reprint Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm
    Bernard Portha
    Lab Physiopathologie de la Nutrition, Université Paris 7 D Diderot, Paris Cedex, France
    Diabetes Metab Res Rev 21:495-504. 2005
  3. ncbi request reprint [Transmitted beta-cell dysfunction as a cause for type 2-diabetes]
    Bernard Portha
    Groupe Régulations métaboliques et diabètes, Laboratoire de Physiopathologie de la Nutrition, CNRS UMR 7059, Universite Paris 7 Denis Diderot, 2, place Jussieu, 75251 Paris Cedex 05, France
    Med Sci (Paris) 19:847-53. 2003
  4. ncbi request reprint Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion
    Jamileh Movassat
    Centre National pour la Recherche Scientific, Unité Mixte de Reserche 7059, Université Paris 7 D Diderot, 2, place Jussieu, F 75251 Paris, France
    Am J Physiol Endocrinol Metab 294:E168-75. 2008
  5. ncbi request reprint Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period
    Sophie Calderari
    Laboratoire de Physiopathologie de la Nutrition, UMR CNRS 7059, Universite Paris 7, Paris, France
    Pancreas 33:412-7. 2006
  6. doi request reprint Diabetic GK/Par rat beta-cells are spontaneously protected against H2O2-triggered apoptosis. A cAMP-dependent adaptive response
    Gregory Lacraz
    Laboratoire Biologie et Pathologie du Pancréas Endocrine, Unité Biologie Fonctionnelle et Adaptive, Equipe 1, Université Paris Diderot et CNRS EAC 4413, Paris, France
    Am J Physiol Endocrinol Metab 298:E17-27. 2010
  7. pmc Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses
    Gregory Lacraz
    Equipe B2PE Biologie et Pathologie du Pancréas Endocrine, Unité BFA Biologie Fonctionnelle et Adaptative, Université Paris Diderot et CNRS EAC7059, Paris, France
    PLoS ONE 4:e6500. 2009
  8. pmc Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat
    Florence Figeac
    University Paris Diderot, Sorbonne Paris Cité, Laboratory of Biology and Pathology of the Endocrine Pancreas, BFA Unit Biologie Fonctionnelle et Adaptive, CNRS EAC 4413 CNRS, Paris, France
    Mol Ther 20:1944-52. 2012
  9. doi request reprint cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1
    Manuel Dolz
    Universite Paris Diderot, Sorbonne Paris Cité, Laboratoire B2PE Biologie et Pathologie du Pancréas Endocrine, Unité Biologie Fonctionnelle et Adaptive, EAC 4413, Centre National de Recherche Scientifique, Paris, France
    Am J Physiol Endocrinol Metab 301:E797-806. 2011
  10. ncbi request reprint Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat
    Francoise Homo-Delarche
    Unité Mixte de Recherche 7059, National Center for Scientific Research, Diderot University, Paris, France
    Diabetes 55:1625-33. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony
    B Portha
    Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Université D Diderot, Paris, France
    Diabetes 50:S89-93. 2001
    ....
  2. ncbi request reprint Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm
    Bernard Portha
    Lab Physiopathologie de la Nutrition, Université Paris 7 D Diderot, Paris Cedex, France
    Diabetes Metab Res Rev 21:495-504. 2005
    ..An important message is that the 'heritable' determinants of T2DM are not simply dependant on genetic factors, but probably involve transgenerational epigenetic responses...
  3. ncbi request reprint [Transmitted beta-cell dysfunction as a cause for type 2-diabetes]
    Bernard Portha
    Groupe Régulations métaboliques et diabètes, Laboratoire de Physiopathologie de la Nutrition, CNRS UMR 7059, Universite Paris 7 Denis Diderot, 2, place Jussieu, 75251 Paris Cedex 05, France
    Med Sci (Paris) 19:847-53. 2003
    ..A better understanding of the mechanisms involved in the failure of beta-cell function in the GK model will lead to identification of new therapeutic targets for both the prevention and treatment of type 2 diabetes...
  4. ncbi request reprint Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion
    Jamileh Movassat
    Centre National pour la Recherche Scientific, Unité Mixte de Reserche 7059, Université Paris 7 D Diderot, 2, place Jussieu, F 75251 Paris, France
    Am J Physiol Endocrinol Metab 294:E168-75. 2008
    ....
  5. ncbi request reprint Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period
    Sophie Calderari
    Laboratoire de Physiopathologie de la Nutrition, UMR CNRS 7059, Universite Paris 7, Paris, France
    Pancreas 33:412-7. 2006
    ....
  6. doi request reprint Diabetic GK/Par rat beta-cells are spontaneously protected against H2O2-triggered apoptosis. A cAMP-dependent adaptive response
    Gregory Lacraz
    Laboratoire Biologie et Pathologie du Pancréas Endocrine, Unité Biologie Fonctionnelle et Adaptive, Equipe 1, Université Paris Diderot et CNRS EAC 4413, Paris, France
    Am J Physiol Endocrinol Metab 298:E17-27. 2010
    ..Finally, we show that such a phenotype is not innate but is spontaneously acquired after diabetes onset as the result of an adaptive response to the diabetic environment...
  7. pmc Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses
    Gregory Lacraz
    Equipe B2PE Biologie et Pathologie du Pancréas Endocrine, Unité BFA Biologie Fonctionnelle et Adaptative, Université Paris Diderot et CNRS EAC7059, Paris, France
    PLoS ONE 4:e6500. 2009
    ..Here, we have evaluated islet OS status and beta-cell response to ROS using the GK/Par rat as a model of type 2 diabetes...
  8. pmc Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat
    Florence Figeac
    University Paris Diderot, Sorbonne Paris Cité, Laboratory of Biology and Pathology of the Endocrine Pancreas, BFA Unit Biologie Fonctionnelle et Adaptive, CNRS EAC 4413 CNRS, Paris, France
    Mol Ther 20:1944-52. 2012
    ..Our study designates GSK3β as a viable drug target for therapeutic intervention on diseases of endocrine and exocrine pancreas associated with cell deficiency...
  9. doi request reprint cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1
    Manuel Dolz
    Universite Paris Diderot, Sorbonne Paris Cité, Laboratoire B2PE Biologie et Pathologie du Pancréas Endocrine, Unité Biologie Fonctionnelle et Adaptive, EAC 4413, Centre National de Recherche Scientifique, Paris, France
    Am J Physiol Endocrinol Metab 301:E797-806. 2011
    ..This GLP-1 effect takes place in the absence of any improvement of the [Ca(2+)](i) response and correlates with activation of the cAMP-dependent PKA-dependent pathway...
  10. ncbi request reprint Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat
    Francoise Homo-Delarche
    Unité Mixte de Recherche 7059, National Center for Scientific Research, Diderot University, Paris, France
    Diabetes 55:1625-33. 2006
    ..These data demonstrate that marked inflammatory reaction accompanies GK islet fibrosis and suggest that islet alterations in this nonobese model of type 2 diabetes develop in a way reminiscent of microangiopathy...
  11. doi request reprint Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats
    Florence Figeac
    University Paris Diderot Centre National de la Recherche Scientifique Equipe d Accueil Conventionnée 4413, Laboratory of Biology and Pathology of the Endocrine Pancreas, Paris, France
    Am J Physiol Endocrinol Metab 298:E245-56. 2010
    ..These findings might have potential clinical applications in the regenerative therapy of diabetes...
  12. doi request reprint Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival
    Julien Véret
    Universite Paris Diderot, Sorbonne Paris Cité, Laboratoire de Biologie et Pathologie du Pancréas Endocrine, Unité BFA, CNRS EAC 4413, Paris, France
    Biochim Biophys Acta 1831:251-62. 2013
    ....
  13. ncbi request reprint Comparison between D-[3-3H]- and D-[5-3H]glucose and fructose utilization in pancreatic islets from control and hereditarily diabetic rats
    Marie Helene Giroix
    Laboratory of Nutrition Physiopathology, Centre National de la Recherche Scientifique, UMR 7059, University of Paris 7, F 75251, Paris, France
    Arch Biochem Biophys 408:111-23. 2002
    ....
  14. ncbi request reprint Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy
    Eric Bertin
    Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique UMR 7059, Université Paris 7 D Diderot, 75251 Paris Cedex 05, France
    Am J Physiol Regul Integr Comp Physiol 283:R623-30. 2002
    ..Moreover, our results support the hypothesis that taurine might play an important role in fetal beta-cell mass function...
  15. pmc Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat
    Gregory Lacraz
    Laboratory of Biology and Pathology of Endocrine Pancreas, Functional and Adaptive Biology Unit CNRS EA 7059, University Paris Diderot, Paris, France
    PLoS ONE 4:e6963. 2009
    ..We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) receptor antagonist (IL-1Ra)...
  16. ncbi request reprint Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    Cécile Tourrel
    LPPN, CNRS UMR 7059, Universite Paris 7, Paris, France
    Diabetes 51:1443-52. 2002
    ..Under these conditions, GLP-1 represents a unique tool because of its beta-cell replenishing effect in spontaneously diabetic rodents. It may prove to be an invaluable agent for the prevention of human type 2 diabetes...
  17. doi request reprint The GK rat: a prototype for the study of non-overweight type 2 diabetes
    Bernard Portha
    Laboratoire B2PE Biologie et Pathologie du Pancréas Endocrine, Unité BFA Biologie Fonctionnelle et Adaptive, Universite Paris Diderot, CNRS EAC 4413, Paris, France
    Methods Mol Biol 933:125-59. 2012
    ....
  18. ncbi request reprint Early administration of keratinocyte growth factor improves {beta}-cell regeneration in rat with streptozotocin-induced diabetes
    Jamileh Movassat
    Laboratoire de Physiopathologie de la Nutrition CNRS UMR 7059, Universite Paris 7, 2, place Jussieu, 75005 Paris, France
    J Endocrinol 195:333-40. 2007
    ..KGF exerts strong mitogenic effect on the pancreatic duct cells, thus expanding the population of precursor cells that subsequently differentiate into insulin-producing beta-cells...
  19. ncbi request reprint Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production
    Manuel Dolz
    Unité Mixte de Recherche UMR 7059, National Center for Scientific Research CNRS and Paris University 7 D Diderot, Paris, France
    Diabetes 54:3229-37. 2005
    ..In conclusion, ACh acts mainly through activation of the cAMP/PKA pathway to potently enhance Ca2+-stimulated insulin release in the GK beta-cell and, in doing so, normalizes its defective glucose responsiveness...
  20. doi request reprint Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells
    Julien Véret
    Universite Paris Diderot, Sorbonne Paris Cité, Laboratoire de Biologie et Pathologie du Pancréas Endocrine, Unité BFA, CNRS EAC 4413, Paris, France
    Biochem J 438:177-89. 2011
    ....
  21. pmc Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation
    Benjamin Uzan
    Department of Life Science, Laboratory of Pathophysiology of Nutrition, Paris Diderot Paris 7 University, CNRS UMR, Paris, France
    PLoS ONE 4:e4734. 2009
    ..Here we investigated the intracellular signaling pathways involved in the mediation of pancreatic ductal cell proliferation and differentiation induced by exogenous KGF during beta-cell regeneration in diabetic rat...
  22. ncbi request reprint Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes
    Patricia Serradas
    Laboratory of Physiopathology of Nutrition, Universite Paris, Paris, France
    Diabetes 51:392-7. 2002
    ..In conclusion, in GK fetuses at 21.5 dpc, the defective IGF-2 production appears to be an early landmark in the pathological sequence leading to retardation of beta-cell growth in the fetal GK rat...
  23. ncbi request reprint Metabolism of D-[3-3H]glucose, D-[5-3H]glucose, D-[U-14C]glucose, D-[1-14C]glucose and D-[6-14C]glucose in pancreatic islets in an animal model of type-2 diabetes
    Marie Helene Giroix
    Laboratory of Nutrition Physiopathology, Unité Mixte de Recherche du Centre National de la Recherche Scientifique 7059, University of Paris 7, F 75251 Paris 05, France
    Int J Mol Med 9:381-4. 2002
    ....
  24. ncbi request reprint Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging
    Isabelle Iltis
    Centre de Resonance Magnetique Biologique et Medicale, Faculte de Medecine de Marseille, Marseille, France
    Invest Radiol 40:19-26. 2005
    ..In this work, we aimed at characterizing in vivo myocardial blood flow and left ventricular function of the Goto-Kakizaki (GK) rat as a nonobese model of type 2 diabetes...
  25. ncbi request reprint Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat
    M A Martin
    Instituto de Bioquimica, Consejo Superior de Investigaciones Cientificas Universidad Complutense de Madrid, Facultad de Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain
    Endocrinology 146:1364-71. 2005
    ....
  26. ncbi request reprint Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats
    Patrick C Even
    Laboratoire de Physiologie de la Nutrition et du Comportement Alimentaire, Unité Mixte de Recherche 914, Institut National de la Recherche Agronomique, Institut National Agronomique Paris Grignon, 75231 Paris Cedex 05, France
    Am J Physiol Regul Integr Comp Physiol 284:R751-9. 2003
    ..These results suggest that rats adapt to a low P/E in the diet by burning part of their excess nonprotein energy and storing the remaining excess in subcutaneous adipose tissue...