P Pollak

Summary

Country: France

Publications

  1. ncbi request reprint Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
  2. doi request reprint Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantation
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Arch Neurol 65:612-6. 2008
  3. ncbi request reprint Treatment results: Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
    Mov Disord 17:S75-83. 2002
  4. pmc Clozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up
    P Pollak
    Department of Neurology, University Hospital of Grenoble, 38043 Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 75:689-95. 2004
  5. ncbi request reprint Movement disorders: Parkinson's disease dominates
    Pierre Pollak
    Movement Disorders Unit, Department of Neurology, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, France
    Lancet Neurol 3:15. 2004
  6. ncbi request reprint Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
  7. doi request reprint Levodopa-resistant freezing of gait and executive dysfunction in Parkinson's disease
    M U Ferraye
    Universite J Fourier Grenoble 1, INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    Eur Neurol 69:281-8. 2013
  8. doi request reprint Pedunculopontine nucleus stimulation induces monocular oscillopsia
    M U Ferraye
    Universite Joseph Fourier, Grenoble, France and INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France
    J Neurol Neurosurg Psychiatry 80:228-31. 2009
  9. ncbi request reprint Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy
    A L Benabid
    Department of Neurosurgery, CHU A Michallon, Grenoble, France
    J Neurol 248:III37-47. 2001
  10. pmc Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery
    V Fraix
    Department of Neurology, University Hospital of Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 76:246-8. 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
    ..The understanding of the mechanism has opened a new field of research, which will call for reappraisal of the basic effects of electricity on the living tissues...
  2. doi request reprint Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantation
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Arch Neurol 65:612-6. 2008
    ..The misplacement of electrodes is a possible explanation for suboptimal response to bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease...
  3. ncbi request reprint Treatment results: Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
    Mov Disord 17:S75-83. 2002
    ..Intracranial electrode implantation can induce a hematoma or contusion. Most authors agree that the benefit to risk ratio of DBS is favorable...
  4. pmc Clozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up
    P Pollak
    Department of Neurology, University Hospital of Grenoble, 38043 Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 75:689-95. 2004
    ..To compare the efficacy and safety of clozapine in drug induced psychosis in Parkinson's disease (PD)...
  5. ncbi request reprint Movement disorders: Parkinson's disease dominates
    Pierre Pollak
    Movement Disorders Unit, Department of Neurology, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, France
    Lancet Neurol 3:15. 2004
  6. ncbi request reprint Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms...
  7. doi request reprint Levodopa-resistant freezing of gait and executive dysfunction in Parkinson's disease
    M U Ferraye
    Universite J Fourier Grenoble 1, INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    Eur Neurol 69:281-8. 2013
    ..However, since some patients develop L-FOG despite the preservation of executive functions, lesions or dysfunction of other neuronal structures are likely to be involved...
  8. doi request reprint Pedunculopontine nucleus stimulation induces monocular oscillopsia
    M U Ferraye
    Universite Joseph Fourier, Grenoble, France and INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France
    J Neurol Neurosurg Psychiatry 80:228-31. 2009
    ..These results emphasise the difficulty of stimulating this mesencephalic region...
  9. ncbi request reprint Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy
    A L Benabid
    Department of Neurosurgery, CHU A Michallon, Grenoble, France
    J Neurol 248:III37-47. 2001
    ..It is therefore possible that DBS in STN as well as in other targets could become a potent therapeutic tool in the near future for neurological disorders...
  10. pmc Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery
    V Fraix
    Department of Neurology, University Hospital of Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 76:246-8. 2005
    ..The parkinsonian motor state is greatly improved by bilateral STN stimulation even in patients with previous thalamic surgery, and STN stimulation is more effective than VIM stimulation in tremor dominant parkinsonian patients...
  11. doi request reprint Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP217, 38043 Grenoble Cedex 9, France
    Brain 133:205-14. 2010
    ....
  12. doi request reprint Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
    M U Ferraye
    University J Fourier Grenoble 1, 38041, Grenoble, France
    J Neural Transm 118:1469-75. 2011
    ....
  13. ncbi request reprint Pyramidal tract side effects induced by deep brain stimulation of the subthalamic nucleus
    G Tommasi
    Department of Neurology, University Hospital, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 79:813-9. 2008
    ..To study the pyramidal tract side effects (PTSEs) induced by the spread of current from the subthalamic nucleus (STN) to the pyramidal tract (PT), in patients with parkinsonism undergoing STN stimulation...
  14. doi request reprint High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a review
    R Carron
    Department of Neurosurgery, University Hospital, Grenoble, France
    J Neural Transm 118:915-24. 2011
    ....
  15. ncbi request reprint Subthalamic stimulation for Parkinson's disease
    A L Benabid
    Department of Neurosciences, University Hospital of Grenoble, Grenoble, France
    Arch Med Res 31:282-9. 2000
    ..6, 48.6, and 27%, respectively, when compared with the previous preoperative level. From our experience, HFS of the STN could be considered the surgical therapy of choice at advanced stages of Parkinson's disease...
  16. ncbi request reprint Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism
    P Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 54:2182-4. 2000
    ..This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery...
  17. ncbi request reprint Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait
    J Xie
    Department of Clinical and Biological Neurosciences, Centre Hospitalier Universitaire de Grenoble, France
    J Neurol 248:1068-72. 2001
    ..The UPDRS motor score was significantly (p < 0.001) decreased after both stimulation and levodopa. In conclusion, STN stimulation is effective on parkinsonian gait...
  18. ncbi request reprint [Deep brain stimulation]
    V Fraix
    Departement de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble
    Rev Neurol (Paris) 160:511-21. 2004
    ..Such studies, including cost benefit studies would be useful to assess the respective value of these different techniques...
  19. doi request reprint Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Neurology 70:1431-7. 2008
    ..We studied the effects of subthalamic nucleus (STN) stimulation vs levodopa on freezing of gait (FOG) and gait impairments in a large consecutive series of patients with Parkinson disease with bilateral STN stimulation...
  20. ncbi request reprint Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?
    E Chevrier
    Department of Neurology, Movement Disorders Unit, Grenoble University Hospital, Grenoble, Cedex 09, France
    Eur J Neurol 13:496-8. 2006
    ..All patients except one experienced physical pain and psychological suffering, alleviated by physiotherapy. These preliminary results need to be confirmed in a prospective randomized study...
  21. ncbi request reprint Implication of the subthalamic nucleus in the pathophysiology and pathogenesis of Parkinson's disease
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, Grenoble, France
    Cell Transplant 9:215-21. 2000
    ..The evidence reviewed in the present article clearly demonstrates that the STN is implicated in the pathophysiology and pathogenesis of Parkinson's disease...
  22. doi request reprint [Deep brain stimulation and gait disorders in Parkinson disease]
    M U Ferraye
    INSERM, U836, Université de Grenoble, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Rev Neurol (Paris) 166:178-87. 2010
    ..Gait disorders and freezing of gait (FOG) are seen in most patients with advanced Parkinson disease. Response to levodopa and deep brain stimulation is variable across patients...
  23. ncbi request reprint Mirthful laughter induced by subthalamic nucleus stimulation
    P Krack
    Neuroscience Department, University of Grenoble, Grenoble, France
    Mov Disord 16:867-75. 2001
    ..Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation...
  24. doi request reprint [Assessment of hyper- and hypodopaminergic behaviors in Parkinson's disease]
    C Ardouin
    INSERM U836, Service de Neurologie, CHU de Grenoble, Université de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Rev Neurol (Paris) 165:845-56. 2009
    ....
  25. ncbi request reprint Preservation of cognitive function in dystonia treated by pallidal stimulation
    B Pillon
    INSERM U679, Neurology and Experimental Therapeutics, Department of Neurology, Hopital de la Pitie Salpetriere, Paris, France
    Neurology 66:1556-8. 2006
    ....
  26. ncbi request reprint Bilateral subthalamic nucleus stimulation improves health-related quality of life in PD
    E Lagrange
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:1976-8. 2002
    ..All aspects of quality of life, including motor (+48%), systemic (+34%), emotional (+29%), and social (+63%) dimensions, significantly improved with long-term STN stimulation...
  27. pmc Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
    A Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 75:834-9. 2004
    ..Long term effects of subthalamic nucleus (STN) stimulation on cognition, mood, and behaviour are unknown...
  28. ncbi request reprint Functional neurosurgery: past, present, and future
    A L Benabid
    University Joseph Fourier, Grenoble, France
    Clin Neurosurg 52:265-70. 2005
  29. ncbi request reprint Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian voice
    M Gentil
    INSERM, Unité 318, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Brain Lang 78:233-40. 2001
    ..Relative intensity was unchanged in both conditions. Further acoustic analyses are warranted to clarify the role of STN stimulation on parkinsonian speech...
  30. pmc Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism
    M Gentil
    INSERM, Unit 318, CHU Grenoble, France
    J Neurol Neurosurg Psychiatry 67:329-33. 1999
    ..To assess the oral system of parkinsonian patients treated with chronic stimulation of the bilateral subthalamic nucleus (STN) to evaluate precisely the effectiveness of this procedure on the articulatory organs...
  31. ncbi request reprint Effect of bilateral deep-brain stimulation on oral control of patients with parkinsonism
    M Gentil
    INSERM Unit 318, CHU Grenoble, France
    Eur Neurol 44:147-52. 2000
    ..The target of stimulation differently influences the oral system and modulates neuronal structures involved in speech...
  32. ncbi request reprint Predictors of effective bilateral subthalamic nucleus stimulation for PD
    P D Charles
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:932-4. 2002
    ..Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation...
  33. ncbi request reprint Contraversive eye deviation during stimulation of the subthalamic region
    Paul Sauleau
    Department of Neurophysiology, Universite de Rennes 1, CHU de Rennes, France
    Mov Disord 22:1810-3. 2007
    ..Interestingly, this report shows that CED may be corrected by bilateral stimulation and that CED may not necessarily implicate electrode repositioning...
  34. ncbi request reprint Acute deep-brain stimulation of the internal and external globus pallidus in primary dystonia: functional mapping of the pallidum
    Jean Luc Houeto
    Service de Neurologie, Centre Hospitalier Universitaire La Miletrie, BP 577, 86021 Poitiers Cedex, France
    Arch Neurol 64:1281-6. 2007
    ..Patients with the severe and generalized forms can benefit from bilateral high-frequency pallidal stimulation...
  35. ncbi request reprint Comparison of two techniques to postoperatively localize the electrode contacts used for subthalamic nucleus stimulation
    Serge Pinto
    Department of Neurology, Centre Hospitalier Universitaire de Grenoble, and INSERM U318, Neurosciences Précliniques, Grenoble, France
    Neurosurgery 60:285-92; discussion 292-4. 2007
    ..To our knowledge, this is the first study attempting to compare the "gold standard" of stereotactic accuracy (Vg) with the anatomic resolution provided by MRI scans...
  36. ncbi request reprint Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulation
    Elena Moro
    Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, Grenoble, France
    Brain 125:2408-17. 2002
    ..In addition, the persistence of levodopa intake after surgery might hinder this beneficial process...
  37. ncbi request reprint Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study
    Marie Vidailhet
    INSERM U679, Neurology and Experimental Therapeutics, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Lancet Neurol 6:223-9. 2007
    ....
  38. ncbi request reprint Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
    Abdelhamid Benazzouz
    Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
    Mov Disord 17:S145-9. 2002
    ..In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN...
  39. ncbi request reprint Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
    ....
  40. ncbi request reprint Glutamate measurement in Parkinson's disease using MRS at 3 T field strength
    Nils Kickler
    INSERM, U594, Neuroimagerie Fonctionnelle et Métabolique, Grenoble, France
    NMR Biomed 20:757-62. 2007
    ..Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed...
  41. ncbi request reprint Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Mov Disord 22:2436-9. 2007
    ..A close monitoring of patients and an anticipation of IPG replacement in the case of a low-battery signal are recommended...
  42. doi request reprint Are parkin patients particularly suited for deep-brain stimulation?
    Ebba Lohmann
    INSERM, U679, Paris, France
    Mov Disord 23:740-3. 2008
    ..Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results...
  43. doi request reprint Subthalamic stimulation improves orienting gaze movements in Parkinson's disease
    Paul Sauleau
    Department of Neurophysiology, University Hospital of Rennes, University of Rennes 1, France
    Clin Neurophysiol 119:1857-63. 2008
    ..To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD)...
  44. ncbi request reprint Postoperative management of subthalamic nucleus stimulation for Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S188-97. 2002
    ..Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects...
  45. ncbi request reprint Imaging of subthalamic nucleus and ventralis intermedius of the thalamus
    Alim Louis Benabid
    Department of Clinical and Biological Neurosciences, Institut National de la Sante et de la Recherche Medicale, Preclinical Neurosciences U 318, Joseph Fourier University of Grenoble, Hopital A Michallon, France
    Mov Disord 17:S123-9. 2002
    ..These shortcomings no doubt will be corrected in the near future, and the technologies will better assist us in the proper placement of electrodes, which will provide the patient with the highest possible benefit...
  46. ncbi request reprint Results of deep brain stimulation for dystonia: a critical reappraisal
    Laurent Vercueil
    Neurological Department, Grenoble University Hospital, France
    Mov Disord 17:S89-93. 2002
    ..A careful assessment of the efficacy by using improved clinical scale is also warranted...
  47. ncbi request reprint Mechanisms of deep brain stimulation
    Alim L Benabid
    Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble, France
    Mov Disord 17:S73-4. 2002
    ..It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments...
  48. ncbi request reprint Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
  49. ncbi request reprint Deep brain stimulation: what does it offer?
    Alim Louis Benabid
    Department of Clinical Neurosciences, University Joseph Fourier, Grenoble, France
    Adv Neurol 91:293-302. 2003
  50. ncbi request reprint Effects of subthalamic nucleus stimulation on actual and imagined movement in Parkinson's disease : a PET study
    Stephane Thobois
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, Lyon
    J Neurol 249:1689-98. 2002
    ..PET studies in moderately affected Parkinson's disease (PD) patients reveal abnormal cerebral activation during motor execution and imagery, but the effects of subthalamic nucleus (STN) stimulation are not well established...
  51. ncbi request reprint A probabilistic functional atlas of the human subthalamic nucleus
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Institute for Infocomm Research 21 Heng Hui Keng Terrace, Singapore
    Neuroinformatics 2:381-98. 2004
    ..The presented method is general and can be applied for constructing human and animal probabilistic brain atlases...
  52. ncbi request reprint Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Mov Disord 18:524-30. 2003
    ....
  53. ncbi request reprint Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia
    Marie Vidailhet
    Department of Neurology, Saint Antoine Hospital, Paris, France
    N Engl J Med 352:459-67. 2005
    ..Severe forms of dystonia respond poorly to medical treatment. Deep-brain stimulation is a reversible neurosurgical procedure that has been used for the treatment of dystonia, but assessment of its efficacy has been limited to open studies...
  54. ncbi request reprint Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria
    Michèle Gentil
    INSERM, Unit 318, CHU, Service neurologie, BP 217 38043, Grenoble Cedex 9, France
    Brain Lang 85:190-6. 2003
    ..We also noted a large beneficial effect on voice with a significant improvement in respiratory and phonatory functions...
  55. ncbi request reprint Role of dopaminergic treatment in dopamine receptor down-regulation in advanced Parkinson disease: a positron emission tomographic study
    Stephane Thobois
    Neurological Department D, The Pierre Wertheimer Neurological Hospital and INSERM U 534, Lyon, France
    Arch Neurol 61:1705-9. 2004
    ....
  56. ncbi request reprint Young-onset Parkinson disease with and without parkin gene mutations: a fluorodopa F 18 positron emission tomography study
    Stephane Thobois
    Service de Neurologie D and Cycloton Unit, CERMEP, Hopital Neurologique Pierre Wertheimer, Lyon, France
    Arch Neurol 60:713-8. 2003
    ..Mutations of the parkin gene are frequently encountered in patients with young-onset Parkinson disease (YOPD), but the effects of this mutation on the nigrostriatal dopaminergic degeneration are not well established...
  57. ncbi request reprint Globus pallidus internus stimulation in primary generalized dystonia: a H215O PET study
    Olivier Detante
    Department of Biological and Clinical Neurosciences, Grenoble University Hospital, Grenoble, France
    Brain 127:1899-908. 2004
    ..According to the present study, generalized dystonia is associated with prefrontal overactivation which can be reversed by effective GPi DBS...
  58. ncbi request reprint Off-period dystonia in Parkinson's disease but not generalized dystonia is improved by high-frequency stimulation of the subthalamic nucleus
    Olivier Detante
    Department of Biological and Clinical Neurosciences, INSERM, Joseph Fourier University, Department of Neurology, CHU Grenoble, Grenoble, France
    Adv Neurol 94:309-14. 2004
    ..Assuming that the mechanism of action of STN-HFS is similar regardless of the cause of dystonia, our findings suggest that the STN is not similarly involved in off-period dystonia of IPD and others dystonias...
  59. ncbi request reprint [Therapeutic and physiopathological contribution of electric stimulation of deep brain structures in Parkinson's disease]
    Alim Louis Benabid
    Pavillon B, CHU Albert Michalon 38043 Grenoble
    Bull Acad Natl Med 187:305-19; discussion 319-22. 2003
    ..Moreover the physiopathogenic hypothesis suggests the possibility of a neuroprotective effect of the stimulation, which still needs to be clearly established at the experimental level as well as at the level of clinical applications...
  60. ncbi request reprint Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study
    Serge Pinto
    INSERM U318, Grenoble, France
    Brain 127:602-15. 2004
    ..STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson's disease dysarthria...
  61. ncbi request reprint Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
    ..Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown...
  62. ncbi request reprint Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
    Serge Pinto
    Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
    Mov Disord 20:1507-15. 2005
    ..These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems...
  63. ncbi request reprint Utility of the Mattis dementia rating scale to assess the efficacy of rivastigmine in dementia associated with Parkinson's disease
    Kathy Dujardin
    Neurology and Movement Disorders Unit, Faculty of Medicine and Lille University Hospital, EA2683, Lille, France
    J Neurol 253:1154-9. 2006
    ....
  64. ncbi request reprint Bilateral subthalamic stimulation effects on oral force control in Parkinson's disease
    Serge Pinto
    Service de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    J Neurol 250:179-87. 2003
    ..Nevertheless, to confirm the persistence of the beneficial effect of STN stimulation on parkinsonian dysarthria, a longitudinal evaluation is still needed...
  65. ncbi request reprint Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography
    Sorin Breit
    INSERM U 318, Department of Neurobiology, University Joseph Fourier, Grenoble, France
    Neurosurgery 58:ONS83-95. 2006
    ..The purpose of this study was to evaluate the accuracy of the preoperative MRI targeting as compared with ventriculography in terms of both the STN target as well as the internal landmarks...
  66. ncbi request reprint LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans
    Suzanne Lesage
    Institut National de la Santé et de la Recherche Médicale Unité 679, Neurology and Experimental Therapeutics, and Faculté de Médecine, Universite Pierre et Marie Curie, 75651 Paris Cedex 13, France
    Arch Neurol 64:425-30. 2007
    ..Mutations in leucine-rich repeat kinase 2 gene (LRRK2), particularly the G2019S mutation in exon 41, have been detected in familial and sporadic Parkinson disease (PD) cases...
  67. ncbi request reprint LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
    Suzanne Lesage
    N Engl J Med 354:422-3. 2006
  68. ncbi request reprint G2019S LRRK2 mutation in French and North African families with Parkinson's disease
    Suzanne Lesage
    Institut National de la Sante et de la Recherche Médicale U679 formerly U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris
    Ann Neurol 58:784-7. 2005
    ..There were also 15 unaffected mutation carriers, aged 32 to 74 years. LRRK2 mutations appear to be a common cause of autosomal dominant PD, particularly in North Africa...
  69. ncbi request reprint Head tremor in Parkinson's disease
    Emmanuel Roze
    Department of Neurology, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Mov Disord 21:1245-8. 2006
    ..We describe five patients with Parkinson's disease and head tremor in whom clinical and neurophysiological findings suggested that head tremor was a manifestation of Parkinson's disease...
  70. ncbi request reprint Reliability of the Burke-Fahn-Marsden scale in a multicenter trial for dystonia
    Pierre Krystkowiak
    Department of Neurology and Movement Disorders, Lille University Medical Center, Lille, France
    Mov Disord 22:685-9. 2007
    ..However, the reliability of this tool has rarely been evaluated and its use in a multicenter study has never been assessed prospectively...
  71. ncbi request reprint Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations
    Michael Schüpbach
    centre d investigation clinique, Hopital de la Pitie Salpetriere, AP HP, Paris, France
    Mov Disord 22:119-22. 2007
    ..Two patients with the G2019S LRRK2 mutation still benefited from STN stimulation, 9 and 10 years after surgery. Patients with LRRK2 mutations are, therefore, good candidates for STN stimulation...
  72. ncbi request reprint Effects of pulse width variations in pallidal stimulation for primary generalized dystonia
    Laurent Vercueil
    Neurology and Neurosurgery, CHU Grenoble, 38043 Grenoble, France
    J Neurol 254:1533-7. 2007
    ..Various pulse widths (from 60-450 mus) have been used for bilateral pallidal stimulation in generalized dystonia but, to date, no comparison of this parameter's effects is available...
  73. ncbi request reprint Statistical analysis of 168 bilateral subthalamic nucleus implantations by means of the probabilistic functional atlas
    Wieslaw L Nowinski
    Biomedical Imaging Laboratory, Institute for Infocomm Research, Singapore 119613, Singapore
    Neurosurgery 57:319-30; discussion 319-30. 2005
    ..These results may potentially be useful in planning subthalamic implantation of electrodes...
  74. ncbi request reprint Deep brain stimulation for dystonia: make the lame walk
    Marie Vidailhet
    Ann Neurol 57:613-4. 2005